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Volumn 46, Issue , 2017, Pages 14-22

Metabolic reprograming of anti-tumor immunity

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ACTIVITY; CELL DESTRUCTION; CELL METABOLISM; HUMAN; IMMUNOTHERAPY; MODULATION; T LYMPHOCYTE; TUMOR CELL; TUMOR IMMUNITY; TUMOR RESISTANCE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; ENERGY METABOLISM; IMMUNITY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MITOCHONDRION; NEOPLASM; PATHOLOGY; PROCEDURES; TREATMENT OUTCOME; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT;

EID: 85017464655     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2017.03.011     Document Type: Review
Times cited : (79)

References (61)
  • 1
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: a question of life or death
    • 1 Mehlen, P., Puisieux, A., Metastasis: a question of life or death. Nat Rev Cancer 6 (2006), 449–458.
    • (2006) Nat Rev Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 2
    • 0036307010 scopus 로고    scopus 로고
    • Second and subsequent lines of chemotherapy for metastatic breast cancer: what did we learn in the last two decades?
    • 2 Cardoso, F., et al. Second and subsequent lines of chemotherapy for metastatic breast cancer: what did we learn in the last two decades?. Ann Oncol 13 (2002), 197–207.
    • (2002) Ann Oncol , vol.13 , pp. 197-207
    • Cardoso, F.1
  • 3
    • 84904694305 scopus 로고    scopus 로고
    • Drug resistance to molecular targeted therapy and its consequences for treatment decisions in non-small-cell lung cancer
    • 3 Spaans, J.N., Goss, G.D., Drug resistance to molecular targeted therapy and its consequences for treatment decisions in non-small-cell lung cancer. Front Oncol, 4, 2014, 190.
    • (2014) Front Oncol , vol.4 , pp. 190
    • Spaans, J.N.1    Goss, G.D.2
  • 4
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • An update on recent developments in the field of adoptive immunotherapy using conventional T cell receptors to treat melanoma and other common epithelial cancers.
    • 4• Rosenberg, S.A., Restifo, N.P., Adoptive cell transfer as personalized immunotherapy for human cancer. Science 348 (2015), 62–68 An update on recent developments in the field of adoptive immunotherapy using conventional T cell receptors to treat melanoma and other common epithelial cancers.
    • (2015) Science , vol.348 , pp. 62-68
    • Rosenberg, S.A.1    Restifo, N.P.2
  • 5
    • 79952304769 scopus 로고    scopus 로고
    • Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
    • 5 Robbins, P.F., et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol 29 (2011), 917–924.
    • (2011) J Clin Oncol , vol.29 , pp. 917-924
    • Robbins, P.F.1
  • 6
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • 6 Sharma, P., Allison, J.P., The future of immune checkpoint therapy. Science 348 (2015), 56–61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 7
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • 7 Kochenderfer, J.N., et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 119 (2012), 2709–2720.
    • (2012) Blood , vol.119 , pp. 2709-2720
    • Kochenderfer, J.N.1
  • 8
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • 8 Grupp, S.A., et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 368 (2013), 1509–1518.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1
  • 9
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • 9 Rosenberg, S.A., et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res 17 (2011), 4550–4557.
    • (2011) Clin Cancer Res , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1
  • 10
    • 85002396993 scopus 로고    scopus 로고
    • T-cell transfer therapy targeting mutant KRAS in cancer
    • 10 Tran, E., et al. T-cell transfer therapy targeting mutant KRAS in cancer. N Engl J Med 375 (2016), 2255–2262.
    • (2016) N Engl J Med , vol.375 , pp. 2255-2262
    • Tran, E.1
  • 11
    • 84961736633 scopus 로고    scopus 로고
    • Emerging concepts of T cell metabolism as a target of immunotherapy
    • This comprehensive review covers the basic metabolic pathways in T cells, and discusses about the relationship between metabolism and T cell function and longevity and covers discussions in which T cells might be manipulated by the reprogramming of metabolic pathways for therapeutic purposes.
