-
1
-
-
84947591002
-
T cell metabolism drives immunity
-
Buck, M.D., O'Sullivan, D. & Pearce, E.L. T cell metabolism drives immunity. J. Exp. Med. 212, 1345-1360 (2015
-
(2015)
J. Exp. Med
, vol.212
, pp. 1345-1360
-
-
Buck, M.D.1
O'Sullivan, D.2
Pearce, E.L.3
-
2
-
-
84961290082
-
Targeting T cell metabolism for therapy
-
O'Sullivan, D. & Pearce, E.L. Targeting T cell metabolism for therapy. Trends Immunol. 36, 71-80 (2015
-
(2015)
Trends Immunol
, vol.36
, pp. 71-80
-
-
O'Sullivan, D.1
Pearce, E.L.2
-
3
-
-
84865301337
-
Mtor, metabolism, and the regulation of T-cell differentiation and function
-
Waickman, A.T. & Powell, J.D. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol. Rev. 249, 43-58 (2012
-
(2012)
Immunol. Rev
, vol.249
, pp. 43-58
-
-
Waickman, A.T.1
Powell, J.D.2
-
4
-
-
79953172571
-
Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek, R.D., et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011
-
(2011)
J. Immunol
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
-
5
-
-
44449165597
-
Glucose uptake is limiting in T cell activation and requires CD28- mediated Akt-dependent and independent pathways
-
Jacobs, S.R., et al. Glucose uptake is limiting in T cell activation and requires CD28- mediated Akt-dependent and independent pathways. J. Immunol. 180, 4476-4486 (2008
-
(2008)
J. Immunol
, vol.180
, pp. 4476-4486
-
-
Jacobs, S.R.1
-
6
-
-
17044422629
-
Glucose availability regulates IFN-g production and p70S6 kinase activation in CD8+ effector T cells
-
Cham, C.M. & Gajewski, T.F. Glucose availability regulates IFN-g production and p70S6 kinase activation in CD8+ effector T cells. J. Immunol. 174, 4670-4677 (2005
-
(2005)
J. Immunol
, vol.174
, pp. 4670-4677
-
-
Cham, C.M.1
Gajewski, T.F.2
-
7
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang, C.H., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239-1251 (2013
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.H.1
-
8
-
-
84886672916
-
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
-
Doedens, A.L., et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat. Immunol. 14, 1173-1182 (2013
-
(2013)
Nat. Immunol
, vol.14
, pp. 1173-1182
-
-
Doedens, A.L.1
-
9
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi, L.Z., et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011
-
(2011)
J. Exp. Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
-
10
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang, R., et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882 (2011
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
-
11
-
-
52249090234
-
ERRa: A metabolic function for the oldest orphan
-
Villena, J.A. & Kralli, A. ERRa: a metabolic function for the oldest orphan. Trends Endocrinol. Metab. 19, 269-276 (2008
-
(2008)
Trends Endocrinol. Metab
, vol.19
, pp. 269-276
-
-
Villena, J.A.1
Kralli, A.2
-
12
-
-
81055126129
-
Estrogen-related receptor-A is a metabolic regulator of effector T-cell activation and differentiation
-
Michalek, R.D., et al. Estrogen-related receptor-A is a metabolic regulator of effector T-cell activation and differentiation. Proc. Natl. Acad. Sci. USA 108, 18348-18353 (2011
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 18348-18353
-
-
Michalek, R.D.1
-
13
-
-
84886720433
-
The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells
-
Man, K., et al. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat. Immunol. 14, 1155-1165 (2013
-
(2013)
Nat. Immunol
, vol.14
, pp. 1155-1165
-
-
Man, K.1
-
14
-
-
84887507709
-
Interferon regulatory factor 4 sustains CD8+ T cell expansion and effector differentiation
-
Yao, S., et al. Interferon regulatory factor 4 sustains CD8+ T cell expansion and effector differentiation. Immunity 39, 833-845 (2013
-
(2013)
Immunity
, vol.39
, pp. 833-845
-
-
Yao, S.1
-
15
-
-
80054726323
-
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
-
MacIver, N.J., et al. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J. Immunol. 187, 4187-4198 (2011
