Medicinal plants and phytochemicals with anti-obesogenic potentials: A review

Biomedicine and Pharmacotherapy

Volumn 89, Issue , 2017, Pages 1442-1452

  Mopuri, Ramgopal ^a   Islam, Md Shahidul ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Bioactive compounds; Clinical; In vitro; In vivo; Medicinal plants; Obesity

Indexed keywords

ACTINIDIA ARGUTE EXTRACT; AESCULIS TURBINATA EXTRACT; AFROMOMUM MELEGUETTA EXTRACT; ANTIOBESITY AGENT; ATRACTYLODES MACROCEPHALA EXTRACT; BOESENBERGIA PANDURATE EXTRACT; BOUSSINGAULTI GRACILIS EXTRACT; CASSIA TORA EXTRACT; CENTELLA ASIATICA EXTRACT; COCCINIA GRANDIS EXTRACT; CURCUMA LONGA EXTRACT; FICUS DELTOIDEA EXTRACT; GARCINIA CAMBOGIA EXTRACT; GARLIC EXTRACT; HIPPOPHAE RHAMNOIDES EXTRACT; MORUS BOMBYCIS EXTRACT; NELUMBO NUCIFERA EXTRACT; PANAX JAPONICUS EXTRACT; PENAX QUINQUEFOLIUS EXTRACT; PLANT EXTRACT; PLATYCODON GRANDIFLORUM EXTRACT; SASA QUELPAERTENSIS EXTRACT; SIDA RHOMBIFOLIA EXTRACT; SPILANTHES ACMELLA EXTRACT; TARAXACUM OFFICINALE EXTRACT; TECOMELLA UNDULATA EXTRACT; TERMINALIA BELLIRICA EXTRACT; TERMINALIA SERICEA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; WASABIA JAPONICA EXTRACT; PHYTOCHEMICAL;

3T3 CELL LINE; ACTINIDIA; ACTINIDIA ARGUTE; ADIPOCYTE; ADIPOGENESIS; AESCULIS TURBINATA; AFROMOMUM MELEGUETTA; ANTI OBESOGENIC ACTIVITY; ANTIRHEA BORBONICA; ATRACTYLODES; ATRACTYLODES MACROCEPHALA; BODY WEIGHT; BOESENBERGIA PANDURATE; BOUSSINGAULTI GRACILIS; CARBOHYDRATE METABOLISM; CENTELLA ASIATICA; COCCINIA GRANDIS; CURCUMA LONGA; DIET RESTRICTION; DORATOXYLON APETALUM; DOWN REGULATION; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; FATTY LIVER; FICUS; GARCINIA CAMBOGIA; GARLIC; GENE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; GOUANIA MAURITIANA; HIPPOPHAE RHAMNOIDES; HUMAN; HYRPAGOPHYTUM PROCUMBENS; IN VITRO STUDY; IN VIVO STUDY; LIGUSTRUM; LIGUSTRUM ROBUSTUM; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; MEDICINAL PLANT; MELISSA OFFICINALIS; MORUS; MORUS BOMBYCIS; NELUMBO NUCIFERA; NONHUMAN; OBESITY; PANAX JAPONICUS; PLATYCODON; POMEGRANATE; PRIORITY JOURNAL; PROADIPOCYTE; REVIEW; SASA; SASA QUELPAERTENSIS; SENNA TORA; SIDA RHOMBIFOLIA; SYSTEMATIC REVIEW; TARAXACUM OFFICINALE; TECOMA STANS; TECOMELLA UNDULATA; TERMINALIA; TERMINALIA BELLIRICA; TERMINALIA PANICULATA; TERMINALIA SERICEA; UPREGULATION; VITIS; VITIS THUNBERGII; WASABI; ANIMAL; CHEMISTRY; COMPLICATION; NON INSULIN DEPENDENT DIABETES MELLITUS;

ANIMALS; ANTI-OBESITY AGENTS; DIABETES MELLITUS, TYPE 2; HUMANS; OBESITY; PHYTOCHEMICALS; PLANTS, MEDICINAL;

EID: 85016393633     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.02.108     Document Type: Review

References (130)

1. [1] Kopelman, P.G., Obesity as a medical problem. Nature 404 (2000), 635–643.
2. [2] Lois, K., Kumar, S., Obesity and diabetes. Endocrinol. Nutr. 56 (2009), S38–S42.
