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Volumn 25, Issue 3, 2013, Pages 313-324

Crosstalk between HER2 signaling and angiogenesis in breast cancer: Molecular basis, clinical applications and challenges

Author keywords

angiogenesis; breast cancer; human epidermal growth factor receptor 2; vascular endothelial growth factor

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CELECOXIB; CYCLOOXYGENASE 2; CYCLOPHOSPHAMIDE; DNA; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; EVEROLIMUS; FLUOROURACIL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NAVELBINE; PACLITAXEL; PANITUMUMAB; PAZOPANIB; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SUNITINIB; TRASTUZUMAB; VARLITINIB; VASCULOTROPIN;

EID: 84876286931     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32835ff362     Document Type: Review
Times cited : (47)

References (107)
  • 1
    • 34547221505 scopus 로고    scopus 로고
    • Understanding the biology of angiogenesis: Review of the most important molecular mechanisms
    • Otrock ZK, Mahfouz RA, Makarem JA, Shamseddine AI. Understanding the biology of angiogenesis: review of the most important molecular mechanisms. Blood Cells Mol Dis 2007; 39:212-220.
    • (2007) Blood Cells Mol Dis , vol.39 , pp. 212-220
    • Otrock, Z.K.1    Mahfouz, R.A.2    Makarem, J.A.3    Shamseddine, A.I.4
  • 2
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002; 2:795-803.
    • (2002) Nat Rev Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 3
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J, Aldrighetti D, Zucchinelli P, et al. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1    Aldrighetti, D.2    Zucchinelli, P.3
  • 5
    • 5044245200 scopus 로고    scopus 로고
    • Breast cancer: The role of angiogenesis and antiangiogenic therapy
    • Miller KD, Dul CL. Breast cancer: the role of angiogenesis and antiangiogenic therapy. Hematol Oncol Clin North Am 2004; 18:1071-1086.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 1071-1086
    • Miller, K.D.1    Dul, C.L.2
  • 6
    • 0028777164 scopus 로고
    • Angiogenesis and risk of breast cancer in women with fibrocystic disease
    • Guinebretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease. J Natl Cancer Inst 1994; 86:635-636.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 635-636
    • Guinebretiere, J.M.1    Le Monique, G.2    Gavoille, A.3
  • 7
    • 15544391142 scopus 로고    scopus 로고
    • Angiogenesis of breast cancer
    • Schneider BP, Miller KD. Angiogenesis of breast cancer. J Clin Oncol 2005; 23:1782-1790.
    • (2005) J Clin Oncol , vol.23 , pp. 1782-1790
    • Schneider, B.P.1    Miller, K.D.2
  • 8
    • 0017335455 scopus 로고
    • Angiogenesis: A marker for neoplastic transformation of mammary papillary hyperplasia
    • Brem S, Gullino P, Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science 1977; 195: 880-882.
    • (1977) Science , vol.195 , pp. 880-882
    • Brem, S.1    Gullino, P.2    Medina, D.3
  • 9
    • 0019986657 scopus 로고
    • Angiogenesis induced by "normal" human breast tissue: A probable marker for precancer
    • Jensen H, Chen I, DeVault M, Lewis A. Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer. Science 1982; 218:293-295.
    • (1982) Science , vol.218 , pp. 293-295
    • Jensen, H.1    Chen, I.2    Devault, M.3    Lewis, A.4
  • 10
    • 0028777164 scopus 로고
    • Angiogenesis and risk of breast cancer in women with fibrocystic disease
    • Guinebretière JM, Lê Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease. J Natl Cancer Inst 1994; 86:635-636.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 635-636
    • Guinebretière, J.M.1    Lê Monique, G.2    Gavoille, A.3
  • 11
    • 0028203848 scopus 로고
    • Microvessel density and distribution in ductal carcinoma in situ of the breast
    • Guidi AJ, Fischer L, Harris JR, Schnitt SJ. Microvessel density and distribution in ductal carcinoma in situ of the breast. J Natl Cancer Inst 1994; 86:614-619.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 614-619
    • Guidi, A.J.1    Fischer, L.2    Harris, J.R.3    Schnitt, S.J.4
  • 12
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000; 406:747-752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 13
    • 0034638917 scopus 로고    scopus 로고
    • Overexpression of ErbB2 in cancer and ErbB2-targeting strategies
    • Yu D, Hung MC. Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene 2000; 19:6115-6121.