-
(2011)
J. Immunol
, vol.187
, pp. 4187-4198
-
-
MacIver, N.J.1
-
16
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang, C.H., et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 162, 1229-1241 (2015
-
(2015)
Cell
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
-
17
-
-
84941366350
-
Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
-
Ho, P.C., et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell 162, 1217-1228 (2015
-
(2015)
Cell
, vol.162
, pp. 1217-1228
-
-
Ho, P.C.1
-
18
-
-
84921309472
-
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo
-
Blagih, J., et al. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity 42, 41-54 (2015
-
(2015)
Immunity
, vol.42
, pp. 41-54
-
-
Blagih, J.1
-
19
-
-
44849141880
-
AMP-Activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
-
Mayer, A., Denanglaire, S., Viollet, B., Leo, O. & Andris, F. AMP-Activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function. Eur. J. Immunol. 38, 948-956 (2008
-
(2008)
Eur. J. Immunol
, vol.38
, pp. 948-956
-
-
Mayer, A.1
Denanglaire, S.2
Viollet, B.3
Leo, O.4
Andris, F.5
-
20
-
-
84922080059
-
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
-
Berod, L., et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327-1333 (2014
-
(2014)
Nat. Med
, vol.20
, pp. 1327-1333
-
-
Berod, L.1
-
21
-
-
84903842364
-
Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells
-
Ananieva, E.A., Patel, C.H., Drake, C.H., Powell, J.D. & Hutson, S.M. Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells. J. Biol. Chem. 289, 18793-18804 (2014
-
(2014)
J. Biol. Chem
, vol.289
, pp. 18793-18804
-
-
Ananieva, E.A.1
Patel, C.H.2
Drake, C.H.3
Powell, J.D.4
Hutson, S.M.5
-
22
-
-
84897505811
-
Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity
-
Lee, J., et al. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J. Immunol. 192, 3190-3199 (2014
-
(2014)
J. Immunol
, vol.192
, pp. 3190-3199
-
-
Lee, J.1
-
23
-
-
34247352844
-
Inhibitory effect of tumor cell-derived lactic acid on human T cells
-
Fischer, K., et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812-3819 (2007
-
(2007)
Blood
, vol.109
, pp. 3812-3819
-
-
Fischer, K.1
-
24
-
-
84938702403
-
Lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and effector functions
-
Haas, R., et al. Lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and effector functions. PLoS Biol. 13, e1002202 (2015
-
(2015)
PLoS Biol
, vol.13
, pp. e1002202
-
-
Haas, R.1
-
25
-
-
19344377474
-
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2, 3-dioxygenase
-
Munn, D.H., et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2, 3-dioxygenase. Immunity 22, 633-642 (2005
-
(2005)
Immunity
, vol.22
, pp. 633-642
-
-
Munn, D.H.1
-
26
-
-
80054041992
-
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
-
Opitz, C.A., et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478, 197-203 (2011
-
(2011)
Nature
, vol.478
, pp. 197-203
-
-
Opitz, C.A.1
-
27
-
-
78649880396
-
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
-
Mezrich, J.D., et al. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J. Immunol. 185, 3190-3198 (2010
-
(2010)
J. Immunol
, vol.185
, pp. 3190-3198
-
-
Mezrich, J.D.1
-
28
-
-
34848915783
-
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2, 3-dioxygenase
-
Sharma, M.D., et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2, 3-dioxygenase. J. Clin. Invest. 117, 2570-2582 (2007
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2570-2582
-
-
Sharma, M.D.1
-
29
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce, E.L., et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460, 103-107 (2009
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
-
30
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki, K., et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112 (2009
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
-
31
-
