Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

Nature Genetics

Volumn 49, Issue 5, 2017, Pages 674-679

  Wright, Daniel J ^a   Day, Felix R ^a   Kerrison, Nicola D ^a   Zink, Florian ^b   Cardona, Alexia ^a   Sulem, Patrick ^b   Thompson, Deborah J ^c   Sigurjonsdottir, Svanhvit ^b   Gudbjartsson, Daniel F ^b   Helgason, Agnar ^b   Chapman, J Ross ^d   Jackson, Steve P ^c,e   Langenberg, Claudia ^a   Wareham, Nicholas J ^a   Scott, Robert A ^a   Thorsteindottir, Unnur ^b,f   Ong, Ken K ^a,c   Stefansson, Kari ^b,f   Perry, John R B ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b DECODE GENETICS   (Iceland)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF ICELAND   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADULT; AGED; ANEUPLOIDY; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CELL CYCLE; CELL CYCLE REGULATION; CELL PROLIFERATION; CENPN GENE; CHROMOSOME LOSS; CHROMOSOME MOSAICISM; DNA DAMAGE RESPONSE; DNA SYNTHESIS; EPIGENETICS; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE IDENTIFICATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENETIC VARIATION; GENOMIC INSTABILITY; HUMAN; MAD1L1 GENE; MAJOR CLINICAL STUDY; MALE; MITOSIS; PMF1 GENE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; X CHROMOSOME; Y CHROMOSOME; CHROMOSOME DELETION; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN GENOME; INDEL MUTATION; NEOPLASM; PATHOLOGY; PROCEDURES; STATISTICS AND NUMERICAL DATA;

CELL CYCLE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, X; CHROMOSOMES, HUMAN, Y; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOMIC INSTABILITY; GENOTYPE; HUMANS; INDEL MUTATION; MALE; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 85016089260     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3821     Document Type: Article

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