    • 11•• Chang, C.H., Pearce, E.L., Emerging concepts of T cell metabolism as a target of immunotherapy. Nat Immunol 17 (2016), 364–368 This comprehensive review covers the basic metabolic pathways in T cells, and discusses about the relationship between metabolism and T cell function and longevity and covers discussions in which T cells might be manipulated by the reprogramming of metabolic pathways for therapeutic purposes.
    • (2016) Nat Immunol , vol.17 , pp. 364-368
    • Chang, C.H.1    Pearce, E.L.2
  • 12
    • 80053997259 scopus 로고    scopus 로고
    • A human memory T cell subset with stem cell-like properties
    • 12 Gattinoni, L., et al. A human memory T cell subset with stem cell-like properties. Nat Med 17 (2011), 1290–1297.
    • (2011) Nat Med , vol.17 , pp. 1290-1297
    • Gattinoni, L.1
  • 13
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • 13 Pearce, E.L., et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460 (2009), 103–107.
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1
  • 14
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • 14 Michalek, R.D., et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol 186 (2011), 3299–3303.
    • (2011) J Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1
  • 15
    • 84899095306 scopus 로고    scopus 로고
    • The short and sweet of T-cell therapy: restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
    • 15 Sukumar, M., Gattinoni, L., The short and sweet of T-cell therapy: restraining glycolysis enhances the formation of immunological memory and antitumor immune responses. Oncoimmunology, 3, 2016, e27573.
    • (2016) Oncoimmunology , vol.3 , pp. e27573
    • Sukumar, M.1    Gattinoni, L.2
  • 16
    • 41149097574 scopus 로고    scopus 로고
    • Adoptive cell transfer: a clinical path to effective cancer immunotherapy
    • 16 Rosenberg, S.A., et al. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 8 (2008), 299–308.
    • (2008) Nat Rev Cancer , vol.8 , pp. 299-308
    • Rosenberg, S.A.1
  • 17
    • 22144437688 scopus 로고    scopus 로고
    • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells
    • 17 Klebanoff, C.A., et al. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A 102 (2005), 9571–9576.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9571-9576
    • Klebanoff, C.A.1
  • 18
    • 67650465237 scopus 로고    scopus 로고
    • Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
    • 18 Gattinoni, L., et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med 15 (2009), 808–813.
    • (2009) Nat Med , vol.15 , pp. 808-813
    • Gattinoni, L.1
  • 19
    • 47649122633 scopus 로고    scopus 로고
    • Tumor-specific Th17-polarized cells eradicate large established melanoma
    • 19 Muranski, P., et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112 (2008), 362–373.
    • (2008) Blood , vol.112 , pp. 362-373
    • Muranski, P.1
  • 20
    • 84955396567 scopus 로고    scopus 로고
    • Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy
    • This study has shown that the level of mitochondrial membrane potential (ΔΨm) in T cells and HSC may regulate the stemness, differentiation and functionality, with low-ΔΨm is associated with enhanced stemness (TSCM and LT-HSC), while high-ΔΨm is associated with increased differentiation, cytokine production, ROS and oxidative stress.
    • 20•• Sukumar, M., et al. Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy. Cell Metab 23 (2016), 63–76 This study has shown that the level of mitochondrial membrane potential (ΔΨm) in T cells and HSC may regulate the stemness, differentiation and functionality, with low-ΔΨm is associated with enhanced stemness (TSCM and LT-HSC), while high-ΔΨm is associated with increased differentiation, cytokine production, ROS and oxidative stress.
    • (2016) Cell Metab , vol.23 , pp. 63-76
    • Sukumar, M.1
  • 21
    • 33644746220 scopus 로고    scopus 로고
    • Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    • 21 Luckey, C.J., et al. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A 103 (2006), 3304–3309.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3304-3309
    • Luckey, C.J.1
  • 22
    • 84991677482 scopus 로고    scopus 로고
    • Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
    • 22 Vannini, N., et al. Specification of haematopoietic stem cell fate via modulation of mitochondrial activity. Nat Commun, 7, 2016, 13125.
