Disease variants alter transcription factor levels and methylation of their binding sites

Nature Genetics

Volumn 49, Issue 1, 2017, Pages 131-138

  Bonder, Marc Jan ^a   Luijk, René ^b   Zhernakova, Daria V ^a   Moed, Matthijs ^b   Deelen, Patrick ^a   Vermaat, Martijn ^b   Van Iterson, Maarten ^b   Van Dijk, Freerk ^a   Van Galen, Michiel ^a   Bot, Jan ^c   Slieker, Roderick C ^b   Jhamai, P Mila ^d   Verbiest, Michael ^a   Suchiman, H Eka D ^b   Verkerk, Marijn ^d   Van Der Breggen, Ruud ^b   Van Rooij, Jeroen ^d   Lakenberg, Nico ^b   Arindrarto, Wibowo ^b   Kielbasa, Szymon M ^b   Jonkers, Iris ^a   Van't Hof, Peter ^b   Nooren, Irene ^c   Beekman, Marian ^b   Deelen, Joris ^b   Van Heemst, Diana ^b   Zhernakova, Alexandra ^a   Tigchelaar, Ettje F ^a   Swertz, Morris A ^a   Hofman, Albert ^d   Uitterlinden, André G ^d   Pool, René ^e   Van Dongen, Jenny ^e   Hottenga, Jouke J ^e   Stehouwer, Coen D A ^f,g   Van Der Kallen, Carla J H ^f,g   Schalkwijk, Casper G ^f,g   Van Den Berg, Leonard H ^h   Van Zwet, Erik W ^b   Mei, Hailiang ^b   Li, Yang ^a   Lemire, Mathieu ⁱ   Hudson, Thomas J ^i,j   Slagboom, P Eline ^b   Wijmenga, Cisca ^a   Veldink, Jan H ^h   Van Greevenbroek, Marleen M J ^f,g   Van Duijn, Cornelia M ^d   Boomsma, Dorret I ^e   Isaacs, Aaron ^d,g,k   Jansen, Rick ^l   Van Meurs, Joyce B J ^d   Hoen't, Peter A C ^b   Franke, Lude ^a   Heijmans, Bastiaan T ^b   more..

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c SURFSARA   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

^f MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^g MAASTRICHT UNIVERSITY   (Netherlands)

^h UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

ⁱ ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^j UNIVERSITY OF TORONTO   (Canada)

^k MAASTRICHT UNIVERSITY   (Netherlands)

^l VU UNIVERSITY MEDICAL CENTER   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CTCF;

ADULT; AGED; ARTICLE; BINDING SITE; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIATION; GENOTYPE; HETEROCHROMATIN; HUMAN; HUMAN CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION SITE; VERY ELDERLY; COHORT ANALYSIS; DISEASES; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN GENOME; METABOLISM; MIDDLE AGED; PHENOTYPE;

BINDING SITES; COHORT STUDIES; DISEASE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; TRANSCRIPTION FACTORS;

EID: 85002263457     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3721     Document Type: Article

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