Spontaneous mutations in the Big Blue® transgenic system are primarily mouse derived

Mutation Research - Reviews in Mutation Research

Volumn 436, Issue 1, 1999, Pages 11-19

  Hill, Kathleen A ^a   Buettner, Victoria L ^a   Glickman, Barry W ^b   Sommer, Steve S ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Big Blue ; DNA sequencing; Jackpot mutation; lacI transgene; Mutation pattern; Mutation signature; Validation

Indexed keywords

CYCLOPHOSPHAMIDE; DIMETHYLBENZ[A]ANTHRACENE; ETHYLNITROSOUREA; HEPTACHLOR; MESYLIC ACID; MUTAGENIC AGENT; PHENOBARBITAL;

ANIMAL CELL; ARTICLE; ASSAY; DNA SEQUENCE; GENOTYPE; MOUSE; MUTAGENESIS; MUTATION RATE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SPONTANEOUS MUTATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ARTIFACTS; BACTERIAL PROTEINS; DNA MUTATIONAL ANALYSIS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MICE; MICE, TRANSGENIC; MOSAICISM; MUTATION; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS; TRANSGENES;

MAMMALIA; MURINAE; MUS MUSCULUS; PROKARYOTA;

EID: 0032897250     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(98)00024-6     Document Type: Article

References (49)

