Temporal changes in K-ras mutant fraction in lung tissue of Big Blue B6C3F1 mice exposed to ethylene oxide

Toxicological Sciences

Volumn 136, Issue 1, 2013, Pages 26-38

  Parsons, Barbara L ^a   Manjanatha, Mugimane G ^a   Myers, Meagan B ^a   McKim, Karen L ^a   Shelton, Sharon D ^a   Wang, Yiying ^a   Gollapudi, B Bhaskar ^b,e   Moore, Nigel P ^c,f   Haber, Lynne T ^d   Moore, Martha M ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c DOW EUROPE GMBH   (Switzerland)

^d Toxicology Excellence for Risk Assessment   (United States)

^e EXPONENT INC   (United States)

^f Penman Consulting BVBA   (Belgium)

Author keywords

CII mutation frequency; Dose response; Mode of action; Oxidative stress; Reactive oxygen species; Risk assessment

Indexed keywords

DNA; ETHYLENE OXIDE; K RAS PROTEIN; MUTANT PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MUTANT; CHEMICAL CARCINOGENESIS; CODON; CONTROLLED STUDY; DNA ADDUCT; DNA STRAND BREAKAGE; EXON; GENOTOXICITY; INHALATION; INTRON; LUNG CARCINOGENESIS; LUNG PARENCHYMA; LUNG TOXICITY; MALE; MOUSE; MUTATION; MUTATION RATE; NONHUMAN; OXIDATIVE STRESS; RISK ASSESSMENT;

CII MUTATION FREQUENCY; DOSE RESPONSE.; MODE OF ACTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RISK ASSESSMENT;

ANIMALS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; CODON; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE OXIDE; INHALATION EXPOSURE; LUNG; LUNG NEOPLASMS; MALE; MICE; MUTATION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84887919032     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft190     Document Type: Article

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