3. [3] World Health Organisation (WHO), (2014).
4. [4] Nahal, S., Valery, L.L., King, J., Globesity-The Global Fight Against Obesity. 2012, Bank of America Merrill Lynch.
5. [5] Marie, N., Tom, F., Margaret, R., Blake, T., Nicholas, G., Christopher, M., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384 (2014), 766–781.
6. [6] Gill, T., Epidemiology and health impact of obesity: an Asia pacific perspective. Asia Pac. J. Clin. Nutr. 15 (2006), 3–14.
7. [7] Ogden, C.L., Yanovski, S.Z., Carroll, M.D., Flegal, K.M., The epidemiology of obesity. Gastroenterology 132 (2007), 2087–2102.
8. [8] Low, S., Chin, M.C., Deurenberg-Yap, M., Review on epidemic of obesity. Ann. Acad. Med. Singap. 38 (2009), 57–59.
9. [9] Chan, R.S., Woo, J., Prevention of overweight and obesity: how effective is the current public health approach. Int. J. Environ. Res. Public Health 7 (2010), 765–783.
10. [10] Bray, G.A., Medical therapy for obesity–current status and future hopes. Med. Clin. North Am. 91 (2007), 1225–1253.
11. [11] Ogden, C.L., Carroll, M.D., Flegal, K.M., Epidemiologic trends in overweight and obesity. Endocrinol. Metab. Clin. N. Am. 32 (2003), 741–760.
12. [12] Li, M., Leptin and beyond: an odyssey to the central control of body weight. Yale J. Biol. Med. 84 (2011), 1–7.
13. [13] Shimomura, I., Robert, E.H., James, A.R., Shinji, I., Yuriy, B., Joseph, L., Brown, Michael S., Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12 (1998), 3182–3194.
14. [14] Chaput, J.P., St-Pierre, S., Tremblay, A., Currently available drugs for the treatment of obesity: sibutramine and orlistat. Med. Chem. 7 (2007), 3–10.
15. [15] Ballinger, A., Peikin, S.R., Orlistat: its current status as an anti-obesity drug. Eur. J. Pharmacol 440 (2002), 109–117.
16. [16] Drew, B.S., Dixon, A.F., Dixon, J.B., Obesity management: update on orlistat. Vasc. Health Risk Manage. 3 (2007), 817–821.
17. [17] Hutton, B., Fergusson, D., Changes in body weight and serum lipid profile in obese patients treated with orlistat in addition to ahypocaloric diet: a systematic review of randomized clinical trials. Am. J. Clin. Nutr. 80 (2004), 1461–1468.
18. [18] Thurairajah, P.H., Syn, W.K., Neil, D.A., Stell, D., Haydon, G., Orlistat (xenical) − induced subacute liver failure. Eur. J. Gastroenterol. Hepatol. 17 (2005), 1437–1438.
19. [19] Lean, M.E., How does sibutramine work?. Int. J. Obes. Relat. Metab. Disord. 4 (2001), S8–S11.
20. [20] Poston, W.S., Foreyt, J.P., Sibutramine and the management of obesity. Expert Opin. Pharm. 5 (2004), 633–642.
21. [21] Tziomalos, K., Krassas, G.E., Tzotzas, T., The use of sibutramine in the management of obesity and related disorders: an update. Vasc. Health Risk Manage. 5 (2009), 441–452.
22. [22] De, S.G., D'Addeo, G., Sibutramine: balancing weight loss benefit and possible cardiovascular risk. Nutr. Metab. Cardiovasc. Dis. 18 (2008), 337–341.
23. [23] Karamadoukis, L., Shivashankar, G.H., Ludeman, L., Williams, A.J., An unusual complication of treatment with orlistat. Clin. Nephrol. 71 (2009), 430–432.
24. [24] Slovacek, L., Pavlik, V., Slovackova, B., The effect of sibutramine therapy on occurrence of depression symptoms among obese patients. Nutr. Metab. Cardiovasc. Dis. 18 (2008), 43–44.
25. [25] Halford, J.C., Obesity drugs in clinical development. Curr. Opin. Investig. Drugs 7 (2006), 312–318.
26. [26] Yun, J.W., Possible anti-obesity therapeutics from nature—a review. Phytochemistry 71 (2010), 1625–1641.
