In vivo transgenic mutation assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 540, Issue 2, 2003, Pages 141-151

  Thybaud, Véronique ^a   Dean, Stephen ^b   Nohmi, Takehiko ^c   De Boer, Johan ^d   Douglas, George R ^e   Glickman, Barry W ^d   Gorelick, Nancy J ^f   Heddle, John A ^g   Heflich, Robert H ^h   Lambert, Iain ^e   Martus, Hans Jörg ⁱ   Mirsalis, Jon C ^j   Suzuki, Takayoshi ^c   Yajima, Nobuhiro ^k  

^a SANOFI   (France)

^b HUNTINGDON LIFE SCIENCES   (United Kingdom)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d UNIVERSITY OF VICTORIA   (Canada)

^e HEALTH CANADA   (Canada)

^f 5410 Arbor Meadows ^*  (United States)

^g YORK UNIVERSITY   (Canada)

^h NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

ⁱ NOVARTIS PHARMA AG   (Switzerland)

^j SRI INTERNATIONAL   (United States)

^k Snow Brand Labio CO LTD   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; 1,3 BUTADIENE; 3 METHYLCHOLANTHRENE; 4 BIPHENYLAMINE; ACETIC ACID; ACETONE; ACRYLAMIDE; ACRYLONITRILE; ARSENIC TRIOXIDE; CACODYLIC ACID; CARBON TETRACHLORIDE; CARCINOGEN; CHLOROFORM; CYCLOPHOSPHAMIDE; ETHYLENE OXIDE; EUGENOL; FOLIC ACID; HEPTACHLOR; MITOMYCIN C; NICKEL; OXAZEPAM; PHENOBARBITAL; QUINOLINE; SACCHARIN SODIUM; STREPTOZOCIN; SUCROSE; TAMOXIFEN; TRICHLOROETHYLENE; UNINDEXED DRUG; URETHAN;

CARCINOGENICITY; CELL PROLIFERATION; COLONY FORMATION; GENDER; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENOTOXICITY; HUMAN; MOLECULAR CLONING; MUTAGENICITY; MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES; STATISTICAL ANALYSIS; TOXICITY TESTING;

ANIMALIA; RODENTIA;

EID: 0141785156     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2003.07.004     Document Type: Article

References (62)

