메뉴 건너뛰기




Volumn 41, Issue 1, 2003, Pages 1-6

Treatment and sampling protocols for transgenic mutation assays

Author keywords

Expression; Fixation; Manifestation; Neutral; Tissue specificity

Indexed keywords

MUTAGENIC AGENT;

EID: 0037255626     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10131     Document Type: Article
Times cited : (43)

References (30)
  • 1
    • 0034633645 scopus 로고    scopus 로고
    • Proliferation is necessary for both repair and mutation in transgenic mouse cells
    • Bielas J, Heddle, JA. 2000. Proliferation is necessary for both repair and mutation in transgenic mouse cells. Proc Natl Acad Sci USA 97:11391-11396.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11391-11396
    • Bielas, J.1    Heddle, J.A.2
  • 2
    • 0032749588 scopus 로고    scopus 로고
    • Treatment of lacZ plasmid-based transgenic mice with benzo[a]pyrene: Measurement of DNA adduct levels, mutant frequencies, and mutant spectra
    • Boerrigter ME. 1999. Treatment of lacZ plasmid-based transgenic mice with benzo[a]pyrene: measurement of DNA adduct levels, mutant frequencies, and mutant spectra. Environ Mol Mutagen 34:140-147.
    • (1999) Environ Mol Mutagen , vol.34 , pp. 140-147
    • Boerrigter, M.E.1
  • 3
    • 0027170192 scopus 로고
    • ENU-induced mutagenesis at a single A:T base pair in transgenic mice containing phi X174
    • Burkhart JG, Burkhart BA, Sampson KS, Malling HV. 1993. ENU-induced mutagenesis at a single A:T base pair in transgenic mice containing phi X174. Mutat Res 292:69-81.
    • (1993) Mutat Res , vol.292 , pp. 69-81
    • Burkhart, J.G.1    Burkhart, B.A.2    Sampson, K.S.3    Malling, H.V.4
  • 4
    • 0016692602 scopus 로고
    • Mutation selection and the natural history of cancer
    • Cairns J. 1975. Mutation selection and the natural history of cancer. Nature 255:197-200.
    • (1975) Nature , vol.255 , pp. 197-200
    • Cairns, J.1
  • 5
    • 0030329707 scopus 로고    scopus 로고
    • A test for neutrality of mutations of the lacZ transgene
    • Cosentino L, Heddle JA. 1996. A test for neutrality of mutations of the lacZ transgene. Environ Mol Mutagen 28:313-316.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 313-316
    • Cosentino, L.1    Heddle, J.A.2
  • 6
    • 0032742438 scopus 로고    scopus 로고
    • Effects of extended chronic exposures on endogenous and transgenic loci: Implications for low dose extrapolations
    • Cosentino L, Heddle JA. 1999. Effects of extended chronic exposures on endogenous and transgenic loci: implications for low dose extrapolations. Environ Mol Mutagenesis 34:208-215.
    • (1999) Environ Mol Mutagenesis , vol.34 , pp. 208-215
    • Cosentino, L.1    Heddle, J.A.2
  • 7
    • 0034613927 scopus 로고    scopus 로고
    • Differential mutation of transgenic and endogenous loci in vivo
    • Cosentino L, Heddle JA. 2000. Differential mutation of transgenic and endogenous loci in vivo. Mutat Res 454:1-10.
    • (2000) Mutat Res , vol.454 , pp. 1-10
    • Cosentino, L.1    Heddle, J.A.2
  • 8
    • 33846374349 scopus 로고    scopus 로고
    • Response of the φX174 am3, cs70 transgene to ENU: Implications for protocol design
    • Cosentino L, Malling HV, Heddle JA. 2002. Response of the φX174 am3, cs70 transgene to ENU: implications for protocol design. Mutat Res 518:113-121.
    • (2002) Mutat Res , vol.518 , pp. 113-121
    • Cosentino, L.1    Malling, H.V.2    Heddle, J.A.3
  • 9
    • 0030337742 scopus 로고    scopus 로고
    • Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice
    • Douglas GR, Jiao J, Gingerich JD, Soper LM, Gossen JA. 1996. Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice. Environ Mol Mutagen 28:317-324.
    • (1996) Environ Mol Mutagen , vol.28 , pp. 317-324
    • Douglas, G.R.1    Jiao, J.2    Gingerich, J.D.3    Soper, L.M.4    Gossen, J.A.5
  • 15
    • 0034532018 scopus 로고    scopus 로고
    • Distribution of spontaneous CpG-associated G:C → A:T mutations in the lacZ gene of Muta mice: Effects of CpG methylation, the sequence context of CpG sites, and severity of mutations on the activity of the lacZ gene product
    • Ikehata H, Takatsu M, Saito Y, Ono T. 2000. Distribution of spontaneous CpG-associated G:C → A:T mutations in the lacZ gene of Muta mice: effects of CpG methylation, the sequence context of CpG sites, and severity of mutations on the activity of the lacZ gene product. Environ Mol Mutagen 36:301-311.
    • (2000) Environ Mol Mutagen , vol.36 , pp. 301-311
    • Ikehata, H.1    Takatsu, M.2    Saito, Y.3    Ono, T.4
  • 16
    • 0029810641 scopus 로고    scopus 로고
