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Volumn 39, Issue 3, 2017, Pages

Salinomycin: A new paradigm in cancer therapy

Author keywords

cancer; cancer stem cells; multidrug resistance; Salinomycin

Indexed keywords

CISPLATIN; COLCHICINE; CYTARABINE; DOCETAXEL; DOXORUBICIN; GEMCITABINE; IMATINIB; LAPATINIB; METFORMIN; NANOPARTICLE; PACLITAXEL; POLYGLACTIN; SALINOMYCIN; SALINOMYCIN DERIVATIVE; TRASTUZUMAB; VERAPAMIL; VINBLASTINE; PYRAN DERIVATIVE; TUMOR PROTEIN;

EID: 85016924820     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1177/1010428317695035     Document Type: Review
Times cited : (98)

References (105)
  • 1
    • 0016262114 scopus 로고
    • Salinomycin, a new polyether antibiotic
    • Miyazaki Y, Shibuya M, Sugawara H. Salinomycin, a new polyether antibiotic. J Antibiot 1974; 27: 814–821.
    • (1974) J Antibiot , vol.27 , pp. 814-821
    • Miyazaki, Y.1    Shibuya, M.2    Sugawara, H.3
  • 2
    • 70449724577 scopus 로고    scopus 로고
    • Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells
    • Fuchs D, Heinold A, Opelz G. Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Biochem Biophys Res Commun 2009; 390: 743–749.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 743-749
    • Fuchs, D.1    Heinold, A.2    Opelz, G.3
  • 3
    • 0017158502 scopus 로고
    • Salinomycin effects on mitochondrial ion translocation and respiration
    • Mitani M, Yamanishi T, Miyazaki Y. Salinomycin effects on mitochondrial ion translocation and respiration. Antimicrob Agents Chemother 1976; 9: 655–660.
    • (1976) Antimicrob Agents Chemother , vol.9 , pp. 655-660
    • Mitani, M.1    Yamanishi, T.2    Miyazaki, Y.3
  • 4
    • 0017490470 scopus 로고
    • Anticoccidial activity of salinomycin in battery raised broiler chickens
    • Danforth HD, Ruff MD, Reid WM. Anticoccidial activity of salinomycin in battery raised broiler chickens. Poult Sci 1977; 56: 926–932.
    • (1977) Poult Sci , vol.56 , pp. 926-932
    • Danforth, H.D.1    Ruff, M.D.2    Reid, W.M.3
  • 5
    • 0021250234 scopus 로고
    • Effect of salinomycin-Na on malaria parasites (Plasmodium falciparum and P. berghei)
    • Mehlhorn H, Ganster HJ, Raether W. Effect of salinomycin-Na on malaria parasites (Plasmodium falciparum and P. berghei). Zentralbl Bakteriol Mikrobiol Hyg A 1984; 256: 305–313.
    • (1984) Zentralbl Bakteriol Mikrobiol Hyg A , vol.256 , pp. 305-313
    • Mehlhorn, H.1    Ganster, H.J.2    Raether, W.3
  • 6
    • 0027514156 scopus 로고
    • Effects of some ionophore antibiotics and polyoxins on the growth of anaerobic rumen fungi
    • Cann IK, Kobayashi Y, Onoda A. Effects of some ionophore antibiotics and polyoxins on the growth of anaerobic rumen fungi. J Appl Bacteriol 1993; 74: 127–133.
    • (1993) J Appl Bacteriol , vol.74 , pp. 127-133
    • Cann, I.K.1    Kobayashi, Y.2    Onoda, A.3
  • 7
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta PB, Onder TT, Jiang G. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009; 138: 645–659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3
  • 8
    • 84887963510 scopus 로고    scopus 로고
    • Salinomycin: a novel anti-cancer agent with known anti-coccidial activities
    • Zhou S, Wang F, Wong ET. Salinomycin: a novel anti-cancer agent with known anti-coccidial activities. Curr Med Chem 2013; 20: 4095–4101.
    • (2013) Curr Med Chem , vol.20 , pp. 4095-4101
    • Zhou, S.1    Wang, F.2    Wong, E.T.3
  • 9
    • 84930711810 scopus 로고    scopus 로고
    • Anticancer activity of polyether ionophore-salinomycin
    • Antoszczak M, Huczynski A., Anticancer activity of polyether ionophore-salinomycin. Anticancer Agents Med Chem 2015; 15: 575–591.
    • (2015) Anticancer Agents Med Chem , vol.15 , pp. 575-591
    • Antoszczak, M.1    Huczynski, A.2
  • 10
    • 77953126613 scopus 로고    scopus 로고
    • The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor
    • Riccioni R, Dupuis ML, Bernabei M. The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor. Blood Cells Mol Dis 2010; 45: 86–92.