27. [27] Ono, Y., Eri, H., Yukitaka, F., Shoji, I., Yasushi, O., Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J. Ethanopharmacol. 106 (2006), 238–244.
28. [28] Ma, C., Jinjun, W., Hongmei, C., Xiaoxiao, Z., Zhenhua, W., Honglun, W., Gang, L., Purification and characterization of Aporphine Alkaloids from leaves of Nelumbo nucifera gaertn and their effects on glucose consumption in 3T3-L1 adipocytes. Int. J. Mol. Sci. 15 (2014), 3481–3494.
29. [29] Ogawa, T., Tabata, H., Katsube, T., Ohta, Y., Yamasaki, Y., Yamasaki, K., Shiwaku, K., Suppressive effect of hot water extract of Wasabi (Wasabia japonica Matsum) leaves on the differentiation of 3T3-L1 preadipocytes. Food. Chem. 118 (2010), 239–244.
30. [30] Kim, H., Choung, S., Anti-obesity effects of Boussingaultia gracilis Miers var Pseudobaselloides Bailey via activation of AMP-activated protein kinase in 3T3-L1 cells. J. Med. Food. 15 (2012), 811–817.
31. [31] Liu, W., Zheng, Y., Han, L., Wang, H., Saito, M., Ling, M., Kimura, Y., Feng, Y., Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high fat diet induced obesity in mice. Phytomedicine 15 (2008), 1140–1145.
32. [32] Liu, R., Zhang, J., Liu, W., Kimura, Y., Zheng, Y., Anti-obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L) in mice fed with a high fat diet. Fitoterapia 81 (2010), 1079–1087.
33. [33] Thounaojam, M.C., Jadeja, R.N., Ramani, U.V., Devkar, R.V., Ramachandran, A.V., Sida rhomboidea. Roxb leaf extract down regulates expression of PPARγ2 and leptin genes in high fat diet fed C57BL/6J mice and retards in vitro 3T3L1 pre-adipocytes differentiation. Int. J. Mol. Sci. 12 (2011), 4661–4677.
34. [34] Kimura, H., Ogawa, S., Katsube, T., Jisaka, M., Yokota, K., Anti-obese effects of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinate BLUME) after treatment with wood ashes. J. Agric. Food. Chem. 56 (2008), 4783–4788.
35. [35] Hu, J., Zhu, X., Han, Ln., Saito, M., Sun, Y., et al. Anti-obesity effects of Escins extracted from the seeds of Aesculus turbinate Blume (Hippocastanaceae). Chem. Pharm. Bull. 56 (2008), 12–16.
36. [36] Tzeng, T., Lu, H., Liou, S., Chang, C.J., Liu, I.M., Reduction of lipid accumulation in white adipose tissues by Cassia tora (Leguminosae) seed extract is associated with AMPK activation. Food Chem. 136 (2013), 1086–1094.
37. [37] Jang, S., Lee, G.Y., Kim, J., Lee, Y.M., et al. A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta. Arch. Pharm. Res. 31:31 (2008), 666–670.
38. [38] Kim, J., Jang, D.S., Kim, H., Kim, J.S., Anti-lipase and lipolytic activities of Ursolic acid isolated from the roots of Actinidia arguta. Arch. Pharm. Res. 32 (2009), 983–987.
39. [39] Karu, N., Reifen, R., Kerem, Z., Weight gain reduction in mice fed Panax ginseng saponin: a pancreatic lipase inhibitor. J. Agric. Food Chem. 5 (2007), 2824–2828.
40. [40] Kim, C.K., Kim, M., Oh, S.D., Lee, S.M., et al. Effects of Atractylodes macrocephala koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity. J. Ehtanopharmacol. 137 (2011), 396–402.
41. [41] Jeong, S.Y., Yun, J.L., Kyung, S.K., Sung, H.K., Kyung, J.C., Anti-obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre-adipocytes and rats fed a high-fat diet. J. Sci. Food Agric. 94 (2014), 568–575.
42. [42] Muchizuki, M.H., Acceleration of lipid degradation by sericoside of Terminalia sericea roots in fully differentiated 3T3-L1 cells. Phytother. Res. 20 (2006), 1020–1021.
43. [43] Ekanem, A.P., Wang, M., Simon, J.E., Moreno, D.A., Anti-obesity properties of two African plants (Afromomum meleguetta and Spilanthes acmella) by pancreatic inhibition. Phytother. Res. 21 (2007), 1253–1255.