1. Heddle J.A., Dean S., Nohmi T., Boerrigter M., Casciano D., Douglas G.R., Glickman B., Gorelick N., Mirsalis J., Martus H.J., Skopek T., Thybaud V., Tindall K., Yajima N. In vivo transgenic mutation assays. Environ. Mol. Mutagen. 35:2000;253-259.
2. Parsons B.L., Heflich R.H. Genotypic selection methods for the direct analysis of point mutations. Mutat. Res. 387:1997;97-121.
3. McKinzie P.B., Delongchamp R.R., Heflich R.H., Parsons B.L. Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment. Mutat. Res. 489:2001;47-78.
4. Jones I.M., Burkhart-Shultz K., Carrano A.V. A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes. Mutat. Res. 147:1985;97-105.
5. Winton D.J., Blount M.A., Ponder B.A.J. A clonal marker induced by mutation in mouse intestinal epithelium. Nature. 333:1988;463-466.
6. Aidoo A., Lyn-Cook L., Mittelstaedt R.A., Heflich R.H., Casciano D.A. Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environ. Mol. Mutagen. 17:1991;141-151.
7. Gossen J.A., de Leeuw W.J.F., Tan C.H.T., Lohman P.H.M., Berends F., Knook D.L., Zwarthoff E.C., Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. U.S.A. 86:1989;7981-7985.
8. RlacI shuttle vector in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 88:1991;7958-7962.
9. Burkhart J.G., Winn R.N., VanBeneden R., Malling H.V. The ΦX174 bacteriophage shuttle vector for the study of mutagenesis. Environ. Mol. Mutagen. 19(Suppl. 20):1992;8.
10. Boerrigter M.E.T.I., Dollé M.E.T., Martus H.-J., Gossen J.A., Vijg J. Plasmid-based transgenic mouse model for studying in vivo mutations. Nature (Lond). 377:1995;657-659.
11. Manjanatha M.G., Shelton S.D., Aidoo A., Lyn-Cook L.E., Casciano D.A. Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene in Big Blue™ rats treated with 7,12-dimethylbenz[a]anthracene (DMBA). Mutat. Res. 401:1998;165-178.
12. Tao K.S., Urlando C., Heddle J.A. Comparison of somatic mutation in a transgenic versus host locus. Proc. Natl. Acad. Sci. U.S.A. 90:1993a; 10681-10685.
13. Cosentino L., Heddle J.A. A test for neutrality of mutations of the lacZ transgene. Environ. Mol. Mutagen. 28:1996;313-316.
14. Swiger R.R., Cosentino L., Shima N., Heddle J.A. Properties of the cII locus in the Muta™mouse system. Environ. Mol. Mutagen. 34:1999;201-207.
15. Dobrovolsky V.N., Chen T., Heflich R.H. Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes. Environ. Mol. Mutagen. 34:1999;30-38.
16. Von Tungeln L.S., Hamilton L.P., Dobrovolsky V.N., Bishop M.E., Shaddock J.G., Heflich R.H., Beland F.A. Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F1/Tk+/- mice treated neonatally with zidovudine and lamivudine. Carcinogenesis. 23:2002;1427-1432.
17. Dean S.W., Brooks T.M., Burlinson B., Mirsalis J., Myhr B., Recio L., Thybaud V. Transgenic mouse mutation assay systems can play an important role in regulatory mutagenesis testing in vivo for the detection of site-of-contact mutagens. Mutagenesis. 14:1999;141-151.
18. Morrison V., Ashby J. A preliminary evaluation of the performance of the Muta™mouse (lacZ) and Big Blue™ (lacI) transgenic mouse mutation assays. Mutagenesis. 4:1994;367-375.
19. Gorelick N.J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol. Mutagen. 25:1995;218-230.
20. I. Lambert, G. Douglas, 2003 (manuscript in preparation).
21. - and 6-thioguanine selections. Environ. Mol. Mutagen. 28:1996;465-470.
22. - selection: an efficient method to detect X-ray-induced deletions in transgenic mice. Environ. Mol. Mutagen. 34:1999;9-15.
23. - selection. Environ. Mol. Mutagen. 43:1999;106-111.
24. Masumura K., Matsui M., Kato M., Horiya N., Ueda O., Tanabe H., Yamada M., Suzuki H., Sofuni T., Nohmi T. Spectra of gpt mutations in ethylnitrosourea-treated and untreated transgenic mice. Environ. Mol. Mutagen. 31:1999;1-8.
25. Masumura K., Matsui K., Yamada M., Horiguchi M., Ishida K., Watanabe M., Wakabayashi K., Nohmi T. Characterization of mutants induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G:C deletions beside runs of identical bases. Carcinogenesis. 21:2000;2049-2056.
26. J. Vijg, G.R. Douglas, Bacteriophage lambda and plasmid lacZ transgenic mice for studying mutations in vivo, in: G.P. Pfeifer (Ed.), Technologies for Detection of DNA Damage and Mutation, Plenum Press, New York, 1996, pp. 391-410.
27. Nohmi T., Suzuki T., Masumura K. Recent advances in the protocols of transgenic mouse mutation assays. Mutat. Res. 455:2000;191-215.
28. Chen T., Mittelstaedt R.A., Aidoo A., Hamilton L.P., Beland F.A., Casciano D.A., Heflich R.H. Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorine-treated Big Blue rats. Environ. Mol. Mutagen. 37:2001;195-202.
29. Heddle J.A., Shaver-Walker P., Tao K.S., Zhang X.B. Treatment protocols for transgenic mutation assays in vivo. Mutagenesis. 10:1995;467-470.
30. Zhang X.B., Felton J., Tucker J.D., Urlando C., Heddle J.A. Intestinal mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and amino(α)carboline (AαC) in transgenic mice. Carcinogenesis. 17:1996;2259-2265.
31. Kohara A., Suzuki T., Honma M., Ohwada T., Hayashi M. Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (Muta™mouse). Mutat. Res. 515:2002a;63-72.
