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Volumn 15, Issue 6, 2016, Pages 454-459

Progress on the role of DNA methylation in aging and longevity

Author keywords

Age related disease; Aging; DNA methylation; Epigenetics; Longevity

Indexed keywords

AZACITIDINE; DECITABINE; DNA;

EID: 85016001155     PISSN: 20412649     EISSN: 20412657     Source Type: Journal    
DOI: 10.1093/bfgp/elw009     Document Type: Article
Times cited : (41)

References (87)
  • 2
    • 0037218826 scopus 로고    scopus 로고
    • The biology of aging
    • Troen BR. The biology of aging. Mt Sinai J Med 2003;70:3-22.
    • (2003) Mt Sinai J Med , vol.70 , pp. 3-22
    • Troen, B.R.1
  • 3
    • 84865262696 scopus 로고    scopus 로고
    • World Health Organization
    • World Health Organization. Global Health and Ageing. World Health Organization, 2011. http://www.who.int/ageing/publi cations/global_health/en/.
    • (2011) Global Health and Ageing
  • 4
    • 0030062815 scopus 로고    scopus 로고
    • The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900
    • Herskind AM, McGue M, Holm NV, et al. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum Genet 1996;97:319-23.
    • (1996) Hum Genet , vol.97 , pp. 319-323
    • Herskind, A.M.1    McGue, M.2    Holm, N.V.3
  • 5
    • 0027482067 scopus 로고
    • Longevity is moderately heritable in a sample of Danish twins born 1870-1880
    • McGue M, Vaupel JW, Holm N, et al. Longevity is moderately heritable in a sample of Danish twins born 1870-1880. J Gerontol 1993;48:B237-44.
    • (1993) J Gerontol , vol.48 , pp. B237-B244
    • McGue, M.1    Vaupel, J.W.2    Holm, N.3
  • 6
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003;33:245-54.
    • (2003) Nat Genet , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 8
    • 0027689976 scopus 로고
    • Dynamics of DNA methylation during development
    • Brandeis M, Ariel M, Cedar H. Dynamics of DNA methylation during development. BioEssays 1993;15:709-13.
    • (1993) BioEssays , vol.15 , pp. 709-713
    • Brandeis, M.1    Ariel, M.2    Cedar, H.3
  • 9
    • 0016692220 scopus 로고
    • X inactivation, differentiation, and DNA methylation
    • Riggs AD. X inactivation, differentiation, and DNA methylation. Cytogenet Genome Res 1975;14:9-25.
    • (1975) Cytogenet Genome Res , vol.14 , pp. 9-25
    • Riggs, A.D.1
  • 10
    • 84932600238 scopus 로고    scopus 로고
    • DNA methylation regulates neuronal glutamatergic synaptic scaling
    • Meadows JP, Guzman-Karlsson MC, Phillips S, et al. DNA methylation regulates neuronal glutamatergic synaptic scaling. Sci Signal 2015;8:ra61.
    • (2015) Sci Signal , vol.8
    • Meadows, J.P.1    Guzman-Karlsson, M.C.2    Phillips, S.3
  • 11
    • 77952886110 scopus 로고    scopus 로고
    • Cortical DNA methylation maintains remote memory
    • Miller CA, Gavin CF, White JA, et al. Cortical DNA methylation maintains remote memory. Nat Neurosci 2010;13:664-6.
    • (2010) Nat Neurosci , vol.13 , pp. 664-666
    • Miller, C.A.1    Gavin, C.F.2    White, J.A.3
  • 12
    • 84861391922 scopus 로고    scopus 로고
    • DNA methylation screening identifies driver epigenetic events of cancer cell survival
    • De Carvalho DD, Sharma S, You JS, et al. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell 2012;21:655-67.
    • (2012) Cancer Cell , vol.21 , pp. 655-667
    • De Carvalho, D.D.1    Sharma, S.2    You, J.S.3
  • 13
    • 84943780149 scopus 로고    scopus 로고
    • The inheritance of acquired epigenetic variations
    • Jablonka E, Lamb MJ. The inheritance of acquired epigenetic variations. Int J Epidemiol 2015;44:1094-103.