    • (2000) Oncogene , vol.19 , pp. 6115-6121
    • Yu, D.1    Hung, M.C.2
  • 14
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 15
    • 78650243014 scopus 로고    scopus 로고
    • HER2-positive status is an independent predictor for coexisting invasion of ductal carcinoma in situ of the breast presenting extensive DCIS component
    • Liao N, Zhang GC, Liu YH, et al. HER2-positive status is an independent predictor for coexisting invasion of ductal carcinoma in situ of the breast presenting extensive DCIS component. Pathol Res Pract 2011; 207:1-7.
    • (2011) Pathol Res Pract , vol.207 , pp. 1-7
    • Liao, N.1    Zhang, G.C.2    Liu, Y.H.3
  • 16
    • 78651380337 scopus 로고    scopus 로고
    • New therapeutic approaches in breast cancer
    • Davies E, Hiscox S. New therapeutic approaches in breast cancer. Maturitas 2011; 68:121-128.
    • (2011) Maturitas , vol.68 , pp. 121-128
    • Davies, E.1    Hiscox, S.2
  • 17
    • 0026502860 scopus 로고
    • Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer
    • Wright C, Nicholson S, Angus B, et al. Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer. Br J Cancer 1992; 65:118-121.
    • (1992) Br J Cancer , vol.65 , pp. 118-121
    • Wright, C.1    Nicholson, S.2    Angus, B.3
  • 18
    • 0026059293 scopus 로고
    • Association of c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer
    • Kallioniemi OP, Holli K, Visakorpi T, et al. Association of c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer. Int J Cancer 1991; 49:650-655.
    • (1991) Int J Cancer , vol.49 , pp. 650-655
    • Kallioniemi, O.P.1    Holli, K.2    Visakorpi, T.3
  • 19
    • 0029658149 scopus 로고    scopus 로고
    • Inhibition of p185neu kinase activity and cellular transformation by co-expression of a truncated neu protein
    • Qian X, O'Rourke DM, Zhao H, Greene MI. Inhibition of p185neu kinase activity and cellular transformation by co-expression of a truncated neu protein. Oncogene 1996; 13:2149-2157.
    • (1996) Oncogene , vol.13 , pp. 2149-2157
    • Qian, X.1    O'Rourke, D.M.2    Zhao, H.3    Greene, M.I.4
  • 20
    • 78651437988 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor-2-positive breast cancer: Current management of early, advanced, and recurrent disease
    • Callahan R, Hurvitz S. Human epidermal growth factor receptor-2-positive breast cancer: current management of early, advanced, and recurrent disease. Curr Opin Obstet Gynecol 2011; 23:37-43.
    • (2011) Curr Opin Obstet Gynecol , vol.23 , pp. 37-43
    • Callahan, R.1    Hurvitz, S.2
  • 21
    • 10744230127 scopus 로고    scopus 로고
    • An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
    • Burgess AW, Cho HS, Eigenbrot C, et al. An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell 2003; 12:541-552.
    • (2003) Mol Cell , vol.12 , pp. 541-552
    • Burgess, A.W.1    Cho, H.S.2    Eigenbrot, C.3
  • 22
    • 2442701289 scopus 로고    scopus 로고
    • The ErbB/HER receptor protein-tyrosine kinases and cancer
    • Roskoski R Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 2004; 319:1-11.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 1-11
    • Roskoski Jr., R.1
  • 23
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103:211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 24
    • 0037019186 scopus 로고    scopus 로고
    • Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells
    • Neve RM, Holbro T, Hynes NE. Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells. Oncogene 2002; 21:4567-4576.
    • (2002) Oncogene , vol.21 , pp. 4567-4576
    • Neve, R.M.1    Holbro, T.2    Hynes, N.E.3
  • 25
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of ErbB-2 and ErbB-3
    • Citri A, Skaria KB, Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 2003; 284:54-65.
    • (2003) Exp Cell Res , vol.284 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 26
    • 0028335209 scopus 로고
    • The erbB3 gene product is a receptor for heregulin
    • Carraway KL 3rd, Sliwkowski MK, Akita R, et al. The erbB3 gene product is a receptor for heregulin. J Biol Chem 1994; 269:14303-14306.
    • (1994) J Biol Chem , vol.269 , pp. 14303-14306
    • Carraway III, K.L.1    Sliwkowski, M.K.2    Akita, R.3
  • 27
    • 0033608993 scopus 로고    scopus 로고
    • The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors
    • Klapper LN, Glathe S, Vaisman N, et al. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci USA 1999; 96:4995-5000.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4995-5000
    • Klapper, L.N.1    Glathe, S.2    Vaisman, N.3
  • 28
    • 0028358856 scopus 로고
    • Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin
    • Sliwkowski MX, Schaefer G, Akita RW, et al. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J Biol Chem 1994; 269:14661-14665.