44. [44] Park, Y.S., Yoon, Y., Hong, S.A., Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World J. Gastroenterol. 13 (2007), 3493–3499.
45. [45] Roy, S., Shah, H., Rink, C., Khanna, S., Bagchi, D., Bagchi, M., Sen, C.K., Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement. DNA Cell Biol. 26 (2007), 627–639.
46. [46] Guo, A.J., Choi, R.C., Cheung, A.W., Li, J., et al. Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines. Chin. Med. 26 (2009), 4–5.
47. [47] Kim, Y.S., Lee, Y.M., Kim, H., et al. Anti-obesity effect of Morus bombycis root extract: anti-lipase activity and lipolytic effect. J. Ethanopharmacol. 130 (2010), 621–624.
48. [48] Overman, A., Bumrungpert, A., Kennedy, A., et al. Polyphenol-rich grape powder extract attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int. J. Obes. 34 (2010), 800–808.
49. [49] Chen, L., He, T., Han, Y., et al. Pentamethylquercetin improves adiponectin expression in differentiated 3T3-L1Cells via a mechanism that implicates PPARγ together with TNF-α and IL-6. Molecules 16 (2011), 5754–5768.
50. [50] Xie, X.Y., Kong, P.R., Wu, J.F., Li, Y., Li, Y.X., Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes. Phytomedicine 20 (2012), 3–8.
51. [51] Sun, X., Zhang, K., Ji, X., Jeffrey, Z., Tong, Y., Gao, H., Zhang, J., Wang, Z., Screening of pancreatic lipase and alpha-glucosidase inhibitors from Chinese dietary herbs. Zhongguo Zhong Yao Za Zhi 37 (2012), 1319–1323.
52. [52] Kim, D.Y., Kim, M.S., Sa, B.K., Kim, M.B., Hwang, J.K., Boesenbergia pandurata attenuates diet induced obesity by activating AMP-activated protein kinase and regulating lipid metabolism. Int. J. Mol. Sci. 13 (2012), 994–1005.
53. [53] Park, U., Jeong, J., Jang, J., et al. Negative regulation of adipogenesis by Kaempferol: a component of Rhizoma polygonati falcatum in3T3-L1 cells. Biol. Pharm. Bull. 35 (2012), 1525–1533.
54. [54] Seung-Woo, K., Seong-Il, K., Hye-Sun, S., Sasa quelpaertensis Nakai extract and its constituent p-coumaric acid inhibit adipogenesis in 3T3-L1 cells through activation of the AMPK pathway. Food Chem. Toxic. 59 (2013), 380–385.
55. [55] Makihara, H., Shimada, T., Machida, E., et al. Preventive effect of Terminalia bellirica on obesity and metabolic disorders in spontaneously obese type 2 diabetic model mice. J. Nat. Med. 66 (2012), 459–467.
56. [56] Kim, E.J., Lee, D.H., et al. Thiacremonone a sulfur compound isolated from garlic, attenuates lipid accumulation partially mediated via AMPK activation in 3T3-L1 adipocytes. J. Nutr. Biochem. 23 (2012), 1552–1558.
57. [57] Ado, M.A., Abas, F., Mohammed, A.S., Ghazali, H.M., Anti- and pro-lipase activity of selected medicinal herbal and aquatic plants, and structure elucidation of an anti-lipase compound. Molecules 18 (2013), 14651–14669.
58. [58] Alvala, R., Alvala, M., Sama, V., et al. Scientific evidence for traditional claim of anti-obesity activity of Tecomella undulata bark. J. Ethnopharmacol. 148 (2013), 441–448.
59. [59] Yang, Z.G., Wen, X.Y., Li, Y.H., et al. Inhibitory effects of the constituents of Hippophae rhamnoides on 3T3-L1 cell differentiation and nitric oxide production in RAW264.7 cells. Chem. Pharm. Bull. (Tokyo) 61 (2013), 279–285.
60. [60] Zhang, J., Kang, M., Kim, M., et al. Pancreatic lipase inhibitory activity of taraxacum officinale in vitro and in vivo. Nitro Res. Pract. 2 (2008), 200–203.
