Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 37, 2014, Pages 13433-13438

  Brennan, Patrick J ^a   Tatituri, Raju V V ^a   Heiss, Christian ^b   Watts, Gerald F M ^a   Hsu, Fong Fu ^c   Veerapen, Natacha ^d   Cox, Liam R ^d   Azadi, Parastoo ^d   Besra, Gurdyal S ^d   Brenner, Michael B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSYLCERAMIDASE; GLUCOSYLCERAMIDE;

ANIMAL; BOVINE; CHEMISTRY; DRUG EFFECTS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; METABOLISM; MILK; MOUSE; NATURAL KILLER T CELL; THIN LAYER CHROMATOGRAPHY;

ANIMALS; CATTLE; CHROMATOGRAPHY, THIN LAYER; GLUCOSYLCERAMIDASE; GLUCOSYLCERAMIDES; HUMANS; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; MICE; MILK; NATURAL KILLER T-CELLS;

EID: 84907289353     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415357111     Document Type: Article

References (39)

1. Young MH, Gapin L (2011) Group 1:CD1.
2. Brennan PJ, Brigl M, Brenner MB (2013) Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol 13(2):101-117.
3. Kawano T, et al. (1997) CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 278(5343):1626-1629.
4. Kinjo Y, et al. (2005) Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434(7032):520-525.
5. Mattner J, et al. (2005) Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434(7032):525-529.
6. Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR (2005) Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur J Immunol 35(6):1692-1701.
7. Kinjo Y, et al. (2006) Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol 7(9):978-986.
8. Kinjo Y, et al. (2011) Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 12(10):966-974.
9. Gapin L (2010) iNKT cell autoreactivity: What is 'self' and how is it recognized? Nat Rev Immunol 10(4):272-277.
10. Zhou D, et al. (2004) Lysosomal glycosphingolipid recognition by NKT cells. Science 306(5702):1786-1789.
11. Fox LM, et al. (2009) Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol 7(10):e1000228.
12. Facciotti F, et al. (2012) Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol 13(5):474-480.
13. Brennan PJ, et al. (2011) Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol 12(12):1202-1211.
14. Sanderson JP, et al. (2013) CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells. Eur J Immunol 43(3):815-825.
15. Wang J, et al. (2010) Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci USA 107(4):1535-1540.
16. Dawson G, Kruski AW, Scanu AM (1976) Distribution of glycosphingolipids in the serum lipoproteins of normal human subjects and patients with hypo- and hyperlipidemias. J Lipid Res 17(2):125-131.
17. Ishibashi Y, Kohyama-Koganeya A, Hirabayashi Y (2013) New insights on glucosylated lipids: Metabolism and functions. Biochim Biophys Acta 1831(9):1475-1485.
18. Quehenberger O, Dennis EA (2011) The human plasma lipidome. N Engl J Med 365(19):1812-1823.
19. Sullards MC, Lynch DV, Merrill AH, Jr, Adams J (2000) Structure determination of soybean and wheat glucosylceramides by tandem mass spectrometry. J Mass Spectrom 35(3):347-353.
20. Yu ED, et al. (2012) Structural basis for the recognition of C20:2-αGalCer by the invariant natural killer T cell receptor-like antibody L363. J Biol Chem 287(2):1269-1278.
21. Yu KO, et al. (2007) Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d. J Immunol Methods 323(1):11-23.
22. Hölzl G, et al. (2005) Processive lipid galactosyl/glucosyltransferases from Agrobacterium tumefaciens and Mesorhizobium loti display multiple specificities. Glycobiology 15(9):874-886.
23. Veerapen N, Reddington F, Bricard G, Porcelli SA, Besra GS (2010) Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha- D-galactosyl ceramide KRN7000. Bioorg Med Chem Lett 20(11):3223-3226.
24. Watanabe K, Matsubara T, Hakomori S (1976) alpha-L-Fucopyranosylceramide, a novel glycolipid accumulated in some of the human colon tumors. J Biol Chem 251(8): 2385-2387.
25. Beckman EM, et al. (1994) Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. Nature 372(6507):691-694.
26. Bendelac A, et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268(5212):863-865.
27. Chang YJ, et al. (2011) Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. J Clin Invest 121(1):57-69.
28. Ito Y, et al. (2013) Helicobacter pylori cholesteryl α-glucosides contribute to its pathogenicity and immune response by natural killer T cells. PLoS ONE 8(12):e78191.
29. An D, et al. (2014) Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 156(1-2):123-133.
30. Wieland Brown LC, et al. (2013) Production of α-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol 11(7):e1001610.
31. Pellicci DG, et al. (2011) Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol 12(9):827-833.
32. Yu ED, Girardi E, Wang J, Zajonc DM (2011) Cutting edge: Structural basis for the recognition of β-linked glycolipid antigens by invariant NKT cells. J Immunol 187(5): 2079-2083.
33. Albacker LA, et al. (2013) Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nat Med 19(10):1297-1304.
34. Vesper H, et al. (1999) Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J Nutr 129(7):1239-1250.
35. Courtney AN, et al. (2009) Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens. Vaccine 27(25-26): 3335-3341.
36. Silk JD, et al. (2004) Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy. J Clin Invest 114(12):1800-1811.
37. Wei B, et al. (2010) Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. J Immunol 184(3):1218-1226.
38. Wingender G, et al. (2012) Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice. Gastroenterology 143(2):418-428.
39. Jyonouchi S, et al. (2011) Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. J Allergy Clin Immunol 128(1):102-109.