    • (2016) Nat Commun , vol.7 , pp. 13125
    • Vannini, N.1
  • 23
    • 85008450490 scopus 로고    scopus 로고
    • Oxidative status predicts quality in human mesenchymal stem cells
    • 23 Bertolo, A., et al. Oxidative status predicts quality in human mesenchymal stem cells. Stem Cell Res Ther, 8, 2017, 3.
    • (2017) Stem Cell Res Ther , vol.8 , pp. 3
    • Bertolo, A.1
  • 24
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • 24 Tothova, Z., et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128 (2007), 325–339.
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1
  • 25
    • 7244250309 scopus 로고    scopus 로고
    • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    • 25 Ito, K., et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431 (2004), 997–1002.
    • (2004) Nature , vol.431 , pp. 997-1002
    • Ito, K.1
  • 26
    • 84874242919 scopus 로고    scopus 로고
    • Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
    • 26 Sena, L.A., et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 38 (2013), 225–236.
    • (2013) Immunity , vol.38 , pp. 225-236
    • Sena, L.A.1
  • 27
    • 84924975551 scopus 로고    scopus 로고
    • Mitochondria in the regulation of innate and adaptive immunity
    • 27 Weinberg, S.E., Sena, L.A., Chandel, N.S., Mitochondria in the regulation of innate and adaptive immunity. Immunity 42 (2015), 406–417.
    • (2015) Immunity , vol.42 , pp. 406-417
    • Weinberg, S.E.1    Sena, L.A.2    Chandel, N.S.3
  • 28
    • 84963525930 scopus 로고    scopus 로고
    • Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation
    • 28 Pollizzi, K.N., et al. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nat Immunol 17 (2016), 704–711.
    • (2016) Nat Immunol , vol.17 , pp. 704-711
    • Pollizzi, K.N.1
  • 29
    • 84964527036 scopus 로고    scopus 로고
    • Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
    • 29 Verbist, K.C., et al. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature 532 (2016), 389–393.
    • (2016) Nature , vol.532 , pp. 389-393
    • Verbist, K.C.1
  • 30
    • 84955561490 scopus 로고    scopus 로고
    • Modulation of mTOR signalling triggers the formation of stem cell-like memory T cells
    • 30 Scholz, G., et al. Modulation of mTOR signalling triggers the formation of stem cell-like memory T cells. EBioMedicine 4 (2016), 50–61.
    • (2016) EBioMedicine , vol.4 , pp. 50-61
    • Scholz, G.1
  • 31
    • 80051997049 scopus 로고    scopus 로고
    • The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    • 31 Yang, K., et al. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol 12 (2011), 888–897.
    • (2011) Nat Immunol , vol.12 , pp. 888-897
    • Yang, K.1
  • 32
    • 67650074206 scopus 로고    scopus 로고
    • mTOR regulates memory CD8 T-cell differentiation
    • 32 Araki, K., et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460 (2009), 108–112.
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1
  • 33
    • 84929008302 scopus 로고    scopus 로고
    • mTORC1 and mTORC2 selectively regulate CD8(+) T cell differentiation
    • 33 Pollizzi, K.N., et al. mTORC1 and mTORC2 selectively regulate CD8(+) T cell differentiation. J Clin Invest 125 (2015), 2090–2108.
    • (2015) J Clin Invest , vol.125 , pp. 2090-2108
    • Pollizzi, K.N.1
  • 34
    • 84907886513 scopus 로고    scopus 로고
    • Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs
    • 34 Shrestha, S., et al. Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs. Proc Natl Acad Sci U S A 111 (2014), 14858–14863.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 14858-14863
    • Shrestha, S.1
  • 35
    • 74649085700 scopus 로고    scopus 로고
    • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
    • 35 Rao, R.R., et al. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 32 (2010), 67–78.
