A novel approach for concurrent quantitation of glutathione, glutathione disulfide, and 2-hydroxyethylated glutathione in lungs of mice exposed to ethylene oxide, using liquid chromatography-positive electrospray tandem mass spectrometry

Biomedical Chromatography

Volumn 29, Issue 9, 2015, Pages 1364-1374

  Zhang, Fagen ^a   Bartels, Michael J ^a   Lebaron, Matthew J ^a   Schisler, Melissa R ^a   Gollapudi, B Bhaskar ^a,c   Moore, Nigel P ^b,d  

^a DOW CHEMICAL COMPANY   (United States)

^b DOW EUROPE GMBH   (Switzerland)

^c EXPONENT INC   (United States)

^d Penman Consulting BVBA   (Belgium)

Author keywords

2 hydroxyethylated glutathione; Ethylene; Ethylene oxide; Glutathione; glutathione disulfide; Liquid chromatography tandem mass spectrometry; Simultaneous quantitation

Indexed keywords

BIOLOGICAL ORGANS; ETHYLENE; MAMMALS; MASS SPECTROMETRY; PEPTIDES; SULFUR COMPOUNDS;

2-HYDROXYETHYLATED GLUTATHIONE; ANALYTES; ETHYLENE OXIDES; GLUTATHIONE DISULFIDE; GLUTATHIONE;; GLUTHATHIONE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; SIMULTANEOUS QUANTITATION;

BIOMARKERS;

2 HYDROXYETHYLATED GLUTATHIONE; ETHYLENE OXIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONTROLLED STUDY; DERIVATIZATION; ELECTROSPRAY MASS SPECTROMETRY; EXPOSURE; GENOTOXICITY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LUNG PARENCHYMA; MALE; MEASUREMENT ACCURACY; MOUSE; NONHUMAN; PROTEIN STRUCTURE; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SIGNAL NOISE RATIO; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; EVALUATION STUDY; LUNG; PROCEDURES; SENSITIVITY AND SPECIFICITY;

MUS;

ANIMALS; CHROMATOGRAPHY, LIQUID; ETHYLENE OXIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LUNG; MALE; MICE; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84939129008     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3432     Document Type: Article

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