Salinomycin toxicosis in horses

Journal of the American Veterinary Medical Association

Volumn 230, Issue 12, 2007, Pages 1822-1826

  Aleman, Monica ^a   Magdesian, K Gary ^a   Peterson, Tracy S ^a   Galey, Francis D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WYOMING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; PYRAN DERIVATIVE; SALINOMYCIN;

ANIMAL; ANIMAL FOOD; ARTICLE; CASE REPORT; CHEMICALLY INDUCED DISORDER; DIFFERENTIAL DIAGNOSIS; FATALITY; FEMALE; FOOD CONTAMINATION; HORSE; HORSE DISEASE; PATHOLOGY;

ANIMAL FEED; ANIMALS; ANTI-BACTERIAL AGENTS; DIAGNOSIS, DIFFERENTIAL; FATAL OUTCOME; FEMALE; FOOD CONTAMINATION; HORSE DISEASES; HORSES; PYRANS;

EQUIDAE;

EID: 34250309644     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.230.12.1822     Document Type: Article

References (46)

1. Mayhew IGJ. The diseased spinal cord, in Proceedings. 45th Annu Conv Am Assoc Equine Pract 1999;67-84.
2. Alonso MA, Carrasco L. Molecular basis of the permeabilization of mammalian cells by ionophores. Eur J Biochem 1982;127:567-569.
3. Doebler JA. Comparative effects of carboxylic ionophores on membrane potential and resistance of NG108-15 cells. Toxicol In Vitro 2000;14:235-243.
4. Novilla MN, Folkerts TM. Ionophores: monensin, lasalocid, salinomycin, narasin. In: Howard JL, ed. Current veterinary therapy, Food animal practice. New York: Academic Press, 1986;359-363.
5. Novilla MN. The veterinary importance of the toxic syndrome induced by ionophores. Vet Hum Toxicol 1992;34:66-70.
6. Story P, Doube A. A case of human poisoning by salinomycin, an agricultural antibiotic. N Z Med J 2004;117:U799.
7. Novilla MN, Owen NV, Todd GC. The comparative toxicology of narasin in laboratory animals. Vet Hum Toxicol 1994;36:318-323.
8. Van Der Linde-Sipman JS, Van Den Ingh TSGAM, Van Nes JJ, et al. Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. Vet Pathol 1999;36:152-156.
9. Perelman B, Pirak M, Smith B. Effects of the accidental feeding of lasalocid sodium to broiler breeder chickens. Vet Rec 1993;132:271-273.
10. Kavanagh NT, Sparrow DSH. Salinomycin toxicity in pigs. Vet Rec 1990;127:507.
11. Osweiler GD, Carson TL, Buck WB, et al. Monensin. In: Clinical and diagnostic veterinary toxicology. 3rd ed. Dubuque, Iowa: Kendall/Hunt Publishing Co, 1973;152-159.
12. Amend JF, Mallon FM, Wren WB, et al. Equine monensin toxicosis: some experimental clinicopathologic observations. Compend Contin Educ Pract Vet 1980;2:S173-S182.
13. Shier WT, Dubourdieu DJ. Sodium and calcium dependent steps in the mechanism of neonatal rat cardiac myocyte killing by ionophores: the calcium-carrying ionophore, A23187. Toxicol Appl Pharmacol 1992;116:47-56.
14. Van Vleet JF, Ferrans VJ. Ultrastructural myocardial alterations in monensin toxicosis in cattle. Am J Vet Res 1983;44:1629-1636.
15. Van Amstel SR, Guthrie AJ. Salinomycin poisoning in horses: case report, in Proceedings. 31st Annu Conv Am Assoc Equine Pract 1985;373-382.
16. Blomme EAG, Perle KMD, Wilkins PA, et al. Ionophore toxicity in horses. Equine Vet Educ 1999;11:153-158.
17. Hanson LJ, Eisenbeis HG, Givens SV. Toxic effects of lasalocid in horses. Am J Vet Res 1981;42:456-461.
18. Rollinson J, Taylor FG, Chesney J. Salinomycin poisoning in horses. Vet Rec 1987;121:126-128.
19. Niepon J, Czerw P, Harps O, et al. Salinomycin poisoning in a Polish stud horse [in German]. Tierarztl Prax Ausg G Grosstiere Nutztiere 1997;25:438-441.
20. Matsuoka T. Evaluation of monensin toxicity in the horse. J Am Vet Med Assoc 1976;169:1098-1100.
21. Gerhards H, Fenner A, Schoon HA. Monensin poisoning in horses. Dtsch Tierarztl Wochenschr 1986;93:323-326.