61. [61] Marta, G., Belen, G., Raquel, F., et al. Reduction of adipogenesis and lipid accumulation by Taraxacum officinale (Dandelion) extracts in T3TL1 adipocyes: an in vitro study. Phytother. Res. 28 (2014), 745–752.
62. [62] Woon, S.M., Yew, W.S., Anna, P.K., et al. Anti adipogenic effects of extracts of Vicus deltoidea var deltoidea and var. angustifolia on 3T3-L1 adipocytes. J. Zhejiang. Univ. Sci. B: (Biomed. Biotechnol.) 15 (2014), 295–302.
63. [63] Supkamonseni, N., Thinkratok, A., Meksuriyen, D., Srisawat, R., Hypolipidemic and hyperglycaemic effects of Centella asiatica (L.) extract in vitro and in vivo. Ind. J. Exp Biol. 52 (2014), 965–971.
64. [64] Bunkrongcheap, R., Nongporn, H.T., Noipha, K., et al. Ivy gourd (Coccinia graddis L. Voigt) root suppresses adipocytes differentiation in 3T3-L1 cells. Lipids Health Dis., 13, 2014, 88.
65. [65] Cristina, T.F., Theeuwes, W.F., McMullen, M.K., et al. Devil's Claw to suppress appetite-Ghrelin receptor modulation potential of a Harpagophytum procumbens root extract. PLoS One, 9, 2014, e103118.
66. [66] Hadrich, F., Cherif, S., Gargouri, Y.T., Adel, S., et al. Antioxidant and lipase inhibitory activities and essential oil composition of Pomegranate peel extracts. J. Oleo. Sci. 63 (2014), 515–525.
67. [67] Ruthaiwan, H., Nongporn, H., Kusumarn, N., et al. Ivy gourd (Coccinia grandis L Voigt) root suppresses adipocyte differentiation in 3T3-L1 cells. Lipids Health Dis., 13, 2014, 88.
68. [68] Mopuri, R., Meriga, B., Anti-lipase and anti-obesity activities of Terminalia paniculata bark in high calorie diet-induced obese rats. Glob. J. Pharmacol. 8 (2014), 114–119.
69. [69] Park, Y.J., Kim, M.S., Kim, H.R., et al. Ethanol extract of Alismatis rhizome inhibits adipocyte differentiation of OP9Cells. Evid. Based Complement. Alternat. Med., 2014, 1–9.
70. [70] Yu, Z., Gao, H., Zhang, Z., et al. Inhibitory effects of Ligustrum robustum (Rxob.) blume extract on α-amylase and α-glucosidase. J. Funct. Foods 19 (2015), 204–213.
71. [71] Lin, Y.S., Chen, C.R., Wu, W., Hou, W.C., et al. Anti-α-glucosidase and anti-dipeptidyl peptidase-IV activities of extracts and purified compounds from Vitis thunbergii var taiwaniana. J. Agric. Food. Chem. 63 (2015), 6393–6401.
72. [72] Marimoutou, M., Fanny, L.S., Jacqueline, S., et al. Antioxidant polyphenol-rich extracts from the medicinal plants Antirhea borbonica, Doratoxylon apetalum and Gouania mauritiana protect 3T3-L1 preadipocytes against H2O2, TNF(and LPL inflammatory mediators by regulating the expression of superoxide dismutase and KF-kB genes. J. Inflam., 12, 2015, 10.
73. [73] Ramirez, G., Zamilpa, A., Zavala, M., Tortoriello, J., et al. Chrysoeriol and other polyphenols from Tecoma stans with lipase inhibitory activity. J. Ethnopharmacol. 185 (2016), 1–8.
74. [74] Woo, S., Yoon, M., Kim, J., et al. The anti-angiogenic herbal extract from Melissa officinalis inhibits adipogenesis in 3T3-L1 adipocytes and suppresses adipocyte hypertrophy in high fat diet-induced obese C57BL/6J mice. J. Ethnopharmacol. 3 (2016), 238–254.
75. [75] Wu, C., Yang, M., Chan, K., Chung, P., et al. Improvement in high fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid rich extract in mice. J. Agric. Food Chem. 58 (2010), 7075–7081.
76. [76] Du, H., You, J., Xu, Z., Park, J., et al. Anti-obesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J. Biomed. Sci., 17, 2010, S42.
77. [77] Feng, L., Yu, C., Ying, K., et al. Hypolipidemic and antioxidant effects of total flavonoids of Perilla frutescens leaves in hyperlipidemia rats induced by high fat diet. Food Res. Int. 44 (2011), 404–409.