    • Analysis of genetic instability during mammary tumor progression using a novel selection based assay for in vivo mutations in a bacteriophage λtarget
    • Jakubczak JL, Merlino G, French GE. Muller WJ, Paul B, Adhya S, Garges S. 1996. Analysis of genetic instability during mammary tumor progression using a novel selection based assay for in vivo mutations in a bacteriophage λtarget. Proc Natl Acad Sci USA 93:9073-9078.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9073-9078
    • Jakubczak, J.L.1    Merlino, G.2    French, G.E.3    Muller, W.J.4    Paul, B.5    Adhya, S.6    Garges, S.7
  • 18
    • 0029556957 scopus 로고
    • Transgenic models for detection of mutations in tumors and normal tissues of rodents
    • Mirsalis JC. 1995. Transgenic models for detection of mutations in tumors and normal tissues of rodents. Toxicol Lett 82:131-134.
    • (1995) Toxicol Lett , vol.82 , pp. 131-134
    • Mirsalis, J.C.1
  • 19
    • 0035832367 scopus 로고    scopus 로고
    • Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue rodents
    • Monroe JJ, Manjanatha MG, Skopek TR. 2001. Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue rodents. Mutat Res 476:1-11.
    • (2001) Mutat Res , vol.476 , pp. 1-11
    • Monroe, J.J.1    Manjanatha, M.G.2    Skopek, T.R.3
  • 22
    • 0029612230 scopus 로고
    • Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposures to ethylnitrosourea
    • Shaver-Walker PM, Urlando C, Tao KS, Zhang XB, Heddle JA. 1995. Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposures to ethylnitrosourea. Proc Natl Acad Sci USA 92:11470-11474.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11470-11474
    • Shaver-Walker, P.M.1    Urlando, C.2    Tao, K.S.3    Zhang, X.B.4    Heddle, J.A.5
  • 23
    • 0028991066 scopus 로고
    • Relative of the sensitivity endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice
    • Skopek TR, Kort KL, Marino DR. 1995. Relative of the sensitivity endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice. Environ Mol Mutagen 26:9-15.
    • (1995) Environ Mol Mutagen , vol.26 , pp. 9-15
    • Skopek, T.R.1    Kort, K.L.2    Marino, D.R.3
  • 24
    • 0033151332 scopus 로고    scopus 로고
    • Somatic mutation in the mammary gland: Influence of time and estrus
    • Sun B, Shima N, Heddle JA. 1999. Somatic mutation in the mammary gland: influence of time and estrus. Mutat Res 427:11-19.
    • (1999) Mutat Res , vol.427 , pp. 11-19
    • Sun, B.1    Shima, N.2    Heddle, J.A.3
  • 26
    • 0034940988 scopus 로고    scopus 로고
    • Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo
    • Swiger RR, Cosentino L. Masumura KI, Nohmi T, Heddle JA. 2001. Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo. Environ Mol Mutagen 37:297-303.
    • (2001) Environ Mol Mutagen , vol.37 , pp. 297-303
    • Swiger, R.R.1    Cosentino, L.2    Masumura, K.I.3    Nohmi, T.4    Heddle, J.A.5
  • 27
    • 0027421332 scopus 로고
    • Comparison of somatic mutation in a transgenic versus host locus
    • Tao KS, Urlando C, Heddle JA. 1993. Comparison of somatic mutation in a transgenic versus host locus. Proc Natl Acad Sci USA 90:10681-10685.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10681-10685
    • Tao, K.S.1    Urlando, C.2    Heddle, J.A.3
  • 28
    • 0028177266 scopus 로고
    • The accumulation and persistence of somatic mutations
    • Tao KS, Heddle JA. 1994. The accumulation and persistence of somatic mutations. Mutagenesis 9:187-191.
    • (1994) Mutagenesis , vol.9 , pp. 187-191
    • Tao, K.S.1    Heddle, J.A.2
  • 29
    • 0035697779 scopus 로고    scopus 로고
    • Dose dependent induction of DNA adducts, gene mutations, and cell proliferation by the antiandrogenic drug cyproterone acetate in rat liver
    • Wolff T, Topinka J, Deml E, Oesterle D, Schwarz LR. 2001. Dose dependent induction of DNA adducts, gene mutations, and cell proliferation by the antiandrogenic drug cyproterone acetate in rat liver. Adv Exp Med Biol 500:687-696.
    • (2001) Adv Exp Med Biol , vol.500 , pp. 687-696
    • Wolff, T.1    Topinka, J.2    Deml, E.3    Oesterle, D.4    Schwarz, L.R.5
  • 30
    • 0032406223 scopus 로고    scopus 로고
    • Methylation of CpG dinucleotides in the lacI gene of the Big Blue transgenic mouse
    • You YH, Halangoda A, Buettner V, Hill K, Sommer S, Pfeifer G. 1998. Methylation of CpG dinucleotides in the lacI gene of the Big Blue transgenic mouse. Mutat Res 420:55-65.
    • (1998) Mutat Res , vol.420 , pp. 55-65
    • You, Y.H.1    Halangoda, A.2    Buettner, V.3    Hill, K.4    Sommer, S.5    Pfeifer, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.