Magnolia extract (BL153) protection of heart from lipid accumulation caused cardiac oxidative damage, inflammation, and cell death in high-fat diet fed mice

Oxidative Medicine and Cellular Longevity

Volumn 2014, Issue , 2014, Pages

  Sun, Weixia ^a,b   Zhang, Zhiguo ^a,b   Chen, Qiang ^b,c   Yin, Xia ^a   Fu, Yaowen ^a   Zheng, Yang ^a   Cai, Lu ^b,d   Kim, Ki Soo ^e   Kim, Ki Ho ^f   Tan, Yi ^b,d   Kim, Young Heui ^f  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b University of Louisville School of Medicine   (United States)

^c JILIN UNIVERSITY   (China)

^d WENZHOU MEDICAL UNIVERSITY   (China)

^e Bioland Biotec Co Ltd Zhangjiang Modern Medical Device Park   (China)

^f Bioland Ltd   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHROPOMETRY; CELL DEATH; MAMMALS; NUTRITION; OXIDATIVE STRESS; PATHOLOGY;

ANTI-INFLAMMATION; ANTI-OXIDATIVE STRESS; CARDIAC HYPERTROPHY; CELL-DEATH PATHWAYS; INSULIN RESISTANCE; LIPID ACCUMULATIONS; OIL RED O STAINING; OXIDATIVE DAMAGE;

HEART;

4 HYDROXYNONENAL; CASPASE 3; INTERCELLULAR ADHESION MOLECULE 1; MAGNOLIA EXTRACT; OIL; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; CARDIOTONIC AGENT; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CARDITIS; CONTROLLED STUDY; DIET; DRUG EFFECT; FEEDING; HEART INJURY; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; LOW FAT DIET; MAGNOLIACEAE; MALE; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; OBESITY; OXIDATIVE STRESS; STAINING; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; BLOOD; C57BL MOUSE; CALORIC INTAKE; CELL DEATH; CHEMISTRY; DRUG EFFECTS; ENDOPLASMIC RETICULUM STRESS; FEEDING BEHAVIOR; HEART FUNCTION TEST; HEART MUSCLE; INFLAMMATION; LIPID METABOLISM; MAGNOLIA; METABOLISM; ORGAN SIZE; PATHOLOGY; PHYTOTHERAPY; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CARDIOTONIC AGENTS; CELL DEATH; DIET, HIGH-FAT; ENDOPLASMIC RETICULUM STRESS; ENERGY INTAKE; FEEDING BEHAVIOR; HEART FUNCTION TESTS; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; MAGNOLIA; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MYOCARDIUM; ORGAN SIZE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 84896109406     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2014/205849     Document Type: Article

References (54)