78. [78] Kimura, H., Ogawa, S., Sugiyama, A., et al. Anti-obesity effects of highly polymeric proanthocyanidins from seed shells of Japanese horse chestnut (Aesculus turbinate Blume). Food Res. Int. 44 (2011), 121–126.
79. [79] Ikarashi, N., Toda, T., Okaniwa, T., et al. Anti-obesity and anti-diabetic effects of Acacia polyphenol in obese diabetic KKAy mice fed high fat diet. Evid. Based Compl. Altern. Med., 2011, 1–10.
80. [80] Mopuri, R., Banavathy, S.K., Damineni, S., Balaji, M., Terminalia paniculata bark extract attenuates non-alcoholic fatty liver via down regulation of fatty acid synthase in high fat diet fed obese rats. Lipids Health Dis., 13, 2014, 13 58.
81. [81] Mopuri, R., Muniswamy, G., Kruthika, S.B., Brahma, N.P., Balaji, M., Evaluation of anti-obesity activities of ethanolic extract of Terminalia paniculata bark on high fat diet induced obese rats. BMC Complement. Altern. Med. 15 (2015), 1–11.
82. [82] Huang, T.H., Yang, Q., Harada, M., et al. Salacia oblonga root improves cardiac lipid metabolism in Zuker diabetic fatty rats: modulation of cardiac PPAR-α mediated transcription of fatty acid metabolic genes. Toxicol. Appl. Pharmacol. 210 (2006), 78–85.
83. [83] Bhat, B.M., D'Souza, V., Manjrekar, P.A., Antidiabetic and hypolipidemic effect of salacia oblonga in streptozotocin induced diabetic rats. J. Clin. Diagn. Res. 6 (2012), 1685–1687.
84. [84] Singh, G., Gupta, P., Rawat, P., Anti-dyslipidemic activity of polyprenol from Coccinia grandis in high fat diet fed hamster model. Phytomed 14 (2007), 792–798.
85. [85] Lei, F., Xn, Z., Wang, W., et al. Evidence of anti-obesity effects of the pomegranate leaf extract in high fat diet induced obese mice. Int. J. Obes. 31 (2007), 1023–1029.
86. [86] Oluyemi, K.A., Omotuyi, I.O., Jimoh, O.R., et al. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol. Appl. Biochem. 46 (2007), 69–72.
87. [87] Sripradha, R., Magadi, S.G., Efficacy of Garcinia cambogia on body weight: inflammation and glucose tolerance in high fat fed male Wistar rats. J. Clin. Diagn. Res. 9 (2015), BF01–BF04.
88. [88] Yamada, K., Masaya, H., Chizumi, Y., et al. Dietary Corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biol. Pharm. Bull. 31 (2008), 651–655.
89. [89] Zhao, H.L., Harding, S.V., Marinangeli, C.P.F., et al. Hypocholesterolemic and anti obesity effects of Saponins from Platycodon grandiflorum in hamsters fed atherogenic diets. J. Food Sci. 73 (2008), 195–200.
90. [90] Terra, X., Montagut, G., Bustos, M., Liopiz, N., et al. Grape seed procyanidins prevent low grade inflammation by modulating cytokine expression in rats fed a high fat diet. J. Nutr. Biochem. 20 (2009), 210–218.
91. [91] Charradi, K., Sebai, H., Elkahoui, F.B., Limam, F., Grape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosis. Cardiovasc. Toxicol. 11 (2011), 28–37.
92. [92] Charradi, K., Elkahoui, S., Karkouch, I., et al. Grape seed and skin extract prevents high fat diet induced brain lipotoxicity in rat. Neurochem. Res. 37 (2012), 2004–2013.
93. [93] Kim, M.J., Kim, H.K., Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet. Phytother. Res. 23 (2009), 1685–1690.
94. [94] Lim, W.A.Y., Chia, Y.Y., Liong, S.Y., et al. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally administered glycyrrhizic acid-treated rats. Lipids Health Dis., 8, 2009, 31.
95. [95] Eu, C.H., Lim, W.Y., Ton, S.H., Abdul, K.K., Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids Health Dis., 29, 2010, 81.