    • (2015) Int J Epidemiol , vol.44 , pp. 1094-1103
    • Jablonka, E.1    Lamb, M.J.2
  • 14
    • 68149100569 scopus 로고    scopus 로고
    • The role of epigenetics in aging and age-related diseases
    • Calvanese V, Lara E, Kahn A, et al. The role of epigenetics in aging and age-related diseases. Ageing Res Rev 2009;8:268-76.
    • (2009) Ageing Res Rev , vol.8 , pp. 268-276
    • Calvanese, V.1    Lara, E.2    Kahn, A.3
  • 15
    • 0344321897 scopus 로고    scopus 로고
    • Impact of aging on DNA methylation
    • Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2003;2:245-61.
    • (2003) Ageing Res Rev , vol.2 , pp. 245-261
    • Richardson, B.1
  • 16
    • 79954838543 scopus 로고    scopus 로고
    • Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus
    • Chouliaras L, Van den Hove D, Kenis G, et al. Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus. Brain Behav Immun 2011;25: 616-23.
    • (2011) Brain Behav Immun , vol.25 , pp. 616-623
    • Chouliaras, L.1    Van den Hove, D.2    Kenis, G.3
  • 17
    • 84887611390 scopus 로고    scopus 로고
    • Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects
    • Switzeny OJ, Müllner E, Wagner K-H, et al. Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects. Clin Epigenetics 2012;4:19.
    • (2012) Clin Epigenetics , vol.4 , pp. 19
    • Switzeny, O.J.1    Müllner, E.2    Wagner, K.-H.3
  • 18
    • 79954416175 scopus 로고    scopus 로고
    • DNA hypermethylation as a chemotherapy target
    • Ren J, Singh BN, Huang Q, et al. DNA hypermethylation as a chemotherapy target. Cell Signal 2011;23:1082-93.
    • (2011) Cell Signal , vol.23 , pp. 1082-1093
    • Ren, J.1    Singh, B.N.2    Huang, Q.3
  • 19
    • 84957846754 scopus 로고
    • The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography
    • Hotchkiss RD. The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography. J Biol Chem 1948;175:315-32.
    • (1948) J Biol Chem , vol.175 , pp. 315-332
    • Hotchkiss, R.D.1
  • 20
    • 0023216891 scopus 로고
    • CpG islands in vertebrate genomes
    • Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol 1987;196:261-82.
    • (1987) J Mol Biol , vol.196 , pp. 261-282
    • Gardiner-Garden, M.1    Frommer, M.2
  • 21
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • Deaton AM, Bird A. CpG islands and the regulation of transcription. Gene Dev 2011;25:1010-22.
    • (2011) Gene Dev , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 22
    • 0026742792 scopus 로고
    • CpG islands as gene markers in the human genome
    • Larsen F, Gundersen G, Lopez R, et al. CpG islands as gene markers in the human genome. Genomics 1992;13:1095-107.
    • (1992) Genomics , vol.13 , pp. 1095-1107
    • Larsen, F.1    Gundersen, G.2    Lopez, R.3
  • 23
    • 0027141519 scopus 로고
    • Number of CpG islands and genes in human and mouse
    • Antequera F, Bird A. Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci USA 1993;90:11995-9.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11995-11999
    • Antequera, F.1    Bird, A.2
  • 24
    • 0029926820 scopus 로고    scopus 로고
    • S-Adenosylmethionine and methylation
    • Chiang P, Gordon R, Tal J, et al. S-Adenosylmethionine and methylation. FASEB J 1996;10:471-80.
    • (1996) FASEB J , vol.10 , pp. 471-480
    • Chiang, P.1    Gordon, R.2    Tal, J.3
  • 25
    • 0035933336 scopus 로고    scopus 로고
    • The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA
    • Fatemi M, Hermann A, Pradhan S, et al. The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J Mol Biol 2001;309: 1189-99.
