메뉴 건너뛰기




Volumn 84, Issue 1, 2011, Pages 1-7

Leptin and beyond: An odyssey to the central control of body weight

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MELANOCORTIN;

EID: 79959798820     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (52)

References (51)
  • 1
    • 77957223178 scopus 로고    scopus 로고
    • Lasker lauds leptin
    • Flier JS, Maratos-Flier E. Lasker lauds leptin. Cell. 2010;143(1):9-12.
    • (2010) Cell , vol.143 , Issue.1 , pp. 9-12
    • Flier, J.S.1    Maratos-Flier, E.2
  • 2
    • 77957768653 scopus 로고    scopus 로고
    • A tale of two hormones
    • Friedman JM. A tale of two hormones. Nat Med. 2010;16(10):1100-6.
    • (2010) Nat Med , vol.16 , Issue.10 , pp. 1100-1106
    • Friedman, J.M.1
  • 3
    • 2942716780 scopus 로고    scopus 로고
    • Modern science versus the stigma of obesity
    • Friedman JM. Modern science versus the stigma of obesity. Nat Med. 2004;10(6):563-9.
    • (2004) Nat Med , vol.10 , Issue.6 , pp. 563-569
    • Friedman, J.M.1
  • 4
    • 0037423247 scopus 로고    scopus 로고
    • A war on obesity, not the obese
    • Friedman JM. A war on obesity, not the obese. Science. 2003;299(5608):856-8.
    • (2003) Science , vol.299 , Issue.5608 , pp. 856-858
    • Friedman, J.M.1
  • 5
    • 1542437791 scopus 로고    scopus 로고
    • National Medical Spending Attributable to Over-weight and Obesity: How Much, and Who's Paying?
    • Jan-Jun;Suppl Web Exclusives:W3
    • Finkelstein EA, Fiebelkorn IC, Wang G. National medical spending attributable to over-weight and obesity: How much, and who's paying? Health Aff (Millwood). 2003 Jan-Jun;Suppl Web Exclusives:W3,219-26.
    • (2003) Health Aff (Millwood) , pp. 219-226
    • Finkelstein, E.A.1    Fiebelkorn, I.C.2    Wang, G.3
  • 6
    • 1642428143 scopus 로고    scopus 로고
    • State-level estimates of annual medical expenditures attributable to obesity
    • Finkelstein EA, Fiebelkorn IC, Wang G. State-level estimates of annual medical expenditures attributable to obesity. Obes Res. 2004;12(1):18-24.
    • (2004) Obes Res , vol.12 , Issue.1 , pp. 18-24
    • Finkelstein, E.A.1    Fiebelkorn, I.C.2    Wang, G.3
  • 7
    • 0032010796 scopus 로고    scopus 로고
    • Current estimates of the economic cost of obesity in the United States
    • Wolf AM, Colditz GA. Current estimates of the economic cost of obesity in the United States. Obes Res. 1998;6(2):97-106.
    • (1998) Obes Res , vol.6 , Issue.2 , pp. 97-106
    • Wolf, A.M.1    Colditz, G.A.2
  • 8
    • 0032040382 scopus 로고    scopus 로고
    • What is The Economic Case For Treating Obesity?
    • Wolf AM. What is the economic case for treating obesity? Obes Res. 1998;6(Suppl 1):2S-7S.
    • (1998) Obes Res , vol.6 , Issue.SUPPL.1
    • Wolf, A.M.1
  • 9
    • 84958689411 scopus 로고
    • The role of depot fat in the hypothalamic control of food intake in the rat
    • Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci. 1953;140(901):578-96.
    • (1953) Proc R Soc Lond B Biol Sci , vol.140 , Issue.901 , pp. 578-596
    • Kennedy, G.C.1
  • 10
    • 63749097442 scopus 로고    scopus 로고
    • Fuel utilization by hypothalamic neurons: Roles For ROS
    • Horvath TL, Andrews ZB, Diano S. Fuel utilization by hypothalamic neurons: Roles for ROS. Trends Endocrinol Metab. 2009;20(2):78-87.
    • (2009) Trends Endocrinol Metab , vol.20 , Issue.2 , pp. 78-87
    • Horvath, T.L.1    Andrews, Z.B.2    Diano, S.3
  • 11
    • 0000721133 scopus 로고
    • The spontaneous activity and food intake of rats with hypothalamic lesions
    • Hetherington AW, Ranson SW. The spontaneous activity and food intake of rats with hypothalamic lesions. Am J Physiol. 1942;136:609.
    • (1942) Am J Physiol , vol.136 , pp. 609
    • Hetherington, A.W.1    Ranson, S.W.2
  • 12
    • 70449255388 scopus 로고
    • The effects of lesions in the hypothalamus in parabiotic rats
    • Hervey GR. The effects of lesions in the hypothalamus in parabiotic rats. J Physiol. 1959;145(2):336-52.
    • (1959) J Physiol , vol.145 , Issue.2 , pp. 336-352
    • Hervey, G.R.1
  • 13
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered.1950;41(12):317-8.
    • (1950) J Hered , vol.41 , Issue.12 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 14
    • 0014004384 scopus 로고
    • Diabetes, a new mutation in the mouse
    • Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science. 1966;153(740):1127-8.
    • (1966) Science , vol.153 , Issue.740 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 15
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973;9(4):294-8.
    • (1973) Diabetologia , vol.9 , Issue.4 , pp. 294-298