    • (1994) J Biol Chem , vol.269 , pp. 14661-14665
    • Sliwkowski, M.X.1    Schaefer, G.2    Akita, R.W.3
  • 29
    • 0035230358 scopus 로고    scopus 로고
    • Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network
    • Troyer KL, Lee DC. Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network. J Mammary Gland Biol Neoplasia 2001; 6:7-21.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 7-21
    • Troyer, K.L.1    Lee, D.C.2
  • 31
    • 2342492317 scopus 로고    scopus 로고
    • Review of epidermal growth factor receptor biology
    • Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 2004; 59 (2 Suppl):21-26.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , Issue.2 SUPPL. , pp. 21-26
    • Herbst, R.S.1
  • 32
    • 1542329005 scopus 로고    scopus 로고
    • The erbB family: Targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors
    • Rowinsky EK. The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors. Annu Rev Med 2004; 55:433-457.
    • (2004) Annu Rev Med , vol.55 , pp. 433-457
    • Rowinsky, E.K.1
  • 33
    • 0029965411 scopus 로고    scopus 로고
    • Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities
    • Beerli RR, Hynes NE. Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J Biol Chem 1996; 271:6071-6076.
    • (1996) J Biol Chem , vol.271 , pp. 6071-6076
    • Beerli, R.R.1    Hynes, N.E.2
  • 34
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1a (HIF-1a) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, et al. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1a (HIF-1a) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001; 21:3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3
  • 35
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 1997; 151:1523-1530.
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3
  • 36
    • 0034691674 scopus 로고    scopus 로고
    • Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
    • Yen L, You XL, Al Moustafa AE, et al. Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene 2000; 19:3460-3469.
    • (2000) Oncogene , vol.19 , pp. 3460-3469
    • Yen, L.1    You, X.L.2    Al Moustafa, A.E.3
  • 37
    • 0036316476 scopus 로고    scopus 로고
    • Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor
    • Pegram MD, Reese DM. Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor. Semin Oncol 2002; 29 (3 Suppl 11):29-37.
    • (2002) Semin Oncol , vol.29 , Issue.3 SUPPL. 11 , pp. 29-37
    • Pegram, M.D.1    Reese, D.M.2
  • 38
    • 10744232812 scopus 로고    scopus 로고
    • Evaluation of the prognostic role of vascular endothelial growth factor and microvessel density in stages i and II breast cancer patients
    • Ludovini V, Sidoni A, Pistola L, et al. Evaluation of the prognostic role of vascular endothelial growth factor and microvessel density in stages I and II breast cancer patients. Breast Cancer Res Treat 2003; 81:159-168.
    • (2003) Breast Cancer Res Treat , vol.81 , pp. 159-168
    • Ludovini, V.1    Sidoni, A.2    Pistola, L.3
  • 39
    • 0035866387 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-(1-activated p38 signaling pathway enhances endothelial cell migration
    • Xiong S, Grijalva R, Zhang L, et al. Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-(1-activated p38 signaling pathway enhances endothelial cell migration. Cancer Res 2001; 61:1727-1732.
    • (2001) Cancer Res , vol.61 , pp. 1727-1732
    • Xiong, S.1    Grijalva, R.2    Zhang, L.3
  • 40
    • 33644529055 scopus 로고    scopus 로고
    • ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells
    • Klos KS, Wyszomierski SL, Sun M, et al. ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. Cancer Res 2006; 66:2028-2037.
    • (2006) Cancer Res , vol.66 , pp. 2028-2037
    • Klos, K.S.1    Wyszomierski, S.L.2    Sun, M.3
  • 41
    • 12144291334 scopus 로고    scopus 로고
    • Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
    • Konecny GE, Meng YG, Untch M, et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004; 10:1706-1716.
    • (2004) Clin Cancer Res , vol.10 , pp. 1706-1716
    • Konecny, G.E.1    Meng, Y.G.2    Untch, M.3
  • 42
    • 4544376914 scopus 로고    scopus 로고
    • Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
    • Wang S-C, Lien H-C, Xia W, et al. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell 2004; 6:251-261.
    • (2004) Cancer Cell , vol.6 , pp. 251-261
    • Wang, S.-C.1    Lien, H.-C.2    Xia, W.3
  • 43
    • 77954759289 scopus 로고    scopus 로고
    • Nuclear trafficking of the epidermal growth factor receptor family membrane proteins
    • Wang YN, Yamaguchi H, Hsu JM, Hung MC. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene 2010; 29:3997-4006.
    • (2010) Oncogene , vol.29 , pp. 3997-4006
    • Wang, Y.N.1    Yamaguchi, H.2    Hsu, J.M.3    Hung, M.C.4
  • 44
    • 28544448741 scopus 로고    scopus 로고
    • Endosomal transport of ErbB-2: Mechanism for nuclear entry of the cell surface receptor
    • Giri DK, Ali-Seyed M, Li L-Y, et al. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Mol Cell Biol 2005; 25:11005-11018.