32. Kohara A., Suzuki T., Honma M., Oomori T., Ohwada T., Hayashi M. Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta™mouse). Mutat. Res. 515:2002b;73-83.
33. Davies R., Oreffo V.I., Martin E.A., Festing M.F., White I.N., Smith L.L., Styles J.A. Tamoxifen causes gene mutations in the livers of lambda/lacI transgenic rats. Cancer Res. 57:1997;1288-1293.
34. Mirsalis J.C., Montfort J.A., Winegar R.A. Transgenic animal models for measuring mutations in vivo. Crit. Rev. Toxicol. 24:1994;255-280.
35. Mirsalis J.C., Provost G.S., Matthews C.D., Hamner R.T., Schindler J.E., O'Loughlin K.G., MacGregor J.T., Short J.M. Induction of hepatic mutations in lacI transgenic mice. Mutagenesis. 8:1993;265-271.
36. Douglas G., Jiao J., Gingerich J.R., Soper L.M., Gossen J.A. Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice. Environ. Mol. Mutagen. 28:1996;317-324.
37. - selection, Environ. Mol. Mutagen. 41 (2003) 253-259.
38. Brault D., Renault D., Tombolan F., Thybaud V. Kinetics of induction of DNA damage and lacZ gene mutations in stomach mucosa of mice treated with β-propiolactone and N-methyl-N′-nitro-N-nitrosoguanidine, using single-cell gel electrophoresis and Muta™mouse models. Environ. Mol. Mutagen. 34:1999;182-189.
39. A. Takeiri, M. Mishima, K. Tanaka, A. Shioda, O. Ueda, H. Suzuki, M. Inoue, K. Masumura, T. Nohmi, Molecular characterization of mitomycin C-induced large deletions and tandem-base substitutions in the bone marrow of gpt delta transgenic mice, Chem. Res. Toxicol. 16 (2003) 171-179.
40. G. Douglas, Personal communication, 2002a.
41. D. Douglas, Personal communication, 2002b.
42. Wolff T., Topinka J., Deml E., Oesterle D., Schwarz L.R. Dose dependent induction of DNA adducts, gene mutations, and cell proliferation by the antiandrogenic drug cyproterone acetate in rat liver. Adv. Exp. Med. Biol. 500:2001;687-696.
43. Tao K.S., Urlando C., Heddle J.A. Mutagenicity of methyl methanesulphonate (MMS) in vivo in the Dlb-1 native locus and the lacI transgene. Environ. Mol. Mutagen. 22:1993b;293-296.
44. T. Suzuki, S. Itoh, M. Nakajima, N. Hachiya, T. Hara, Target organ and time-course in the mutagenicity of five carcinogens in mutamouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS, Mutat. Res. 444 (1999) 259-268.
45. Heddle J.A. Mutant manifestation: the time factor in somatic mutagenesis. Mutagenesis. 14:1999;1-3.
46. J.A. Heddle, H.-R. Martus, G.R. Douglas, Treatment and sampling protocols for transgenic mutation assays, Environ. Mol. Mutagen. 41 (2003) 1-6.
47. Ashby J., Gorelick N.J., Shelby M.D. Mutation assays in male germ cells from transgenic mice: overview of study and conclusions. Mutat. Res. 388:1997;111-122.
48. Tombolan F., Renault D., Brault D., Guffroy M., Périn-Roussel O., Périn F., Thybaud T. Kinetics of induction of DNA adducts, cell proliferation and gene mutations in the liver of Muta™mice treated with 5,9-dimethyl-dibenzo[c,g]carbazole. Carcinogenesis. 20:1999a;125-132.
49. Tombolan F., Renault D., Brault D., Guffroy M., Périn F., Thybaud T. Effect of mitogenic or regenerative cell proliferation on lacZ mutant frequency in the liver of Muta™mice treated with 5,9-dimethyl-dibenzo[c,g]carbazole. Carcinogenesis. 20:1999b;1357-1362.
50. ICH Harmonised Tripartite Guideline (S2A) Guidance on Specific Aspects of Regulatory Genotoxicity tests, 1995.
51. ICH Harmonised Tripartite Guideline (S2B) Genotoxicity: A Standard Battery for Genotoxicity Testing of Pharmaceuticals, 1997.
52. OECD Guideline for the Testing of Chemicals. Mammalian Erythrocyte Micronucleus Test, Adopted 21 July 1997, No. 474.
53. OECD Guideline for the Testing of Chemicals. Mammalian Bone Marrow Chromosome Aberration Test, Adopted 21 July 1997, No. 475.
54. Grubbs F.E. Procedures for detecting outlying observations in samples. Technometrics. 11:1969;1-21.
55. Douglas G.R., Gingerich J.D., Soper L.M. Evidence for in vivo non-mutagenicity of the carcinogen hydrazine sulfate in target tissues of lacZ transgenic mice. Carcinogenesis. 16:1995a;801-804.
56. Douglas G.R., Jiao J., Gingerich J.D., Gossen J.A., Soper L.M. Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 92:1995b;7485-7489.
57. Jiang T., Glickman B.W., de Boer J.G. Protective effect of green tea against benzo[a]pyrene-induced mutations in the liver of Big Blue transgenic mice. Mutat. Res. 480:2001;147-151.
58. M.G. Manjanatha, S.D. Shelton, M. Bishop, J.S. Shaddock, V. Dobrovolsky, R.H. Heflich, S.J. Culp, G:C → A:T mutations in the liver lacI gene of Big Blue rats fed leucomalachite green, Mutagenesis (2002).
59. J. De Boer, 2002, personal communication.
60. W.T. Adams, T.R. Skopek, Statistical tests for comparison of samples from mutational spectra, J. Mol. Biol. 194 (1987) 391-396.
61. Carr G.J., Gorelick N. Mutational spectra in transgenic animal research: data analysis and study design based upon the mutant or mutation frequency. Environ. Mol. Mutagen. 28:1996;405-413.
62. Dunson D.B., Tindall K. Bayesian analysis of mutational spectra. Genetics. 156:2000;1411-1418.