Ethylene oxide dosimetry in the mouse

Toxicology and Applied Pharmacology

Volumn 148, Issue 2, 1998, Pages 215-221

  Brown, Carl D ^a,b   Asgharian, Bahman ^a   Turner, Max J ^a   Fennell, Timothy R ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; ETHYLENE OXIDE; GLUTATHIONE; MUTAGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; ENVIRONMENTAL EXPOSURE; KIDNEY; LIVER; LUNG; MALE; MOUSE; NONHUMAN; TESTIS; TOXICITY TESTING; XENOBIOTIC METABOLISM;

ANIMALIA; RODENTIA;

EID: 0032004963     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8349     Document Type: Article

References (41)

1. Arms, A. D. C. C. Travis, 1988, Reference Physiological Parameters in Pharmacokinetic Modeling, Washington, DC.
2. Brown C. D., Wong B. A., Fennell T. R. In vivo and in vitro kinetics of ethylene oxide metabolism in rodents. Toxicol. Appl. Pharmacol. 136:1996;8-19.
3. Brugnone F., Perbellini L., Faccini G. B., Bartolucci G. B., DeRosa E. Ethylene oxide exposure: Biological monitoring by analysis of alveolar air and blood. Int. Arch. Occup. Environ. Health. 58:1986;105-112.
4. Ehrenberg L., Hussain S. Genetic toxicity of some important epoxides. Mutat. Res. 86:1982;1-113.
5. Ellman G. L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82:1959;70-77.
6. Filser J. G., Bolt H. M. Inhalation pharmacokinetics based on gas uptake studies. VI. Comparative evaluation of ethylene oxide and butadiene monoepoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats. Arch. Toxicol. 55:1984;219-223.
7. Filser J. G., Denk B., Tornqvist M., Kessler W., Ehrenberg L. Pharmacokinetics of ethylene in man: Body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene. Arch. Toxicol. 66:1992;157-163.
8. Gad S. G., Weil C. S. Statistics for Toxicologists. Principles and Methods of Toxicology. 1984;Raven Press, New York. p. 70-92.
9. Generoso W. M., Cain K. T., Cornett C. V., Cacheiro N. L. A., Hughes L. A. Concentration-response curves for ethylene-oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:1990;126-131.
10. Generoso W. M., Cain K. T., Hughes L. A., Sega G. A., Braden P. W., Gosslee D. G., Shelby M. D. Ethylene oxide dose and dose-rate effects in the mouse dominant lethal test. Environ. Mutagen. 8:1986;1-7.
11. Hattis, D. 1987, A Pharmacokinetic/Mechanism-Based Analysis of the Carcinogenic Risk of Ethylene Oxide, Center for Technology Policy and Industrial Development at the Massachusetts Institute of Technology, Cambridge, MA.
12. Himmelstein M. W., Turner M. J., Asgharian B., Bond J. A. Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation. Carcinogenesis. 15:1994;1479-1486.
13. Hogdstedt C., Aringer L., Gustavsson A. Epidemiological support for ethylene oxide as a cancer causing agent. J. Am. Med. Assoc. 255:1986;1575-1578.
14. Hogdstedt C., Rohlen O., Berndtsson B., Axelson O., Ehrenberg L. A cohort study of mortality and cancer incidence in ethylene oxide production workers. Br. J. Ind. Med. 36:1979;276-280.
15. ILSI Risk Science Institute Working Group on Physiological Parameters, 1994, Physiological Parameter Values for PBPK Models.
16. Scand. J. Work Environ. Health. 20:1994;227-229.
17. Johanson G. Modelling of respiratory exchange of polar solvents. Ann. Occup. Hyg. 25:1991;323-339.
18. Jones A. R., Wells G. The comparative metabolism of 2-bromoethanol and ethylene oxide in the rat. Xenobiotica. 11:1981;763-770.
19. Kaplowitz N., Aw T. Y., Ookhtens M. The regulation of hepatic glutathione. Annu. Rev. Pharmacol. Toxicol. 25:1985;715-744.
20. Krishnan K., Gargas M., Fennell T. R., Andersen M. E. A physiologically-based description of ethylene oxide dosimetry in the rat. Toxicol. Ind. Health. 8:1992;121-140.
