Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis

Journal of Biological Chemistry

Volumn 282, Issue 5, 2007, Pages 3083-3094

  Jennemann, Richard ^a   Sandhoff, Roger ^a   Langbein, Lutz ^a   Kaden, Sylvia ^a   Rothermel, Ulrike ^a   Gallala, Hichem ^b   Sandhoff, Konrad ^b   Wiegandt, Herbert ^a   Gröne, Hermann Josef ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLCCER SYNTHESIS; STRATUM CORNEUM; STRATUM GRANULOSUM;

FATTY ACIDS; MAMMALS; PROTEINS; SKIN; SYNTHESIS (CHEMICAL);

AMIDES;

CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; GLUCOSYLCERAMIDE; LIPID; SPHINGOMYELIN; URIDINE DIPHOSPHATE GLUCOSE; GLUCOSYLTRANSFERASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DEATH; DESQUAMATION; ENZYME DEFICIENCY; EPIDERMIS; INTRACELLULAR SPACE; KERATINOCYTE; LAMELLAR BODY; MOUSE; NONHUMAN; PERINATAL PERIOD; PERMEABILITY BARRIER; PRIORITY JOURNAL; SKIN WATER LOSS; STRATUM CORNEUM; ANIMAL; ENZYMOLOGY; EXON; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ANIMALIA; MAMMALIA;

ANIMALS; BASE SEQUENCE; EPIDERMIS; EXONS; GENOTYPE; GLUCOSYLCERAMIDES; GLUCOSYLTRANSFERASES; LIPIDS; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN PHYSIOLOGY;

EID: 33846912073     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610304200     Document Type: Article

References (48)