    • (2005) Mol Cell Biol , vol.25 , pp. 11005-11018
    • Giri, D.K.1    Ali-Seyed, M.2    Li, L.-Y.3
  • 45
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S, et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93:705-716.
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3
  • 46
    • 0034530889 scopus 로고    scopus 로고
    • The contributions of cyclooxygenase-2 to tumor angiogenesis
    • Gately S. The contributions of cyclooxygenase-2 to tumor angiogenesis. Cancer Metastasis Rev 2000; 19:19-27.
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 19-27
    • Gately, S.1
  • 47
    • 0347717578 scopus 로고    scopus 로고
    • Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression
    • Chang S-H, Liu CH, Conway R, et al. Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci USA 2004; 101:591-596.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 591-596
    • Chang, S.-H.1    Liu, C.H.2    Conway, R.3
  • 48
    • 0347087225 scopus 로고    scopus 로고
    • Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch
    • Wang D, DuBois RN. Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch. Proc Natl Acad Sc USA 2004; 101: 415-416.
    • (2004) Proc Natl Acad Sc USA , vol.101 , pp. 415-416
    • Wang, D.1    Dubois, R.N.2
  • 49
    • 0037166271 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer
    • Subbaramaiah K, Norton L, Gerald W, Dannanberg AJ. Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer. J Biol Chem 2002; 277:18649-18657.
    • (2002) J Biol Chem , vol.277 , pp. 18649-18657
    • Subbaramaiah, K.1    Norton, L.2    Gerald, W.3    Dannanberg, A.J.4
  • 50
    • 27544512985 scopus 로고    scopus 로고
    • HER2/neu-Induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice
    • Howe LR, Chang S-H, Tolle KC, et al. HER2/neu-Induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Res 2005; 65:10113-10119.
    • (2005) Cancer Res , vol.65 , pp. 10113-10119
    • Howe, L.R.1    Chang, S.-H.2    Tolle, K.C.3
  • 51
    • 79952284127 scopus 로고    scopus 로고
    • Weinberg, hallmarks of cancer: The next generation
    • Hanahan D, Robert A. Weinberg, hallmarks of cancer: the next generation. Cell 2011; 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Robert, A.2
  • 52
    • 33750584030 scopus 로고    scopus 로고
    • HER2 signaling modulates the equilibrium between pro-and antiangiogenic factors via distinct pathways: Implications for HER2-targeted antibody therapy
    • Wen XF, Yang G, Mao W, et al. HER2 signaling modulates the equilibrium between pro-and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene 2006; 25:6986-6996.
    • (2006) Oncogene , vol.25 , pp. 6986-6996
    • Wen, X.F.1    Yang, G.2    Mao, W.3
  • 53
    • 57349164272 scopus 로고    scopus 로고
    • Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that over-express HER2
    • Le XF, Mao W, Lu C, et al. Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that over-express HER2. Cell Cycle 2008; 7:3747-3758.
    • (2008) Cell Cycle , vol.7 , pp. 3747-3758
    • Le Mao, X.F.W.1    Lu, C.2
  • 54
    • 60549087905 scopus 로고    scopus 로고
    • A specific vascular endothelial growth factor receptor tyrosine kinase inhibitor enhances the antiproliferative effect of trastuzumab in human epidermal growth factor receptor 2 over-expressing breast cancer cell lines
    • Kim EM, Lobocki C, Dubay L, Mittal VK. A specific vascular endothelial growth factor receptor tyrosine kinase inhibitor enhances the antiproliferative effect of trastuzumab in human epidermal growth factor receptor 2 over-expressing breast cancer cell lines. Am J Surg 2009; 197:331-336.
    • (2009) Am J Surg , vol.197 , pp. 331-336
    • Kim, E.M.1    Lobocki, C.2    Dubay, L.3    Mittal, V.K.4
  • 55
    • 0037149539 scopus 로고    scopus 로고
    • Tumour biology: Herceptin acts as an antiangiogenic cocktail
    • Izumi Y, Xu L, Tomaso E, et al. Tumour biology: herceptin acts as an antiangiogenic cocktail. Nature 2002; 416:279-280.
    • (2002) Nature , vol.416 , pp. 279-280
    • Izumi, Y.1    Xu, L.2    Tomaso, E.3
  • 56
    • 59949090933 scopus 로고    scopus 로고
    • Modified resistance to chemotherapy and trastuzumab by bevacizumab in locally recurrent breast cancer
    • Farhat MH, El-Saghir NS, Shamseddine AI. Modified resistance to chemotherapy and trastuzumab by bevacizumab in locally recurrent breast cancer. Breast 2009; 18:66-68.
