메뉴 건너뛰기




Volumn 17, Issue 16, 2016, Pages 1940-1962

Phospholipase A2 isoforms as novel targets for prevention and treatment of inflammatory and oncologic diseases

Author keywords

Cancer; Inflammation; Phospholipase A2; PLA2 isoform specific inhibitors

Indexed keywords

ARACHIDONIC ACID; ARISTOLOCHIC ACID; BETA GLUCURONIDASE; CYCLOOXYGENASE 1; ELLAGIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLAVONOID; G PROTEIN COUPLED RECEPTOR; ICOSANOID; IMMUNOGLOBULIN E; INTERLEUKIN 1; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LIPOXYGENASE; LYSOPHOSPHOLIPID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PLATELET DERIVED GROWTH FACTOR; QUERCETIN; RUTOSIDE; SILIBININ; SPHINGOSINE 1 PHOSPHATE; TUMOR NECROSIS FACTOR; UROCORTIN; ISOPROTEIN; PHOSPHOLIPASE A2 INHIBITOR;

EID: 85015680446     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450116666150727122501     Document Type: Review
Times cited : (67)

References (229)
  • 1
    • 0034523901 scopus 로고    scopus 로고
    • The role of cyclooxygenase and lipoxygenase in cancer chemoprevention
    • Cuendet M, Pezzuto JM. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact 2000; 17: 109-57.
    • (2000) Drug Metabol Drug Interact , vol.17 , pp. 109-157
    • Cuendet, M.1    Pezzuto, J.M.2
  • 2
    • 84890806672 scopus 로고    scopus 로고
    • Inhibitors of the arachidonic acid cascade: Interfering with multiple pathways
    • Karin M, Dieter S, Ewgenij P. Inhibitors of the arachidonic acid cascade: Interfering with multiple pathways. Basic Clin Pharmacol Toxicol 2014; 114: 83-91.
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , pp. 83-91
    • Karin, M.1    Dieter, S.2    Ewgenij, P.3
  • 3
    • 33645056429 scopus 로고    scopus 로고
    • Cyclooxygenase-1 is overex-pressed in multiple genetically engineered mouse models of epithelial ovarian cancer
    • Takiko D, Susanne T, Irina NT, et al. Cyclooxygenase-1 is overex-pressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Res 2006; 66: 2527-531.
    • (2006) Cancer Res , vol.66 , pp. 2527-2531
    • Takiko, D.1    Susanne, T.2    Irina, N.T.3
  • 4
    • 33845199658 scopus 로고    scopus 로고
    • Inhibition of 5- lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells
    • Cianchi F, Cortesini C, Magnelli L, et al. Inhibition of 5- lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. Mol Cancer Ther 2006; 5: 2716-26.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2716-2726
    • Cianchi, F.1    Cortesini, C.2    Magnelli, L.3
  • 5
    • 84861618589 scopus 로고    scopus 로고
    • Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr
    • Kit YC, Khalit M, Audrey JAO, Zamrie, I, Lip YC. Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr. Fitoterapia 2012; 83: 961-7.
    • (2012) Fitoterapia , vol.83 , pp. 961-967
    • Kit, Y.C.1    Khalit, M.2    Audrey, J.A.O.3    Zamrie, I.4    Lip, Y.C.5
  • 6
    • 0027294984 scopus 로고
    • Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs
    • Hudson N, Balsitis M, Everitt S, Hawkey CJ. Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut 1993; 34: 742-7.
    • (1993) Gut , vol.34 , pp. 742-747
    • Hudson, N.1    Balsitis, M.2    Everitt, S.3    Hawkey, C.J.4
  • 7
    • 0038147318 scopus 로고    scopus 로고
    • Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs
    • Martel PJ, Lajeunesse D, Reboul P, Pelletier JP. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis 2003; 62: 501-9.
    • (2003) Ann Rheum Dis , vol.62 , pp. 501-509
    • Martel, P.J.1    Lajeunesse, D.2    Reboul, P.3    Pelletier, J.P.4
  • 8
    • 40549108939 scopus 로고    scopus 로고
    • Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade
    • Tavolari S, Bonafè M, Marini M, Ferreri C, Bartolini G, Brighenti E. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis 2008; 29: 371-80.
    • (2008) Carcinogenesis , vol.29 , pp. 371-380
    • Tavolari, S.1    Bonafè, M.2    Marini, M.3    Ferreri, C.4    Bartolini, G.5    Brighenti, E.6
  • 9
    • 84871462349 scopus 로고    scopus 로고
    • Cy-clooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells
    • Ganesh R, Marks DJ, Sales K, Winslet MC, Seifalian AM. Cy-clooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. World J Surg Oncol 2012; 10: 200.
    • (2012) World J Surg Oncol , vol.10 , pp. 200
    • Ganesh, R.1    Marks, D.J.2    Sales, K.3    Winslet, M.C.4    Seifalian, A.M.5
  • 10
    • 84871163836 scopus 로고    scopus 로고
    • Arachidonic acid and cancer risk: A systematic review of observational studies
    • Mai S, Saki K, Chika H, et al. Arachidonic acid and cancer risk: a systematic review of observational studies. BMC Cancer 2012; 12: 606.
    • (2012) BMC Cancer , vol.12 , pp. 606
    • Mai, S.1    Saki, K.2    Chika, H.3
  • 11
    • 0029126484 scopus 로고
    • Lysophospholipids activate ovarian and breast cancer cells
    • Xu Y, Fang XJ, Casey G, Mills GB. Lysophospholipids activate ovarian and breast cancer cells. Biochem J 1995; 309: 933-40.
    • (1995) Biochem J , vol.309 , pp. 933-940
    • Xu, Y.1    Fang, X.J.2    Casey, G.3    Mills, G.B.4
  • 12
    • 66349090778 scopus 로고    scopus 로고
    • Phospholipase A2 structure/function, mechanism, and signaling
    • John EB, Edward AD. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res 2009; 50: S237-S242.
    • (2009) J Lipid Res , vol.50 , pp. S237-S242
    • John, E.B.1    Edward, A.D.2
  • 13
    • 80054082654 scopus 로고    scopus 로고
    • Phospholipase A2 enzymes: Physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention
    • Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev 2011; 111: 6130-85.
    • (2011) Chem Rev , vol.111 , pp. 6130-6185
    • Dennis, E.A.1    Cao, J.2    Hsu, Y.H.3    Magrioti, V.4    Kokotos, G.5
  • 14
    • 0031596818 scopus 로고    scopus 로고
    • Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears
    • Qu, X.D.; Lehrer, R.L. Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears. Infect Immun 1998; 66: 2791-7.
    • (1998) Infect Immun , vol.66 , pp. 2791-2797
    • Qu, X.D.1    Lehrer, R.L.2
  • 15
    • 30044438111 scopus 로고    scopus 로고
    • Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells
    • Mitsuishi, M.; Masuda, S.; Kudo, I.; Murakami, M. Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells. Biochem J 2006; 393: 97-106.
    • (2006) Biochem J , vol.393 , pp. 97-106
    • Mitsuishi, M.1    Masuda, S.2    Kudo, I.3    Murakami, M.4
  • 16
    • 33646538505 scopus 로고    scopus 로고
    • Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis
    • Balestrieri B, Hsu VW, Gilbert H, et al. Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. J Biol Chem 2006; 281: 6691-8.
    • (2006) J Biol Chem , vol.281 , pp. 6691-6698
    • Balestrieri, B.1    Hsu, V.W.2    Gilbert, H.3
  • 17
    • 65249115433 scopus 로고    scopus 로고
    • Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans
    • Balestrieri B, Maekawa A, Xing W, Gelb MH, Katz HR, Arm JP. Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans. J Immunol 2009; 182: 4891-8.
    • (2009) J Immunol , vol.182 , Issue.8 , pp. 4891
    • Balestrieri, B.1    Maekawa, A.2    Xing, W.3    Gelb, M.H.4    Katz, H.R.5    Arm, J.P.6
  • 18
    • 77954584202 scopus 로고    scopus 로고
    • A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis
    • Boilard E, Lai Y, Larabee K, et al. A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis. EMBO Mol Med 2010; 2: 172-87.