1. Yamashita, T., Wada, R., Sasaki, T., Deng, C., Bierfreund, U., Sandhoff, K., and Proia, R. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9142-9147
2. Jennemann, R., Sandhoff, R., Wang, S., Kiss, E., Gretz, N., Zuliani, C., Martin-Villalba, A., Jager, R., Schorle, H., Kenzelmann, M., Bonrouhi, M., Wiegandt, H., and Grone, H. J. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 12459-12464
3. Yamashita, T., Allende, M. L., Kalkofen, D. N., Werth, N., Sandhoff, K., and Proia, R. L. (2005) Genesis 43, 175-180
4. Futerman, A. H., and Pagano, R. E. (1991) Biochem. J. 280, 295-302
5. Jeckel, D., Karrenbauer, A., Burger, K. N., van Meer, G., and Wieland, F. (1992) J. Cell Biol. 117, 259-267
6. Madison, K. C., Wertz, P. W., Strauss, J. S., and Downing, D. T. (1986) J. Investig. Dermatol. 87, 253-259
7. Doering, T., Proia, R. L., and Sandhoff, K. (1999) FEBS Lett. 447, 167-170
8. Grayson, S., Johnson-Winegar, A. G., Wintroub, B. U., Isseroff, R. R., Epstein, E. H., Jr., and Elias, P. M. (1985) J. Investig. Dermatol. 85, 289-294
9. Holleran, W. M., Takagi, Y., Menon, G. K., Legler, G., Feingold, K. R., and Elias, P. M. (1993) J. Clin. Investig. 91, 1656-1664
10. Bouwstra, J. A., Honeywell-Nguyen, P. L., Gooris, G. S., and Ponec, M. (2003) Prog. Lipid Res. 42, 1-36
11. Madison, K. C. (2003) J. Investig. Dermatol. 121, 231-241
12. Doering, T., Holleran, W. M., Potratz, A., Vielhaber, G., Elias, P. M., Suzuki, K., and Sandhoff, K. (1999) J. Biol. Chem. 274, 11038-11045
13. Schuette, C. G., Doering, T., Kolter, T., and Sandhoff, K. (1999) Biol. Chem. 380, 759-766
14. Marekov, L. N., and Steinert, P. M. (1998) J. Biol. Chem. 273, 17763-17770
15. Candi, E., Schmidt, R., and Melino, G. (2005) Nat. Rev. Mol. Cell Biol. 6, 328-340
16. Byrne, C., Tainsky, M., and Fuchs, E. (1994) Development 120, 2369-2383
17. McGowan, K. M., and Coulombe, P. A. (1998) J. Cell Biol. 143, 469-486
18. Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., and Birchmeier, W. (2001) Cell 105, 533-545
19. Indra, A. K., Li, M., Brocard, J., Warot, X., Bornert, J. M., Gerard, C., Messaddeq, N., Chambon, P., and Metzger, D. (2000) Horm. Res. (Basel) 54, 296-300
20. Li, M., Indra, A. K., Warot, X., Brocard, J., Messaddeq, N., Kato, S., Metzger, D., and Chambon, P. (2000) Nature 407, 633-636
21. Diaz, L. A., Heaphy, M. R., Calvanico, N. J., Tomasi, T. B., and Jordon, R. E. (1977) J. Investig. Dermatol. 68, 36-38
22. Mertens, A. E., Rygiel, T. P., Olivo, C., van der Kammen, R., and Collard, J. G. (2005) J. Cell Biol. 170, 1029-1037
23. Jennemann, R., Mennel, H. D., Bauer, B. L., and Wiegandt, H. (1994) Acta Neurochir. 126, 170-178
24. Jennemann, R., Rodden, A., Bauer, B. L., Mennel, H. D., and Wiegandt, H. (1990) Cancer Res. 50, 7444-7449
25. Brugger, B., Erben, G., Sandhoff, R., Wieland, F. T., and Lehmann, W. D. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2339-2344
26. Sandhoff, R., Hepbildikler, S. T., Jennemann, R., Geyer, R., Gieselmann, V., Proia, R. L., Wiegandt, H., and Grone, H. J. (2002) J. Biol. Chem. 277, 20386-20398
27. Herrmann, T., van der Hoeven, F., Grone, H. J., Stewart, A. F., Langbein, L., Kaiser, I., Liebisch, G., Gosch, I., Buchkremer, F., Drobnik, W., Schmitz, G., and Stremmel, W. (2003) J. Cell Biol. 161, 1105-1115
28. Matsuki, M., Yamashita, F., Ishida-Yamamoto, A., Yamada, K., Kinoshita, C., Fushiki, S., Ueda, E., Morishima, Y., Tabata, K., Yasuno, H., Hashida, M., Iizuka, H., Ikawa, M., Okabe, M., Kondoh, G., Kinoshita, T., Takeda, J., and Yamanishi, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1044-1049
29. Langbein, L., Rogers, M. A., Praetzel, S., Winter, H., and Schweizer, J. (2003) J. Investig. Dermatol. 120, 512-522
30. Langbein, L., and Schweizer, J. (2005) Int. Rev. Cytol. 243, 1-78
31. Langbein, L., Grund, C., Kuhn, C., Praetzel, S., Kartenbeck, J., Brandner, J. M., Moll, I., and Franke, W. W. (2002) Eur. J. Cell Biol. 81, 419-435
32. Hanley, K., Jiang, Y., Holleran, W. M., Elias, P. M., Williams, M. L., and Feingold, K. R. (1997) J. Lipid Res. 38, 576-584
33. Doering, T., Brade, H., and Sandhoff, K. (2002) J. Lipid Res. 43, 1727-1733
34. Elias, P. M., Brown, B. E., Fritsch, P., Goerke, J., Gray, G. M., and White, R. J. (1979) J. Investig. Dermatol. 73, 339-348
35. Vielhaber, G., Pfeiffer, S., Brade, L., Lindner, B., Goldmann, T., Vollmer, E., Hintze, U., Wittern, K. P., and Wepf, R. (2001) J. Investig. Dermatol. 117, 1126-1136
36. Freinkel, R. K., and Traczyk, T. N. (1985) J. Investig. Dermatol. 85, 295-298
37. Holleran, W. M., Ginns, E. I., Menon, G. K., Grundmann, J. U., Fartasch, M., McKinney, C. E., Elias, P. M., and Sidransky, E. (1994) J. Clin. Investig. 93, 1756-1764
38. Uchida, Y., Hara, M., Nishio, H., Sidransky, E., Inoue, S., Otsuka, F., Suzuki, A., Elias, P. M., Holleran, W. M., and Hamanaka, S. (2000) J. Lipid Res. 41, 2071-2082
39. Potten, C. S. (1981) Int. Rev. Cytol. 69, 271-318
40. Chujor, C. S., Feingold, K. R., Elias, P. M., and Holleran, W. M. (1998) J. Lipid Res. 39, 277-285
41. Sprong, H., Degroote, S., Claessens, T., van Drunen, J., Oorschot, V., Westerink, B. H., Hirabayashi, Y., Klumperman, J., van der Sluijs, P., and van Meer, G. (2001) J. Cell Biol. 155, 369-380
42. Tamboli, I. Y., Prager, K., Barth, E., Heneka, M., Sandhoff, K., and Walter, J. (2005) J. Biol. Chem. 280, 28110-28117
43. Furuse, M., and Tsukita, S. (2006) Trends Cell Biol. 16, 181-188
44. Kirfel, J., Magin, T. M., and Reichelt, J. (2003) Cell. Mol. Life Sci. 60, 56-71
45. Ku, N. O., Michie, S., Resurreccion, E. Z., Broome, R. L., and Omary, M. B. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 4373-4378
46. Tsukita, S., Furuse, M., and Itoh, M. (2001) Nat. Rev. Mol. Cell Biol. 2, 285-293
47. Lorand, L., and Graham, R. M. (2003) Nat. Rev. Mol. Cell Biol. 4, 140-156
48. Schweizer, J., Bowden, P. E., Coulombe, P. A., Langbein, L., Lane, E. B., Magin, T. M., Maltais, L., Omary, M. B., Parry, D. A., Rogers, M. A., and Wright, M. W. (2006) J. Cell Biol. 174, 169-174