22. Schweitzer D, Kimberling C, Spraker T, et al. Accidental monensin sodium intoxication of feedlot cattle. J Am Vet Med Assoc 1984;184:1273-1276.
23. Confer AW, Revis DU, Panciera RJ. Light and electron microscopic changes in cardiac and skeletal muscle of sheep with experimental monensin toxicosis. Vet Pathol 1983;20:590-602.
24. Plumlee KH, Johnson B, Galey FD. Acute salinomycin toxicosis in pigs. J Vet Diagn Invest 1995;7:419-420.
25. Morgan JH, Collins P, Aitken IA, et al. An experimental study of the toxic interaction between tiamulin and salinomycin in pigs. Acta Vet Scand 1991;87:S365-S367.
26. Miller DJ, O'Connor JJ, Roberts NL. Tiamulin/salinomycin interactions in pigs. Vet Rec 1986;118:73-75.
27. Lehel J, Laczay P, Mora Z, et al. Toxicological studies on potentiated ionophores in chickens. Tolerance study. Acta Vet Hung 1995;43:321-333.
28. Andreasen JR, Schleifer JH. Salinomycin toxicosis in male breeder turkeys. Avian Dis 1995;39:638-642.
29. Safran N, Aizenberg I, Bark H. Paralytic syndrome attributed to lasalocid residues in a commercial ration fed to dogs. J Am Vet Med Assoc 1993;202:1273-1275.
30. Salles MS, Barros CSL, Barros SS. Ionophore antibiotic (narasin) poisoning in rabbits. Vet Hum Toxicol 1944;36:437-444.
31. Donoho AL, Manthey J, Occolowitz J, et al. Metabolism of monensin in the steer and rat. J Agric Food Chem 1978;26:1090-1095.
32. Flaminio J, Oehme FW. A review of equine toxicoses from dietary feedstuffs. Vet Clin Nutr 1997;4:12-24.
33. Oehme FW, Pickrell JA. An analysis of the chronic oral toxicity of polyether ionophore antibiotics in animals. Vet Hum Toxicol 1999;4:251-257.
34. Kronfeld DS. Lasalocid toxicosis is inadequately quantified for horses. Vet Hum Toxicol 2002;44:245-247.
35. Van Vleet JF, Ferrans VJ. Myocardial diseases of animals. Am J Pathol 1986;124:98-178.
36. Bezerra PS, Driemeier D, Loretti AP, et al. Monensin poisoning in Brazilian horses. Vet Hum Toxicol 1999;41:383-385.
37. Bila CG, Perreira CL, Gruys E. Accidental monensin toxicosis in horses in Mozambique. J S Afr Vet Assoc 2001;72:163-164.
38. Galitzer SJ, Oehme FW, Bartley EE, et al. Lasalocid toxicity in cattle: acute clinicopathological changes. J Anim Sci 1986;62:1308-1316.
39. Newsholme SJ, Howerth EW, Bastianello SS, et al. Fatal cardiomyopathy in feedlot sheep attributed to monensin toxicosis. J S Afr Vet Assoc 1983;54:29-32.
40. Whitlock RH. Feed additives and contaminants as a cause of equine disease. Vet Clin North Am Equine Pract 1990;6:467-478.
41. Van Vleet JF, Ferrans VJ. Ultrastructural alterations in skeletal muscle of pigs with acute monensin myotoxicosis. Am J Pathol 1984;114:462-471.
42. Ebel JG, Wachs T, Henion JD. Rapid forensic selected reaction monitoring liquid chromatography/mass spectrometry determination of ionophore antibiotics found at toxic levels in animal feeds. J AOAC Int 2004;87:25-30.
43. Cabadaj R, Nagy J, Popelka P, et al. The determination of salinomycin residues in the tissues of broiler chickens by using microbiological diffusion methods. Slov Vet Res 2002;39:137-143.
44. Peek SF, Marques FD, Morgan J, et al. Atypical acute monensin toxicosis and delayed cardiomyopathy in Belgian draft horses. J Vet Intern Med 2004;18:761-764.
45. Yin HS, Yang MF. Effect of monensin on the neuronal ultrastructure and endocytic pathway of macromolecules in cultured brain neurons. Cell Mol Neurobiol 1992;12:297-307.
46. Van Vleet JF, Amstutz HE, Weirich WE, et al. Acute monensin toxicosis in swine: effect of graded doses of rumensin and protection of swine by pretreatment with selenium-vitamin E. Am J Vet Res 1983;44:1460-1468.