-
84856183120
-
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
-
van der Windt, G.J., et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, 68-78 (2012
-
(2012)
Immunity
, vol.36
, pp. 68-78
-
-
Van Der Windt, G.J.1
-
32
-
-
84876454059
-
AMPKa1: A glucose sensor that controls CD8 T-cell memory
-
Rolf, J., et al. AMPKa1: a glucose sensor that controls CD8 T-cell memory. Eur. J. Immunol. 43, 889-896 (2013
-
(2013)
Eur. J. Immunol
, vol.43
, pp. 889-896
-
-
Rolf, J.1
-
33
-
-
84883423963
-
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
-
van der Windt, G.J., et al. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc. Natl. Acad. Sci. USA 110, 14336-14341 (2013
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 14336-14341
-
-
Van Der Windt, G.J.1
-
34
-
-
84880756431
-
Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting
-
Fraser, K.A., Schenkel, J.M., Jameson, S.C., Vezys, V. & Masopust, D. Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting. Immunity 39, 171-183 (2013
-
(2013)
Immunity
, vol.39
, pp. 171-183
-
-
Fraser, K.A.1
Schenkel, J.M.2
Jameson, S.C.3
Vezys, V.4
Masopust, D.5
-
35
-
-
84904392273
-
Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
-
O'Sullivan, D., et al. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, 75-88 (2014
-
(2014)
Immunity
, vol.41
, pp. 75-88
-
-
O'Sullivan, D.1
-
36
-
-
84928975351
-
IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T Cell longevity
-
Cui, G., et al. IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T Cell longevity. Cell 161, 750-761 (2015
-
(2015)
Cell
, vol.161
, pp. 750-761
-
-
Cui, G.1
-
37
-
-
84925284022
-
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake
-
Maekawa, Y., et al. Notch controls the survival of memory CD4+ T cells by regulating glucose uptake. Nat. Med. 21, 55-61 (2015
-
(2015)
Nat. Med
, vol.21
, pp. 55-61
-
-
Maekawa, Y.1
-
38
-
-
79951670258
-
Temsirolimus an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
-
Wang, Y., Wang, X.Y., Subjeck, J.R., Shrikant, P.A. & Kim, H.L. Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br. J. Cancer 104, 643-652 (2011
-
(2011)
Br. J. Cancer
, vol.104
, pp. 643-652
-
-
Wang, Y.1
Wang, X.Y.2
Subjeck, J.R.3
Shrikant, P.A.4
Kim, H.L.5
-
39
-
-
84942847541
-
Rapamycin impairs antitumor CD8+ T-cell responses and vaccine-induced tumor eradication
-
Chaoul, N., et al. Rapamycin impairs antitumor CD8+ T-cell responses and vaccine-induced tumor eradication. Cancer Res. 75, 3279-3291 (2015
-
(2015)
Cancer Res
, vol.75
, pp. 3279-3291
-
-
Chaoul, N.1
-
40
-
-
77952203723
-
Pharmacologic induction of CD8+ T cell memory: Better living through chemistry
-
Gattinoni, L., Klebanoff, C.A. & Restifo, N.P. Pharmacologic induction of CD8+ T cell memory: better living through chemistry. Sci. Transl. Med. 1, 11ps12 (2009
-
(2009)
Sci. Transl. Med
, vol.1
, pp. 11ps12
-
-
Gattinoni, L.1
Klebanoff, C.A.2
Restifo, N.P.3
-
41
-
-
84925688346
-
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
-
Patsoukis, N., et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat. Commun. 6, 6692 (2015
-
(2015)
Nat. Commun
, vol.6
, pp. 6692
-
-
Patsoukis, N.1
-
42
-
-
84888013970
-
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor
-
Calvaresi, E.C., et al. Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. ChemBioChem 14, 2263-2267 (2013
-
(2013)
ChemBioChem
, vol.14
, pp. 2263-2267
-
-
Calvaresi, E.C.1
-
43
-
-
84912138759
-
Bispecific antibody platforms for cancer immunotherapy
-
Lameris, R., et al. Bispecific antibody platforms for cancer immunotherapy. Crit. Rev. Oncol. Hematol. 92, 153-165 (2014
-
(2014)
Crit. Rev. Oncol. Hematol
, vol.92
, pp. 153-165
-
-
Lameris, R.1
-
44
-
-
84940497441
-
Nanoparticle-mediated drug delivery for treating melanoma
-
Mundra, V., Li, W. & Mahato, R.I. Nanoparticle-mediated drug delivery for treating melanoma. Nanomedicine (Lond.) 10, 2613-2633 (2015
-
(2015)
Nanomedicine (Lond.)