    • (2010) Immunity , vol.32 , pp. 67-78
    • Rao, R.R.1
  • 36
    • 84978148203 scopus 로고    scopus 로고
    • A guide to immunometabolism for immunologists
    • An elegant review that discusses the recent advances in the field of immunometabolism. This review covers the complex interplay between metabolic reprogramming and immunity, providing a better understanding of the immune system in health and disease.
    • 36• O'Neill, L.A., Kishton, R.J., Rathmell, J., A guide to immunometabolism for immunologists. Nat Rev Immunol 16 (2016), 553–565 An elegant review that discusses the recent advances in the field of immunometabolism. This review covers the complex interplay between metabolic reprogramming and immunity, providing a better understanding of the immune system in health and disease.
    • (2016) Nat Rev Immunol , vol.16 , pp. 553-565
    • O'Neill, L.A.1    Kishton, R.J.2    Rathmell, J.3
  • 37
    • 84904057246 scopus 로고    scopus 로고
    • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
    • 37 Macintyre, A.N., et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab 20 (2014), 61–72.
    • (2014) Cell Metab , vol.20 , pp. 61-72
    • Macintyre, A.N.1
  • 38
    • 84920481006 scopus 로고    scopus 로고
    • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
    • 38 Gerriets, V.A., et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest 125 (2015), 194–207.
    • (2015) J Clin Invest , vol.125 , pp. 194-207
    • Gerriets, V.A.1
  • 39
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • 39 Wang, R., et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35 (2011), 871–882.
    • (2011) Immunity , vol.35 , pp. 871-882
    • Wang, R.1
  • 40
    • 84856183120 scopus 로고    scopus 로고
    • Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
    • 40 van der Windt, G.J., et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36 (2012), 68–78.
    • (2012) Immunity , vol.36 , pp. 68-78
    • van der Windt, G.J.1
  • 41
    • 84885055994 scopus 로고    scopus 로고
    • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
    • 41 Sukumar, M., et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest 123 (2013), 4479–4488.
    • (2013) J Clin Invest , vol.123 , pp. 4479-4488
    • Sukumar, M.1
  • 42
    • 84925688346 scopus 로고    scopus 로고
    • PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
    • This study provided the first evidence that upon PD-1 ligation, activated T cells had increased expression of CPT1a, fatty acid oxidation and are unable to engage in glycolysis. This study suggested that the enhancement of FAO may provide a mechanism for the longevity of T cells receiving PD-1 signals in patients with cancer.
    • 42• Patsoukis, N., et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun, 6, 2015, 6692 This study provided the first evidence that upon PD-1 ligation, activated T cells had increased expression of CPT1a, fatty acid oxidation and are unable to engage in glycolysis. This study suggested that the enhancement of FAO may provide a mechanism for the longevity of T cells receiving PD-1 signals in patients with cancer.
    • (2015) Nat Commun , vol.6 , pp. 6692
    • Patsoukis, N.1
  • 43
    • 84990861953 scopus 로고    scopus 로고
    • Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
    • 43 Peng, M., et al. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science 354 (2016), 481–484.
    • (2016) Science , vol.354 , pp. 481-484
    • Peng, M.1
  • 44
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • 44 Chang, C.H., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153 (2013), 1239–1251.
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1
  • 45
    • 84921044688 scopus 로고    scopus 로고
    • Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics
    • 45 Crompton, J.G., et al. Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics. Cancer Res 75 (2015), 296–305.
    • (2015) Cancer Res , vol.75 , pp. 296-305
    • Crompton, J.G.1
  • 46
    • 84962381625 scopus 로고    scopus 로고
    • Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism
    • 46 Yang, W., et al. Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature 531 (2016), 651–655.