    • (2010) Blood Cells Mol Dis , vol.45 , pp. 86-92
    • Riccioni, R.1    Dupuis, M.L.2    Bernabei, M.3
  • 11
    • 84869095791 scopus 로고    scopus 로고
    • Antiproliferative activity of salinomycin and its derivatives
    • Huczynski A, Janczak J, Antoszczak M. Antiproliferative activity of salinomycin and its derivatives. Bioorg Med Chem Lett 2012; 22: 7146–7150.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 7146-7150
    • Huczynski, A.1    Janczak, J.2    Antoszczak, M.3
  • 13
    • 0032502686 scopus 로고    scopus 로고
    • Vaults are up-regulated in multidrug-resistant cancer cell lines
    • Kickhoefer VA, Rajavel KS, Scheffer GL. Vaults are up-regulated in multidrug-resistant cancer cell lines. J Biol Chem 1998; 273: 8971–8974.
    • (1998) J Biol Chem , vol.273 , pp. 8971-8974
    • Kickhoefer, V.A.1    Rajavel, K.S.2    Scheffer, G.L.3
  • 14
    • 58349102840 scopus 로고    scopus 로고
    • Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy
    • Ullah MF., Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy. Asian Pac J Cancer Prev 2008; 9: 1–6.
    • (2008) Asian Pac J Cancer Prev , vol.9 , pp. 1-6
    • Ullah, M.F.1
  • 15
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman MM., Mechanisms of cancer drug resistance. Annu Rev Med 2002; 53: 615–627.
    • (2002) Annu Rev Med , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 16
    • 0024548599 scopus 로고
    • Expression of a multidrug resistance gene in human cancers
    • Goldstein LJ, Galski H, Fojo A. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 1989; 81: 116–124.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 116-124
    • Goldstein, L.J.1    Galski, H.2    Fojo, A.3
  • 17
    • 0345688604 scopus 로고    scopus 로고
    • Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
    • Doyle L, Ross DD., Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 2003; 22: 7340–7358.
    • (2003) Oncogene , vol.22 , pp. 7340-7358
    • Doyle, L.1    Ross, D.D.2
  • 18
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: the multidrug resistance-associated proteins
    • Borst P, Evers R, Kool M. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 2000; 92: 1295–1302.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3
  • 20
    • 84867757134 scopus 로고    scopus 로고
    • Multidrug resistance in breast cancer: from in vitro models to clinical studies
    • Wind NS, Holen I., Multidrug resistance in breast cancer: from in vitro models to clinical studies. Int J Breast Cancer 2011; 2011: 967419.
    • (2011) Int J Breast Cancer , vol.2011 , pp. 967419
    • Wind, N.S.1    Holen, I.2
  • 21
    • 0026341148 scopus 로고
    • Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression
    • Nygren P, Larsson R, Gruber A. Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression. Br J Cancer 1991; 64: 1011–1018.
    • (1991) Br J Cancer , vol.64 , pp. 1011-1018
    • Nygren, P.1    Larsson, R.2    Gruber, A.3
  • 22
    • 0030444003 scopus 로고    scopus 로고
    • Overexpression of the ABC transporter TAP in multidrug-resistant human cancer cell lines
    • Izquierdo MA, Neefjes JJ, Mathari AE. Overexpression of the ABC transporter TAP in multidrug-resistant human cancer cell lines. Br J Cancer 1996; 74: 1961–1967.
    • (1996) Br J Cancer , vol.74 , pp. 1961-1967
    • Izquierdo, M.A.1    Neefjes, J.J.2    Mathari, A.E.3
  • 23
    • 84871395763 scopus 로고    scopus 로고
    • Salinomycin as a drug for targeting human cancer stem cells
    • Naujokat C, Steinhart R., Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol 2012; 2012: 950658.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 950658
    • Naujokat, C.1    Steinhart, R.2
  • 24
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R, Wang X, Chen GY. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007; 356: 217–226.
    • (2007) N Engl J Med , vol.356 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3
  • 25
    • 77956178360 scopus 로고    scopus 로고
    • Emt, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • Singh A, Settleman J., Emt, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010; 29: 4741–4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 26
    • 84881247532 scopus 로고    scopus 로고
    • What makes cancer stem cell markers different?
    • Karsten U, Goletz S., What makes cancer stem cell markers different? SpringerPlus 2013; 2: 301.
    • (2013) SpringerPlus , vol.2 , pp. 301
    • Karsten, U.1    Goletz, S.2
  • 27
    • 84882959995 scopus 로고    scopus 로고
    • Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species
    • Zhou J, Li P, Xue X. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. Toxicol Lett 2013; 222: 139–145.
    • (2013) Toxicol Lett , vol.222 , pp. 139-145
    • Zhou, J.1    Li, P.2    Xue, X.3
  • 28
    • 35448935218 scopus 로고    scopus 로고
    • Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors
    • Bao F, Polk P, Nordberg ML. Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res 2007; 31: 1511–1520.