96. [96] Myoung, H., Kim, G., Nam, K.W., Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth) inhibits food intake inC57BL/6J mice. Arch. Pharm. Res. 33 (2010), 1741–1746.
97. [97] Okabe, T., Toda, T., Nukitrangsan, N., et al. Peucedanum japonicam Thunb inhibits high fat diet induced obesity in mice. Phytother. Res. 25 (2011), 870–877.
98. [98] Miyata, M., Koyama, T., Yazawa, K., Water extract of Houttuynia cordata Thunb: leaves extracts anti-obesity effects by inhibiting fatty acid and glycerol absorption. J. Nutr. Sci. Vitamnol. 56 (2010), 150–156.
99. [99] Birari, R., Vishal, J., Bhutani, K.K., Antiobesity and lipid lowering effects of Murraya koenigii (L.) spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia 81 (2010), 1129–1133.
100. [100] Wang, L., Masayuki, Y., Takuya, K., et al. Anti obesity effect of polyphenolic compounds from molokheiya (Corchorus olitorius L.) leaves in LDL receptor-deficient mice. Eur. J. Nutr. 50 (2011), 127–133.
101. [101] Wang, J., Zhang, W., Zhu, D., et al. Hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L in mice fed a high fat diet. J. Sci. Food. Agric. 91 (2011), 1446–1451.
102. [102] Subramaniam, S., Subramaniam, R., Rajapandian, S., et al. Anti-atherogenic activity of ethanolic fraction of Terminalia arjuna bark on hypercholesterolemic rabbits. Evid. Based Complement. Altern. Med., 2011, 487916.
103. [103] Misawa, E., Tanaka, M., Nabeshima, K., Nomaguchi, K., et al. Administration of dried Aloe vera Gel powder reduced body fat mass in diet induced obesity rats. J. Nutr. Sci. Vitaminol. 58 (2012), 195–201.
104. [104] Pichiah, P.B.T., Moon, H., Park, J., Moon, Y., Cha, Y., Ethanolic extract of sea buckthorn (Hippophae rhamnoides L) prevents high fat diet induced obesity in mice through down regulation of adipogenic and lipogenic gene expression. Nutr. Res. 32 (2012), 856–864.
105. [105] Lenquiste, S.A., Batista, A.G., Marineli, R.S., et al. Freeze dried Jaboticaba peel added to high fat diet increases HDL-cholesterol and improves insulin resistance in obese rats. Food Res. Int. 49 (2012), 153–160.
106. [106] Tamura, Y., Iwasaki, Y., Narukawa, M., Watanabe, T., Ingestion of Cinnamaldehyde a TRPA1 agonist, reduces visceral fats in mice fed high fat diet and high sucrose diet. J. Nut. Sci. Vitamin 58 (2012), 1–13.
107. [107] Saeed, C.A., Ali, Z., Soheila, T., et al. The effects of Portulaca oleracea alcoholic extract on induced hypercholesteroleomia in rats. Zahedan J. Res. Med. Sci. 15 (2013), 34–39.
108. [108] Yamasaki, M., Ogawa, T., Li, W., et al. Anti obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum L). Nutr. Res. Pract. 7 (2013), 267–272.
109. [109] Lee, S.E., Lee, E.H., Lee, T.J., et al. Anti-obesity effect and action mechanism of Adenophora triphylla root ethanol extract in C57BL/6 obese mice fed a high fat diet. Biosci. Biotechnol. Biochem. 77 (2013), 544–550.
110. [110] Gupta, P., Goyal, R., Chauhan, Y., Sharma, P.L., Possible modulation of FAS and PTP-1B signalling in ameliorative potential of Bombax ceiba against high fat diet induced obesity. BMC Compl. Altern. Med., 13, 2013, 218.
111. [111] Subash, A.K., Augustine, A., Hypolipidaemic effects of methanol extract of Holoptelea integrifolia (Roxb) planchon bark in diet induced obese rats. Appl. Biochem. Biotechnol. 169 (2013), 546–553.
112. [112] Mishra, S.K., Tiwari, S., Shrivastava, S., et al. Pharmacological evaluation of the efficacy of Dysoxylum binectariferum stem bark and its active constituent rohitukine in regulation of dyslipidemia in rats. J. Nat. Med., 2014, 1–9.
113. [113] Cui, W., Wang, Y., Chen, Q., et al. Magnolia extract (BL153) ameliorates kidney damage in a high fat diet induced obesity mouse model. Oxid. Med. Cell Long., 2013, 1–9.