    • (2010) EMBO Mol Med , vol.2 , pp. 172-187
    • Boilard, E.1    Lai, Y.2    Larabee, K.3
  • 19
    • 0034739464 scopus 로고    scopus 로고
    • Roles of secretory phospholipases A(2) in inflammatory diseases and trauma
    • Nevalainen TJ, Haapamäki MM, Grönroos JM. Roles of secretory phospholipases A(2) in inflammatory diseases and trauma. Biochim Biophys Acta 2000; 1488: 83-90.
    • (2000) Biochim Biophys Acta , vol.1488 , pp. 83-90
    • Nevalainen, T.J.1    Haapamäki, M.M.2    Grönroos, J.M.3
  • 20
    • 84872500083 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 and its role in cancer
    • Jia JH, Gang T, Ning Z. Cytosolic phospholipase A2 and its role in cancer. Clin Oncol Cancer Res 2011; 8: 71-76.
    • (2011) Clin Oncol Cancer Res , vol.8 , pp. 71-76
    • Jia, J.H.1    Gang, T.2    Ning, Z.3
  • 21
    • 22044457854 scopus 로고    scopus 로고
    • Jesu´s B, Edward AD. Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs
    • Yasuhito S, Jesu´s B, Edward AD. Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs. Biochimica et Biophysica Acta, 2005; 1735: 119-29.
    • (2005) Biochimica Et Biophysica Acta , vol.1735 , pp. 119-129
    • Yasuhito, S.1
  • 22
    • 38349107040 scopus 로고    scopus 로고
    • Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phos-pholipids in vivo
    • Kono N, Inoue T, Yoshida Y, et al., Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phos-pholipids in vivo. J Biol Chem 2008; 283: 1628-36.
    • (2008) J Biol Chem , vol.283 , pp. 1628-1636
    • Kono, N.1    Inoue, T.2    Yoshida, Y.3
  • 23
    • 0031449808 scopus 로고    scopus 로고
    • Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II
    • Atsushi M, Kenji H, Junken A, Hiroyuki A, Keizo I. Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II. J Biol Chem 1997; 272: 32315-20.
    • (1997) J Biol Chem , vol.272 , pp. 32315-32320
    • Atsushi, M.1    Kenji, H.2    Junken, A.3    Hiroyuki, A.4    Keizo, I.5
  • 25
    • 45749133451 scopus 로고    scopus 로고
    • Interaction of n group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry
    • Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL, Dennis EA. Interaction of n group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry 2008; 47: 6451-9.
    • (2008) Biochemistry , vol.47 , pp. 6451-6459
    • Burke, J.E.1    Karbarz, M.J.2    Deems, R.A.3    Li, S.4    Woods, V.L.5    Dennis, E.A.6
  • 26
    • 0028338536 scopus 로고
    • Diversity of group types, regulation, and function of phospholipase A2
    • Dennis EA. Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem 1994; 269(18): 13057-60.
    • (1994) J Biol Chem , vol.269 , Issue.18 , pp. 13057-13060
    • Dennis, E.A.1
  • 28
    • 0035438421 scopus 로고    scopus 로고
    • Interfacial enzymology: The secreted phospholipase A(2)-paradigm
    • Berg OG, Gelb MH, Tsai MD, Jain MK. Interfacial enzymology: the secreted phospholipase A(2)-paradigm. Chem Rev 2001; 101: 2613-54.
    • (2001) Chem Rev , vol.101 , pp. 2613-2654
    • Berg, O.G.1    Gelb, M.H.2    Tsai, M.D.3    Jain, M.K.4
  • 29
    • 0033617291 scopus 로고    scopus 로고
    • Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism
    • Dessen A, Tang J, Schmidt H, et al. Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Cell 1999; 97: 349-60.
    • (1999) Cell , vol.97 , pp. 349-360
    • Dessen, A.1    Tang, J.2    Schmidt, H.3
  • 30
    • 84867875513 scopus 로고    scopus 로고
    • Phospholipase signalling networks in cancer
    • Park JB, Lee CS, Jang JH, et al. Phospholipase signalling networks in cancer. Nat Rev Cancer 2012; 12: 782-92.
    • (2012) Nat Rev Cancer , vol.12 , pp. 782-792
    • Park, J.B.1    Lee, C.S.2    Jang, J.H.3
  • 31
    • 0031806559 scopus 로고    scopus 로고
    • Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2
    • Lio YC, Dennis EA. Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2. Biochim Biophys Acta 1998; 1392: 320-32.
    • (1998) Biochim Biophys Acta , vol.1392 , pp. 320-332
    • Lio, Y.C.1    Dennis, E.A.2
  • 32
    • 0034739445 scopus 로고    scopus 로고
    • Calcium-independent phospholipase A(2): Structure and function
    • Winstead MV, Balsinde J, Dennis EA Calcium-independent phospholipase A(2): structure and function. Biochim Biophys Acta 2000; 1488: 28-39.
    • (2000) Biochim Biophys Acta , vol.1488 , pp. 28-39
    • Winstead, M.V.1    Balsinde, J.2    Dennis, E.A.3
  • 33
    • 57649123149 scopus 로고    scopus 로고
    • Crystal structure of human plasma platelet-activating factor acetylhydrolase: Structural implication to lipoprotein binding and catalysis
    • Samanta U, Bahnson BJ. Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. J Biol Chem 2008; 283: 31617-24.
    • (2008) J Biol Chem , vol.283 , pp. 31617-31624
    • Samanta, U.1    Bahnson, B.J.2
  • 34
    • 0028968049 scopus 로고
    • Anti-inflammatory properties of a platelet-activating factor acetylhydrolase
    • Tjoelker LW, Wilder C, Eberhardt C, et al. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 1995; 374(6522): 549-53.
    • (1995) Nature , vol.374 , Issue.6522 , pp. 549-553
    • Tjoelker, L.W.1    Wilder, C.2    Eberhardt, C.3
  • 35
    • 0034753473 scopus 로고    scopus 로고
    • N-linked glycosylation of macrophage-derived PAF-AH is a major determinant of enzyme association with plasma HDL
    • Tselepis AD, Karabina SA, Stengel D, Piédagnel R, Chapman MJ, Ninio E. N-linked glycosylation of macrophage-derived PAF-AH is a major determinant of enzyme association with plasma HDL. J Lipid Res 2001; 42: 1645-54.
    • (2001) J Lipid Res , vol.42 , pp. 1645-1654
    • Tselepis, A.D.1    Karabina, S.A.2    Stengel, D.3    Piédagnel, R.4    Chapman, M.J.5    Ninio, E.6
  • 37
    • 27444444715 scopus 로고    scopus 로고
    • Structure and function of lysosomal phospholipase A2: Identification of the catalytic triad and the role of cysteine residues
    • Hiraoka M, Abe A, Shayman JA. Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues. J Lipid Res 2005; 46: 2441-7.
    • (2005) J Lipid Res , vol.46 , pp. 2441-2447
    • Hiraoka, M.1    Abe, A.2    Shayman, J.A.3
  • 38
    • 67449116736 scopus 로고    scopus 로고
    • The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type
    • Uyama T, Morishita J, Jin XH, Okamoto Y, Tsuboi K, Ueda N. The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type. J Lipid Res 2009; 50(4): 685-93.
    • (2009) J Lipid Res , vol.50 , Issue.4 , pp. 685-693
    • Uyama, T.1    Morishita, J.2    Jin, X.H.3    Okamoto, Y.4    Tsuboi, K.5    Ueda, N.6
  • 41
    • 84904638907 scopus 로고    scopus 로고
    • Secretory phospholipase A2 enzymes as pharmacological targets for treatment of diseases
    • Nhat DQ, Robert DA, Brian SC. Secretory phospholipase A2 enzymes as pharmacological targets for treatment of diseases. Biochem Pharmacol 2014; 90: 338-48.
    • (2014) Biochem Pharmacol , vol.90 , pp. 338-348
    • Nhat, D.Q.1    Robert, D.A.2    Brian, S.C.3
  • 42
    • 0037591839 scopus 로고    scopus 로고
    • 2α activity that is responsible for arachidonic acid release
    • 2α activity that is responsible for arachidonic acid release. J Biol Chem 2003; 278: 24153-63.