    • (2001) J Mol Biol , vol.309 , pp. 1189-1199
    • Fatemi, M.1    Hermann, A.2    Pradhan, S.3
  • 26
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation andmammalian development
    • Okano M, Bell DW, Haber DA, et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation andmammalian development. Cell 1999;99:247-57.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3
  • 28
    • 79959899772 scopus 로고    scopus 로고
    • A comparative analysis of DNA methylation across human embryonic stem cell lines
    • Chen P-Y, Feng S, Joo J, et al. A comparative analysis of DNA methylation across human embryonic stem cell lines. Genome Biol 2011;12:R62.
    • (2011) Genome Biol , vol.12 , pp. R62
    • Chen, P.-Y.1    Feng, S.2    Joo, J.3
  • 29
    • 0028106737 scopus 로고
    • Dependence of transcriptional repression on CpG methylation density
    • Hsieh C-L. Dependence of transcriptional repression on CpG methylation density. Mol Cell Biol 1994;14:5487-94.
    • (1994) Mol Cell Biol , vol.14 , pp. 5487-5494
    • Hsieh, C.-L.1
  • 30
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • Weber M, Hellmann I, Stadler MB, et al. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet 2007;39:457-66.
    • (2007) Nat Genet , vol.39 , pp. 457-466
    • Weber, M.1    Hellmann, I.2    Stadler, M.B.3
  • 31
    • 78751693154 scopus 로고    scopus 로고
    • Replication timingrelated and gene body-specific methylation of active human genes
    • Aran D, Toperoff G, Rosenberg M, et al. Replication timingrelated and gene body-specific methylation of active human genes. Hum Mol Genet 2011;20:670-80.
    • (2011) Hum Mol Genet , vol.20 , pp. 670-680
    • Aran, D.1    Toperoff, G.2    Rosenberg, M.3
  • 32
    • 58849091905 scopus 로고    scopus 로고
    • A human B cell methylome at 100 base pair resolution
    • Rauch TA, Wu X, Zhong X, et al. A human B cell methylome at 100 base pair resolution. Proc Natl Acad Sci USA 2009;106: 671-8.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 671-678
    • Rauch, T.A.1    Wu, X.2    Zhong, X.3
  • 33
    • 64349091471 scopus 로고    scopus 로고
    • Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
    • Ball MP, Li JB, Gao Y, et al. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol 2009;27:361-8.
    • (2009) Nat Biotechnol , vol.27 , pp. 361-368
    • Ball, M.P.1    Li, J.B.2    Gao, Y.3
  • 34
    • 0030694713 scopus 로고    scopus 로고
    • Imprinted expression of the Igf2r gene depends on an intronic CpG island
    • Wutz A, Smrzka OW, Schweifer N, et al. Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature 1997;389:745-9.
    • (1997) Nature , vol.389 , pp. 745-749
    • Wutz, A.1    Smrzka, O.W.2    Schweifer, N.3
  • 35
    • 0036782079 scopus 로고    scopus 로고
    • Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity
    • Guilleret I, Yan P, Grange F, et al. Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity. Int J Cancer 2002;101:335-41.
    • (2002) Int J Cancer , vol.101 , pp. 335-341
    • Guilleret, I.1    Yan, P.2    Grange, F.3
  • 36
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • Wilson VL, Jones PA. DNA methylation decreases in aging but not in immortal cells. Science 1983;220:1055-7.
    • (1983) Science , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 37
    • 0024552485 scopus 로고
    • Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA
    • Drinkwater RD, Blake TJ, Morley AA, et al. Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA. Mutat Res 1989;219: 29-37.
    • (1989) Mutat Res , vol.219 , pp. 29-37
    • Drinkwater, R.D.1    Blake, T.J.2    Morley, A.A.3
  • 38
    • 0024988560 scopus 로고
    • Quantitative changes in T cell DNA methylation occur during differentiation and ageing
    • Golbus J, Palella TD, Richardson BC. Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur J Immunol 1990;20:1869-72.
    • (1990) Eur J Immunol , vol.20 , pp. 1869-1872
    • Golbus, J.1    Palella, T.D.2    Richardson, B.C.3
  • 41
    • 60849100524 scopus 로고    scopus 로고
    • Decline in genomic DNA methylation through aging in a cohort of elderly subjects
    • Bollati V, Schwartz J, Wright R, et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2009;130:234-9.