    • Coleman, D.L.1
  • 16
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372(6505):425-32.
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 18
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269(5223):540-3.
    • (1995) Science , vol.269 , Issue.5223 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3    Hecht, R.4    Winters, D.5    Boone, T.6
  • 19
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269(5223):546-9.
    • (1995) Science , vol.269 , Issue.5223 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 21
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, et al. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996;84(3):491-5.
    • (1996) Cell , vol.84 , Issue.3 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6
  • 22
  • 25
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, doseescalation trial
    • Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, et al. Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, doseescalation trial. JAMA. 1999;282(16):1568-75.
    • (1999) JAMA , vol.282 , Issue.16 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3    Dixon, R.M.4    Kushner, R.5    Hunt, T.6
  • 27
    • 84981834057 scopus 로고
    • The relation of various hypothalamic lesions to adiposity in the rat
    • Hetherington AW, Ranson SW. The relation of various hypothalamic lesions to adiposity in the rat. J Comp Neurol. 1942;76:475.
    • (1942) J Comp Neurol , vol.76 , pp. 475
    • Hetherington, A.W.1    Ranson, S.W.2
  • 28
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (ob-R) in mouse brain and other tissues
    • Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, et al. Anatomic localization of alternatively spliced leptin receptors (ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA. 1997;94(13):7001-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.13 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3    Lee, G.H.4    Zhao, C.5    Darnell, R.6
  • 29
    • 3543020266 scopus 로고
    • The relation of various hypothalamic lesions to adiposity and other phenomena in the rat
    • Hetherington AW. The relation of various hypothalamic lesions to adiposity and other phenomena in the rat. Am J Physiol. 1941;133:326.
    • (1941) Am J Physiol , vol.133 , pp. 326
    • Hetherington, A.W.1
  • 30
    • 3542998657 scopus 로고
    • Non-production of hypothalamic obesity in the rat by lesions rostral or dorsal to the ventromedial hypothalamic nuclei
    • Hetherington AW. Non-production of hypothalamic obesity in the rat by lesions rostral or dorsal to the ventromedial hypothalamic nuclei. J Comp Neurol. 1944;80:33.
    • (1944) J Comp Neurol , vol.80 , pp. 33
    • Hetherington, A.W.1
  • 31
    • 84990756135 scopus 로고
    • Hypothalamic lesions and adipocity in the rat
    • Hetherington AW, Ranson SW. Hypothalamic lesions and adipocity in the rat. Anat Rec. 1940;78:149.
    • (1940) Anat Rec , vol.78 , pp. 149
    • Hetherington, A.W.1    Ranson, S.W.2
  • 32
    • 0000833791 scopus 로고
    • Mechanism of the development of obesity in animals with hypothalamic lesions
    • Brobeck JR. Mechanism of the development of obesity in animals with hypothalamic lesions. Physiol Rev. 1946;26(4):541-59.
    • (1946) Physiol Rev , vol.26 , Issue.4 , pp. 541-559
    • Brobeck, J.R.1
  • 33
    • 0018756428 scopus 로고
    • Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis
    • Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis. Physiol Rev. 1979;59(3):719-809.
    • (1979) Physiol Rev , vol.59 , Issue.3 , pp. 719-809
    • Bray, G.A.1    York, D.A.2
  • 34
    • 80053070975 scopus 로고
    • Effect of experimental obesity upon carbohydrate metabolism
    • Brobeck JR, Tepperman J, Long CNH. Effect of experimental obesity upon carbohydrate metabolism. Yale J Biol Med. 1943;15:893.
    • (1943) Yale J Biol Med , vol.15 , pp. 893
    • Brobeck, J.R.1    Tepperman, J.2    Long, C.N.H.3
  • 35
    • 84964125510 scopus 로고
    • Localization of a "feeding center" in the hypothalamus of the rat
    • Anand BK, Brobeck JR. Localization of a "feeding center" in the hypothalamus of the rat. Proc Soc Exp Biol Med. 1951;77(2):323-4.
    • (1951) Proc Soc Exp Biol Med , vol.77 , Issue.2 , pp. 323-324
    • Anand, B.K.1    Brobeck, J.R.2
  • 36
    • 0002244632 scopus 로고
    • The physiology of motivation
    • Stellar E. The physiology of motivation. Psychol Rev. 1954;61(1):5-22.
    • (1954) Psychol Rev , vol.61 , Issue.1 , pp. 5-22
    • Stellar, E.1
  • 37
    • 0029845169 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA expression in mouse brain