21. Lynch D. W., Lewis T. R., Moorman W. J., Burg J. R., Groth D. H., Khan A., Acherman L. J., Cockrell B. Y. Carcinogenic and toxicologic effects of ethylene oxide and propylene oxide in F-344 rats. Toxicol. Appl. Pharmacol. 76:1984;69-84.
22. Maples K. R., Dahl A. R. Levels of epoxides in blood during inhalation of alkenes and alkene oxides. Inhal. Toxicol. 5:1993;43-54.
23. McKelvey J. A., Zemaitis M. A. The effects of ethylene oxide (EO) exposure on tissue glutathione levels in rats and mice. Drug Chem. Toxicol. 9:1986;51-66.
24. Medinsky M., Kimball J., Morris J., Gerde P., Overton J. Advances in biologically based models for respiratory tract uptake of inhaled volitiles. Fundam. Appl. Toxicol. 20:1993;265-272.
25. National Toxicology Program (NTP), 1988, Toxicology and carcinogenesis studies of ethylene oxide in B6C3F1 mice, U.S. Dept. of Health and Human Services, Public Health Service, NIH, Research Triangle Park, NC.
26. Osterman-Golkar S., Ehrenberg L., Segerback D., Hallstrom I. Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat. Res. 34:1976;1-10.
27. Osterman-Golkar S., Farmer P. B., Segerback D., Bailey E., Calleman C. J., Svensson K., Ehrenberg L. Dosimetry of ethylene oxide in the rat by quantitation of alkylated histidine in hemoglobin. Teratog. Carcinog. Mutagen. 3:1983;395-405.
28. 14. Arch. Toxicol. Suppl. 13:1989;254-257.
29. Preston R. J., Fennell T. R., Lieber A. P., Sielken R. L. Jr., Swenberg J. A. A reconsideration of the genetic risk assessment for ethylene oxide exposures. Environ. Mol. Mutagen. 26:1995;189-202.
30. Rhomberg L., Dellarco V. L., Siegel-Scott C., Dearfield K. L., Jacobson-Kram D. Quantitative estimation of the genetic risk associated with the induction of heritable translocations at low-dose exposure: Ethylene oxide as an example. Environ. Mol. Mutagen. 16:1990;104-125.
31. Sega G. A., Brimer P. A., Generoso E. E. Ethylene oxide inhalation at different exposure-rates affects binding levels in mouse germ cells and hemoglobin. Possible explanation for the effect. Mutat. Res. 249:1991;339-349.
32. Shore R. E., Gardner M. J., Pannett B. Ethylene oxide: An assessment of the epidemiologic evidence on carcinogenicity. Br. J. Ind. Med. 50:1993;971-977.
33. Snellings W. M., Weil C. S., Maronpot R. R. A two year inhalation study of carcinogenic potential of ethylene oxide in Fischer 344 rats. Toxicol. Appl. Pharmacol. 75:1984;105-117.
34. Steenland K., Stayner L., Greife A., Halperin W., Hayes R., Hornung R., Nowlin S. Mortality among workers exposed to ethylene oxide. N. Engl. J. Med. 324:1991;1402-1407.
35. 13. Toxicologist. 13:1993;1576.
36. Tardif R., Goyal R., Brodeur J., Gerin M. Species differences in the urinary disposition of some metabolites of ethylene oxide. Fundam. Appl. Toxicol. 9:1987;448-453.
37. Törnqvist M., Mowrer J., Jensen S., Ehrenberg L. Monitoring of environmental cancer initiators through hemoglobin adducts by a modified degradation method. Anal. Biochem. 154:1986;255-266.
38. 14, Bushy Run Research Center, Export, PA.
39. Walker V. E., Fennell T. R., Upton P. B., Skopek T. R., Prevost V., Shuker D. E. G., Swenberg J. A. Molecular dosimetry of ethylene oxide. II. Formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice. Cancer Res. 52:1992a;4328-4334.
40. Walker V. W., MacNeela J. P., Swenberg J. A., Turner M. A., Fennell T. R. Molecular dosimetry of ethylene oxide. I. Formation and persistence of N-(2-hydroxyethyl)valine in hemoglobin following repeated exposures of rats and mice. Cancer Res. 52:1992b;4320-4327.
41. Wigaeus E., Holm S., Astrand I. Exposure to acetone: Uptake and elimination in man. Scand. J. Work Environ. 7:1981;84-94.