Obesity and diabetes

Endocrinologia y Nutricion

Volumn 56, Issue SUPPL. 4, 2009, Pages 38-42

  Lois, Konstantinos ^a   Kumar, Sudhesh ^a  

^a UNIVERSITY HOSPITAL COVENTRY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; 4 PHENYLBUTYRIC ACID; ADAMANTYLTRIAZOLE DERIVATIVE; ANTIOBESITY AGENT; CHROMIUM; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCOCORTICOID RECEPTOR ANTAGONIST; INSULIN SENSITIZING AGENT; INT 131; LEPTIN; MAGNESIUM; MBX 2044; METAGLIDASEN; METFORMIN; ORAL ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PREBIOTIC AGENT; PROBIOTIC AGENT; SALUBRINAL; SIBUTRAMINE; TAUROURSODEOXYCHOLIC ACID; TETRAHYDROLIPSTATIN; THIAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D;

ADIPOSE TISSUE; ARTICLE; DIABETES MELLITUS; DISEASE ASSOCIATION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIFESTYLE MODIFICATION; LIPID STORAGE; LOW CALORY DIET; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; SUBCUTANEOUS FAT;

ACUTE-PHASE PROTEINS; ADIPOSE TISSUE; ATHEROSCLEROSIS; COMORBIDITY; CYTOKINES; DIABETES MELLITUS, TYPE 2; ENERGY INTAKE; FATTY ACIDS, NONESTERIFIED; HORMONES; HUMANS; HYPOGLYCEMIC AGENTS; INFLAMMATION; INSULIN RESISTANCE; MODELS, BIOLOGICAL; OBESITY; OXIDATIVE STRESS;

EID: 77953254909     PISSN: 15750922     EISSN: 15792021     Source Type: Journal    
DOI: 10.1016/S1575-0922(09)73516-8     Document Type: Article

References (20)

1. Greenstein B., and Wood D. The endocrine system at a glance. 2nd ed. (2006), Wiley p. 92.
2. Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease. Am J Clin Nutr 4 (1956) 20-34
3. Kissebah A.H., and Krakower G.R. Regional adiposity and morbidity. Physiological Reviews 74 (1994) 761-809
4. Randle P.J., Garland P.B., Hales C.N., and Newsholme E.A. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 (1963) 785-789
5. Ferrannini E., Barrett E.J., Bevilacqua S., and DeFronzo R.A. Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72 (1983) 1737-1747
6. Frayn K., Humphreys S., and Coppack S. Net carbon flux across subcutaneous adipose tissue after a standard meal in normal weight and and insulin resistant obese subjects. Int J Obes Rel Metab Disord 20 (1996) 795-800
7. Lönnqvist F., Thörne A., Nilsell K., Hoffstedt J., and Arner P. A pathogenic role of visceral β3-adrenoceptors in obesity. J Clin Invest 95 (1995) 1109-1116
8. Van Harmelen V., Lonnqvist F., Thorne A., Wennlund A., Large V., Reynisdottir S., et al. Noradrenaline-induced lipolysis in isolated mesenteric, omental and subcutaneous adipocytes from obese subjects. Int J Obes Relat Metab Disord 21 (1997) 972-979
9. Stewart P.M., Boulton A., Kumar S., Clark P.M.S., and Shackleton C.H.L. Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84 (1999) 1022-1027
10. Ravussin E., and Smith S.R. Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann N Y Acad Sci 967 (2002) 363-378
11. Lewis G.F., Carpentier A., Adeli K., and Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23 (2002) 201-229
12. Ahima R.S., and Flier J.S. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11 (2000) 327-332
13. Westerbacka J., Yki-Järvinen H., Vehkavaara S., Häkkinen A.M., Andrew R., Wake D.J., et al. Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. J Clin Endocrinol Metab 88 (2003) 4924-4931
14. Senn J.J., Klover P.J., Nowak I.A., and Mooney R.A. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51 (2002) 3391-3399
15. Hirosumi J., Tuncman G., Chang L., Görgün C.Z., Uysal K.T., Maeda K., et al. A central role for JNK in obesity and insulin resistance. Nature 420 (2002) 333-336
16. Xu H., Barnes G.T., Yang Q., Tang G., Yang D., Chou C.J., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112 (2003) 1821-1830
17. Weisberg S.P., Mc Cann D., Desai M., Rosenbaum M., Leibel R.L., and Ferrante A.W.J. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 (2003) 1796-1808
18. Montague C.T., Prins J.B., Sanders L., Zhang J., Sewter C.P., Digby J., et al. Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes 47 (1998) 1384-1391
19. Wang Y., Rimm E.B., Stampfer M.J., Willett W.C., and Hu F.B. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr 81 (2005) 555-563
20. De Luca C., and Olefsky J.M. Inflammation and insulin resistance. FEBS Lett 582 (2008) 97-105