    • (2003) J Biol Chem , vol.278 , pp. 24153-24163
    • Won, K.H.1    Adam, S.2    Cheng, C.H.3
  • 43
    • 17744405787 scopus 로고
    • Biosynthesis and functions of eicosanoids. Recent data
    • Lagarde M. Biosynthesis and functions of eicosanoids. Recent data. C R Seances Soc Biol Fil 1995; 1189: 839-51.
    • (1995) C R Seances Soc Biol Fil , vol.1189 , pp. 839-851
    • Lagarde, M.1
  • 44
    • 0034257927 scopus 로고    scopus 로고
    • Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells
    • Fonteh AN, Atsumi G, LaPorte T, Chilton FH. Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells. J Immunol 2000; 165: 2773-82.
    • (2000) J Immunol , vol.165 , pp. 2773-2782
    • Fonteh, A.N.1    Atsumi, G.2    Laporte, T.3    Chilton, F.H.4
  • 45
    • 84866987709 scopus 로고    scopus 로고
    • Group IIa sPLA2 inhibition attenuates NF-kappaB activity and promotes apoptosis of lung cancer cells
    • Yu JA, Kalatardi S, Dohse J, et al. Group IIa sPLA2 inhibition attenuates NF-kappaB activity and promotes apoptosis of lung cancer cells. Anticancer Res 2012; 32: 3601-3607.
    • (2012) Anticancer Res , vol.32 , pp. 3601-3607
    • Ja, Y.1    Kalatardi, S.2    Dohse, J.3
  • 46
    • 84885961926 scopus 로고    scopus 로고
    • PLA2R1 mediates tumor suppression by activating JAK2
    • Vindrieux D, Augert A, Girard CA. PLA2R1 mediates tumor suppression by activating JAK2. Cancer Res 2013; 73: 6334-45.
    • (2013) Cancer Res , vol.73 , pp. 6334-6345
    • Vindrieux, D.1    Augert, A.2    Girard, C.A.3
  • 47
  • 48
    • 0038399752 scopus 로고    scopus 로고
    • Phospholipase A2 isoforms: A perspective
    • Chakraborti S. Phospholipase A2 isoforms: a perspective. Cell Signal 2003; 15: 637-65.
    • (2003) Cell Signal , vol.15 , pp. 637-665
    • Chakraborti, S.1
  • 49
    • 0037207142 scopus 로고    scopus 로고
    • The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism
    • Edwards SH, Thompson D, Baker SF, Wood SP, Wilton DC. The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism. Biochemistry 2002; 41: 15468-76.
    • (2002) Biochemistry , vol.41 , pp. 15468-15476
    • Edwards, S.H.1    Thompson, D.2    Baker, S.F.3    Wood, S.P.4    Wilton, D.C.5
  • 50
    • 36849000746 scopus 로고    scopus 로고
    • Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: Cooperation between PPARbeta and the protooncogene BCL-6
    • Ravaux L, Denoyelle C, Monne C, Limon I, Raymondjean M, El HK. Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the protooncogene BCL-6. Mol Cell Biol 2007; 27: 8374-87.
    • (2007) Mol Cell Biol , vol.27 , pp. 8374-8387
    • Ravaux, L.1    Denoyelle, C.2    Monne, C.3    Limon, I.4    Raymondjean, M.5    El, H.K.6
  • 52
    • 84904399684 scopus 로고    scopus 로고
    • Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells
    • Dong Z,, Meller J, Succop P, et al. Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. Int J Oncol 2014; 45: 978-84.
    • (2014) Int J Oncol , vol.45 , pp. 978-984
    • Dong, Z.1    Meller, J.2    Succop, P.3
  • 53
    • 78650109792 scopus 로고    scopus 로고
    • Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: Another inflammation-cancer link
    • Hernández M, Martin R, Garcia-Cubillas MD, Maeso-Hernández P, Nieto ML. Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: another inflammation-cancer link. Neuro-Oncol. 2010; 12: 1014-23.
    • (2010) Neuro-Oncol , vol.12 , pp. 1014-1023
    • Hernández, M.1    Martin, R.2    Garcia-Cubillas, M.D.3    Maeso-Hernández, P.4    Nieto, M.L.5
  • 54
    • 77957265728 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis
    • Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst 2010; 102: 1398-412.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1398-1412
    • Linkous, A.G.1    Yazlovitskaya, E.M.2    Hallahan, D.E.3
  • 55
    • 38449114271 scopus 로고    scopus 로고
    • MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2
    • Gorovetz M, Schwob OM, Yedgar S, Reich R. MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2. Front Biosci 2008; 13: 1917-25.
    • (2008) Front Biosci , vol.13 , pp. 1917-1925
    • Gorovetz, M.1    Schwob, O.M.2    Yedgar, S.3    Reich, R.4
  • 56
    • 0028987885 scopus 로고
    • Cytosolic phospholipase A2 gene in human and rat: Chromosomal localization and polymorphic markers
    • Tay A, Simon JS, Squire J, Hamel K, Jacob HJ, Skorecki K. Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers. Genomics 1995; 26: 138-41.
    • (1995) Genomics , vol.26 , pp. 138-141
    • Tay, A.1    Simon, J.S.2    Squire, J.3    Hamel, K.4    Jacob, H.J.5    Skorecki, K.6
  • 57
    • 77957266685 scopus 로고    scopus 로고
    • Cytosolic PLA2α and cancer: A role in tumor angiogenesis
    • Govianna T, Marta S, Ombretta S. Cytosolic PLA2α and cancer: A role in tumor angiogenesis. J Natl Cancer Inst 2010; 102: 1377-9.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1377-1379
    • Govianna, T.1    Marta, S.2    Ombretta, S.3
  • 58
    • 32944456146 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells
    • D'Orazi G, Sciulli MG, Di SV, et al. Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells. Clin Cancer Res. 2006; 12: 735-41.
    • (2006) Clin Cancer Res , vol.12 , pp. 735-741
    • D'orazi, G.1    Sciulli, M.G.2    Di, S.V.3
  • 59
    • 0034739466 scopus 로고    scopus 로고
    • Cellular components that functionally interact with signaling phospholipase A2s
    • Makoto M, Yoshihito N, Hiroshi K, Ichiro K. Cellular components that functionally interact with signaling phospholipase A2s. Biochimica et Biophysica Acta 2000; 1488; 159-66.
    • (2000) Biochimica Et Biophysica Acta , vol.1488 , pp. 159-166
    • Makoto, M.1    Yoshihito, N.2    Hiroshi, K.3    Ichiro, K.4
  • 61
    • 28244449007 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopoly-saccharide-stimulated macrophages
    • Hai YQ, James HS. Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopoly-saccharide-stimulated macrophages. J Biol Chem, 2005; 280: 38969-75.
    • (2005) J Biol Chem , vol.280 , pp. 38969-38975
    • Hai, Y.Q.1    James, H.S.2
  • 63
    • 33750081484 scopus 로고    scopus 로고
    • G-protein-gated inwardly rectifying potassium channels regulates ADP-induced cPLA2 activity in platelets through Src family kinases
    • Haripriya S, Bryan, NK, Janani P, Parth L, Soochong K, Satya, PK. G-protein-gated inwardly rectifying potassium channels regulates ADP-induced cPLA2 activity in platelets through Src family kinases. Blood 2006; 108: 3027-34.
    • (2006) Blood , vol.108 , pp. 3027-3034
    • Haripriya, S.1    Bryan, N.K.2    Janani, P.3    Parth, L.4    Soochong, K.5    Satya, P.K.6
  • 64
    • 45149123112 scopus 로고    scopus 로고
    • TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia
    • Gong, P.; Angelini, D.J.; Yang, S. et al. TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia. J Biol Chem 2008; 283: 13437-49.
    • (2008) J Biol Chem , vol.283 , pp. 13437-13449
    • Gong, P.1    Angelini, D.J.2    Yang, S.3
  • 65
    • 41549143653 scopus 로고    scopus 로고
    • TLR3-dependent induction of nitric oxide synthase in RAW 264.7 macrophage-like cells via a cytosolic phospholipase A2/cyclooxygenase-2 pathway
    • Pindado J, Balsinde J, Balboa MA. TLR3-dependent induction of nitric oxide synthase in RAW 264.7 macrophage-like cells via a cytosolic phospholipase A2/cyclooxygenase-2 pathway. J Immunol 2007; 179: 4821-8.