, vol.10
, pp. 2613-2633
-
-
Mundra, V.1
Li, W.2
Mahato, R.I.3
-
45
-
-
84920481006
-
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
-
Gerriets, V.A., et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J. Clin. Invest. 125, 194-207 (2015
-
(2015)
J. Clin. Invest
, vol.125
, pp. 194-207
-
-
Gerriets, V.A.1
-
46
-
-
84876514626
-
Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
-
Sinclair, L.V., et al. Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat. Immunol. 14, 500-508 (2013
-
(2013)
Nat. Immunol
, vol.14
, pp. 500-508
-
-
Sinclair, L.V.1
-
47
-
-
84897002504
-
Adoptive immunotherapy for cancer or viruses
-
Maus, M.V., et al. Adoptive immunotherapy for cancer or viruses. Annu. Rev. Immunol. 32, 189-225 (2014
-
(2014)
Annu. Rev. Immunol
, vol.32
, pp. 189-225
-
-
Maus, M.V.1
-
48
-
-
84885055994
-
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
-
Sukumar, M., et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J. Clin. Invest. 123, 4479-4488 (2013
-
(2013)
J. Clin. Invest
, vol.123
, pp. 4479-4488
-
-
Sukumar, M.1
-
49
-
-
84955396567
-
Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy
-
Sukumar, M., et al. Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy. Cell Metab. 23, 63-76 (2015
-
(2015)
Cell Metab
, vol.23
, pp. 63-76
-
-
Sukumar, M.1
-
50
-
-
84884271914
-
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti CTLA-4 therapy against melanoma
-
Simpson, T.R., et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti CTLA-4 therapy against melanoma. J. Exp. Med. 210, 1695-1710 (2015
-
(2015)
J. Exp. Med
, vol.210
, pp. 1695-1710
-
-
Simpson, T.R.1
-
52
-
-
84929650331
-
-
Zenarruzabeitia, O., Vitallé, J., Eguizabal, C., Simhadri, V.R. & Borrego, F. J. Immunol. 194, 5053-5060 (2015
-
(2015)
J. Immunol
, vol.194
, pp. 5053-5060
-
-
Zenarruzabeitia, O.1
Vitallé, J.2
Eguizabal, C.3
Simhadri, V.R.4
Borrego, F.5
-
55
-
-
84903204012
-
-
Tanaka, T., et al. Sci. Rep. 4, 5412 (2014
-
(2014)
Sci. Rep
, vol.4
, pp. 5412
-
-
Tanaka, T.1
-
56
-
-
61949472508
-
-
Torchinsky, M.B., Garaude, J., Martin, A.P. & Blander, J.M. Nature 458, 78-82 (2009
-
(2009)
Nature
, vol.458
, pp. 78-82
-
-
Torchinsky, M.B.1
Garaude, J.2
Martin, A.P.3
Blander, J.M.4
-
57
-
-
34047173496
-
-
Nenci, A., et al. Nature 446, 557-561 (2007
-
(2007)
Nature
, vol.446
, pp. 557-561
-
-
Nenci, A.1
-
58
-
-
84907210946
-
-
Dannappel, M., et al. Nature 513, 90-94 (2014
-
(2014)
Nature
, vol.513
, pp. 90-94
-
-
Dannappel, M.1
-
59
-
-
84901410158
-
-
Cerovic, V., Bain, C.C., Mowat, A.M. & Milling, S.w. Trends Immunol. 35, 270-277 (2014
-
(2014)
Trends Immunol.
, vol.35
, pp. 270-277
-
-
Cerovic, V.1
Bain, C.C.2
Mowat, A.M.3
Milling, S.W.4
-
60
-
-
84940547063
-
-
Ohnmacht, C., et al. Science 349, 989-993 (2015
-
(2015)
Science
, vol.349
, pp. 989-993
-
-
Ohnmacht, C.1
-
61
-
-
84940077758
-
-
Sefik, E., et al. Science 349, 993-997 (2015
-
(2015)
Science
, vol.349
, pp. 993-997
-
-
Sefik, E.1
-
62
-
-
84940380928
-
-
Arpaia, N., et al. Cell 162, 1078-1089 (2015
-
(2015)
Cell
, vol.162
, pp. 1078-1089
-
-
Arpaia, N.1
|