Human mincle binds to cholesterol crystals and triggers innate immune responses

Journal of Biological Chemistry

Volumn 290, Issue 42, 2015, Pages 25322-25332

  Kiyotake, Ryoko ^a,b   Oh Hora, Masatsugu ^a   Ishikawa, Eri ^a   Miyamoto, Tomofumi ^a   Ishibashi, Tatsuro ^b   Yamasaki, Sho ^a,c  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ANALYSIS; CHOLESTEROL; CRYSTALS; CYTOLOGY; LIGANDS; MACROPHAGES; PATTERN RECOGNITION; PROTEINS;

CHOLESTEROL CRYSTALS; HUMAN DENDRITIC CELLS; INFLAMMATORY GENES; INFLAMMATORY RESPONSE; INNATE IMMUNE RESPONSE; MURINE MACROPHAGES; PATTERN RECOGNITION RECEPTORS; PRO-INFLAMMATORY CYTOKINES;

IMMUNE SYSTEM;

CHOLESTEROL; CYTOKINE; INNATE IMMUNE RECEPTOR; LECTIN; LIPID; MINCLE; PATTERN RECOGNITION RECEPTOR; UNCLASSIFIED DRUG; AUTACOID; CLEC4D PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; PROTEIN BINDING;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; LIVER; LYSOSOME; MACROPHAGE; MASS SPECTROMETRY; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; ANIMAL; CELL LINE; CHEMISTRY; CRYSTALLIZATION; GENETIC TRANSCRIPTION; METABOLISM;

ANIMALS; CELL LINE; CHOLESTEROL; CRYSTALLIZATION; HUMANS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; LECTINS, C-TYPE; MICE; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; TRANSCRIPTION, GENETIC;

EID: 84944463360     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.645234     Document Type: Article

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