    • (2009) Mech Ageing Dev , vol.130 , pp. 234-239
    • Bollati, V.1    Schwartz, J.2    Wright, R.3
  • 42
    • 84862979818 scopus 로고    scopus 로고
    • Distinct DNA methylomes of newborns and centenarians
    • Heyn H, Li N, Ferreira HJ, et al. Distinct DNA methylomes of newborns and centenarians. Natl Acad Sci USA 2012;109: 10522-7.
    • (2012) Natl Acad Sci USA , vol.109 , pp. 10522-10527
    • Heyn, H.1    Li, N.2    Ferreira, H.J.3
  • 43
    • 77950657253 scopus 로고    scopus 로고
    • Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
    • Rakyan VK, Down TA, Maslau S, et al. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res 2010;20:434-9.
    • (2010) Genome Res , vol.20 , pp. 434-439
    • Rakyan, V.K.1    Down, T.A.2    Maslau, S.3
  • 44
    • 0036757811 scopus 로고    scopus 로고
    • Infrequent occurrence of age-dependent changes in CpG island methylation as detected by restriction landmark genome scanning
    • Tra J, Kondo T, Lu Q, et al. Infrequent occurrence of age-dependent changes in CpG island methylation as detected by restriction landmark genome scanning. Mech Ageing Dev 2002;123:1487-503.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1487-1503
    • Tra, J.1    Kondo, T.2    Lu, Q.3
  • 45
    • 70149099610 scopus 로고    scopus 로고
    • Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    • Christensen BC, Houseman EA, Marsit CJ, et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 2009;5: e1000602.
    • (2009) PLoS Genet , vol.5
    • Christensen, B.C.1    Houseman, E.A.2    Marsit, C.J.3
  • 46
    • 84871317178 scopus 로고    scopus 로고
    • Human epigenetics: showing your age
    • Burgess DJ. Human epigenetics: showing your age. Nat Rev Genet 2013;14:6.
    • (2013) Nat Rev Genet , vol.14 , pp. 6
    • Burgess, D.J.1
  • 48
    • 84896718645 scopus 로고    scopus 로고
    • Aging of blood can be tracked by DNA methylation changes at just three CpG sites
    • Weidner CI, Lin Q, Koch CM, et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol 2014;15:1-12.
    • (2014) Genome Biol , vol.15 , pp. 1-12
    • Weidner, C.I.1    Lin, Q.2    Koch, C.M.3
  • 49
    • 84886111619 scopus 로고    scopus 로고
    • DNA methylation age of human tissues and cell types
    • Horvath S. DNA methylation age of human tissues and cell types. Genome Biol 2013;14:1-20.
    • (2013) Genome Biol , vol.14 , pp. 1-20
    • Horvath, S.1
  • 50
    • 84896718645 scopus 로고    scopus 로고
    • Aging of blood can be tracked by DNA methylation changes at just three CpG sites
    • Weidner CI, Lin Q, Koch CM, et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol 2014;15:R24.
    • (2014) Genome Biol , vol.15 , pp. R24
    • Weidner, C.I.1    Lin, Q.2    Koch, C.M.3
  • 51
    • 84908317108 scopus 로고    scopus 로고
    • Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science
    • Zbiec-Piekarska R, Spolnicka M, Kupiec T, et al. Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science. Forensic Sci Int Genet 2015;14:161-7.
    • (2015) Forensic Sci Int Genet , vol.14 , pp. 161-167
    • Zbiec-Piekarska, R.1    Spolnicka, M.2    Kupiec, T.3
  • 52
    • 84949257649 scopus 로고    scopus 로고
    • A novel strategy for forensic age prediction by DNA methylation and support vector regression model
    • Xu C, Qu H, Wang G, et al. A novel strategy for forensic age prediction by DNA methylation and support vector regression model. Sci Rep 2015;5:1-10.