    • (2007) J Immunol , vol.179 , pp. 4821-4828
    • Pindado, J.1    Balsinde, J.2    Balboa, M.A.3
  • 66
    • 84900008258 scopus 로고    scopus 로고
    • TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells
    • Yang CM, Lee IT, Chi PL, Cheng SE, Hsiao LD, Hsu CK. TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2014; 306: L543-L551.
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.306 , pp. L543-L551
    • Yang, C.M.1    Lee, I.T.2    Chi, P.L.3    Cheng, S.E.4    Hsiao, L.D.5    Hsu, C.K.6
  • 67
    • 84884362696 scopus 로고    scopus 로고
    • TNF-α induces cytosolic phospholipase A2 expression in human lung epithelial cells via JNK1/2- and p38 MAPK-dependent AP-1 activation
    • Lee IT, Lin CC, Cheng SE, Hsiao LD, Hsiao YC, Yang CM. TNF-α induces cytosolic phospholipase A2 expression in human lung epithelial cells via JNK1/2- and p38 MAPK-dependent AP-1 activation. PLoS One 2013; 8: e72783.
    • (2013) Plos One , vol.8
    • Lee, I.T.1    Lin, C.C.2    Cheng, S.E.3    Hsiao, L.D.4    Hsiao, Y.C.5    Yang, C.M.6
  • 68
    • 53449086884 scopus 로고    scopus 로고
    • Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells
    • Luo SF, Lin, CC, Chen HC, et al. Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells. Toxicol Appl Pharmacol 2008; 232: 396-407.
    • (2008) Toxicol Appl Pharmacol , vol.232 , pp. 396-407
    • Luo, S.F.1    Lin, C.C.2    Chen, H.C.3
  • 69
    • 0032617299 scopus 로고    scopus 로고
    • Interleukin-1β regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38MAPK signaling pathways in cardiac myocytes
    • Margot, C.L.; Esma, I. Interleukin-1β regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38MAPK signaling pathways in cardiac myocytes. Hypertension 1999; 33: 276-82.
    • (1999) Hypertension , vol.33 , pp. 276-282
    • Margot, C.L.1    Esma, I.2
  • 70
    • 77950271949 scopus 로고    scopus 로고
    • Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro
    • Angelo, YM, Nilda, MM, Lucille, NM, et al. Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro. J Inflamm 2010; 7: 14.
    • (2010) J Inflamm , vol.7 , pp. 14
    • Angelo, Y.M.1    Nilda, M.M.2    Lucille, N.M.3
  • 71
    • 85015621033 scopus 로고
    • Keith BG, Peter V. Phospholipase A2 in clinical inflammation-molecular approaches to pathophysiology. CRC press, Francis and Taylor group 1995. ISBN 9780849385445. p100.
    • (1995) ISBN , pp. 100
  • 72
    • 84862094449 scopus 로고    scopus 로고
    • Regulation of cytosolic phospholipase A2 phosphorylation by proteolytic cleavage of annexin A1 in activated mast cells
    • Kwon JH, Lee JH, Kim KS, Chung YW, Kim IY. Regulation of cytosolic phospholipase A2 phosphorylation by proteolytic cleavage of annexin A1 in activated mast cells. J Immunol 2012; 188: 5665-73.
    • (2012) J Immunol , vol.188 , pp. 5665-5673
    • Kwon, J.H.1    Lee, J.H.2    Kim, K.S.3    Chung, Y.W.4    Kim, I.Y.5
  • 73
    • 0023248479 scopus 로고
    • An elucidation of the arachidonic acid cascade. Discovery of prostaglandins, thromboxane and leukotrienes
    • Samuelsson B. An elucidation of the arachidonic acid cascade. Discovery of prostaglandins, thromboxane and leukotrienes. Drugs 1987; 33: 2-9.
    • (1987) Drugs , vol.33 , pp. 2-9
    • Samuelsson, B.1
  • 74
    • 52149084591 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells
    • Li-Yuan C, Grzegorz W, Sahrudaya N, Carolea L, James HS. Cytosolic phospholipase A2 activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008; 295: L326-L335.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , pp. L326-L335
    • Li-Yuan, C.1    Grzegorz, W.2    Sahrudaya, N.3    Carolea, L.4    James, H.S.5
  • 75
    • 73249149543 scopus 로고    scopus 로고
    • Role of PI3K/AKT, cPLA2 and ERK1/2 signaling pathways in insulin regulation of vascular smooth muscle cells proliferation
    • Isenović ER, Kedees MH, Tepavčević S, et al. Role of PI3K/AKT, cPLA2 and ERK1/2 signaling pathways in insulin regulation of vascular smooth muscle cells proliferation. Cardiovasc Hematol Disord Drug Targets 2009; 9: 172-80.
    • (2009) Cardiovasc Hematol Disord Drug Targets , vol.9 , pp. 172-180
    • Isenović, E.R.1    Kedees, M.H.2    Tepavčević, S.3
  • 76
    • 0038322002 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells
    • Yellaturu CR, Rao GN. Cytosolic phospholipase A2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells. J Biol Chem 2003; 278: 9986-92.
    • (2003) J Biol Chem , vol.278 , pp. 9986-9992
    • Yellaturu, C.R.1    Rao, G.N.2
  • 77
    • 84896714087 scopus 로고    scopus 로고
    • Urocortin affects migration of hepatic cancer cell lines via differential regulation of cPLA2 and iPLA2
    • Zhu C, Sun Z, Li C, Guo R, Li L, Jin L, Wan R, Li, S. Urocortin affects migration of hepatic cancer cell lines via differential regulation of cPLA2 and iPLA2. Cell Signal 2014; 26: 1125-34.
    • (2014) Cell Signal , vol.26 , pp. 1125-1134
    • Zhu, C.1    Sun, Z.2    Li, C.3    Guo, R.4    Li, L.5    Jin, L.6    Wan, R.7    Li, S.8
  • 78
    • 79251616588 scopus 로고    scopus 로고
    • Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells
    • Cheng SE, Lin CC, Lee IT, Hsu CK, Kou YR, Yang CM. Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells. J Cell Biochem 2011; 112: 589-99.
    • (2011) J Cell Biochem , vol.112 , pp. 589-599
    • Cheng, S.E.1    Lin, C.C.2    Lee, I.T.3    Hsu, C.K.4    Kou, Y.R.5    Yang, C.M.6
  • 79
    • 0024554009 scopus 로고
    • Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid
    • Seilhamer JJ, Pruzanski W, Vadas P, et al. Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid. J Biol Chem 1989; 264: 5335-8.
    • (1989) J Biol Chem , vol.264 , pp. 5335-5338
    • Seilhamer, J.J.1    Pruzanski, W.2    Vadas, P.3
  • 80
    • 0037561999 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis
    • Hegen M, Sun L, Uozumi N, et al. Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis. J Exp Med 2003; 197: 1297-302.
    • (2003) J Exp Med , vol.197 , pp. 1297-1302
    • Hegen, M.1    Sun, L.2    Uozumi, N.3
  • 81
    • 34247362323 scopus 로고    scopus 로고
    • Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
    • Henderson WR Jr, Chi EY, Bollinger JG, et al. Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med 2007; 204: 865-77.
    • (2007) J Exp Med , vol.204 , pp. 865-877
    • Henderson, W.R.1    Chi, E.Y.2    Bollinger, J.G.3
  • 82
    • 0028081488 scopus 로고
    • Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis
    • Minami T, Tojo H, Shinomura Y, Matsuzawa Y, Okamoto M. Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis. Gut 1994; 35: 1593-8.
    • (1994) Gut , vol.35 , pp. 1593-1598
    • Minami, T.1    Tojo, H.2    Shinomura, Y.3    Matsuzawa, Y.4    Okamoto, M.5
  • 84
    • 0022814387 scopus 로고
    • Purification of soluble phospholipaseA2 from synovial fluid in rheumatoid arthritis
    • Stefanski E, Pruzanski W, Sternby B, Vadas P. Purification of soluble phospholipaseA2 from synovial fluid in rheumatoid arthritis. J Biochem 1986; 100: 1297-303.
