Smoking is associated with mosaic loss of chromosome Y

Science

Volumn 347, Issue 6217, 2015, Pages 81-83

  Dumanski, Jan P ^a   Rasi, Chiara ^a   Lönn, Mikael ^b   Davies, Hanna ^a   Ingelsson, Martin ^c   Giedraitis, Vilmantas ^c   Lannfelt, Lars ^c   Magnusson, Patrik K E ^d   Lindgren, Cecilia M ^e,f   Morris, Andrew P ^e,g   Cesarini, David ^h   Johannesson, Magnus ⁱ   Janson, Eva Tiensuu ^a   Lind, Lars ^a   Pedersen, Nancy L ^d   Ingelsson, Erik ^a   Forsberg, Lars A ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b School of Life Sciences Södertörn University   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g UNIVERSITY OF LIVERPOOL   (United Kingdom)

^h NEW YORK UNIVERSITY   (United States)

ⁱ STOCKHOLM SCHOOL OF ECONOMICS   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CHROMOSOME; COHORT ANALYSIS; DISEASE INCIDENCE; DOSE-RESPONSE RELATIONSHIP; MORTALITY; MUTATION; RESPIRATORY DISEASE; RISK FACTOR; SMOKING; TOBACCO;

AGED; ARTICLE; BLOOD CELL; CANCER RISK; CHROMOSOME LOSS; CHROMOSOME MOSAICISM; COHORT ANALYSIS; DISEASE ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTAGENIC ACTIVITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SMOKING; Y CHROMOSOME; FEMALE; GENETICS; INCIDENCE; LUNG NEOPLASMS; METABOLISM; MIDDLE AGED; MUTAGENESIS; RISK FACTOR; SEX DIFFERENCE; SWEDEN; VERY ELDERLY;

NICOTIANA TABACUM;

AGED; AGED, 80 AND OVER; BLOOD CELLS; CHROMOSOMES, HUMAN, Y; COHORT STUDIES; FEMALE; HUMANS; INCIDENCE; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTAGENESIS; RISK FACTORS; SEX FACTORS; SMOKING; SWEDEN;

EID: 84922481318     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1262092     Document Type: Article

References (24)

1. P. Jha, Natl. Rev. 9, 655-664 (2009).
2. P. Jha et al., N. Engl. J. Med. 368, 341-350 (2013).
3. M. B. Cook, K. A. McGlynn, S. S. Devesa, N. D. Freedman, W. F. Anderson, Cancer Epidemiol. Biomarkers Prev. 20, 1629-1637 (2011).
4. G. Edgren, L. Liang, H. O. Adami, E. T. Chang, Eur. J. Epidemiol. 27, 187-196 (2012).
5. L. A. Forsberg et al., Nat. Genet. 46, 624-628 (2014).
6. P. Lichtenstein et al., Twin Res. Hum. Genet. 9, 875-882 (2006).
7. P. K. Magnusson et al., Twin Res. Hum. Genet. 16, 317-329 (2013).
8. H. Hedstrand, Ups. J. Med. Sci. Suppl. 19, 1-61 (1975).
9. L. Lind, N. Fors, J. Hall, K. Marttala, A. Stenborg, Arterioscler. Thromb. Vasc. Biol. 25, 2368-2375 (2005).
10. M. J. Thun et al., N. Engl. J. Med. 368, 351-364 (2013).
11. G. P. Dunn, A. T. Bruce, H. Ikeda, L. J. Old, R. D. Schreiber, Nat. Immunol. 3, 991-998 (2002).
12. B. Lemos, L. O. Araripe, D. L. Hartl, Science 319, 91-93 (2008).
13. B. Lemos, A. T. Branco, D. L. Hartl, Proc. Natl. Acad. Sci. U.S.A. 107, 15826-15831 (2010).
14. A. G. Clark, Nature 508, 463-465 (2014).
15. D. W. Bellott et al., Nature 508, 494-499 (2014).
16. D. Cortez et al., Nature 508, 488-493 (2014).
17. L. A. Forsberg et al., Am. J. Hum. Genet. 90, 217-228 (2012).
18. L. A. Forsberg, D. Absher, J. P. Dumanski, J. Med. Genet. 50, 1-10 (2013).
19. T. Davoli et al., Cell 155, 948-962 (2013).
20. A. Schneider-Gädicke, P. Beer-Romero, L. G. Brown, R. Nussbaum, D. C. Page, Cell 57, 1247-1258 (1989).
21. L. J. Zhang, E. S. Shin, Z. X. Yu, S. B. Li, Chin. Med. J. (Engl.) 120, 2002-2005 (2007).
22. N. O. Bianchi, Mutat. Res. 682, 21-27 (2009).
23. L. C. Silva Veiga, N. A. Bérgamo, P. P. Reis, L. P. Kowalski, S. R. Rogatto, Braz. J. Med. Biol. Res. 45, 172-178 (2012).
24. P. H. Duijf, N. Schultz, R. Benezra, Int. J. Cancer 132, 2316-2326 (2013).