    • (2015) Sci Rep , vol.5 , pp. 1-10
    • Xu, C.1    Qu, H.2    Wang, G.3
  • 53
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005;102:10604-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 54
    • 17444403604 scopus 로고    scopus 로고
    • Phenotypic differences in genetically identical organisms: the epigenetic perspective
    • Wong AH, Gottesman II, Petronis A. Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 2005;14:R11-18.
    • (2005) Hum Mol Genet , vol.14 , pp. R11-R18
    • Wong, A.H.1    Gottesman, I.I.2    Petronis, A.3
  • 55
    • 84955194730 scopus 로고    scopus 로고
    • DNA methylation age is associated with mortality in a longitudinal Danish twin study
    • Christiansen L, Lenart A, Tan Q, et al. DNA methylation age is associated with mortality in a longitudinal Danish twin study. Aging Cell 2016;15:149-54.
    • (2016) Aging Cell , vol.15 , pp. 149-154
    • Christiansen, L.1    Lenart, A.2    Tan, Q.3
  • 56
    • 84860881828 scopus 로고    scopus 로고
    • Global DNA methylation in old subjects is correlated with frailty
    • Bellizzi D, D'Aquila P, Montesanto A, et al. Global DNA methylation in old subjects is correlated with frailty. Age 2012;34: 169-79.
    • (2012) Age , vol.34 , pp. 169-179
    • Bellizzi, D.1    D'Aquila, P.2    Montesanto, A.3
  • 57
    • 84869841618 scopus 로고    scopus 로고
    • Alu and LINE-1 methylation and lung function in the normative ageing study
    • Lange NE, Sordillo J, Tarantini L, et al. Alu and LINE-1 methylation and lung function in the normative ageing study. BMJ Open 2012;2:e001231.
    • (2012) BMJ Open , vol.2
    • Lange, N.E.1    Sordillo, J.2    Tarantini, L.3
  • 58
    • 84939789611 scopus 로고    scopus 로고
    • Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes
    • Tserel L, Kolde R, Limbach M, et al. Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes. Sci Rep 2015;5:1-11.
    • (2015) Sci Rep , vol.5 , pp. 1-11
    • Tserel, L.1    Kolde, R.2    Limbach, M.3
  • 59
    • 84860572791 scopus 로고    scopus 로고
    • Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
    • Bell JT, Tsai P-C, Yang T-P, et al. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 2012;8:e1002629.
    • (2012) PLoS Genet , vol.8
    • Bell, J.T.1    Tsai, P.-C.2    Yang, T.-P.3
  • 60
    • 84855400734 scopus 로고    scopus 로고
    • Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood
    • Toperoff G, Aran D, Kark JD, et al. Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet 2012;21:371-83.
    • (2012) Hum Mol Genet , vol.21 , pp. 371-383
    • Toperoff, G.1    Aran, D.2    Kark, J.D.3
  • 61
    • 78951472134 scopus 로고    scopus 로고
    • Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets
    • Yang BT, Dayeh TA, Kirkpatrick CL, et al. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets. Diabetologia 2011;54:360-7.
    • (2011) Diabetologia , vol.54 , pp. 360-367
    • Yang, B.T.1    Dayeh, T.A.2    Kirkpatrick, C.L.3
  • 62
    • 84858800629 scopus 로고    scopus 로고
    • DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
    • Volkmar M, Dedeurwaerder S, Cunha DA, et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 2012;31: 1405-26.
    • (2012) EMBO J , vol.31 , pp. 1405-1426
    • Volkmar, M.1    Dedeurwaerder, S.2    Cunha, D.A.3
  • 63
    • 84878944565 scopus 로고    scopus 로고
    • Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
    • Chouliaras L, Mastroeni D, Delvaux E, et al. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol Aging 2013;34:2091-9.
    • (2013) Neurobiol Aging , vol.34 , pp. 2091-2099
    • Chouliaras, L.1    Mastroeni, D.2    Delvaux, E.3
  • 64
    • 0029440466 scopus 로고
    • Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
    • West RL, Lee JM, Maroun LE. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient. J Mol Neurosci 1995;6:141-6.
