A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Lehne, Benjamin ^a   Drong, Alexander W ^b   Loh, Marie ^a,c   Zhang, Weihua ^a,d   Scott, William R ^a,e   Tan, Sian Tsung ^d,e   Afzal, Uzma ^a,d   Scott, James ^e   Jarvelin, Marjo Riitta ^a,c,f,g   Elliott, Paul ^a   McCarthy, Mark I ^b,h   Kooner, Jaspal S ^d,e,i   Chambers, John C ^a,d,i  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OULU   (Finland)

^d EALING HOSPITAL NHS TRUST   (United Kingdom)

^e NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^f OULU UNIVERSITY HOSPITAL   (Finland)

^g NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ARTICLE; AUTOSOMAL MARKER; BATCH CORRECTION; CELL SUBPOPULATION; COMPUTER SIMULATION; CONTROLLED STUDY; CPG ISLAND; DATA NORMALIZATION; DATA PROCESSING; DATA QUALITY; DNA METHYLATION; DNA MICROARRAY; EPIGENOME WIDE ASSOCIATION STUDY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC PARAMETERS; HUMAN; HUMAN CELL; INCORPORATING CONTROL PROBE ADJUSTMENT AND REDUCTION OF GLOBAL CORRELATION; INFORMATION PROCESSING; LEUKOCYTE; MALE; MARKER CALL RATE; MICROARRAY ANALYSIS; NULL HYPOTHESIS; PHENOTYPE; PREDICTIVE VALUE; QUALITY CONTROL; QUALITY CONTROL PROCEDURES; QUANTITATIVE TRAIT LOCUS; STATISTICAL DISTRIBUTION; SYSTEMATIC ERROR; TECHNICAL BIAS; Y CHROMOSOME; COMPUTER PROGRAM; EPIGENETICS; GENETIC EPIGENESIS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN GENOME; PROCEDURES;

CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; QUANTITATIVE TRAIT LOCI; SOFTWARE;

EID: 84934441142     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0600-x     Document Type: Article

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