    • (2009) Breast , vol.18 , pp. 66-68
    • Farhat, M.H.1    El-Saghir, N.S.2    Shamseddine, A.I.3
  • 57
    • 69949096157 scopus 로고    scopus 로고
    • Phase II study of neoadjuvant bevacizumab and trastuzumab administered with albumin-bound paclitaxel (nab paclitaxel) and carboplatin in HER2+ locally advanced breast cancer
    • Raefsky E, Castillo R, Lahiry A, et al. Phase II study of neoadjuvant bevacizumab and trastuzumab administered with albumin-bound paclitaxel (nab paclitaxel) and carboplatin in HER2+ locally advanced breast cancer. ASCO Meeting Abstracts 2008; 26 (15 suppl):627.
    • (2008) ASCO Meeting Abstracts , vol.26 , Issue.15 SUPPL. , pp. 627
    • Raefsky, E.1    Castillo, R.2    Lahiry, A.3
  • 58
    • 84876291029 scopus 로고    scopus 로고
    • Epirubicin plus cyclophosphamide followed by docetaxel plus trastuzumab and bevacizumab as neoadjuvant therapy for HER2-positive locally advanced breast cancer (LABC) or as adjuvant therapy for HER2-positive pathologic stage III breast cancer (PS3BC): A phase II trial of the NSABP Foundation Research Group
    • Smith JW, Buyse M, Rastogi P, et al. Epirubicin plus cyclophosphamide followed by docetaxel plus trastuzumab and bevacizumab as neoadjuvant therapy for HER2-positive locally advanced breast cancer (LABC) or as adjuvant therapy for HER2-positive pathologic stage III breast cancer (PS3BC): A phase II trial of the NSABP Foundation Research Group. ASCO Meeting Abstracts 2009; 27 (15S):580.
    • (2009) ASCO Meeting Abstracts , vol.27 , Issue.15 S , pp. 580
    • Smith, J.W.1    Buyse, M.2    Rastogi, P.3
  • 59
    • 79953859123 scopus 로고    scopus 로고
    • Combination treatment with HER-2 and VEGF peptide mimics induces potent antitumor and antiangiogenic responses in vitro and in vivo
    • Foy KC, Liu Z, Phillips G, Miller M. Combination treatment with HER-2 and VEGF peptide mimics induces potent antitumor and antiangiogenic responses in vitro and in vivo. J Biol Chem 2011; 286:13626-13637.
    • (2011) J Biol Chem , vol.286 , pp. 13626-13637
    • Foy, K.C.1    Liu, Z.2    Phillips, G.3    Miller, M.4
  • 60
    • 84855725650 scopus 로고    scopus 로고
    • Phase II study of neoadjuvant weekly nab-paclitaxel and carboplatin, with bevacizumab and trastuzumab, as treatment for women with locally advanced HER2+ breast cancer
    • Yardley DA, Raefsky E, Castillo R, et al. Phase II study of neoadjuvant weekly nab-paclitaxel and carboplatin, with bevacizumab and trastuzumab, as treatment for women with locally advanced HER2+ breast cancer. Clin Breast Cancer 2011; 11:297-305.
    • (2011) Clin Breast Cancer , vol.11 , pp. 297-305
    • Yardley, D.A.1    Raefsky, E.2    Castillo, R.3
  • 61
    • 84859158912 scopus 로고    scopus 로고
    • Neoadjuvant bevacizumab, trastuzumab, and chemotherapy for primary inflammatory HER2-positive breast cancer (BEVERLY-2): An open-label, single-arm phase 2 study
    • Pierga JY, Petit T, Delozier T, et al. Neoadjuvant bevacizumab, trastuzumab, and chemotherapy for primary inflammatory HER2-positive breast cancer (BEVERLY-2): an open-label, single-arm phase 2 study. Lancet Oncol 2012;13:375-384.
    • (2012) Lancet Oncol , vol.13 , pp. 375-384
    • Pierga, J.Y.1    Petit, T.2    Delozier, T.3
  • 62
    • 84875053244 scopus 로고    scopus 로고
    • A phase II study of lapatinib and bevacizumab as treatment for HER2-overexpressing metastatic breast cancer
    • Rugo HS, Jo Chien A, Franco SX, et al. A phase II study of lapatinib and bevacizumab as treatment for HER2-overexpressing metastatic breast cancer. Breast Cancer Res Treat 2011; 24:24.
    • (2011) Breast Cancer Res Treat , vol.24 , pp. 24
    • Rugo, H.S.1    Jo Chien, A.2    Franco, S.X.3
  • 63
    • 84860148054 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer
    • Martin M, Makhson A, Gligorov J, et al. Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer. Oncologist 2012; 17:469-475.