    • (2016) Nature , vol.531 , pp. 651-655
    • Yang, W.1
  • 47
    • 84958648353 scopus 로고    scopus 로고
    • Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells
    • 47 Kawalekar, O.U., et al. Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells. Immunity 44 (2016), 380–390.
    • (2016) Immunity , vol.44 , pp. 380-390
    • Kawalekar, O.U.1
  • 48
    • 84976478216 scopus 로고    scopus 로고
    • Mitochondrial dynamics controls T cell fate through metabolic programming
    • This study demonstrated that mitochondrial ultrastructure controls T cell fate and metabolism. They showed that memory T cells have fused mitochondria and favored oxidative phosphorylation and FAO in memory T cells. In contrast, mitochondrial fission in effector cells leads to cristae expansion and promoted aerobic glycolysis. This is the first study suggesting that enforcing fusion can improve T cell based adoptive immunotherapy against tumors.
    • 48•• Buck, M.D., et al. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 166 (2016), 63–76 This study demonstrated that mitochondrial ultrastructure controls T cell fate and metabolism. They showed that memory T cells have fused mitochondria and favored oxidative phosphorylation and FAO in memory T cells. In contrast, mitochondrial fission in effector cells leads to cristae expansion and promoted aerobic glycolysis. This is the first study suggesting that enforcing fusion can improve T cell based adoptive immunotherapy against tumors.
    • (2016) Cell , vol.166 , pp. 63-76
    • Buck, M.D.1
  • 49
    • 84992478733 scopus 로고    scopus 로고
    • L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity
    • 49 Geiger, R., et al. L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity. Cell 167 (2016), 829–842.
    • (2016) Cell , vol.167 , pp. 829-842
    • Geiger, R.1
  • 50
    • 84941366350 scopus 로고    scopus 로고
    • Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
    • Together with Ref. [44], this paper describes the Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity. Chang CH  et al., demonstrated that checkpoint blockade antibodies against CTLA-4, PD-1, and PD-L1, restore glucose in tumor microenvironment, permitting T cell glycolysis and IFN-γ production. HO PC et al. shows that phosphoenolpyruvate carboxykinase 1 (PCK1) overexpression in T cells increased effector function that results in restricted tumor growth.
    • 50•• Ho, P.C., et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell 162 (2015), 1217–1228 Together with Ref. [44], this paper describes the Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity. Chang CH  et al., demonstrated that checkpoint blockade antibodies against CTLA-4, PD-1, and PD-L1, restore glucose in tumor microenvironment, permitting T cell glycolysis and IFN-γ production. HO PC et al. shows that phosphoenolpyruvate carboxykinase 1 (PCK1) overexpression in T cells increased effector function that results in restricted tumor growth.
    • (2015) Cell , vol.162 , pp. 1217-1228
    • Ho, P.C.1
  • 51
    • 84886672916 scopus 로고    scopus 로고
    • Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen
    • 51 Doedens, A.L., et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol 14 (2013), 1173–1182.
    • (2013) Nat Immunol , vol.14 , pp. 1173-1182
    • Doedens, A.L.1
  • 52
    • 84983806394 scopus 로고    scopus 로고
    • Oxygen sensing by T cells establishes an immunologically tolerant metastatic niche
    • 1117–1131.e14 This study demonstrated that inhibition of PHD Proteins in CD4+ T cells results in increased HIF1 activity, elevated aerobic glycolysis and heightened effector differentiation. Furthermore, this study highlighted that pharmacological inhibition of PHD proteins in CD4+ T cells can improve T cell effector function and adoptive cell transfer immunotherapy against B16 melanoma.
    • 52• Clever, D., et al. Oxygen sensing by T cells establishes an immunologically tolerant metastatic niche. Cell, 166, 2016 1117–1131.e14 This study demonstrated that inhibition of PHD Proteins in CD4+ T cells results in increased HIF1 activity, elevated aerobic glycolysis and heightened effector differentiation. Furthermore, this study highlighted that pharmacological inhibition of PHD proteins in CD4+ T cells can improve T cell effector function and adoptive cell transfer immunotherapy against B16 melanoma.
