Administration of dried Aloe vera gel powder reduced body fat mass in diet-induced obesity (DIO) Rats

Journal of Nutritional Science and Vitaminology

Volumn 58, Issue 3, 2012, Pages 195-201

  Misawa, Eriko ^a   Tanaka, Miyuki ^a   Nabeshima, Kazumi ^a   Nomaguchi, Kouji ^a   Yamada, Muneo ^a   Toida, Tomohiro ^a   Iwatsuki, Keiji ^a  

^a MORINAGA MILK INDUSTRY CO LTD   (Japan)

Author keywords

Aloe vera gel; Anti obesity; Body fat; Diet induced obesity

Indexed keywords

ALOE VERA EXTRACT; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; GEL; INTRAABDOMINAL FAT; LIPID BLOOD LEVEL; LIPID DIET; MALE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; POWDER; RAT; SUBCUTANEOUS FAT; TREATMENT DURATION; WEIGHT REDUCTION;

ADIPOSITY; ALOE; ANIMALS; ANTI-OBESITY AGENTS; DIET, HIGH-FAT; EATING; ENERGY METABOLISM; LIPIDS; MALE; OBESITY; PHYTOTHERAPY; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT GAIN;

EID: 84930483881     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.58.195     Document Type: Article

References (36)

1. Scaglione R, Chiara TD, Argano C, Corrao S, Licata G. 2010. Hypoadiponectinemia: A link visceral obesity and metabolic syndrome. J Diabetes Endocrinol 1: 27-35.
2. Reynolds T, Dweck AC. 1999. Aloe vera leaf gel: a review update. J Ethnopharm 68: 3-37.
3. Wu JH, Xu C, Shan CY, Tan RX. 2006. Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. chinensis. Life Sci 78: 622-630.
4. Qiu Z, Jones K, Wylie M, Jia WQ, Orndorf S. 2000. Modified Aloe barbadensis polysaccharide with immunoregulatory activity. Planta Med 66: 152-156.
5. Parks LM, Rowe TD. 1941. A phytochemical study of Aloe vera leaf. J Pharm Sci 30: 262-266.
6. Hamman JH. 2008. Composition and applications of Aloe vera leaf gel. Molecules 13: 1599-1616.
7. Shelton RM. 1991. Aloe vera. Its chemical and therapeutic properties. Int J Dermatol 30: 679-683.
8. Vogler BK, Ernst E. 1999. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 49: 823-828.
9. Im SA, Oh ST, Song S, Kim MR, Kim DS, Woo SS, Jo TH, Park YI, Lee CK. 2005. Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. Int Immunopharmacol 5: 271-279.
10. Yagi A, Kabash A, Mizuno K, Moustafa SM, Khalifa TI, Tsuji H. 2003. Radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane A2 synthase from aloe vera gel. Planta Med 69: 269-271.
11. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. 1996. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine 3: 241-243.
12. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. 1996. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 3: 245-248.
13. Okyer A, Can A, Akev N, Baktir G, Sutlupinar E. 2001. Effect of Aloe vera leaves on blood glucose level in type-I and type-II diabetic rat models. Phytother Res 15: 157-161.
14. Rajasekaran D, Sivagnanam K, Ravi K, Subramanian S. 2004. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 7: 61-66.
15. Jain N, Vijayaghavan R, Pant SC, Lomash V, Ali M. 2010. Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats. J Pharm Pharmacol 62: 115-123.
16. Tanaka M, Misawa E, Ito Y, Habara N, Nomaguchi K, Yamada M, Toida T, Hayasawa H, Takase M, Inagaki M, Higuchi R. 2006. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol Pharm Bull 29: 1418-1422.
17. Misawa E, Tanaka M, Nomaguchi K, Yamada M, Toida T, Takase M, Iwatsuki K, Kawada T. 2008. Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats. Obes Res Clin Pract 2: 239-245.
18. Nomaguchi K, Tanaka M, Misawa E, Yamada M, Toida T, Iwatsuki K, Kawada T. 2011. Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with dietinduced obesity. Obes Res Clin Pract 5: e190-e201.
19. Shimada T, Kudo T, Akase T, Aburada M. 2008. Preventive effects of Bofutsushosan on obesity and various metabolic disorders. Biol Pharm Bull 31: 1362-1367.
20. Doucet E, Almeras N, White MD, Despres JP, Bouchard C, Tremblay A. 1998. Dietary fat composition and human adiposity. Eur J Clin Nutr 52: 2-6.
21. Lin S, Thomas TC, Storlien LH, Huang XF. 2000. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord 24: 639-646.
22. Buettner R, Schölmerich J, Bollheimer LC. 2007. Highfat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity 10: 798-808.
23. Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I. 2002. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes 26: 1459-1464.
24. Kishino E, Ito T, Fujita K, Kiuchi Y. 2005. A mixture of the Salacia reticulata (kotala himbutu) aqueous extract and cyclodextrin reduced the accumulation of visceral fat mass in mice and rats with high-fat diet-induced obesity. J Nutr 136: 433-439.
25. Ikeuchi M, Koyama T, Takahashi J, Yazawa K. 2007. Effects of Astaxanthin in obese mice fed a high-fat diet. Biosci Biotechnol Biochem 71: 893-899.
26. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. 2008. A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by high fat diet. Genes Nutr 32: 353-358.
27. Tanaka K, Nishizono S, Tamaru S, Kondo M, Shimada H, Tanaka J, Okada T. 2009. Anti-obesity and hypotriglyceridemic properties of coffee bean extract in SD rats. Food Sci Technol Res 15: 147-152.
28. Digirolamo M, Fine JB, Tagra K, Rossmanith R. 1998. Quantitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum. Am J Physiol 274: R1460-R1467.
29. Caesar R, Manieri M, Kelder T, Boekschoten M, Evelo C, Muller M, Kooistra T, Cinti S, Kleemann R, Drevon CA. 2010. A combined transcriptional and lipidemics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences. PlosONE 5: e11525.
30. Lee Y, Wang M-Y, Kakuma T, Wang Z-W, Babcock E, McCorkle K, Higa M, Zhou Y-T, Unger RH. 2001. Liporegulation in diet-induced obesity. J Biol Chem 276: 5629-5635.
31. Kim K, Kim H, Kwon J, Lee S, Kong H, Im S-A, Lee Y-H, Lee Y-R, Oh S-T, Jo TH, Park YI, Lee C-K, Kim K. 2009. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in amouse model of non-insulin-dependent dia betes mellitus. Phytomedicine 16: 856-863.
32. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD. 2002. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99: 11482-11486.
33. Tu Y, Thupari JN, Kim E-K, Pinn ML, Moran TH, Ronnett GV, Kuhajda FP. 2005. C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure. Endocrinology 146: 486-493.
34. Beppu H, Shimpo K, Chi K, Hara T, Kaneko T, Tamai I, Yamaji S, Ozaki S, Kuzuya H, Sonoda S. 2006. Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocininduced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components. J Ethnopharmacol 103: 468-477.
35. Joseph B, Raj SJ. 2010. Pharmacognostic and phytochemical properties of Aloe vera Linn-An overview. Int J Pharmaceut Sci Rev Res 4: 106-110.
36. Zhang X, Wang H, Song Y, Nie L, Wang L, Liu B, Shen P, Liu Y. 2006. Isolation, structure elucidation, anti-oxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. Bioorg Med Chem Lett 16: 949-953.