    • (1986) J Biochem , vol.100 , pp. 1297-1303
    • Stefanski, E.1    Pruzanski, W.2    Sternby, B.3    Vadas, P.4
  • 85
    • 0030772294 scopus 로고    scopus 로고
    • The inflammatory response to vascular surgery-associated ischaemia and reperfusion in man: Effect on postoperative pulmonary function
    • Groeneveld AB, Raijmakers PG, Rauwerda JA, Hack CE. The inflammatory response to vascular surgery-associated ischaemia and reperfusion in man: effect on postoperative pulmonary function. Eur J Vasc Endovasc Surg 1997; 14: 351-9.
    • (1997) Eur J Vasc Endovasc Surg , vol.14 , pp. 351-359
    • Groeneveld, A.B.1    Raijmakers, P.G.2    Rauwerda, J.A.3    Hack, C.E.4
  • 86
    • 0036010979 scopus 로고    scopus 로고
    • Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk
    • Aufenanger J, Samman M, Quintel M, Fassbender K, Zimmer W, Bertsch T. Pancreatic phospholipase A2 activity in acute pancreatitis: a prognostic marker for early identification of patients at risk. Clin Chem Lab Med 2002; 40: 293-7.
    • (2002) Clin Chem Lab Med , vol.40 , pp. 293-297
    • Aufenanger, J.1    Samman, M.2    Quintel, M.3    Fassbender, K.4    Zimmer, W.5    Bertsch, T.6
  • 87
    • 84891751589 scopus 로고    scopus 로고
    • Effect of phospholipase A2 silencing on acute experimental pancreatitis
    • Zhang KJ, Zhang DL, Jiao XL, Dong C. Effect of phospholipase A2 silencing on acute experimental pancreatitis. Eur Rev Med Pharmacol Sci 2013; 17: 3279-84.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 3279-3284
    • Zhang, K.J.1    Zhang, D.L.2    Jiao, X.L.3    Dong, C.4
  • 88
    • 0027787847 scopus 로고
    • Serum phospholipases A2 in inflammatory diseases
    • Timo JN. Serum phospholipases A2 in inflammatory diseases. Clinical Chem 1993; 39: 2453-9.
    • (1993) Clinical Chem , vol.39 , pp. 2453-2459
    • Timo, J.N.1
  • 89
    • 0344667662 scopus 로고    scopus 로고
    • Interaction of secreted phospholipase A2 and pulmonary surfactant and its pathophysiological relevance in acute respiratory distress syndrome
    • Touqui L, Wu YZ. Interaction of secreted phospholipase A2 and pulmonary surfactant and its pathophysiological relevance in acute respiratory distress syndrome. Acta Pharmacol Sin 2003; 24: 1292-6.
    • (2003) Acta Pharmacol Sin , vol.24 , pp. 1292-1296
    • Touqui, L.1    Wu, Y.Z.2
  • 90
    • 52049114156 scopus 로고    scopus 로고
    • Macrophage secretory Phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology
    • Curfs DM, Ghesquiere SA, Vergouwe MN, et al. Macrophage secretory Phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. J Biol Chem 2008; 283: 21640-8.
    • (2008) J Biol Chem , vol.283 , pp. 21640-21648
    • Curfs, D.M.1    Ghesquiere, S.A.2    Vergouwe, M.N.3
  • 91
    • 33845995114 scopus 로고    scopus 로고
    • Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction
    • Ohtsuki M, Taketomi Y, Arata S, et al., Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction. J Biol Chem 2006; 281: 36420-33.
    • (2006) J Biol Chem , vol.281 , pp. 36420-36433
    • Ohtsuki, M.1    Taketomi, Y.2    Arata, S.3
  • 93
    • 79955757953 scopus 로고    scopus 로고
    • Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity
    • Hallstrand TS, Lai Y, Ni, Z, et al. Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity. Clin Exp Allergy 2011; 41: 801-10.
    • (2011) Clin Exp Allergy , vol.41 , pp. 801-810
    • Hallstrand, T.S.1    Lai, Y.2    Ni, Z.3
  • 94
    • 49449112039 scopus 로고    scopus 로고
    • Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosen-sitized mice
    • Nilda MM, Angelo YM, Jonathan PA, Joseph VB, Wonhwa C, Alan RL. Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosen-sitized mice. J Immunol 2007; 179: 4800-7.
    • (2007) J Immunol , vol.179 , Issue.7 , pp. 4800
    • Nilda, M.M.1    Angelo, Y.M.2    Jonathan, P.A.3    Joseph, V.B.4    Wonhwa, C.5    Alan, R.L.6
  • 95
    • 85015608778 scopus 로고    scopus 로고
    • The involvement of phospholipases A2 in asthma and chronic obstructive pulmonary disease
    • Ewa P, Rafal P. The involvement of phospholipases A2 in asthma and chronic obstructive pulmonary disease. Mediators Inflam 2013; 12.
    • (2013) Mediators Inflam , vol.12
    • Ewa, P.1    Rafal, P.2
  • 97
    • 72849108951 scopus 로고    scopus 로고
    • Secretory phospholipase A2: A multifaceted family of proatherogenic enzymes
    • Rosenson RS, Gelb MH Secretory phospholipase A2: a multifaceted family of proatherogenic enzymes. Curr Cardiol Rep 2009; 11: 445.
    • (2009) Curr Cardiol Rep , vol.11 , pp. 445
    • Rosenson, R.S.1    Gelb, M.H.2
  • 98
    • 0032941386 scopus 로고    scopus 로고
    • Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogene-sis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2
    • Ivandic B, Castellani, LW, Wang, XP, et al. Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogene-sis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2. J. Arterioscler Thromb Vasc Biol 1999; 19: 1284-90.
    • (1999) J. Arterioscler Thromb Vasc Biol , vol.19 , pp. 1284-1290
    • Ivandic, B.1    Castellani, L.W.2    Wang, X.P.3
  • 99
    • 84873159236 scopus 로고    scopus 로고
    • Lentiviral-mediated RNA interference of lipoprotein-associated phospholipase A2 ameliorates inflammation and atherosclerosis in apolipoprotein E-deficient mice
    • Zhang H, Zhang J, Shen D, et al. Lentiviral-mediated RNA interference of lipoprotein-associated phospholipase A2 ameliorates inflammation and atherosclerosis in apolipoprotein E-deficient mice. Int J Mol Med 2013; 31: 651-9.
    • (2013) Int J Mol Med , vol.31 , pp. 651-659
    • Zhang, H.1    Zhang, J.2    Shen, D.3
  • 100
    • 84947235987 scopus 로고    scopus 로고
    • 2 Inhibitors for the Reduction of Cardiovascular Events
    • 2 Inhibitors for the Reduction of Cardiovascular Events. Cardiol Ther 2013; 2: 125-34.
    • (2013) Cardiol Ther , vol.2 , pp. 125-134
    • O’Donoghue, M.L.1
  • 101
    • 77953286792 scopus 로고    scopus 로고
    • Emerging roles for phospholipase A2 enzymes in cancer
    • Scott KF, Sajinovic M, Hein J, et al. Emerging roles for phospholipase A2 enzymes in cancer. Biochimie 2010; 92: 601-10.
    • (2010) Biochimie , vol.92 , pp. 601-610
    • Scott, K.F.1    Sajinovic, M.2    Hein, J.3
  • 102
    • 0036171520 scopus 로고    scopus 로고
    • Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma
    • Jiazhong J, Blake LN, Jeremy R, et al. Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma. Am J Pathol 2002; 160: 667-71.
    • (2002) Am J Pathol , vol.160 , pp. 667-671
    • Jiazhong, J.1    Blake, L.N.2    Jeremy, R.3
  • 103
    • 0026378310 scopus 로고
    • Development of a radio-immunoassay for human group II phospholipase A2 and demonstration of postoperative elevation
    • Matsuda Y, Ogawa M, Sakamoto K, et al. Development of a radio-immunoassay for human group II phospholipase A2 and demonstration of postoperative elevation. Enzyme 1991; 45: 200-8.
    • (1991) Enzyme , vol.45 , pp. 200-208
    • Matsuda, Y.1    Ogawa, M.2    Sakamoto, K.3
  • 104
    • 0028335374 scopus 로고
    • Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency
    • Yamashita S, Yamashita J, Ogawa M. Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency. Br J Cancer 1994; 69: 1166-70.