    • (2012) Oncologist , vol.17 , pp. 469-475
    • Martin, M.1    Makhson, A.2    Gligorov, J.3
  • 64
    • 84856806836 scopus 로고    scopus 로고
    • S4-8: First results of AVEREL a randomized phase III trial to evaluate bevacizumab (BEV) in combination with trastuzumab (H) + docetaxel (DOC) as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer (LR/mBC)
    • Gianni L, Romieu G, Lichinitser M, et al. S4-8: First results of AVEREL, a randomized phase III trial to evaluate bevacizumab (BEV) in combination with trastuzumab (H) + docetaxel (DOC) as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer (LR/mBC). Cancer Res 2012; 71 (Suppl 24):S4-S8.
    • (2012) Cancer Res , vol.71 , Issue.SUPPL. 24
    • Gianni, L.1    Romieu, G.2    Lichinitser, M.3
  • 65
    • 84869205333 scopus 로고    scopus 로고
    • An exploratory study of sunitinib in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive metastatic breast cancer
    • Cardoso F, Canon JL, Amadori D, et al. An exploratory study of sunitinib in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive metastatic breast cancer. Breast 2012; 21: 716-723.
    • (2012) Breast , vol.21 , pp. 716-723
    • Cardoso, F.1    Canon, J.L.2    Amadori, D.3
  • 66
    • 84876281124 scopus 로고    scopus 로고
    • A randomized phase II study (VEG108838) of lapatanib plus pazopanib (L+P) versus lapatanib (L) in patients with ErbB2+ inflammatory breast cancer (IBC)
    • Cristofanilli M, Johnston SRD, Manikhas A, et al. A randomized phase II study (VEG108838) of lapatanib plus pazopanib (L+P) versus lapatanib (L) in patients with ErbB2+ inflammatory breast cancer (IBC). ASCO Meeting Abstracts 2012; 30 (Suppl 15):531.
    • (2012) ASCO Meeting Abstracts , vol.30 , Issue.SUPPL. 15 , pp. 531
    • Cristofanilli, M.1    Johnston, S.R.D.2    Manikhas, A.3
  • 67
    • 0035214416 scopus 로고    scopus 로고
    • Metronomic scheduling: The future of chemotherapy?
    • Gasparini G. Metronomic scheduling: the future of chemotherapy? Lancet Oncol 2001; 2:733-740.
    • (2001) Lancet Oncol , vol.2 , pp. 733-740
    • Gasparini, G.1
  • 68
    • 0035105777 scopus 로고    scopus 로고
    • Pharmacogenetic applications of the Human Genome project
    • Liggett SB. Pharmacogenetic applications of the Human Genome project. Nat Med 2001; 7:281-283.
    • (2001) Nat Med , vol.7 , pp. 281-283
    • Liggett, S.B.1
  • 69
    • 0035461919 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of lower dose cancer chemotherapy
    • Gately S, Kerbel R. Antiangiogenic scheduling of lower dose cancer chemotherapy. Cancer J 2001; 7:427-436.
    • (2001) Cancer J , vol.7 , pp. 427-436
    • Gately, S.1    Kerbel, R.2
  • 70
    • 0033563116 scopus 로고    scopus 로고
    • Purine analogue 6-methylmercapto-purine riboside inhibits early and late phases of the angiogenesis process
    • Presta M, Rusnati M, Belleri M, et al. Purine analogue 6-methylmercapto-purine riboside inhibits early and late phases of the angiogenesis process. Cancer Res 1999; 59:2417-2424.
    • (1999) Cancer Res , vol.59 , pp. 2417-2424
    • Presta, M.1    Rusnati, M.2    Belleri, M.3
  • 71
    • 0032762952 scopus 로고    scopus 로고
    • Antiangiogenesis is produced by nontoxic doses of vinblastine
    • Vacca A, Iurlaro M, Ribatti D, et al. Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood 1999; 94:4143-4155.
    • (1999) Blood , vol.94 , pp. 4143-4155
    • Vacca, A.1    Iurlaro, M.2    Ribatti, D.3
  • 72
    • 0034243694 scopus 로고    scopus 로고
    • High-time chemotherapy or high time for low dose
    • Kamen BA, Rubin E, Aisner J, Glastein E. High-time chemotherapy or high time for low dose. J Clin Oncol 2000; 18:2935-2937.