1. Rössner S., Obesity: the disease of the twenty-first century. International Journal of Obesity 2002 26 4 S2 S4 2-s2.0-0036945834 (Pubitemid 36071962)
2. Jang H., Conklin D. J., Kong M., Piecewise nonlinear mixed-effects models for modeling cardiac function and assessing treatment effects. Comput Methods Programs Biomed 2013 110 3 240 252
3. Subramanian S., Turner M. S., Ding Y., Increased levels of invariant natural killer T lymphocytes worsens metabolic abnormalities and atherosclerosis in obese mice. Journal of Lipid Research 2013 54 10 2831 2841 10.1194/jlr.M041020
4. Younce C. W., Burmeister M. A., Ayala J. E., Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. American Journal of Physiology 2013 304 6 C508 C518
5. Ryden L., Grant P. J., Anker S. D., ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). European Heart Journal 2013 34 39 3035 3087
6. Li W. L., Zheng H. C., Bukuru J., de Kimpe N., Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology 2004 92 1 1 21 2-s2.0-1942424088 10.1016/j.jep.2003.12.031 (Pubitemid 38510258)
7. Kim Y. S., Jung D. H., Kim N. H., Effect of magnolol on TGF-beta1 and fibronectin expression in human retinal pigment epithelial cells under diabetic conditions. European Journal of Pharmacology 2007 562 1 12 19 10.1016/j.ejphar.2007.01.048 (Pubitemid 46466755)
8. Maruyama Y., Kuribara H., Overview of the pharmacological features of honokiol. CNS Drug Reviews 2000 6 1 35 44 2-s2.0-0034035866 (Pubitemid 30179968)
9. Lee J., Jung E., Park J., Jung K., Lee S., Hong S., Park J., Park E., Kim J., Park S., Park D., Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF- B activation signaling. Planta Medica 2005 71 4 338 343 2-s2.0-21044435937 10.1055/s-2005-864100 (Pubitemid 40676458)
10. Kane J. S., Lee K. H., Han M. H., Lee H., Ahn J.-M., Han S.-B., Han G., Lee K., Park S.-K., Kim H. M., Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus. Phytotherapy Research 2008 22 7 883 888 2-s2.0-48749108639 10.1002/ptr.2386
11. Kassuya C. A. L., Cremoneze A., Barros L. F. L., Simas A. S., da Rocha Lapa F., Mello-Silva R., Stefanello M. É. A., Zampronio A. R., Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). Journal of Ethnopharmacology 2009 124 3 369 376 2-s2.0-67650671664 10.1016/j.jep.2009.06.003
12. Tanaka K., Hasegawa J., Asamitsu K., Okamoto T., Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor B. European Journal of Pharmacology 2007 565 1-3 212 219 2-s2.0-34248996892 10.1016/j.ejphar.2007.01.095 (Pubitemid 46782762)
13. Chang W.-C., Yu Y.-M., Hsu Y.-M., Wu C.-H., Yin P.-L., Chiang S.-Y., Hung J.-S., Inhibitory effect of Magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits. Journal of Cardiovascular Pharmacology 2006 47 3 463 468 2-s2.0-33745713612 10.1097/01.fjc.0000211708.03111.6e (Pubitemid 44309702)
14. Wu X.-N., Yu C.-H., Cai W., Hua J., Li S.-Q., Wang W., Protective effect of a polyphenolic rich extract from Magnolia officinalis bark on influenza virus-induced pneumonia in mice. Journal of Ethnopharmacology 2011 134 1 191 194 2-s2.0-79952709247 10.1016/j.jep.2010.11.074
15. Sohn E. J., Kim C.-S., Kim Y. S., Jung D. H., Jang D. S., Lee Y. M., Kim J. S., Effects of magnolol (5,5′-diallyl-2,2′-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. Life Sciences 2007 80 5 468 475 2-s2.0-33845764758 10.1016/j.lfs.2006.09.037 (Pubitemid 46013908)
16. Choi S.-S., Cha B.-Y., Lee Y.-S., Yonezawa T., Teruya T., Nagai K., Woo J.-T., Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sciences 2009 84 25-26 908 914 2-s2.0-67349146720 10.1016/j.lfs.2009.04.001
17. Cui W., Wang Y., Chen Q., Magnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced obesity mouse model. Oxidative Medicine and Cellular Longevity 2013 2013 9 367040 10.1155/2013/367040
18. Ize-Ludlow D., Lightfoot Y. L., Parker M., Xue S., Wasserfall C., Haller M. J., Schatz D., Becker D. J., Atkinson M. A., Mathews C. E., Progressive erosion of β -cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes. Diabetes 2011 60 8 2086 2091 2-s2.0-80052827105 10.2337/db11-0373