    • (2007) Leuk Res , vol.31 , pp. 1511-1520
    • Bao, F.1    Polk, P.2    Nordberg, M.L.3
  • 29
    • 84899726033 scopus 로고    scopus 로고
    • Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells
    • Sahlberg SH, Spiegelberg D, Glimelius B. Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PLoS ONE 2014; 9: e94621.
    • (2014) PLoS ONE , vol.9 , pp. e94621
    • Sahlberg, S.H.1    Spiegelberg, D.2    Glimelius, B.3
  • 30
    • 84869038700 scopus 로고    scopus 로고
    • Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system
    • Fredebohm J, Boettcher M, Eisen C. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS ONE 2012; 7: e48503.
    • (2012) PLoS ONE , vol.7 , pp. e48503
    • Fredebohm, J.1    Boettcher, M.2    Eisen, C.3
  • 31
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy PA., The Hedgehog and Wnt signalling pathways in cancer. Nature 2001; 411: 349–354.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 32
    • 78650003931 scopus 로고    scopus 로고
    • β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells
    • Yeung J, Esposito MT, Gandillet A. β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 2010; 18: 606–618.
    • (2010) Cancer Cell , vol.18 , pp. 606-618
    • Yeung, J.1    Esposito, M.T.2    Gandillet, A.3
  • 33
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105–111.
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3
  • 34
    • 33746888182 scopus 로고    scopus 로고
    • Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer
    • Nakashima H, Nakamura M, Yamaguchi H. Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res 2006; 66: 7041–7049.
    • (2006) Cancer Res , vol.66 , pp. 7041-7049
    • Nakashima, H.1    Nakamura, M.2    Yamaguchi, H.3
  • 35
    • 84905999802 scopus 로고    scopus 로고
    • PTEN loss-mediated Akt activation increases the properties of cancer stem-like cell populations in prostate cancer
    • Kim RJ, Bae E, Hong YK. PTEN loss-mediated Akt activation increases the properties of cancer stem-like cell populations in prostate cancer. Oncology 2014; 87: 270–279.
    • (2014) Oncology , vol.87 , pp. 270-279
    • Kim, R.J.1    Bae, E.2    Hong, Y.K.3
  • 36
    • 84856253626 scopus 로고    scopus 로고
    • Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
    • Aksamitiene E, Kiyatkin A, Kholodenko BN., Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance. Biochem Soc Trans 2012; 40: 139–146.
    • (2012) Biochem Soc Trans , vol.40 , pp. 139-146
    • Aksamitiene, E.1    Kiyatkin, A.2    Kholodenko, B.N.3
  • 37
    • 84855396578 scopus 로고    scopus 로고
    • Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress
    • Ketola K, Hilvo M, Hyotylainen T. Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. Br J Cancer 2012; 106: 99–106.
    • (2012) Br J Cancer , vol.106 , pp. 99-106
    • Ketola, K.1    Hilvo, M.2    Hyotylainen, T.3
  • 39
    • 79959260166 scopus 로고    scopus 로고
    • Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas
    • Basu D, Montone KT, Wang LP. Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas. Cell Cycle 2011; 10: 2008–2016.
    • (2011) Cell Cycle , vol.10 , pp. 2008-2016
    • Basu, D.1    Montone, K.T.2    Wang, L.P.3
  • 40
    • 84871401029 scopus 로고    scopus 로고
    • Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo
    • Wang F, He L, Dai WQ. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo. PLoS ONE 2012; 7: e50638.
    • (2012) PLoS ONE , vol.7 , pp. e50638
    • Wang, F.1    He, L.2    Dai, W.Q.3
  • 41
    • 84933547398 scopus 로고
    • Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells
    • Jangamreddy JR, Ghavami S, Grabarek J. Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells. Biochim Biophys Acta 1833; 2013: 2057–2069.
    • (1833) Biochim Biophys Acta , vol.2013 , pp. 2057-2069
    • Jangamreddy, J.R.1    Ghavami, S.2    Grabarek, J.3
  • 42
    • 84892439729 scopus 로고    scopus 로고
    • Salinomycin inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cell in vitro and suppresses tumor growth in vivo
    • Wu D, Zhang Y, Huang J. Salinomycin inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cell in vitro and suppresses tumor growth in vivo. Biochem Biophys Res Commun 2014; 443: 712–717.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 712-717
    • Wu, D.1    Zhang, Y.2    Huang, J.3
  • 43
    • 84879270601 scopus 로고    scopus 로고
    • Inhibitory effects of salinomycin on cell survival, colony growth, migration, and invasion of human non-small cell lung cancer a549 and lnm35: involvement of nag-1
    • Arafat K, Iratni R, Takahashi T. Inhibitory effects of salinomycin on cell survival, colony growth, migration, and invasion of human non-small cell lung cancer a549 and lnm35: involvement of nag-1. PLoS ONE 2013; 8: e66931.