    • (1995) J Mol Neurosci , vol.6 , pp. 141-146
    • West, R.L.1    Lee, J.M.2    Maroun, L.E.3
  • 65
    • 84987846182 scopus 로고    scopus 로고
    • Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns
    • Sanchez-Mut J, Heyn H, Vidal E, et al. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns. Transl Psychiatry 2016;6:e718.
    • (2016) Transl Psychiatry , vol.6
    • Sanchez-Mut, J.1    Heyn, H.2    Vidal, E.3
  • 66
    • 77958489643 scopus 로고    scopus 로고
    • Ischemic heart disease and stroke in relation to blood DNA methylation
    • Baccarelli A, Wright R, Bollati V, et al. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology 2010;21:819.
    • (2010) Epidemiology , vol.21 , pp. 819
    • Baccarelli, A.1    Wright, R.2    Bollati, V.3
  • 67
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • Issa J-PJ, Ottaviano YL, Celano P, et al. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994;7:536-40.
    • (1994) Nat Genet , vol.7 , pp. 536-540
    • Issa, J.-P.J.1    Ottaviano, Y.L.2    Celano, P.3
  • 68
    • 34447128753 scopus 로고    scopus 로고
    • Age-related DNA methylation changes in normal human prostate tissues
    • Kwabi-Addo B, Chung W, Shen L, et al. Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res 2007;13:3796-802.
    • (2007) Clin Cancer Res , vol.13 , pp. 3796-3802
    • Kwabi-Addo, B.1    Chung, W.2    Shen, L.3
  • 69
    • 84892613108 scopus 로고    scopus 로고
    • Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation
    • Johnson KC, Koestler DC, Cheng C, et al. Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation. Epigenetics 2014;9:268-75.
    • (2014) Epigenetics , vol.9 , pp. 268-275
    • Johnson, K.C.1    Koestler, D.C.2    Cheng, C.3
  • 70
    • 0002458132 scopus 로고
    • The effect of retarded growth upon the length of life span and upon the ultimate body size
    • McCay C, Crowell MF, Maynard L. The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutr 1935;10:63-79.
    • (1935) J Nutr , vol.10 , pp. 63-79
    • McCay, C.1    Crowell, M.F.2    Maynard, L.3
  • 71
    • 67650439330 scopus 로고    scopus 로고
    • Caloric restriction delays disease onset and mortality in rhesus monkeys
    • Colman RJ, Anderson RM, Johnson SC, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009;325:201-4.
    • (2009) Science , vol.325 , pp. 201-204
    • Colman, R.J.1    Anderson, R.M.2    Johnson, S.C.3
  • 72
    • 84866163081 scopus 로고    scopus 로고
    • Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    • Mattison JA, Roth GS, Beasley TM, et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012;489:318-21.
    • (2012) Nature , vol.489 , pp. 318-321
    • Mattison, J.A.1    Roth, G.S.2    Beasley, T.M.3
  • 73
    • 77952305618 scopus 로고    scopus 로고
    • Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression
    • Li Y, Liu L, Tollefsbol TO. Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J 2010;24:1442-53.
    • (2010) FASEB J , vol.24 , pp. 1442-1453
    • Li, Y.1    Liu, L.2    Tollefsbol, T.O.3
  • 74
    • 0000418476 scopus 로고
    • Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
    • Santi DV, Norment A, Garrett CE. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci USA 1984;81:6993-7.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 6993-6997
    • Santi, D.V.1    Norment, A.2    Garrett, C.E.3
  • 75
    • 18944383889 scopus 로고    scopus 로고
    • 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
    • Ghoshal K, Datta J, Majumder S, et al. 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 2005;25:4727-41.
    • (2005) Mol Cell Biol , vol.25 , pp. 4727-4741
    • Ghoshal, K.1    Datta, J.2    Majumder, S.3
  • 76
    • 84890166425 scopus 로고    scopus 로고
    • Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring
    • Gentilini D, Mari D, Castaldi D, et al. Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age 2013;35:1961-73.
