Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females

Aging

Volumn 7, Issue 8, 2015, Pages 568-578

  Gentilini, Davide ^a   Garagnani, Paolo ^b   Pisoni, Serena ^a   Bacalini, Maria Giulia ^b   Calzari, Luciano ^a   Mari, Daniela ^c   Vitale, Giovanni ^a,d   Franceschi, Claudio ^b   Di Blasio, Anna Maria ^a  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

Aging; DNA methylation; Epigenetics; Epimutations; X chromosome inactivation skewing

Indexed keywords

ADOLESCENT; ADULT; AGED; AGING; BODY MASS; CHILD; DNA METHYLATION; FEMALE; GENETIC EPIGENESIS; HUMAN; MIDDLE AGED; MUTATION; PHYSIOLOGY; PRESCHOOL CHILD; VERY ELDERLY; X CHROMOSOME; X CHROMOSOME INACTIVATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, X; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; MIDDLE AGED; MUTATION; X CHROMOSOME INACTIVATION; YOUNG ADULT;

EID: 84941215848     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100792     Document Type: Article

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