    • (2013) PLoS ONE , vol.8 , pp. e66931
    • Arafat, K.1    Iratni, R.2    Takahashi, T.3
  • 44
    • 84867236809 scopus 로고    scopus 로고
    • Impact of salinomycin on human cholangiocarcinoma: induction of apoptosis and impairment of tumor cell proliferation in vitro
    • Lieke T, Ramackers W, Bergmann S. Impact of salinomycin on human cholangiocarcinoma: induction of apoptosis and impairment of tumor cell proliferation in vitro. BMC Cancer 2012; 12: 466.
    • (2012) BMC Cancer , vol.12 , pp. 466
    • Lieke, T.1    Ramackers, W.2    Bergmann, S.3
  • 45
    • 84867775843 scopus 로고    scopus 로고
    • Lower salinomycin concentration increases apoptotic detachment in high-density cancer cells
    • Kim JH, Kim TY, Kim HS. Lower salinomycin concentration increases apoptotic detachment in high-density cancer cells. Int J Mol Sci 2012; 13: 13169–13182.
    • (2012) Int J Mol Sci , vol.13 , pp. 13169-13182
    • Kim, J.H.1    Kim, T.Y.2    Kim, H.S.3
  • 46
    • 84945242580 scopus 로고    scopus 로고
    • Apoptotic effects of salinomycin on human ovarian cancer cell line (ovcar-3)
    • Kaplan F, Teksen F., Apoptotic effects of salinomycin on human ovarian cancer cell line (ovcar-3). Tumour Biol 2016; 37: 3897–3903.
    • (2016) Tumour Biol , vol.37 , pp. 3897-3903
    • Kaplan, F.1    Teksen, F.2
  • 47
    • 84967143897 scopus 로고    scopus 로고
    • Salinomycin exerts anti-angiogenic and anti-tumorigenic activities by inhibiting vascular endothelial growth factor receptor 2-mediated angiogenesis
    • Li T, Liu X, Shen Q. Salinomycin exerts anti-angiogenic and anti-tumorigenic activities by inhibiting vascular endothelial growth factor receptor 2-mediated angiogenesis. Oncotarget 2016; 7: 26580–26592.
    • (2016) Oncotarget , vol.7 , pp. 26580-26592
    • Li, T.1    Liu, X.2    Shen, Q.3
  • 48
    • 84947298511 scopus 로고    scopus 로고
    • The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients
    • He M, Fu Y, Yan Y. The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients. Clin Sci 2015; 129: 809–822.
    • (2015) Clin Sci , vol.129 , pp. 809-822
    • He, M.1    Fu, Y.2    Yan, Y.3
  • 49
    • 84951867374 scopus 로고    scopus 로고
    • Salinomycin promotes anoikis and decreases the CD44+/CD24− stem-like population via inhibition of STAT3 activation in MDA-MB-231 cells
    • An H, Kim JY, Oh E. Salinomycin promotes anoikis and decreases the CD44+/CD24− stem-like population via inhibition of STAT3 activation in MDA-MB-231 cells. PLoS ONE 2015; 10: e0141919.
    • (2015) PLoS ONE , vol.10 , pp. e0141919
    • An, H.1    Kim, J.Y.2    Oh, E.3
  • 50
    • 78651445624 scopus 로고    scopus 로고
    • Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein
    • Kim JH, Chae M, Kim WK. Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein. Br J Pharmacol 2011; 162: 773–784.
    • (2011) Br J Pharmacol , vol.162 , pp. 773-784
    • Kim, J.H.1    Chae, M.2    Kim, W.K.3
  • 51
    • 84880874653 scopus 로고    scopus 로고
    • Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells
    • Li T, Su L, Zhong N. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy 2013; 9: 1057–1068.
    • (2013) Autophagy , vol.9 , pp. 1057-1068
    • Li, T.1    Su, L.2    Zhong, N.3
  • 52
    • 80052144335 scopus 로고    scopus 로고
    • Salinomycin inhibits osteosarcoma by targeting its tumor stem cells
    • Tang QL, Zhao ZQ, Li JC. Salinomycin inhibits osteosarcoma by targeting its tumor stem cells. Cancer Lett 2011; 311: 113–121.
    • (2011) Cancer Lett , vol.311 , pp. 113-121
    • Tang, Q.L.1    Zhao, Z.Q.2    Li, J.C.3
  • 53
    • 84869888380 scopus 로고    scopus 로고
    • Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt
    • Kuo SZ, Blair KJ, Rahimy E. Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt. BMC Cancer 2012; 12: 556.