    • Huang XF, Koutcherov I, Lin S, Wang HQ, Storlien L. Localization of leptin receptor mRNA expression in mouse brain. Neuroreport. 1996;7(15-17):2635-8.
    • (1996) Neuroreport , vol.7 , Issue.15-17 , pp. 2635-2638
    • Huang, X.F.1    Koutcherov, I.2    Lin, S.3    Wang, H.Q.4    Storlien, L.5
  • 39
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (ob-rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (ob-rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 1996;387(2-3):113-6.
    • (1996) FEBS Lett , vol.387 , Issue.2-3 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 41
    • 0026463547 scopus 로고
    • Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: A Light and Electron Microscopic Double Immunostaining Analysis
    • Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: A light and electron microscopic double immunostaining analysis. Endocrinology. 1992;131(5):2461-7.
    • (1992) Endocrinology , vol.131 , Issue.5 , pp. 2461-2467
    • Horvath, T.L.1    Naftolin, F.2    Kalra, S.P.3    Leranth, C.4
  • 42
    • 78651463641 scopus 로고    scopus 로고
    • New aspects of melanocortin signaling: A Role For PRCP In Alpha-MSH Degradation
    • Diano S. New aspects of melanocortin signaling: A role for PRCP in alpha-MSH degradation. Front Neuroendocrinol. 2011;32(1):70-83.
    • (2011) Front Neuroendocrinol , vol.32 , Issue.1 , pp. 70-83
    • Diano, S.1
  • 43
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 1999;23(4):775-86.
    • (1999) Neuron , vol.23 , Issue.4 , pp. 775-786
    • Elias, C.F.1    Aschkenasi, C.2    Lee, C.3    Kelly, J.4    Ahima, R.S.5    Bjorbaek, C.6
  • 44
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411(6836):480-4.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6
  • 45
    • 0030962452 scopus 로고    scopus 로고
    • Control of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity
    • Horvath TL, Garcia-Segura LM, Naftolin F. Control of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity. Gynecol Endocrinol. 1997;11(2):139-43.
    • (1997) Gynecol Endocrinol , vol.11 , Issue.2 , pp. 139-143
    • Horvath, T.L.1    Garcia-Segura, L.M.2    Naftolin, F.3
  • 46
    • 0033343736 scopus 로고    scopus 로고
    • Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
    • Hinney A, Schmidt A, Nottebom K, Heibult O, Becker I, Ziegler A, et al. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin Endocrinol Metab. 1999;84(4):1483-6.
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.4 , pp. 1483-1486
    • Hinney, A.1    Schmidt, A.2    Nottebom, K.3    Heibult, O.4    Becker, I.5    Ziegler, A.6
  • 47
    • 0033927916 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    • Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest. 2000;106(2):253-62.
    • (2000) J Clin Invest , vol.106 , Issue.2 , pp. 253-262
    • Vaisse, C.1    Clement, K.2    Durand, E.3    Hercberg, S.4    Guy-Grand, B.5    Froguel, P.6
  • 48
    • 1842529267 scopus 로고    scopus 로고
    • Rapid rewiring of arcuate nucleus feeding circuits by leptin
    • Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science. 2004;304(5667):110-5.
    • (2004) Science , vol.304 , Issue.5667 , pp. 110-115
    • Pinto, S.1    Roseberry, A.G.2    Liu, H.3    Diano, S.4    Shanabrough, M.5    Cai, X.6
  • 49
    • 27744457512 scopus 로고    scopus 로고
    • Topographic mapping of VMH arcuate nucleus microcircuits and their reorganization by fasting
    • Sternson SM, Shepherd GM, Friedman JM. Topographic mapping of VMH arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci. 2005;8(10):1356-63.
    • (2005) Nat Neurosci , vol.8 , Issue.10 , pp. 1356-1363
    • Sternson, S.M.1    Shepherd, G.M.2    Friedman, J.M.3
  • 50
    • 77951029840 scopus 로고    scopus 로고
    • Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically
    • Stanley S, Pinto S, Segal J, Perez CA, Viale A, DeFalco J, et al. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proc Natl Acad Sci USA. 2010;107(15):7024-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.15 , pp. 7024-7029
    • Stanley, S.1    Pinto, S.2    Segal, J.3    Perez, C.A.4    Viale, A.5    Defalco, J.6
  • 51
    • 77955326815 scopus 로고    scopus 로고
    • Hyperleptinemia is required for the development of leptin resistance
    • Knight ZA, Hannan KS, Greenberg ML, Friedman JM. Hyperleptinemia is required for the development of leptin resistance. PLoS One. 2010;5(6):e11376.
    • (2010) PLoS One , vol.5 , Issue.6
    • Knight, Z.A.1    Hannan, K.S.2    Greenberg, M.L.3    Friedman, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.