Overexpression of the ABC transporter TAP in multidrug-resistant human cancer cell lines

British Journal of Cancer

Volumn 74, Issue 12, 1996, Pages 1961-1967

  Izquierdo, M A ^a,c   Neefjes, J J ^b   Mathari, A E L ^a   Flens, M J ^a   Scheffer, G L ^a   Scheper, R J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c CATALAN INSTITUTE OF ONCOLOGY   (Spain)

Author keywords

ATP binding cassette; Multidrug resistance; Transmembrane transporter; Transporter associated with antigen processing

Indexed keywords

ABC TRANSPORTER; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VINCRISTINE;

ANTIGEN PRESENTATION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LYMPHOBLASTOID CELL LINE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

EID: 0030444003     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.660     Document Type: Article

References (31)

1. BECK WT AND DANKS MK. (1991). Characteristics of multidrug resistance in human tumor cells. In Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells, Roninson IB. (ed.) pp. 3-55. Plenum: New York.
2. CHILDS S AND LING V. (1994). The MDR superfamily of genes and its biological implications. In Important Advances in Oncology, DeVita VT, Hellman S and Rosenberg SA. (eds) pp. 21-36. Lippincott: Philadelphia.
3. COLE SPC, BHARDWAJ G, GERLACH JH, MACKIE JE, GRANT CE, ALMQUIST KC, STEWART AJ, KURZ EU, DUNCAN AMV AND DEELEY RG. (1992). Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science, 258, 1650-1654.
4. COLE SPC, SPARKS KE, FRASER K, LOE DW, GRANT CE, WILSON GM AND DEELEY RG. (1994). Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res., 54, 5902-5910.
5. CROMME FV, AIREY J, HEEMELS MT, PLOEGH HL, KEATING PJ, STERN PL, MEIJER CJ AND WALBOOMERS JM. (1994). Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J. Exp. Med., 179, 335-340.
6. EYTAN GD, BORGNIA MJ, REGEV R AND ASSARAF YG. (1994). Transport of polypeptide ionophores into proteoliposomes reconstituted with rat liver P-glycoprotein. J. Biol. Chem., 269, 26058-26065.
7. FLENS MJ, IZQUIERDO MA, SCHEFFER GL, FRITZ JM, MEIJER CJLM, SCHEPER RJ AND ZAMAN GJ. (1994). Immunochemical detection of MRP in human multidrug-resistant tumor cells By monoclonal antibodies. Cancer Res., 54, 4557-4563.
8. GOTTESMAN MM AND PASTAN I. (1993). Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62, 385-427.
9. GRANT CE, VALDIMARSSON G, HIPFNER DR, ALMQUIST KC, COLE SPC AND DEELEY RG. (1994). Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res., 54, 357-361.
10. GUILD BC, MULLIGAN RC, GROS P AND HOUSMAN DE. (1988). Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection. Proc. Natl Acad. Sci. USA, 85, 1595-1599.
11. HAMADA H AND TSURUO T. Functional role for the 170 to 180 kDa glycoprotein specific to drug resistant tumor cells as revealed by monoclonal antibodies. Proc. Natl Acad. Sci. USA, 83, 7785-7789.
12. HIGGINS CF. (1992). ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol., 8, 67-113.
13. KUIPER CM, BROXTERMAN HJ, BAAS F, SCHUURUHUIS GJ, HAISMA HJ, SCHFFER GL, LANKELMA J AND PINEDO HM. (1990). Drug transport variants without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin. J. Cell Pharmacol., 1, 35-41.
14. MANAVALAN P. SMITH AE AND MCPHERSON JM. (1993). Sequence and structural homology among membrane-associated domains of CFTR and certain transporter proteins. J. Prot. Chem., 12, 279-290.