    • (2012) BMC Cancer , vol.12 , pp. 556
    • Kuo, S.Z.1    Blair, K.J.2    Rahimy, E.3
  • 54
    • 84894456180 scopus 로고    scopus 로고
    • Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2
    • Koo KH, Kim H, Bae YK. Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2. Cell Death Dis 2013; 4: e693.
    • (2013) Cell Death Dis , vol.4 , pp. e693
    • Koo, K.H.1    Kim, H.2    Bae, Y.K.3
  • 55
    • 84952769551 scopus 로고    scopus 로고
    • Salinomycin enhances the apoptosis of t-cell acute lymphoblastic leukemia cell line Jurkat cells induced by vincristine
    • Liu PP, Zhu JC, Liu GX. Salinomycin enhances the apoptosis of t-cell acute lymphoblastic leukemia cell line Jurkat cells induced by vincristine. Zhongguo Shi Yan Xue Te Xue Za Zhi 2015; 23: 653–657.
    • (2015) Zhongguo Shi Yan Xue Te Xue Za Zhi , vol.23 , pp. 653-657
    • Liu, P.P.1    Zhu, J.C.2    Liu, G.X.3
  • 56
    • 77950867732 scopus 로고    scopus 로고
    • Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells
    • Fuchs D, Daniel V, Sadeghi M. Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells. Biochem Biophys Res Commun 2010; 394: 1098–1104.
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 1098-1104
    • Fuchs, D.1    Daniel, V.2    Sadeghi, M.3
  • 57
    • 80052012674 scopus 로고    scopus 로고
    • Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
    • Lu D, Choi MY, Yu J. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A 2011; 108: 13253–13257.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13253-13257
    • Lu, D.1    Choi, M.Y.2    Yu, J.3
  • 58
    • 84957591389 scopus 로고    scopus 로고
    • Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment
    • Mao J, Fan S, Ma W. Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death Dis 2014; 5: e1039.
    • (2014) Cell Death Dis , vol.5 , pp. e1039
    • Mao, J.1    Fan, S.2    Ma, W.3
  • 59
    • 84877584290 scopus 로고    scopus 로고
    • The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells
    • Kusunoki S, Kato K, Tabu K. The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells. Gynecol Oncol 2013; 129: 598–605.
    • (2013) Gynecol Oncol , vol.129 , pp. 598-605
    • Kusunoki, S.1    Kato, K.2    Tabu, K.3
  • 60
    • 84929589903 scopus 로고    scopus 로고
    • Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death
    • Jangamreddy JR, Jain MV, Hallbeck AL. Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death. Oncotarget 2015; 6: 10134–10145.
    • (2015) Oncotarget , vol.6 , pp. 10134-10145
    • Jangamreddy, J.R.1    Jain, M.V.2    Hallbeck, A.L.3
  • 61
    • 0000707605 scopus 로고    scopus 로고
    • Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux
    • McCarthy JV, Cotter TG., Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux. Cell Death Differ 1997; 4: 756–770.
    • (1997) Cell Death Differ , vol.4 , pp. 756-770
    • McCarthy, J.V.1    Cotter, T.G.2
  • 62
    • 84866738560 scopus 로고    scopus 로고
    • Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest
    • Kim WK, Kim JH, Yoon K. Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest. Invest New Drugs 2012; 30: 1311–1318.
    • (2012) Invest New Drugs , vol.30 , pp. 1311-1318
    • Kim, W.K.1    Kim, J.H.2    Yoon, K.3
  • 63
    • 84866536847 scopus 로고    scopus 로고
    • Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species
    • Verdoodt B, Vogt M, Schmitz I. Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species. PLoS ONE 2012; 7: e44132.
    • (2012) PLoS ONE , vol.7 , pp. e44132
    • Verdoodt, B.1    Vogt, M.2    Schmitz, I.3
  • 64
    • 84964297952 scopus 로고    scopus 로고
    • Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of hedgehog signaling
    • Lu Y, Ma W, Mao J. Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of hedgehog signaling. Chem Biol Interact 2015; 228: 100–107.
    • (2015) Chem Biol Interact , vol.228 , pp. 100-107
    • Lu, Y.1    Ma, W.2    Mao, J.3
  • 65
    • 0027467890 scopus 로고
    • Fibronectin promotes the elongation of microvessels during angiogenesis in vitro
    • Nicosia RF, Bonanno E, Smith M., Fibronectin promotes the elongation of microvessels during angiogenesis in vitro. J Cell Physiol 1993; 154: 654–661.
    • (1993) J Cell Physiol , vol.154 , pp. 654-661
    • Nicosia, R.F.1    Bonanno, E.2    Smith, M.3
  • 66
    • 0035983579 scopus 로고    scopus 로고
    • Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies
    • Francis SE, Goh KL, Hodivala-Dilke K. Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol 2002; 22: 927–933.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 927-933
    • Francis, S.E.1    Goh, K.L.2    Hodivala-Dilke, K.3
  • 67
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA., The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420–1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 68
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A, Pintzas A., Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 2009; 1796: 75–90.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 69
    • 84938957001 scopus 로고    scopus 로고
    • Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24
    • Qu H, Ma B, Yuan HF. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med 2015; 8: 578–582.