    • (2000) J Clin Oncol , vol.18 , pp. 2935-2937
    • Kamen, B.A.1    Rubin, E.2    Aisner, J.3    Glastein, E.4
  • 73
    • 0031757277 scopus 로고    scopus 로고
    • Dose-dense therapy with weekly 1-h paclitaxel infusions in the treatment of metastatic breast cancer
    • Seidman AD, Hudis CA, Albanelll J, et al. Dose-dense therapy with weekly 1-h paclitaxel infusions in the treatment of metastatic breast cancer. J Clin Oncol 1998; 16:3353-3361.
    • (1998) J Clin Oncol , vol.16 , pp. 3353-3361
    • Seidman, A.D.1    Hudis, C.A.2    Albanelll, J.3
  • 74
    • 32944458087 scopus 로고    scopus 로고
    • Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts
    • du Manoir JM, Francia G, Man S, et al. Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts. Clin Cancer Res 2006; 12: 904-916.
    • (2006) Clin Cancer Res , vol.12 , pp. 904-916
    • Du Manoir, J.M.1    Francia, G.2    Man, S.3
  • 75
    • 33749416983 scopus 로고    scopus 로고
    • Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer
    • Orlando L, Caedillo A, Ghisini R, et al. Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer. BMC Cancer 2006; 6:225.
    • (2006) BMC Cancer , vol.6 , pp. 225
    • Orlando, L.1    Caedillo, A.2    Ghisini, R.3
  • 76
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 2010; 40:310-322.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 77
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 78
    • 34147121375 scopus 로고    scopus 로고
    • Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
    • Kobayashi S, Kishimoto T, Kamata S, et al. Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci 2007; 98:726-733.
    • (2007) Cancer Sci , vol.98 , pp. 726-733
    • Kobayashi, S.1    Kishimoto, T.2    Kamata, S.3
  • 79
    • 30044432434 scopus 로고    scopus 로고
    • Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
    • Thomas GV, Tran C, Mellinghoff IK, et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006; 12:122-127.
    • (2006) Nat Med , vol.12 , pp. 122-127
    • Thomas, G.V.1    Tran, C.2    Mellinghoff, I.K.3
  • 80
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372:449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 81
    • 79955510505 scopus 로고    scopus 로고
    • Efficacy and safety of sirolimus in lymphangioleiomyomatosis
    • McCormack FX, Inoue Y, Moss J, et al. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med 2011; 364:1595-1606.
    • (2011) N Engl J Med , vol.364 , pp. 1595-1606
    • McCormack, F.X.1    Inoue, Y.2    Moss, J.3
  • 82
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpres-sing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpres-sing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011; 29:3126-3132.
    • (2011) J Clin Oncol , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 83
    • 1542615084 scopus 로고    scopus 로고
    • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity
    • Wei D, Wang L, He Y, et al. Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res 2004; 64:2030-2038.
    • (2004) Cancer Res , vol.64 , pp. 2030-2038
    • Wei, D.1    Wang, L.2    He, Y.3
  • 84
    • 69249114644 scopus 로고    scopus 로고
    • Celecoxib enhanced the sensitivity of cancer cells to anticancer drugs by inhibition of the expression of P-glycoprotein through a COX-2-independent manner
    • Xia W, Zhao T, Lv J, et al. Celecoxib enhanced the sensitivity of cancer cells to anticancer drugs by inhibition of the expression of P-glycoprotein through a COX-2-independent manner. J Cell Biochem 2009; 108:181-194.
    • (2009) J Cell Biochem , vol.108 , pp. 181-194
    • Xia, W.1    Zhao, T.2    Lv, J.3
  • 85
    • 3042621502 scopus 로고    scopus 로고
    • Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments
    • Dang CT, Dannenberg AJ, Subbaramaiah K, et al. Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments. Clin Cancer Res 2004; 10:4062-4067.
    • (2004) Clin Cancer Res , vol.10 , pp. 4062-4067
    • Dang, C.T.1    Dannenberg, A.J.2    Subbaramaiah, K.3
  • 86
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357:2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 87
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Dieras V, Glaspy J, et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 2011; 29:1252-1260.
    • (2011) J Clin Oncol , vol.29 , pp. 1252-1260
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3
  • 88
    • 80054883209 scopus 로고    scopus 로고
    • Efficacy and safety ofbevacizumab in combination with docetaxel for the first-line treatment of elderly patients with locally recurrent or metastatic breast cancer: Results from AVADO
    • Pivot X, Schneeweiss A, Verma S, et al. Efficacy and safety ofbevacizumab in combination with docetaxel for the first-line treatment of elderly patients with locally recurrent or metastatic breast cancer: Results from AVADO. Eur J Cancer 2011; 47:2387-2395.