    • (1994) Br J Cancer , vol.69 , pp. 1166-1170
    • Yamashita, S.1    Yamashita, J.2    Ogawa, M.3
  • 105
    • 84869095607 scopus 로고    scopus 로고
    • Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo
    • Yu JA, Mauchley D, Li, H, et al. Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg 2012; 144: 1185-91.
    • (2012) J Thorac Cardiovasc Surg , vol.144 , pp. 1185-1191
    • Ja, Y.1    Mauchley, D.2    Li, H.3
  • 106
    • 0030948628 scopus 로고    scopus 로고
    • Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line
    • Eiji K, Noriko H, Keiji H, Goro K, Masanori S. Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line. FEBS Lett 1997; 407: 343-6.
    • (1997) FEBS Lett , vol.407 , pp. 343-346
    • Eiji, K.1    Noriko, H.2    Keiji, H.3    Goro, K.4    Masanori, S.5
  • 108
    • 67650403816 scopus 로고    scopus 로고
    • PLA2 (Group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma
    • Buhmeida A, Bendardaf R, Hilska M, et al. PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma. Ann Oncol 2009; 20: 1230-5.
    • (2009) Ann Oncol , vol.20 , pp. 1230-1235
    • Buhmeida, A.1    Bendardaf, R.2    Hilska, M.3
  • 109
    • 84919721716 scopus 로고    scopus 로고
    • Secreted phospholipases A2 in cancer: Diverse mechanisms of action
    • Vesna B, Gerard L, Toni P. Secreted phospholipases A2 in cancer: Diverse mechanisms of action. Biochimie 2014; 107: 114-23.
    • (2014) Biochimie , vol.107 , pp. 114-123
    • Vesna, B.1    Gerard, L.2    Toni, P.3
  • 110
    • 49249097447 scopus 로고    scopus 로고
    • Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene
    • Ganesan K, Ivanova T, Wu Y, et al. Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene. Cancer Res 2008; 68: 4277-86.
    • (2008) Cancer Res , vol.68 , pp. 4277-4286
    • Ganesan, K.1    Ivanova, T.2    Wu, Y.3
  • 111
    • 80052247350 scopus 로고    scopus 로고
    • Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer
    • Xing XF, Li H, Zhong XY, et al. Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer. Histopathology 2011; 59: 198-206.
    • (2011) Histopathology , vol.59 , pp. 198-206
    • Xing, X.F.1    Li, H.2    Zhong, X.Y.3
  • 112
    • 84884412506 scopus 로고    scopus 로고
    • Expression of group IIA phospholipase A2 is an independent predictor of favorable outcome for patients with gastric cancer
    • Wang X, Huang CJ, Yu GZ, et al. Expression of group IIA phospholipase A2 is an independent predictor of favorable outcome for patients with gastric cancer. Hum Pathol 2013; 44(10): 2020-7.
    • (2013) Hum Pathol , vol.44 , Issue.10 , pp. 2020-2027
    • Wang, X.1    Huang, C.J.2    Gz, Y.3
  • 113
    • 0037059002 scopus 로고    scopus 로고
    • Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis
    • Leung SY, Chen X, Chu KM, et al. Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci USA 2002; 99(25): 16203-8.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.25 , pp. 16203-16208
    • Leung, S.Y.1    Chen, X.2    Chu, K.M.3
  • 114
    • 0030797904 scopus 로고    scopus 로고
    • Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis
    • Cormier RT, Hong KH, Halberg RB, et al. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet 1997; 17: 88-91.
    • (1997) Nat Genet , vol.17 , pp. 88-91
    • Cormier, R.T.1    Hong, K.H.2    Halberg, R.B.3
  • 115
    • 70149105950 scopus 로고    scopus 로고
    • Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways
    • Fijneman RJ, Bade LK, Peham JR, et al. Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways. Cell Oncol 2009; 31: 345-56.
    • (2009) Cell Oncol , vol.31 , pp. 345-356
    • Fijneman, R.J.1    Bade, L.K.2    Peham, J.R.3
  • 116
    • 0043123204 scopus 로고    scopus 로고
    • Phospholipase A2 expression in tumours: A target for therapeutic intervention?
    • Laye JP, Gill JH. Phospholipase A2 expression in tumours: a target for therapeutic intervention? Drug Discov Today 2003; 8: 710-6.
    • (2003) Drug Discov Today , vol.8 , pp. 710-716
    • Laye, J.P.1    Gill, J.H.2
  • 118
    • 0034602149 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Apc(Delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene
    • Takaku K, Sonoshita M, Sasaki N. Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J Biol Chem 2000; 275: 34013-6.
    • (2000) J Biol Chem , vol.275 , pp. 34013-34016
    • Takaku, K.1    Sonoshita, M.2    Sasaki, N.3
  • 120
    • 84862293064 scopus 로고    scopus 로고
    • Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells
    • Sundarraj S, Kannan S, Thangam R, Gunasekaran P. Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells. J Cancer Res Clin Oncol 2012; 138: 827-35.
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 827-835
    • Sundarraj, S.1    Kannan, S.2    Thangam, R.3    Gunasekaran, P.4
  • 121
    • 4344658768 scopus 로고    scopus 로고
    • Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2
    • Meyer AM, Dwyer-Nield LD. Hurteau GJ, et al. Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis 2004; 25: 1517-24.
    • (2004) Carcinogenesis , vol.25 , pp. 1517-1524
    • Meyer, A.M.1    Dwyer-Nield, L.D.2    Hurteau, G.J.3
  • 122
    • 16844363476 scopus 로고    scopus 로고
    • Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis
    • Ilsley JN, Nakanishi M, Flynn C, et al. Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis. Cancer Res 2005; 65: 2636-43.
    • (2005) Cancer Res , vol.65 , pp. 2636-2643
    • Ilsley, J.N.1    Nakanishi, M.2    Flynn, C.3
  • 123
    • 62449343121 scopus 로고    scopus 로고
    • Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis
    • Mary CM, Weiser E, Xue QW, et al. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. Cancer Res. 2009; 69: 1733-8.
    • (2009) Cancer Res , vol.69 , pp. 1733-1738
    • Mary, C.M.1    Weiser, E.2    Xue, Q.W.3
  • 124
    • 77958530752 scopus 로고    scopus 로고
    • 2 metabolites play a critical role in pulmonary tumor metastasis in mice
    • 2 metabolites play a critical role in pulmonary tumor metastasis in mice. Anticancer Res 2010; 30: 3421-7.
    • (2010) Anticancer Res , vol.30 , pp. 3421-3427
    • Woo, C.J.1    Kyoung, J.K.2    Hye, W.J.3
  • 126
    • 65549106476 scopus 로고    scopus 로고
    • Activation of cytosolic phospholipase A2-{alpha} as a novel mechanism regulating endothelial cell cycle progression and angiogenesis
    • Herbert SP, Odell AF, Ponnambalam S, Walker JH. Activation of cytosolic phospholipase A2-{alpha} as a novel mechanism regulating endothelial cell cycle progression and angiogenesis. J Biol Chem 2009; 284: 5784-96.
    • (2009) J Biol Chem , vol.284 , pp. 5784-5796
    • Herbert, S.P.1    Odell, A.F.2    Ponnambalam, S.3    Walker, J.H.4
  • 127
    • 84908519693 scopus 로고    scopus 로고
    • Pericyte con-tractility controls endothelial cell cycle progression and sprouting: Insights into angiogenic switch mechanics
    • Durham JT, Surks HK, Dulmovits BM, Herman IM. Pericyte con-tractility controls endothelial cell cycle progression and sprouting: insights into angiogenic switch mechanics. Am J Physiol Cell Physiol 2014; 307: C878-92.
    • (2014) Am J Physiol Cell Physiol , vol.307 , pp. C878-C892
    • Durham, J.T.1    Surks, H.K.2    Dulmovits, B.M.3    Herman, I.M.4
  • 128
    • 34147147435 scopus 로고    scopus 로고
    • Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKCa and theMAPK/ERK cascade
    • Carmelina DA, Gabriella L, Loriana R, et al. Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKCa and theMAPK/ERK cascade. J Lipid Res 2007; 48: 783-93.