    • (2015) Asian Pac J Trop Med , vol.8 , pp. 578-582
    • Qu, H.1    Ma, B.2    Yuan, H.F.3
  • 70
    • 84892385077 scopus 로고    scopus 로고
    • The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma
    • Sanchez-Tillo E, Fanlo L, Siles L. The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma. Cell Death Differ 2014; 21: 247–257.
    • (2014) Cell Death Differ , vol.21 , pp. 247-257
    • Sanchez-Tillo, E.1    Fanlo, L.2    Siles, L.3
  • 71
    • 84960344931 scopus 로고    scopus 로고
    • The impact of metformin and salinomycin on transforming growth factor β-induced epithelial-to-mesenchymal transition in non-small cell lung cancer cell lines
    • Koeck S, Amann A, Huber JM. The impact of metformin and salinomycin on transforming growth factor β-induced epithelial-to-mesenchymal transition in non-small cell lung cancer cell lines. Oncol Lett 2016; 11: 2946–2952.
    • (2016) Oncol Lett , vol.11 , pp. 2946-2952
    • Koeck, S.1    Amann, A.2    Huber, J.M.3
  • 72
    • 84929603385 scopus 로고    scopus 로고
    • Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation
    • Zhou Y, Liang C, Xue F. Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation. Oncotarget 2015; 6: 10350–10365.
    • (2015) Oncotarget , vol.6 , pp. 10350-10365
    • Zhou, Y.1    Liang, C.2    Xue, F.3
  • 73
    • 84958983172 scopus 로고    scopus 로고
    • Salinomycin suppresses TGF-β1-induced epithelial-to-mesenchymal transition in MCF-7 human breast cancer cells
    • Zhang C, Lu Y, Li Q. Salinomycin suppresses TGF-β1-induced epithelial-to-mesenchymal transition in MCF-7 human breast cancer cells. Chem Biol Interact 2016; 248: 74–81.
    • (2016) Chem Biol Interact , vol.248 , pp. 74-81
    • Zhang, C.1    Lu, Y.2    Li, Q.3
  • 75
    • 84858295994 scopus 로고    scopus 로고
    • Epigenetic modifications in cancer
    • Kanwal R, Gupta S., Epigenetic modifications in cancer. Clin Genet 2012; 81: 303–311.
    • (2012) Clin Genet , vol.81 , pp. 303-311
    • Kanwal, R.1    Gupta, S.2
  • 76
    • 78049385776 scopus 로고    scopus 로고
    • Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc
    • Gao FH, Hu XH, Li W. Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. BMC Cancer 2010; 10: 610.
    • (2010) BMC Cancer , vol.10 , pp. 610
    • Gao, F.H.1    Hu, X.H.2    Li, W.3
  • 77
    • 84874007556 scopus 로고    scopus 로고
    • Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
    • Al Dhaheri Y, Attoub S, Arafat K. Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation. Biochim Biophys Acta 2013; 1830: 3121–3135.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 3121-3135
    • Al Dhaheri, Y.1    Attoub, S.2    Arafat, K.3
  • 78
    • 85019980052 scopus 로고    scopus 로고
    • Salinomycin targets EZH2 driven epigenetic repression of death receptors in colon cancer stem cells
    • In:
    • Singh AK, Maheshwari S, Arya RK. Salinomycin targets EZH2 driven epigenetic repression of death receptors in colon cancer stem cells. In: NCRI cancer conferences, 2015, http://abstracts.ncri.org.uk/abstract/salinomycin-targets-ezh2-driven-epigenetic-repression-of-death-receptors-in-colon-cancer-stem-cells-2/
    • (2015) NCRI cancer conferences
    • Singh, A.K.1    Maheshwari, S.2    Arya, R.K.3
  • 79
    • 78649697501 scopus 로고    scopus 로고
    • miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines
    • Henry JC, Park JK, Jiang J. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun 2010; 403: 120–125.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 120-125
    • Henry, J.C.1    Park, J.K.2    Jiang, J.3
  • 80
    • 77953773201 scopus 로고    scopus 로고
    • MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
    • Fornari F, Milazzo M, Chieco P. MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 2010; 70: 5184–5193.
    • (2010) Cancer Res , vol.70 , pp. 5184-5193
    • Fornari, F.1    Milazzo, M.2    Chieco, P.3
  • 81
    • 66849113786 scopus 로고    scopus 로고
    • MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells
    • Pan YZ, Morris ME, Yu AM., MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. Mol Pharmacol 2009; 75: 1374–1379.