    • (2011) Eur J Cancer , vol.47 , pp. 2387-2395
    • Pivot, X.1    Schneeweiss, A.2    Verma, S.3
  • 89
    • 79960241809 scopus 로고    scopus 로고
    • Changing end points in breast-cancer drug approval: The Avastin story
    • D'Agostino RB Sr. Changing end points in breast-cancer drug approval: the Avastin story. N Engl J Med 2011; 365:e2.
    • (2011) N Engl J Med , vol.365
    • D'Agostino Sr., R.B.1
  • 90
    • 84876285095 scopus 로고    scopus 로고
    • Primary results of BEATRICE, a randomized phase III trial evaluating adjuvant bevacizumab-containing therapy in triple-negative breast cancer
    • Cameron D, Brown J, Dent R, et al. Primary results of BEATRICE, a randomized phase III trial evaluating adjuvant bevacizumab-containing therapy in triple-negative breast cancer. Cancer Res 2012; 72 (Suppl 24):S6-5.
    • (2012) Cancer Res , vol.72 , Issue.SUPPL. 24
    • Cameron, D.1    Brown, J.2    Dent, R.3
  • 91
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JM, Lee CR, Cruz-Munoz W, et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15:232-239.
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3
  • 92
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15:220-231.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 93
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005; 8:299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 94
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R, Lu KV, Petritsch C, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008; 13:206-220.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3
  • 95
    • 0242456268 scopus 로고    scopus 로고
    • Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival
    • Darland DC, Massingham LJ, Smith SR, et al. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol 2003; 264:275-288.
    • (2003) Dev Biol , vol.264 , pp. 275-288
    • Darland, D.C.1    Massingham, L.J.2    Smith, S.R.3
  • 96
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003; 111:1287-1295.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3
  • 97
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • Rubenstein JL, Kim J, Ozawa T, et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2000; 2:306-314.
    • (2000) Neoplasia , vol.2 , pp. 306-314
    • Rubenstein, J.L.1    Kim, J.2    Ozawa, T.3
  • 98
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997; 57:963-969.
    • (1997) Cancer Res , vol.57 , pp. 963-969
    • Relf, M.1    Lejeune, S.2    Scott, P.A.3
  • 99
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    • Shojaei F, Wu X, Malik AK, et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol 2007; 25:911-920.
    • (2007) Nat Biotechnol , vol.25 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Malik, A.K.3
  • 100
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009; 360:563-572.
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 101
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27:672-680.
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 102
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 Study
    • Saltz LB, Lenz H-J, Kindler HL, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 Study. J Clin Oncol 2007; 25:4557-4561.
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.-J.2    Kindler, H.L.3
  • 103
    • 75649085336 scopus 로고    scopus 로고
    • More is less-combining targeted therapies in metastatic colorectal cancer
    • Punt CJA, Tol J. More is less-combining targeted therapies in metastatic colorectal cancer. Nat Rev Clin Oncol 2009; 6:731-733.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 731-733
    • Punt, C.J.A.1    Tol, J.2
  • 104
    • 79956205502 scopus 로고    scopus 로고
    • Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis
    • Larsen AK, Ouaret D, El Ouadrani K, Petitprez A. Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Therap 2011; 131:80-90.
    • (2011) Pharmacol Therap , vol.131 , pp. 80-90
    • Larsen, A.K.1    Ouaret, D.2    El Ouadrani, K.3    Petitprez, A.4
  • 105
    • 79952083872 scopus 로고    scopus 로고
    • Congestive heart failure risk in patients with breast cancer treated with bevacizumab
    • Choueiri TK, Mayer EL, Je Y, et al. Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol 2011; 29:632-638.
    • (2011) J Clin Oncol , vol.29 , pp. 632-638
    • Choueiri, T.K.1    Mayer, E.L.2    Je, Y.3
  • 106
    • 79959296552 scopus 로고    scopus 로고
    • Cardiotoxicity in patients treated with bevacizumab is potentially reversible
    • Hawkes EA, Okines AF, Plummer C, Cunningham D. Cardiotoxicity in patients treated with bevacizumab is potentially reversible. J Clin Oncol 2011; 29:e560-e562.
    • (2011) J Clin Oncol , vol.29
    • Hawkes, E.A.1    Okines, A.F.2    Plummer, C.3    Cunningham, D.4
  • 107
    • 84862487751 scopus 로고    scopus 로고
    • Targeted therapies in breast cancer: Are heart and vesselsalso being targeted?
    • Criscitiello C, Matzger-Filho O, Saini KS, et al. Targeted therapies in breast cancer: are heart and vesselsalso being targeted? Breast Cancer Res 2012; 14:209.
    • (2012) Breast Cancer Res , vol.14 , pp. 209
    • Criscitiello, C.1    Matzger-Filho, O.2    Saini, K.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.