Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

Nature Immunology

Volumn 17, Issue 6, 2016, Pages 704-711

  Pollizzi, Kristen N ^a,c   Sun, Im Hong ^a   Patel, Chirag H ^a   Lo, Ying Chun ^a,d   Oh, Min Hee ^a   Waickman, Adam T ^a,e   Tam, Ada J ^a   Blosser, Richard L ^a   Wen, Jiayu ^a   Delgoffe, Greg M ^a,b   Powell, Jonathan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c MEDIMMUNE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; CD8 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASYMMETRIC CELL DIVISION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DAUGHTER CELL; ENZYME ACTIVITY; FEMALE; GENE TRANSLOCATION; LIPID METABOLISM; LONG TERM SURVIVAL; LYMPHOCYTE DIFFERENTIATION; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; GLYCOLYSIS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; PRE T LYMPHOCYTE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; FEMALE; GLYCOLYSIS; IMMUNOLOGIC MEMORY; LIPID METABOLISM; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIPROTEIN COMPLEXES; PRECURSOR CELLS, T-LYMPHOID; PROTEIN TRANSPORT; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84963525930     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3438     Document Type: Article

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