    • (2009) Mol Pharmacol , vol.75 , pp. 1374-1379
    • Pan, Y.Z.1    Morris, M.E.2    Yu, A.M.3
  • 82
    • 80051697939 scopus 로고    scopus 로고
    • Regulatory role of mir-203 in prostate cancer progression and metastasis
    • Saini S, Majid S, Yamamura S. Regulatory role of mir-203 in prostate cancer progression and metastasis. Clin Cancer Res 2011; 17: 5287–5298.
    • (2011) Clin Cancer Res , vol.17 , pp. 5287-5298
    • Saini, S.1    Majid, S.2    Yamamura, S.3
  • 83
    • 84879008066 scopus 로고    scopus 로고
    • Synthesis, spectral properties, antibacterial and antitumor activity of salinomycin complexes with the transition metal ions Co(II), Ni(II), Cu(II) and Zn(II)
    • Ivanova J, Pantcheva IN, Zhorova R. Synthesis, spectral properties, antibacterial and antitumor activity of salinomycin complexes with the transition metal ions Co(II), Ni(II), Cu(II) and Zn(II). J Chem Chem Eng 2012; 6: 551–562.
    • (2012) J Chem Chem Eng , vol.6 , pp. 551-562
    • Ivanova, J.1    Pantcheva, I.N.2    Zhorova, R.3
  • 84
    • 84961959080 scopus 로고    scopus 로고
    • CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel
    • Muntimadugu E, Kumar R, Saladi S. CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel. Colloids Surf B: Biointerfaces 2016; 143: 532–546.
    • (2016) Colloids Surf B: Biointerfaces , vol.143 , pp. 532-546
    • Muntimadugu, E.1    Kumar, R.2    Saladi, S.3
  • 85
    • 84955177581 scopus 로고    scopus 로고
    • Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells
    • Tigli Aydin RS, Kaynak G, Gumusderelioglu M., Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells. J Biomed Mater Res A 2016; 104: 455–464.
    • (2016) J Biomed Mater Res A , vol.104 , pp. 455-464
    • Tigli Aydin, R.S.1    Kaynak, G.2    Gumusderelioglu, M.3
  • 86
    • 84959354076 scopus 로고    scopus 로고
    • Salinomycin efficiency assessment in non-tumor (HB4a) and tumor (MCF-7) human breast cells
    • Niwa AM, D Epiro GF, Marques LA. Salinomycin efficiency assessment in non-tumor (HB4a) and tumor (MCF-7) human breast cells. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 557–571.
    • (2016) Naunyn Schmiedebergs Arch Pharmacol , vol.389 , pp. 557-571
    • Niwa, A.M.1    D Epiro, G.F.2    Marques, L.A.3
  • 87
    • 84879696870 scopus 로고    scopus 로고
    • Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice
    • Ojo OO, Bhadauria S, Rath SK., Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice. PLoS ONE 2013; 8: e69086.
    • (2013) PLoS ONE , vol.8 , pp. e69086
    • Ojo, O.O.1    Bhadauria, S.2    Rath, S.K.3
  • 90
    • 33645555522 scopus 로고    scopus 로고
    • A case of salinomycin intoxication in turkeys
    • Van Assen EJ. A case of salinomycin intoxication in turkeys. Can Vet J 2006; 47: 256–258.
    • (2006) Can Vet J , vol.47 , pp. 256-258
    • Van Assen, E.J.1
  • 91
    • 79959989874 scopus 로고    scopus 로고
    • Salinomycin induces calpain and cytochrome c-mediated neuronal cell death
    • Boehmerle W, Endres M., Salinomycin induces calpain and cytochrome c-mediated neuronal cell death. Cell Death Dis 2011; 2: e168.
    • (2011) Cell Death Dis , vol.2 , pp. e168
    • Boehmerle, W.1    Endres, M.2
  • 93
    • 84867873882 scopus 로고    scopus 로고
    • Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets her2-positive cancer cells and cancer stem cells
    • Oak PS, Kopp F, Thakur C. Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets her2-positive cancer cells and cancer stem cells. Int J Cancer 2012; 131: 2808–2819.
    • (2012) Int J Cancer , vol.131 , pp. 2808-2819
    • Oak, P.S.1    Kopp, F.2    Thakur, C.3
  • 94
    • 84885708784 scopus 로고    scopus 로고
    • Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas
    • Liffers ST, Tilkorn DJ, Stricker I. Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas. BMC Cancer 2013; 13: 490.
    • (2013) BMC Cancer , vol.13 , pp. 490
    • Liffers, S.T.1    Tilkorn, D.J.2    Stricker, I.3
  • 95
    • 82655178039 scopus 로고    scopus 로고
    • Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells
    • Zhang GN, Liang Y, Zhou LJ. Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells. Cancer Lett 2011; 313: 137–144.