114. [114] Sun, W., Zhang, Z., Chen, Q., Yin, X., et al. Magnolia extract (BL153) protection of heart from lipid accumulation caused cardiac oxidative damage: inflammation. and cell death in high fat diet fed mice Oxidative. Med. Cell Long., 2014, 1–13.
115. [115] Zhang, Z., Chen, J., Jiang, X., et al. The Magnolia bioactive constituent 4-O-methylhonokiol protects against high fat diet induced obesity and systemic insulin resistance in mice. Oxid. Med. Cell Long., 2014, 1–10.
116. [116] Joerin, L.I., Kauschka, M., Bonnländer, B., Butterweck, V., Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C. Phytother. Res. 28 (2014), 261–267.
117. [117] Kim, I., Kim, H., Kim, J., Om, A., Beneficial effects of Allium sativum L stem extract on lipid metabolism and anti-oxidant status in obese mice fed a high fat diet. J. Sci. Food Agric. 93 (2013), 2749–2757.
118. [118] Lai, Y., Chen, W., Ho, C., et al. Garlic essential oil protects against obesity-triggered non-alcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. J. Agric. Food Chem. 62 (2014), 5897–5906.
119. [119] Liu, Q., Kim, S.H., Kim, S.B., et al. Anti-obesity effect of (8-E)-niizhenide:a secoiridoid from Ligustrum lucidum.; in high fat diet induced obese mice. Nat. Prod. Commun. 9 (2014), 1399–1401.
120. [120] Hsu, H., Chen, W., Hu, T., Mao, F.C., Supplementation of Vitis thunbergii root extract alleviated high fat diet induced obesity in C57BL/6J mice. BioSci. Biotechnol. Biochem. 78 (2014), 867–873.
121. [121] Lin, S.Y., Huang, G.C., Hsieh, Y.Y., et al. Vitis thunbergii var. Taiwaniana extracts and purified compounds ameliorate obesity in high-fat diet-induced obese mice. J. Agric. Food Chem. 63 (2015), 9286–9294.
122. [122] Lin, Y.S., Chen, C.R., Wu, W.H., et al. Anti-α-glucosidase and anti-dipeptidyl peptidase-IV activities of extracts and purified compounds from Vitis thunbergii var. Taiwaniana. J. Agric. Food. Chem. 63 (2015), 6393–6401.
123. [123] Zang, Y., Zhang, L., lgarashi, K., Changging, Y., The anti-obesity and anti-diabetic effects of Kaempferol glycosides from unripe soyabean leaves in high fat diet mice. Food Funct., 6, 2015, 834.
124. [124] Yang, R., Fang, L., He, Z., et al. Anti-obesity effect of total phenylpropanoid glycosides from Ligustrum robustum Blume in fatty diet fed mice via up regulating leptin. J. Ethanopharmacol. 7 (2015), 1–10.
125. [125] Kim, J.H., Kim, O., Yoon, H., et al. Anti-obesity effect of extract from fermented Curcuma longa L through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. Food Nutr. Res., 60, 2016, 30428.
126. [126] Li, S., Jina, S., Songa, C., et al. The metabolic change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice. J. Ethnopharmacol. 177 (2016), 10–18.
127. [127] Vasques, C.A., Schneider, R., Klein-Júnior, L.C., et al. Hypolipemic effect of Garcinia cambogia in obese women. Phytother. Res. 28 (2014), 887–891.
128. [128] Faizal, P., Suresh, S., Satheesh Kumar, R., et al. A study on the hypoglycemic and hypolipidemic effects of an ayurvedic drug Rajanyamalakadi in diabetic patients. Indian J. Clin. Biochem. 24 (2009), 82–87.
129. [129] Nakata, K., Taniguchi, Y., Yoshioka, N., et al. A mixture of Salacia oblonga extract and IP-PA1 reduces fasting plasma glucose (FPG) and low-density lipoprotein (LDL) cholesterol levels. Nutr. Res. Pract. 5 (2011), 435–442.
130. [130] Ali, M.S., Roya, K., Jelokhanian, H., et al. Clinical effects of portulaca oleracea seeds on dyslipidemia in obese adolescents: a triple-blinded randomized Controlled trial. Arch. Med. 68 (2014), 195–199.