19. Tan Y., Li X., Prabhu S. D., Brittian K. R., Chen Q., Yin X., McClain C. J., Zhou Z., Cai L., Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase c/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner. Journal of the American College of Cardiology 2012 59 16 1477 1486 2-s2.0-84859620774 10.1016/j.jacc.2011.12.034
20. Bai Y., Cui W. P., Xin Y., Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation. Journal of Molecular and Cellular Cardiology 2013 57 82 95 10.1016/j.yjmcc.2013.01.008
21. Jiang X., Zhang C., Xin Y., Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial-and endoplasmic reticulum stress-dependent pathways in the mouse model. Toxicology Letters 2013 219 1 65 76
22. Zhou G., Li X., Hein D. W., Xiang X., Marshall J. P., Prabhu S. D., Cai L., Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart. Journal of the American College of Cardiology 2008 52 8 655 666 2-s2.0-48849086702 10.1016/j.jacc.2008.05.019
23. Després J.-P., Lemieux I., Abdominal obesity and metabolic syndrome. Nature 2006 444 7121 881 887 2-s2.0-33845886915 10.1038/nature05488 (Pubitemid 46024995)
24. Hotamisligil G. S., Shargill N. S., Spiegelman B. M., Adipose expression of tumor necrosis factor- α: direct role in obesity-linked insulin resistance. Science 1993 259 5091 87 91 2-s2.0-0027459878 (Pubitemid 23036092)
25. Abbas A. M., Sakr H. F., Simvastatin and vitamin E effects on cardiac and hepatic oxidative stress in rats fed on high fat diet. Journal of Physiology and Biochemistry 2013 69 4 737 750
26. Listenberger L. L., Schaffer J. E., Mechanisms of lipoapoptosis: implications for human heart disease. Trends in Cardiovascular Medicine 2002 12 3 134 138 2-s2.0-0036233315 10.1016/S1050-1738(02)00152-4 (Pubitemid 34462184)
27. Crow M. T., Mani K., Nam Y.-J., Kitsis R. N., The mitochondrial death pathway and cardiac myocyte apoptosis. Circulation Research 2004 95 10 957 970 2-s2.0-8844235617 10.1161/01.RES.0000148632.35500.d9 (Pubitemid 39532326)
28. Kim I., Xu W., Reed J. C., Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nature Reviews Drug Discovery 2008 7 12 1013 1030 2-s2.0-57049117856 10.1038/nrd2755
29. Candé C., Vahsen N., Garrido C., Kroemer G., Apoptosis-inducing factor (AIF): caspase-independent after all. Cell Death and Differentiation 2004 11 6 591 595 2-s2.0-2942711312 (Pubitemid 38786707)
30. Ouwens D. M., Boer C., Fodor M., De Galan P., Heine R. J., Maassen J. A., Diamant M., Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats. Diabetologia 2005 48 6 1229 1237 2-s2.0-21344455935 10.1007/s00125-005-1755-x (Pubitemid 40909661)
31. Zhou Y.-T., Grayburn P., Karim A., Shimabukuro M., Higa M., Baetens D., Orci L., Unger R. H., Lipotoxic heart disease in obese rats: implications for human obesity. Proceedings of the National Academy of Sciences of the United States of America 2000 97 4 1784 1789 2-s2.0-0034652225 10.1073/pnas.97.4.1784 (Pubitemid 30118520)
32. Christoffersen C., Bollano E., Lindegaard M. L. S., Bartels E. D., Goetze J. P., Andersen C. B., Nielsen L. B., Cardiac lipid accumulation associated with diastolic dysfunction in obese mice. Endocrinology 2003 144 8 3483 3490 2-s2.0-0042315364 10.1210/en.2003-0242 (Pubitemid 36904426)
33. Unger R. H., Lipotoxic diseases. Annual Review of Medicine 2002 53 319 336 2-s2.0-0036182137 10.1146/annurev.med.53.082901.104057 (Pubitemid 34177884)
34. Westermann D., van Linthout S., Dhayat S., Dhayat N., Schmidt A., Noutsias M., Song X.-Y., Spillmann F., Riad A., Schultheiss H.-P., Tschöpe C., Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy. Basic Research in Cardiology 2007 102 6 500 507 2-s2.0-35348835422 10.1007/s00395-007-0673-0 (Pubitemid 47578394)
35. Tan Y., Ichikawa T., Li J., Si Q., Yang H., Chen X., Goldblatt C. S., Meyer C. J., Li X., Cai L., Cui T., Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes 2011 60 2 625 633 2-s2.0-79551575483 10.2337/db10-1164
36. Pagano C., Calcagno A., Granzotto M., Calabrese F., Thiene G., Federspil G., Vettor R., Heart lipid accumulation in obese non-diabetic rats: effect of weight loss. Nutrition, Metabolism and Cardiovascular Diseases 2008 18 3 189 197 2-s2.0-40649083566 10.1016/j.numecd.2006.05.009 (Pubitemid 351374798)
37. Giordano F. J., Oxygen, oxidative stress, hypoxia, and heart failure. Journal of Clinical Investigation 2005 115 3 500 508 2-s2.0-14644442283 10.1172/JCI200524408 (Pubitemid 40322219)