    • (2011) Cancer Lett , vol.313 , pp. 137-144
    • Zhang, G.N.1    Liang, Y.2    Zhou, L.J.3
  • 96
    • 84943588084 scopus 로고    scopus 로고
    • Polymeric micelles of PEG-PLA copolymer as a carrier for salinomycin against gemcitabine-resistant pancreatic cancer
    • Daman Z, Montazeri H, Azizi M. Polymeric micelles of PEG-PLA copolymer as a carrier for salinomycin against gemcitabine-resistant pancreatic cancer. Pharm Res 2015; 32: 3756–3767.
    • (2015) Pharm Res , vol.32 , pp. 3756-3767
    • Daman, Z.1    Montazeri, H.2    Azizi, M.3
  • 97
    • 77956146147 scopus 로고    scopus 로고
    • Kit(low) stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors
    • Bardsley MR, Horvath VJ, Asuzu DT. Kit(low) stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology 2010; 139: 942–952.
    • (2010) Gastroenterology , vol.139 , pp. 942-952
    • Bardsley, M.R.1    Horvath, V.J.2    Asuzu, D.T.3
  • 98
    • 80055112766 scopus 로고    scopus 로고
    • The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles
    • Zhang Y, Zhang H, Wang X. The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles. Biomaterials 2012; 33: 679–691.
    • (2012) Biomaterials , vol.33 , pp. 679-691
    • Zhang, Y.1    Zhang, H.2    Wang, X.3
  • 99
    • 78650859954 scopus 로고    scopus 로고
    • Markers of tumor-initiating cells predict chemoresistance in breast cancer
    • Gong C, Yao H, Liu Q. Markers of tumor-initiating cells predict chemoresistance in breast cancer. PLoS ONE 2010; 5: e15630.
    • (2010) PLoS ONE , vol.5 , pp. e15630
    • Gong, C.1    Yao, H.2    Liu, Q.3
  • 100
    • 84883472741 scopus 로고    scopus 로고
    • Low amount of salinomycin greatly increases Akt activation, but reduces activated p70S6K levels
    • Kim JH, Choi AR, Kim YK. Low amount of salinomycin greatly increases Akt activation, but reduces activated p70S6K levels. Int J Mol Sci 2013; 14: 17304–17318.
    • (2013) Int J Mol Sci , vol.14 , pp. 17304-17318
    • Kim, J.H.1    Choi, A.R.2    Kim, Y.K.3
  • 101
    • 84884211845 scopus 로고    scopus 로고
    • Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting
    • Aydin RS., Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting. J Biomed Mater Res A 2013; 101: 1405–1415.
    • (2013) J Biomed Mater Res A , vol.101 , pp. 1405-1415
    • Aydin, R.S.1
  • 102
    • 0035174126 scopus 로고    scopus 로고
    • The role of HER2 in angiogenesis
    • Kumar R, Yarmand-Bagheri R., The role of HER2 in angiogenesis. Semin Oncol 2001; 28: 27–32.
    • (2001) Semin Oncol , vol.28 , pp. 27-32
    • Kumar, R.1    Yarmand-Bagheri, R.2
  • 103
    • 84876286931 scopus 로고    scopus 로고
    • Crosstalk between HER2 signaling and angiogenesis in breast cancer: molecular basis, clinical applications and challenges
    • Alameddine RS, Otrock ZK, Awada A. Crosstalk between HER2 signaling and angiogenesis in breast cancer: molecular basis, clinical applications and challenges. Curr Opin Oncol 2013; 25: 313–324.
    • (2013) Curr Opin Oncol , vol.25 , pp. 313-324
    • Alameddine, R.S.1    Otrock, Z.K.2    Awada, A.3
  • 104
    • 85017034968 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis by salinomycin and gefitinib through lysosomal and mitochondrial dependent pathway overcomes gefitinib resistance in colorectal cancer
    • 7, October,. Epub ahead of print
    • Zou ZZ, Nie PP, Li YW. Synergistic induction of apoptosis by salinomycin and gefitinib through lysosomal and mitochondrial dependent pathway overcomes gefitinib resistance in colorectal cancer. Oncotarget. Epub ahead of print 7 October 2015. DOI: 10.18632/oncotarget.5628.
    • (2015) Oncotarget
    • Zou, Z.Z.1    Nie, P.P.2    Li, Y.W.3
  • 105
    • 84937762843 scopus 로고    scopus 로고
    • Targeting breast cancer stem cells in triple-negative breast cancer using a combination of LBH589 and salinomycin
    • Kai M, Kanaya N, Wu SV. Targeting breast cancer stem cells in triple-negative breast cancer using a combination of LBH589 and salinomycin. Breast Cancer Res Treat 2015; 151: 281–294.
    • (2015) Breast Cancer Res Treat , vol.151 , pp. 281-294
    • Kai, M.1    Kanaya, N.2    Wu, S.V.3


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