    • (2007) J Lipid Res , vol.48 , pp. 783-793
    • Carmelina, D.A.1    Gabriella, L.2    Loriana, R.3
  • 129
    • 77957266685 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2α and cancer: A role in tumor angiogenesis
    • Giovanna T, Marta S, Ombretta S. Cytosolic phospholipase A2α and cancer: A role in tumor angiogenesis. J Natl Cancer Inst 2010; 102: 1377-9.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1377-1379
    • Giovanna, T.1    Marta, S.2    Ombretta, S.3
  • 130
    • 4644259224 scopus 로고    scopus 로고
    • Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors
    • Waeber C, Blondeau N, Salomone S. Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. Drug News Perspect 2004; 17: 365-82.
    • (2004) Drug News Perspect , vol.17 , pp. 365-382
    • Waeber, C.1    Blondeau, N.2    Salomone, S.3
  • 132
    • 84894041421 scopus 로고    scopus 로고
    • Endothelial PKCα-MAPK/ERK-phospholipase A2 pathway activation as a response of glioma in a triple culture model. A new role for pericytes?
    • Anfuso CD, Motta C, Giurdanella G, Arena V, Alberghina M, Lupo G. Endothelial PKCα-MAPK/ERK-phospholipase A2 pathway activation as a response of glioma in a triple culture model. A new role for pericytes? Biochimie 2014; 99: 77-87.
    • (2014) Biochimie , vol.99 , pp. 77-87
    • Anfuso, C.D.1    Motta, C.2    Giurdanella, G.3    Arena, V.4    Alberghina, M.5    Lupo, G.6
  • 133
    • 79955137383 scopus 로고    scopus 로고
    • Platelet-activating factor and metastasis: Calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung
    • McHowat J, Gullickson G, Hoover RG, Sharma, J, Turk J, Korn-bluth J. Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung. Am J Physiol Cell Physiol 2011; 300: C825-32.
    • (2011) Am J Physiol Cell Physiol , vol.300 , pp. C825-C832
    • McHowat, J.1    Gullickson, G.2    Hoover, R.G.3    Sharma, J.4    Turk, J.5    Korn-Bluth, J.6
  • 134
    • 33746975914 scopus 로고    scopus 로고
    • Lysosomal phospholipase A2 and phospholipidosis
    • Hiraoka M, Abe A, Lu Y, et al. Lysosomal phospholipase A2 and phospholipidosis. Mol Cell Biol 2006; 26: 6139-6148.
    • (2006) Mol Cell Biol , vol.26 , pp. 6139-6148
    • Hiraoka, M.1    Abe, A.2    Lu, Y.3
  • 135
    • 0035415723 scopus 로고    scopus 로고
    • Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat
    • Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001; 56: 683-7.
    • (2001) Farmaco , vol.56 , pp. 683-687
    • Guardia, T.1    Rotelli, A.E.2    Juarez, A.O.3    Pelzer, L.E.4
  • 136
    • 0030612780 scopus 로고    scopus 로고
    • Flavonoids as phospholipase A2 inhibitors: Importance of their structure for selective inhibition of group II phospholipase A2
    • Lindahl M, Tagesson C. Flavonoids as phospholipase A2 inhibitors: importance of their structure for selective inhibition of group II phospholipase A2. Inflammation 1997; 21: 347-56.
    • (1997) Inflammation , vol.21 , pp. 347-356
    • Lindahl, M.1    Tagesson, C.2
  • 137
    • 85015690120 scopus 로고    scopus 로고
    • Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis
    • Hongyan C, Qing M, Miao G, et al. Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. Sci World J 2013; 8.
    • (2013) Sci World J , vol.8
    • Hongyan, C.1    Qing, M.2    Miao, G.3
  • 138
    • 0027208761 scopus 로고
    • Selective inhibition of group II phospholipase A2 by quercetin
    • Lindahl, M, Tagesson C. Selective inhibition of group II phospholipase A2 by quercetin. Inflammation 1993; 17: 573-82.
    • (1993) Inflammation , vol.17 , pp. 573-582
    • Lindahl, M.1    Tagesson, C.2
  • 139
    • 0035001464 scopus 로고    scopus 로고
    • Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation
    • Manthey JA, Guthrie N, Grohmann K. Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation. Curr Med Chem 2001; 8: 135-53.
    • (2001) Curr Med Chem , vol.8 , pp. 135-153
    • Manthey, J.A.1    Guthrie, N.2    Grohmann, K.3
  • 140
    • 84863066655 scopus 로고    scopus 로고
    • Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549
    • Zheng SY, Li Y, Jiang D, Zhao J, Ge JF. Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549. Mol Med Rep 2012; 5: 822-6.
    • (2012) Mol Med Rep , vol.5 , pp. 822-826
    • Zheng, S.Y.1    Li, Y.2    Jiang, D.3    Zhao, J.4    Ge, J.F.5
  • 142
    • 84869783143 scopus 로고    scopus 로고
    • Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt
    • Sivalokanathan S, Subhash CG, Jagadananda G. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Int J Oncol 2012; 41: 2191-9.
    • (2012) Int J Oncol , vol.41 , pp. 2191-2199
    • Sivalokanathan, S.1    Subhash, C.G.2    Jagadananda, G.3
  • 143
    • 84904345835 scopus 로고    scopus 로고
    • The biflavonoid morelloflavone inhibits the enzymatic and biological activities of a snake venom phospholipase A2
    • Pereañez, J.A.; Patiño, A.C.; Núñez, V.; Osorio, E. The biflavonoid morelloflavone inhibits the enzymatic and biological activities of a snake venom phospholipase A2. Chem Biol Interact 2014; 220C: 94-101.
    • (2014) Chem Biol Interact , vol.220C , pp. 94-101
    • Pereañez, J.A.1    Patiño, A.C.2    Núñez, V.3    Osorio, E.4
  • 144
    • 0030888257 scopus 로고    scopus 로고
    • Morelloflavone, a novel biflavonoid inhibitor of human secretory phospholipase A2 with anti-inflammatory activity
    • Gil B, Sanz MJ, Terencio, M.C, Gunasegaran R, Payá M,. Alcaraz MJ. Morelloflavone, a novel biflavonoid inhibitor of human secretory phospholipase A2 with anti-inflammatory activity. Biochem Pharmacol 1997; 53: 733-40.
    • (1997) Biochem Pharmacol , vol.53 , pp. 733-740
    • Gil, B.1    Sanz, M.J.2    Gunasegaran, R.3    Payá, M.4    Alcaraz, M.J.5
  • 145
    • 58349092759 scopus 로고    scopus 로고
    • Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways
    • Pang X, Yi T, Yi Z, et al. Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. Cancer Res 2009; 69: 518-25.
    • (2009) Cancer Res , vol.69 , pp. 518-525
    • Pang, X.1    Yi, T.2    Yi, Z.3
  • 146
    • 84855335541 scopus 로고    scopus 로고
    • Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice
    • Decha P, Nongporn HT. Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice. Am J Physiol Heart Circ Physiol 2012; 302: H451-8.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302 , pp. H451-H458
    • Decha, P.1    Nongporn, H.T.2
  • 147
    • 84902239994 scopus 로고    scopus 로고
    • Silibinin down-regulates expression of secreted phospholipase A2 enzymes in cancer cells
    • Hagelgans A, Nacke B, Zamaraeva M, Siegert G, Menschikowski M. Silibinin down-regulates expression of secreted phospholipase A2 enzymes in cancer cells. Anticancer Res 2014; 34: 1723-9.
    • (2014) Anticancer Res , vol.34 , pp. 1723-1729
    • Hagelgans, A.1    Nacke, B.2    Zamaraeva, M.3    Siegert, G.4    Menschikowski, M.5
  • 148
    • 84939942887 scopus 로고    scopus 로고
    • Silymarin and hepatocellular carcinoma: A systematic, comprehensive, and critical review
    • Mastron JK, Siveen KS, Sethi G, Bishayee A. Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. Anti-cancer Drugs 2015; 26: 475-86.
    • (2015) Anti-Cancer Drugs , vol.26 , pp. 475-486
    • Mastron, J.K.1    Siveen, K.S.2    Sethi, G.3    Bishayee, A.4
  • 149
    • 3242786628 scopus 로고    scopus 로고
    • Synergistic anticancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells
    • Tyagi AK, Agarwal C, Chan DC, Agarwal R. Synergistic anticancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep 2004; 11: 493-9.
