Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 16, 2017, Pages E3285-E3294

  Nagata, Masahiro ^a   Izumi, Yoshihiro ^a   Ishikawa, Eri ^a   Kiyotake, Ryoko ^a   Doi, Rieko ^a   Iwai, Satoru ^a   Omahdi, Zakaria ^a   Yamaji, Toshiyuki ^b   Miyamoto, Tomofumi ^a   Bamba, Takeshi ^a   Yamasaki, Sho ^a,c,d  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d CHIBA UNIVERSITY   (Japan)

Author keywords

C type lectin receptors; Ceramides; Gaucher disease; Glycolipids; Inflammation

Indexed keywords

APC PROTEIN; B7 ANTIGEN; BETA GLUCOSYLCERAMIDE; CD40 ANTIGEN; CD86 ANTIGEN; CXCL3 CHEMOKINE; GALACTOSE; GAMMA INTERFERON; GLUCOSE; GLUCOSYLCERAMIDASE; INTERLEUKIN 17; LECTIN RECEPTOR; LIGAND; MACROPHAGE INDUCIBLE C TYPE LECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CLECSF8 PROTEIN, MOUSE; CYTOKINE; GLUCOSYLCERAMIDE; LECTIN; MEMBRANE PROTEIN;

ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CELL DAMAGE; CELL DEATH; CHEMICAL STRUCTURE; CYTOKINE PRODUCTION; DENDRITIC CELL; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; MASS SPECTROMETRY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; THIN LAYER CHROMATOGRAPHY; THYMOCYTE; THYMUS; UPREGULATION; ANIMAL; C57BL MOUSE; IMMUNIZATION; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CYTOKINES; DENDRITIC CELLS; GLUCOSYLCERAMIDASE; GLUCOSYLCERAMIDES; IMMUNIZATION; INFLAMMATION; LECTINS, C-TYPE; LIGANDS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 85017654440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1618133114     Document Type: Article

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