15. MARQUARDT D AND CENTER MS. (1992). Drug transport mechanisms in HL60 cells isolated for resistance to adryamicin: evidence for nuclear drug accumulation and redistribution in resistant cells. Cancer Res., 52, 3157-3163.
16. MOMBURG F, ORTIZ-NAVARRETE V, NEEFJES J, GOULMY E, VAN DE WAL Y, SPITS H, POWIS SJ, BUTCHER GW, HOWARD JC, WALDEN P AND HAMMERLING J. (1992). Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation. Nature, 360, 174-177.
17. NEEFJES JJ AND PLOEGH HL. (1988). Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosilation on class I subunit association. Eur. J. Immunol., 18, 801-810.
18. NEEFJES JJ, MOMBURG F AND HÄMMERLING GJ. (1993). Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science, 261, 769-771.
19. NEISAG A, ROELFE G, SIJITS AJAM, OSSENDORP F, FEELTKAMP MCW, KAST WM, MELIEF CJM AND NEEFJES JJ. (1995). Major differences in transport-associated with antigen (TAP)-dependent translocation of MHC class I. Presentable peptides and the effect of flanking sequences. J. Immunol., 154, 1273-1279.
20. RESTIFO NP, ESQUIVEL F, KAWAKAMI Y, YEWDELL JW, MULE JJ, ROSENBERG SA AND BENNINK JR. (1993). Identification of human cancers deficient in antigen processing. J. Exp. Med., 177, 265-272.
21. SALTER RD, HOWELL DN AND CRESSWELL P. (1985). Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics, 21, 235-246.
22. SARKADI BS, MÜLLER M, HOMOLYZ, L, HOLLO Z, SEPRODI J, GERMANN VA, GOTTESMAN MM, PRICE EM AND BAUCHER RC. (1994). Interaction of bioactive hydrophobic peptides with the human multidrug transporter. FASEB J., 8, 766-770.
23. SCHEPER RJ, BULTE JW, BRAKKEE JG, QUAK JJ, VAN DER SCHOOT E, BALM AJ, MEIJER CJ, BROXTERMAN HJ, KUIPER CM, LANKELMA J AND PINEDO HM. (1988). Monoclonal antibody JSB-I detects a highly conserved epitope on the P-glycoprotein associated with multidrug-resistance. Int J. Cancer, 42, 389-394.
24. SCHUURHUIS GJ, BROXTERMAN HJ, DE LANGE JHM, PINEDO HM, VAN HEIJNINGEN TH, KUIPER CM, SCHFEER GL, SCHEPER RJ, VAN KALKEN CK, BAAK JP AND LANKELMA J. (1991). Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P- glycoprotein. Br. J. Cancer, 64, 857-861.
25. SHARMA RC, INOUE S, ROITELMAN J, SCHIMKE RT AND SIMONI RD. (1992). Peptide transport by the multidrug resistance pump. J. Biol. Chem., 267, 5731-5734.
26. SLAPAK CA, FRACASSO PM, MARTELL RL, TOPPMEYFR DL, LECERF JM AND LEVY SB. (1994). Overexpression of the multidrug resistance-associated protein (MRP) gene in vincristine but not doxorubicin-selected multidrug-resistant murine erythroleukemia cells. Cancer Res., 54, 5607-5613.
27. STUTTS MJ, GABRIEL SE, OLSEN JC, GATZY JT, O'CONNELL TL, PRICK EM AND BOUCHER RC. (1993). Consequences of heterologous expression of the cystic fibrosis transmembrane conductance regulator in fibroblasts. J. Biol. Chem., 268, 20653-20658.
28. TAKEDA Y, NISHIO K, NIITANI H AND SAIJON. (1994). Reversal of multidrug-resistance by tyrosine kinase inhibitors in a non-P-glycoprotein-mediated multidrug-resistant cell line. Int. J. Cancer, 57, 229-239.
29. WEI LY, STUTTS MJ, HOFFMAN MM AND ROEPE PD. (1995). Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype. Biophys. J., 69, 883- 895.
30. ZAMAN GJR, FLENS MJ, VAN LEUSDEN MR, DE HAAS M, MULDER HS, LANKELMA J, PINEDO HM, SCHEPER RJ, BAAS E, BROXTERMAN HJ AND BORST P. (1994). The human multidrug resistance-associated protein (MRP) is a plasma membrane drug efflux pump. Prof. NAtl Acad. Sci. USA. 91, 8822-8826.
31. ZIJLSTRA JG, DE VRIES EGE AND MULDER NH. (1987). Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line. Cancer Res., 47, 1780-1784.