38. Ungvári Z., Gupte S. A., Recchia F. A., Bátkai S., Pacher P., Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. Current Vascular Pharmacology 2005 3 3 221 229 2-s2.0-21644460615 10.2174/1570161054368607 (Pubitemid 40933045)
39. Takano H., Zou Y., Hasegawa H., Akazawa H., Nagai T., Komuro I., Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases. Antioxidants and Redox Signaling 2003 5 6 789 794 2-s2.0-0345258505 (Pubitemid 37462062)
40. Kunsch C., Medford R. M., Oxidative stress as a regulator of gene expression in the vasculature. Circulation Research 1999 85 8 753 766 2-s2.0-0033570271 (Pubitemid 29480816)
41. Kang K. A., Lee K. H., Kim S. Y., Kim H. S., Kim J. S., Hyun J. W., Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1. Biological and Pharmaceutical Bulletin 2007 30 5 852 858 2-s2.0-34248140585 10.1248/bpb.30.852 (Pubitemid 46708625)
42. Haraguchi H., Ishikawa H., Shirataki N., Fukuda A., Antiperoxidative activity of neolignans from Magnolia obovata. Journal of Pharmacy and Pharmacology 1997 49 2 209 212 2-s2.0-0031050044 (Pubitemid 27096118)
43. Oh J. H., Kang L. L., Ban J. O., Kim Y. H., Kim K. H., Han S. B., Hong J. T., Anti-inflammatory effect of 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis through inhibition of NF- B. Chemico-Biological Interactions 2009 180 3 506 514 2-s2.0-67349090320 10.1016/j.cbi.2009.03.014
44. Chiang J., Shen Y.-C., Wang Y.-H., Hou Y.-C., Chen C.-C., Liao J.-F., Yu M.-C., Juan C.-W., Liou K.-T., Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF- B induced oxidative stress and inflammation. European Journal of Pharmacology 2009 610 1-3 119 127 2-s2.0-65049085035 10.1016/j.ejphar.2009.03.035
45. Szczepaniak L. S., Victor R. G., Orci L., Unger R. H., Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. Circulation Research 2007 101 8 759 767 2-s2.0-35448950503 10.1161/CIRCRESAHA.107.160457 (Pubitemid 350287190)
46. Hickson-Bick D. L. M., Buja M. L., McMillin J. B., Palmitate-mediated alterations in the fatty acid metabolism of rat neonatal cardiac myocytes. Journal of Molecular and Cellular Cardiology 2000 32 3 511 519 2-s2.0-0033840188 10.1006/jmcc.1999.1098
47. Okere I. C., Chandler M. P., McElfresh T. A., Rennison J. H., Sharov V., Sabbah H. N., Tserng K.-Y., Hoit B. D., Ernsberger P., Young M. E., Stanley W. C., Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin. American Journal of Physiology-Heart and Circulatory Physiology 2006 291 1 H38 H44 2-s2.0-33745712681 10.1152/ajpheart.01295.2005
48. Relling D. P., Esberg L. B., Fang C. X., Johnson W. T., Murphy E. J., Carlson E. C., Saari J. T., Ren J., High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. Journal of Hypertension 2006 24 3 549 561 2-s2.0-32944466267 (Pubitemid 43261920)
49. Cai L., Wang Y., Zhou G., Chen T., Song Y., Li X., Kang Y. J., Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. Journal of the American College of Cardiology 2006 48 8 1688 1697 2-s2.0-33749513188 10.1016/j.jacc.2006.07.022 (Pubitemid 44528172)
50. Cai L., Li W., Wang G., Guo L., Jiang Y., James Kang Y., Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 2002 51 6 1938 1948 2-s2.0-0036267006 (Pubitemid 34564309)
51. Asmis R., Begley J. G., Oxidized LDL promotes peroxide-mediated mitochondrial dysfunction and cell death in human macrophages: a caspase-3-independent pathway. Circulation research 2003 92 1 e20 e29 2-s2.0-0037428382
52. An D., Kewalramani G., Chan J. K. Y., Qi D., Ghosh S., Pulinilkunnil T., Abrahani A., Innis S. M., Rodrigues B., Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3. Diabetologia 2006 49 9 2174 2184 2-s2.0-33746752740 10.1007/s00125-006-0338-9 (Pubitemid 44168486)
53. Jiang X., Zhang C., Xin Y., Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model. Toxicology Letters 2013 219 1 65 76 10.1016/j.toxlet.2013.02.022
54. Jin Y. C., Kim K. J., Kim Y. M., Ha Y. M., Kim H. J., Yun U. J., Bae K. H., Kim Y. S., Kang S. S., Seo H. G., Lee J. H., Chang K. C., Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo. Experimental Biology and Medicine 2008 233 10 1280 1288 2-s2.0-54549109211 10.3181/0803-RM-79