mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

Journal of Clinical Investigation

Volumn 125, Issue 5, 2015, Pages 2090-2108

  Pollizzi, Kristen N ^a   Patel, Chirag H ^a   Sun, Im Hong ^a   Oh, Min Hee ^a   Waickman, Adam T ^a,b   Wen, Jiayu ^a   Delgoffe, Greg M ^a,c   Powell, Jonathan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANZYME B; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RHEB PROTEIN; TUBERIN; TUMOR NECROSIS FACTOR ALPHA; AKT1 PROTEIN, MOUSE; CARRIER PROTEIN; DEOXYGLUCOSE; HYBRID PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; NEUROPEPTIDE; OVA-8; OVALBUMIN; PEPTIDE FRAGMENT; RAPAMYCIN; RHEB PROTEIN, MOUSE; RICTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME PHOSPHORYLATION; GENE DELETION; GLYCOLYSIS; IN VITRO STUDY; LONGEVITY; LYMPHOCYTE DIFFERENTIATION; MEMORY T LYMPHOCYTE; METABOLIC RATE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CD4 CD8 RATIO; CONGENIC STRAIN; DEFICIENCY; DRUG EFFECTS; FEMALE; GENETIC TRANSDUCTION; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOPOIESIS; MALE; MELANOMA, EXPERIMENTAL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; REPORTER GENE; THYMOMA; TRANSPLANTATION; TUMOR CELL LINE;

ADOPTIVE TRANSFER; ANIMALS; CARRIER PROTEINS; CD4-CD8 RATIO; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DEOXYGLUCOSE; FEMALE; GENES, REPORTER; GLYCOLYSIS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; LYMPHOPOIESIS; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; NEUROPEPTIDES; OVALBUMIN; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; SIROLIMUS; THYMOMA; TOR SERINE-THREONINE KINASES; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84929008302     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77746     Document Type: Article

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