    • (2013) Age , vol.35 , pp. 1961-1973
    • Gentilini, D.1    Mari, D.2    Castaldi, D.3
  • 77
    • 84957581421 scopus 로고    scopus 로고
    • Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
    • Horvath S, Pirazzini C, Bacalini MG, et al. Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring. Aging 2015;7:1159-70.
    • (2015) Aging , vol.7 , pp. 1159-1170
    • Horvath, S.1    Pirazzini, C.2    Bacalini, M.G.3
  • 78
    • 84858336995 scopus 로고    scopus 로고
    • Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' offspring. Is there a role for allelic imbalance in Healthy Aging and Longevity?
    • Gentilini D, Castaldi D, Mari D, et al. Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' offspring. Is there a role for allelic imbalance in Healthy Aging and Longevity? Aging Cell 2012;11:277-83.
    • (2012) Aging Cell , vol.11 , pp. 277-283
    • Gentilini, D.1    Castaldi, D.2    Mari, D.3
  • 79
    • 84941215848 scopus 로고    scopus 로고
    • Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females
    • Gentilini D, Garagnani P, Pisoni S, et al. Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females. Aging (Albany NY) 2015;7:568.
    • (2015) Aging (Albany NY) , vol.7 , pp. 568
    • Gentilini, D.1    Garagnani, P.2    Pisoni, S.3
  • 80
    • 84925425951 scopus 로고    scopus 로고
    • A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes
    • Xiao F-H, He Y-H, Li Q-G, et al. A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. PloS One 2015;10:e0120388.
    • (2015) PloS One , vol.10
    • Xiao, F.-H.1    He, Y.-H.2    Li, Q.-G.3
  • 81
    • 84945536355 scopus 로고    scopus 로고
    • Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny
    • Marttila S, Kananen L, Jylhava J, et al. Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny. Oncotarget 2015;6:30557-67.
    • (2015) Oncotarget , vol.6 , pp. 30557-30567
    • Marttila, S.1    Kananen, L.2    Jylhava, J.3
  • 82
    • 33646427172 scopus 로고    scopus 로고
    • Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    • Liu Y, Lan Q, Siegfried JM, et al. Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia 2006;8:46-51.
    • (2006) Neoplasia , vol.8 , pp. 46-51
    • Liu, Y.1    Lan, Q.2    Siegfried, J.M.3
  • 83
    • 84873734105 scopus 로고    scopus 로고
    • RNA-guided human genome engineering via Cas9
    • Mali P, Yang L, Esvelt KM, et al. RNA-guided human genome engineering via Cas9. Science 2013;339:823-6.
    • (2013) Science , vol.339 , pp. 823-826
    • Mali, P.1    Yang, L.2    Esvelt, K.M.3
  • 84
    • 84902096048 scopus 로고    scopus 로고
    • Development and applications of CRISPR-Cas9 for genome engineering
    • Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell 2014;157:1262-78.
    • (2014) Cell , vol.157 , pp. 1262-1278
    • Hsu, P.D.1    Lander, E.S.2    Zhang, F.3
  • 85
    • 84890050551 scopus 로고    scopus 로고
    • Correction of a genetic disease in mouse via use of CRISPR-Cas9
    • Wu Y, Liang D, Wang Y, et al. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell stem cell 2013;13:659-62.
    • (2013) Cell stem cell , vol.13 , pp. 659-662
    • Wu, Y.1    Liang, D.2    Wang, Y.3
  • 86
    • 84907200149 scopus 로고    scopus 로고
    • Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
    • Long C, McAnally JR, Shelton JM, et al. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science 2014;345:1184-8.
    • (2014) Science , vol.345 , pp. 1184-1188
    • Long, C.1    McAnally, J.R.2    Shelton, J.M.3
  • 87
    • 84929135130 scopus 로고    scopus 로고
    • Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes frompromoters and enhancers
    • Hilton IB, D'Ippolito AM, Vockley CM, et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes frompromoters and enhancers. Nat Biotechnol 2015;33:510-17.
    • (2015) Nat Biotechnol , vol.33 , pp. 510-517
    • Hilton, I.B.1    D'Ippolito, A.M.2    Vockley, C.M.3


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