Dose and temporal evaluation of ethylene oxide-induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations

Environmental and Molecular Mutagenesis

Volumn 58, Issue 3, 2017, Pages 122-134

  Manjanatha, Mugimane G ^a   Shelton, Sharon D ^a   Chen, Ying ^a   Parsons, Barbara L ^a   Myers, Meagan B ^a   McKim, Karen L ^a   Gollapudi, B Bhaskar ^b,f   Moore, Nigel P ^c,g   Haber, Lynne T ^d,h   Allen, Bruce ^e   Moore, Martha M ^a,i  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c DOW EUROPE GMBH   (Switzerland)

^d Toxicology Excellence for Risk Assessment   (United States)

^e Exponent® ^*  (United States)

^f Center for Toxicology and Mechanistic Biology Exponent   (United States)

^g UBRS GmbH   (Switzerland)

^h UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

ⁱ ENVIRON INTERNATIONAL CORPORATION   (United States)

Author keywords

cII gene; mode of action for cancer; mutation spectrum; transgenic mice

Indexed keywords

CARCINOGEN; DNA; ETHYLENE OXIDE; MUTAGENIC AGENT;

ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; DNA SEQUENCE; EXPOSURE; FEMALE; IN VIVO STUDY; LUNG TUMOR; MALE; MOUSE; MUTAGENIC ACTIVITY; MUTAGENICITY; MUTANT; NONHUMAN; POINT MUTATION; ADVERSE EFFECTS; ANIMAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; GENETICS; INBRED MOUSE STRAIN; LUNG; PATHOLOGY; TIME FACTOR;

ANIMALS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE OXIDE; INHALATION EXPOSURE; LUNG; LUNG NEOPLASMS; MALE; MICE, INBRED STRAINS; MUTAGENS; POINT MUTATION; TIME FACTORS;

EID: 85016246439     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.22080     Document Type: Article

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