LC-MS/MS simultaneous quantitation of 2-hydroxyethylated, oxidative, and unmodified DNA nucleosides in DNA isolated from tissues of mice after exposure to ethylene oxide

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 976-977, Issue , 2015, Pages 33-48

  Zhang, Fagen ^a   Bartels, Michael J ^a   LeBaron, Matthew J ^a   Schisler, Melissa R ^a   Jeong, Yo Chan ^a   Gollapudi, B Bhaskar ^a,c   Moore, Nigel P ^b,d  

^a DOW CHEMICAL COMPANY   (United States)

^b DOW EUROPE GMBH   (Switzerland)

^c Exponent Consulting   (United States)

^d Penman Consulting BVBA   (Belgium)

Author keywords

2 Hydroxyethylated and oxidative DNA nucleoside biomarkers; Ethylene oxide; Liquid chromatography tandem mass spectrometry; Simultaneous quantitation

Indexed keywords

BIOLOGICAL ORGANS; BIOMARKERS; BIOMOLECULES; CHROMATOGRAPHY; ETHYLENE; HISTOLOGY; LIQUID CHROMATOGRAPHY; LIQUIDS; MAMMALS; MASS SPECTROMETRY; SPECTROMETRY; TISSUE;

ATMOSPHERIC CONCENTRATION; DNA NUCLEOSIDES; ETHYLENE OXIDES; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMITS OF QUANTITATIONS; RELATIVE STANDARD DEVIATIONS; SIMULTANEOUS DETERMINATIONS; SIMULTANEOUS QUANTITATION;

DNA;

1 (2 HYDROXYETHYL) 2' DEOXYADENOSINE; 8 HYDROXYDEOXYGUANOSINE; ALPHA METHYL GAMMA HYDROXY 1,N2 PROPANO 2' DEOXYGUANOSINE; DEOXYADENOSINE; DEOXYGUANOSINE; ETHYLENE OXIDE; N2,3 ETHENO 2' DEOXYGUANOSINE; N6 (2 HYDROXYETHYL) 2' DEOXYADENOSINE; NUCLEOSIDE; O6 (2 HYDROXYETHYL) 2' DEOXYGUANOSINE; UNCLASSIFIED DRUG; DNA;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATMOSPHERIC DEPOSITION; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA ADDUCT; DNA EXTRACTION; DNA ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; ENVIRONMENTAL EXPOSURE; GENOTOXICITY; IN VIVO STUDY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY IONIZATION ELECTROSPRAY TANDEM MASS SPECTROMETRY; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; QUALITY CONTROL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; ANIMAL; CHEMISTRY;

MUS;

ANIMALS; CHROMATOGRAPHY, LIQUID; DNA; ETHYLENE OXIDE; MALE; MICE; NUCLEOSIDES; TANDEM MASS SPECTROMETRY;

EID: 84920097613     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.10.042     Document Type: Article

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