1. Albertini R.J., DeMars R. Mosaicism of peripheral blood lymphocyte populations in females heterozygous for the Lesch-Nyhan mutation. Biochem. Genet. 11:1974;397-411.
2. Andrew S.E., Reitmair A.H., Fox J., Hsiao L., Francis A., McKinnon M., Mak T.W., Jirik F.R. Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice. Oncogene. 15:1997;123-129.
3. Ashby J. Transgenic germ cell mutation assays: a small collaborative study. Environ. Mol. Mutagen. 25:1995;1-3.
4. Bottema C.D.K., Ketterling R.P., Vielhaber E., Yoon H., Gostout B., Jacobson D.P., Shapiro A., Sommer S.S. The pattern of spontaneous germline mutation: relative rates of mutation at or near CpG dinucleotides in the factor IX gene. Hum. Genet. 91:1993;496-503.
5. Brown C.D., MacNeela H.P., Wong B., Fennell T.R. DNA and hemoglobin adduct dosimetry in normal and lacI transgene mice exposed to ethylene oxide. Proc. Am. Assoc. Cancer Res. 35:1994;566.
6. Buettner V.L., Nishino H., Sommer S.S. Large deletions detected with Big Blue™ transgenic mouse mutagenesis assay [letter]. Mutat. Res. 361:1996;187-189.
7. Carr G.J., Gorelick N.J. Statistical tests of significance in transgenic mutations assays. Considerations on the experimental unit. Environ. Mol. Mutagen. 24:1994;276-282.
8. Cole J., Green H.M.L., James S.E., Henderson L., Cole H. A further assessment of factors influencing measurements of thioguanine-resistant mutant frequency circulating T-lymphocytes. Mutat. Res. 204:1988;493-507.
9. Cooper D.N., Krawczak M. Cytosine methylation and the fate of CpG dinucleotides in vertebrate genomes. Hum. Genet. 83:1989;181-188.
10. Giannelli F., Green P.M., Sommer S.S., Poon M.-C., Ludwig M., Schwaab R., Reitsma P., Goossens M., Yoshioka A., Figueiredo M.S., Brownlee G.G. Haemophilia B: database of point mutations and short additions and deletions. Nucleic Acids Research. 25:1997;133-135. 7th edn.
11. Gorelick N.J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol. Mutagen. 25:1995;218-230.
12. Gossen J.A., deLeeuw W.J.F., Tan C.H.T., Zwarthoff E.C., Berends F., Lohman P.H.M., Knook D.L., Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA. 86:1989;7971-7975.
13. Gunz D., Shepard S.E., Lutz W.K. Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay? Environ. Mol. Mutagen. 21:1993;209-211.
14. Hakoda M., Akiyana M., Kyoisumi S.S., Kobuke K., Awa A.A., Yamakido M. Measurements of in vivo HGPRT-deficient mutant cell frequency using a modified method for cloning human peripheral blood T-lymphocytes. Mutat. Res. 197:1988;161-169.
15. Heng H.H.Q., Tsui L., Moens P.B. Organization of heterologous DNA inserts on the mouse meiotic chromosome core. Chromosoma. 103:1994;401-407.
16. Johnson R.E., Kovvali G.K., Prakash L., Prakash S. Requirement of the yeast MSH3 and MSH6 genes MSH2-dependent genomic stability. The Journal of Biological Chemistry. 271:1996;7285-7288.
17. Ketterling R.P., Vielhaber E., Sommer S.S. The rates of G:C→T:A and G:C→C:G transversions at CpG dinucleotides in the human factor IX gene. Am. J. Hum. Genet. 54:1994;831-835.
18. Khadakov M., Glickman B.W. Possible factors leading to a misjudgement of mutant frequencies in HPRT assay. Mutat. Res. 354:1996;9-14.
19. Knöll A., Jacobson D.P., Nishino H., Short J.M., Kretz P.L., Sommer S.S. A selectable system for mutation detection in the Big Blue™ lacI transgenic mouse system: what happens to the mutational spectra over time? Mutat. Res. 352:1996;9-22.
20. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Putman D.L., Sorge J.A., Short J.M. Analysis of spontaneous and induced mutations in transgenic mice using a Lambda ZAP/lacI shuttle vector. Environ. Mol. Mutagen. 18:1991;316-321.
21. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., Putman D.L., Short J.M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. USA. 88:1991;7958-7962.
22. Kohler S.W., Provost G.S., Kretz P.L., Fieck A., Short J. An in vivo assay using transgenic mice to analyze spontaneous and induced mutations at the nucleic acid level. Strategies in Mol. Biol. 3:1990;19-21.
23. Lesch M., Nyhan W.L. A familial disorder of uric acid metabolism and central nervous system function. Am. J. Med. 36:1964;561-570.
24. Lundberg K.S., Kretz P.L., Provost G.S., Short J.M. The use of selection in recovery of transgenic targets for mutation analysis. Mutat. Res. 301:1993;99-105.
25. Mirsalis J.C., Monforte J.A., Winegar R.A. Transgenic animal models for measuring mutations in vivo. Crit. Rev. Toxicol. 24:1994;255-280.
