Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Science

Volumn 354, Issue 6311, 2016, Pages 481-484

  Peng, Min ^a   Yin, Na ^a   Chhangawala, Sagar ^a,b   Xu, Ke ^a,b   Leslie, Christina S ^a   Li, Ming O ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; GAMMA INTERFERON; LACTATE DEHYDROGENASE; 3' UNTRANSLATED REGION; ISOENZYME; LACTATE DEHYDROGENASE 5;

ANOXIC CONDITIONS; BIOCHEMISTRY; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNE SYSTEM; PATHOLOGY; PHYSIOLOGICAL RESPONSE; RODENT;

3' UNTRANSLATED REGION; AEROBIC GLYCOLYSIS; ARTICLE; AUTOINFLAMMATORY DISEASE; CELL DIFFERENTIATION; CELL LINEAGE; EPIGENETICS; FLOW CYTOMETRY; GLUCOSE METABOLISM; HISTONE ACETYLATION; IMMUNOPATHOLOGY; INTERNAL RIBOSOME ENTRY SITE; LONG TERM SURVIVAL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH1 CELL; ACETYLATION; AEROBIC METABOLISM; ANIMAL; CYTOLOGY; ENZYMOLOGY; GENE EXPRESSION; GENETIC EPIGENESIS; GENETICS; GLYCOLYSIS; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; REGULATORY T LYMPHOCYTE; TRANSGENIC MOUSE;

MUS;

3' UNTRANSLATED REGIONS; ACETYLATION; AEROBIOSIS; ANIMALS; CELL DIFFERENTIATION; EPIGENESIS, GENETIC; GENE EXPRESSION; GLYCOLYSIS; INTERFERON-GAMMA; ISOENZYMES; L-LACTATE DEHYDROGENASE; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; T-LYMPHOCYTES, REGULATORY; TH1 CELLS;

EID: 84990861953     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf6284     Document Type: Article

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