    • (2016) Cell , vol.166
    • Clever, D.1
  • 53
    • 84989172165 scopus 로고    scopus 로고
    • Ionic immune suppression within the tumour microenvironment limits T cell effector function
    • 53 Eil, R., et al. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature 537 (2016), 539–543.
    • (2016) Nature , vol.537 , pp. 539-543
    • Eil, R.1
  • 54
    • 84997706268 scopus 로고    scopus 로고
    • Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion
    • 54 Bengsch, B., et al. Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion. Immunity 45 (2016), 358–373.
    • (2016) Immunity , vol.45 , pp. 358-373
    • Bengsch, B.1
  • 55
    • 84997766028 scopus 로고    scopus 로고
    • The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
    • This study demonstrated that tumor infiltrating lymphocytes within mouse tumors display reduced levels of mitochondrial mass and metabolism. They further provided evidence that overexpression of PGC-1a in T cells increased mitochondrial biogenesis and effector function of T cells and anti-tumor immunity.
    • 55•• Scharping, N.E., et al. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Immunity 45 (2016), 374–388 This study demonstrated that tumor infiltrating lymphocytes within mouse tumors display reduced levels of mitochondrial mass and metabolism. They further provided evidence that overexpression of PGC-1a in T cells increased mitochondrial biogenesis and effector function of T cells and anti-tumor immunity.
    • (2016) Immunity , vol.45 , pp. 374-388
    • Scharping, N.E.1
  • 56
    • 84999751988 scopus 로고    scopus 로고
    • Constitutive glycolytic metabolism supports CD8+ T cell effector memory differentiation during viral infection
    • + T cell differentiation. By showing that glycolytic metabolism does not hinder differentiation of memory CD8+ T cells, this study proposes an interesting model where increased spare respiratory capacity and a reliance on OXPHOS are not essential for memory CD8+ T cells.
    • + T cell differentiation. By showing that glycolytic metabolism does not hinder differentiation of memory CD8+ T cells, this study proposes an interesting model where increased spare respiratory capacity and a reliance on OXPHOS are not essential for memory CD8+ T cells.
    • (2016) Immunity , vol.45 , pp. 1024-1037
    • Phan, A.T.1
  • 57
    • 0036707398 scopus 로고    scopus 로고
    • Is HIF-1alpha a pro- or an anti-apoptotic protein?
    • 57 Piret, J.P., et al. Is HIF-1alpha a pro- or an anti-apoptotic protein?. Biochem Pharmacol 64 (2002), 889–892.
    • (2002) Biochem Pharmacol , vol.64 , pp. 889-892
    • Piret, J.P.1
  • 58
    • 10744233368 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells
    • 58 Makino, Y., et al. Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells. J Immunol 171 (2003), 6534–6540.
    • (2003) J Immunol , vol.171 , pp. 6534-6540
    • Makino, Y.1
  • 59
    • 84863594742 scopus 로고    scopus 로고
    • Cellular constituents of immune escape within the tumor microenvironment
    • 59 Kerkar, S.P., Restifo, N.P., Cellular constituents of immune escape within the tumor microenvironment. Cancer Res 72 (2012), 3125–3130.
    • (2012) Cancer Res , vol.72 , pp. 3125-3130
    • Kerkar, S.P.1    Restifo, N.P.2
  • 60
    • 84951313126 scopus 로고    scopus 로고
    • Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
    • 60 Zhao, E., et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol 17 (2016), 95–103.
    • (2016) Nat Immunol , vol.17 , pp. 95-103
    • Zhao, E.1
  • 61
    • 82055208627 scopus 로고    scopus 로고
    • An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells
    • 61 Cui, W., et al. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 35 (2011), 792–805.
    • (2011) Immunity , vol.35 , pp. 792-805
    • Cui, W.1


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