26. Mirsalis J.C., Provost G.S., Matthews C.D., Hamner R.T., Schindler J.E., O'Loughlin K.G., MacGregor J.T., Short J.M. Induction of hepatic mutations in lacI transgenic mice. Mutagenesis. 8:1993;265-271.
27. Morrison V., Ashby J. A preliminary evaluation of the performance of the Muta™ Mouse (lacZ) and Big Blue™ (lacI) transgenic mouse mutation assays. Mutagenesis. 9:1994;367-375.
28. Nishi Y., Nasegawa M.M., Inui N. Forward mutation assay of V79 cells to 6-thioguanine resistance in a soft agar technique that eliminates effects of metabolic co-operation. Mutat. Res. 125:1984;105-114.
29. Nishino H., Buettner V.L., Haavik J., Schaid D.J., Sommer S.S. Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type. Environ. Mol. Mutagen. 28:1996;299-312.
30. Nishino H., Buettner V.L., Sommer S.S. Towards validation of the Big Blue transgenic mouse mutagenesis assay: the mutational spectrum of ex vivo pinpoint mutant plaques. Mutat. Res. 372:1996;97-105.
31. O'Kelly J.A., Young R.R., Putman D.L., Gibson D.P., Aardema M.J., Gorelick N.J. Tissue specificity of mutation in ethylnitrosourea (ENU)-treated Big Blue mice. Environ. Mol. Mutagen. 23:1994;50.
32. O'Neill J.P., McGinnis M.J., Berman J.K., Sullivan L.M., Nicklas J.A., Albertini R.J. Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioguanine-resistant mutant frequency in humans. Mutagenesis. 2:1989;87-94.
33. Paashuis-Lew Y., Zhang X.B., Heddle J.A. On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice. Mutat. Res. 373:1997;277-284.
34. Piegorsch W.W., Lockhart A.C., Margolin B.H., Tindall K.R., Gorelick N.J., Short J.M., Carr G.J., Thompson E.D., Shelby M.D. Sources of variability in data from a lacI transgenic mouse mutation assay. Environ. Mol. Mutagen. 23:1994;17-31.
35. Provost G.S., Kohler S.W., Putman D.L., Short J.M. ENU induced germ cell mutations in lambda/lacI C57BL/6 and B6C3F1 transgenic mice. Environ. Mol. Mutagen. 19:1992;51.
36. Provost G.S., Kretz P.L., Hamner R.T., Matthews C.D., Rogers B.J., Lundberg K.S., Dycaico M.J., Short J.M. Transgenic systems for in vivo mutation analysis. Mutat. Res. 288:1993;133-149.
37. Rogers B.J., Provost G.S., Young R., Putman D.L., Short J.M. Intralaboratory optimization and standardization of mutant screening conditions used for a lambda/lacI transgenic mouse mutagenesis assay. Mutat. Res. 327:1995;57-66.
38. Sisk S.C., Preston R.J., Recio I. Determination of circulating micronuclei and mutant frequency in lung, spleen, and germ cells of male B6C3F1 lacI transgenic mice after inhalation exposure to ethylene oxide. Environ. Mol. Mutagen. 23:1994;62.
39. Skopek T.R., Kort K.L., Marino D.R. Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue™ B6C3F1 mice. Environ. Mol. Mutagen. 26:1995;9-15.
40. Skopek T.R., Kort K.L., Marino D.R., Mittal L.V., Umbenhauer D.R., Laws G.M., Adams S.P. Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice. Environ. Mol. Mutagen. 28:1996;376-384.
41. Sommer S.S., Ketterling R.P. How precisely can data from transgenic mouse mutation-detection systems be extrapolated to humans?: lessons from the human factor IX gene. Mutat. Res. 307:1994;517-531.
42. Stamenkovic I., Stegagno M., Wright K.A., Krane S.M., Amento E.P., Colvin R.B., Duquesnoy R.J., Kurnick J.T. Clonal dominance among T-lymphocyte infiltrates in arthritis. Am. J. Med. 36:1998;561-570.
43. Stuart G.R., Gorelick N.J., Andrews J.L., de Boer J.G., Glickman B.W. The genetic analysis of lacI mutations in sectored plaques from Big Blue™ transgenic mice. Environ. Mol. Mutagen. 28:1996;385-392.
44. Suzuki T., Hayashi M., Sofuni T. Initial experiences and future directions for transgenic mouse mutation assays. Mutat. Res. 307:1994;489-494.
45. Tao K.S., Urlando C., Heddle J.A. Comparison of somatic mutation in a transgenic versus host locus. Proc. Natl. Acad. Sci. USA. 90:1993;10681-10685.
46. Thompson E.D., Gorelick N.J., Binder R.L., Myhr B.C., Putman D.L. Interlaboratory comparisons of dimethylbenzanthracene-induced mutations of skin in Muta™ Mouse and the Big Blue™ mouse. Environ. Mol. Mutagen. 19:1992;64.
47. van Zeeland A.A., Simons J.W.I.M. The use of correction factors in the determination of mutant frequencies in populations of human diploid skin fibroblasts. Mutat. Res. 34:1976;149-158.
48. Walker V.E., Gorelick N.J., Andrews J.L., Craft T.R., DeBoer J.G., Glickman B.W., Skopek T.R. Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice. Cancer Res. 56:1996;4654-4661.
49. Young R.R., Rogers B.J., Provost G.S., Short J.M., Putman D.L. Interlab comparison of liver spontaneous mutant frequency from lambda/lacI transgenic mice. Environ. Mol. Mutagen. 21:1993;79.