    • (2004) Oncol Rep , vol.11 , pp. 493-499
    • Tyagi, A.K.1    Agarwal, C.2    Chan, D.C.3    Agarwal, R.4
  • 151
    • 85015611007 scopus 로고
    • Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils
    • Miriam DR, Vishwanath BS, Richard CF. Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils. Toxicon 1987; 25: 939-46.
    • (1987) Toxicon , vol.25 , pp. 939-946
    • Miriam, D.R.1    Vishwanath, B.S.2    Richard, C.F.3
  • 152
  • 153
    • 0023476040 scopus 로고
    • Interaction of phospholipase A2 from Vipera russelli venom with aristolochic acid: A circular dichroism study
    • Vishwanath, BS, Appu, RAG, Gowda TV. Interaction of phospholipase A2 from Vipera russelli venom with aristolochic acid: a circular dichroism study. Toxicon 1987; 25: 939-46.
    • (1987) Toxicon , vol.25 , pp. 939-946
    • Vishwanath, B.S.1    Appu, R.A.G.2    Gowda, T.V.3
  • 154
    • 0036714237 scopus 로고    scopus 로고
    • Structural basis of phospholipase A2 inhibition for the synthesis of prostaglandins by the plant alkaloid aristolochic acid from a 1.7 A crystal structure
    • Chandra V, Jasti J, Kaur P, Srinivasan A, Betzel Ch, Singh TP. Structural basis of phospholipase A2 inhibition for the synthesis of prostaglandins by the plant alkaloid aristolochic acid from a 1.7 A crystal structure. Biochemistry 2002; 41(36): 10914-9.
    • (2002) Biochemistry , vol.41 , Issue.36 , pp. 10914-10919
    • Chandra, V.1    Jasti, J.2    Kaur, P.3    Srinivasan, A.4    Betzel, C.5    Singh, T.P.6
  • 155
    • 0027248443 scopus 로고
    • Effect of aristolochic acid on arachidonic acid cascade and in vivo models of inflammation
    • Moreno JJ. Effect of aristolochic acid on arachidonic acid cascade and in vivo models of inflammation. Immunopharmacol 1993; 26: 1-9.
    • (1993) Immunopharmacol , vol.26 , pp. 1-9
    • Moreno, J.J.1
  • 156
    • 84875192264 scopus 로고    scopus 로고
    • Therapeutic efficiency of aristolochic acid on oral cancer induced experimental rats
    • Mariappan S. Therapeutic efficiency of aristolochic acid on oral cancer induced experimental rats. IOSR J Pharm Biol Sci 2012; 4: 12-20.
    • (2012) IOSR J Pharm Biol Sci , vol.4 , pp. 12-20
    • Mariappan, S.1
  • 157
    • 84927172907 scopus 로고    scopus 로고
    • 2 synthase without affecting cyclooxygenase-1 activity: Different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response
    • 2 synthase without affecting cyclooxygenase-1 activity: Different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response. Nutrients 2014; 6: 3336-52.
    • (2014) Nutrients , vol.6 , pp. 3336-3352
    • Dong, J.S.1    Satoshi, A.2    Jin, T.H.3
  • 158
  • 159
    • 85015687828 scopus 로고    scopus 로고
    • Synthesis, of novel piperine analogs of dipeptidyl boronic acid as antimicrobial and anticancer agents
    • Durvasula VRV, Nagendra SY, Parimi U. Synthesis, of novel piperine analogs of dipeptidyl boronic acid as antimicrobial and anticancer agents. Med Chem 2014; 4: 9.
    • (2014) Med Chem , vol.4 , Issue.9
    • Durvasula, V.R.V.1    Nagendra, S.Y.2    Parimi, U.3
  • 160
    • 84898812785 scopus 로고    scopus 로고
    • Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway
    • Yi L, Jianping X, Hehe L, Lu L, Lei P. Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway. Tumor Biol 2014; 35: 3305-10.
    • (2014) Tumor Biol , vol.35 , pp. 3305-3310
    • Yi, L.1    Jianping, X.2    Hehe, L.3    Lu, L.4    Lei, P.5
  • 161
    • 0022596872 scopus 로고
    • Molecular pharmacology of manoalide: Inactivation of bee venom phospholipase A2
    • Keith B, Robert SJ. Molecular pharmacology of manoalide: Inactivation of bee venom phospholipase A2. Biochem Pharmacol 1986; 35: 449-53.
    • (1986) Biochem Pharmacol , vol.35 , pp. 449-453
    • Keith, B.1    Robert, S.J.2
  • 162
    • 0037085041 scopus 로고    scopus 로고
    • 2 activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex
    • 2 activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex. Biochem Pharmacol 2002; 63: 755-61.
    • (2002) Biochem Pharmacol , vol.63 , pp. 755-761
    • Frédéric, D.1    Rémi, H.2    Fabien, G.3
  • 163
    • 0028216343 scopus 로고
    • Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterter-penes from the marine sponge Hyrtios erecta Chem
    • Kobayashi M, Okamoto T, Hayashi K, Yokoyama N, Sasaki T, Kitagawa I. Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterter-penes from the marine sponge Hyrtios erecta Chem Pharm Bull 1994; 42: 265-70.
    • (1994) Pharm Bull , vol.42 , pp. 265-270
    • Kobayashi, M.1    Okamoto, T.2    Hayashi, K.3    Yokoyama, N.4    Sasaki, T.5    Kitagawa, I.6
  • 164
    • 0024390996 scopus 로고
    • Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide
    • Lister MD, Glaser KB, Ulevitch RJ, Dennis EA. Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. J Biol Chem 1989; 264: 8520-8.
    • (1989) J Biol Chem , vol.264 , pp. 8520-8528
    • Lister, M.D.1    Glaser, K.B.2    Ulevitch, R.J.3    Dennis, E.A.4
  • 165
    • 34548762412 scopus 로고    scopus 로고
    • Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation
    • Monti MC, Casapullo A, Cavasotto CN, Napolitano A, Riccio R. Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation. Chembiochem 2007; 8: 1585-91.
    • (2007) Chembiochem , vol.8 , pp. 1585-1591
    • Monti, M.C.1    Casapullo, A.2    Cavasotto, C.N.3    Napolitano, A.4    Riccio, R.5
  • 166
    • 10944235044 scopus 로고    scopus 로고
    • Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
    • Hyun PK, Kun HS, Hyeun WC, Sam SK. Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms. J Pharmacol Sci 2004; 96: 229-45.
    • (2004) J Pharmacol Sci , vol.96 , pp. 229-245
    • Hyun, P.K.1    Kun, H.S.2    Hyeun, W.C.3    Sam, S.K.4
  • 167
    • 79951758670 scopus 로고    scopus 로고
    • Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines
    • Al-Ashaal HA, El-Sheltawy ST. Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines. Pharm Biol 2011; 49: 276-82.
    • (2011) Pharm Biol , vol.49 , pp. 276-282
    • Al-Ashaal, H.A.1    El-Sheltawy, S.T.2
  • 168
    • 22744450385 scopus 로고    scopus 로고
    • 2 inhibitor from Cordia verbenacea (Boraginaceae): Antiserum action potentiation and molecular interaction
    • 2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction. Toxicon 2005; 46: 318-27.
    • (2005) Toxicon , vol.46 , pp. 318-327
    • Ticli, F.K.1    Hage, L.I.S.2    Cambraia, R.S.3
  • 170
    • 84858600666 scopus 로고    scopus 로고
    • Anti-tumor activity of rosmarinic acid in 7,12- dimethylbenz(A)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice
    • Sharmila R, Manoharan S. Anti-tumor activity of rosmarinic acid in 7,12- dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. Indian J Exp Biol 2012; 50: 187-94.
    • (2012) Indian J Exp Biol , vol.50 , pp. 187-194
    • Sharmila, R.1    Manoharan, S.2
  • 171
    • 84908288440 scopus 로고    scopus 로고
    • Protective activity of medicinal plants and their isolated compounds against the toxic effects from the venom of Naja (Cobra) species
    • Arham S, Muhammad S, Paul M, Glenda CG. Protective activity of medicinal plants and their isolated compounds against the toxic effects from the venom of Naja (cobra) species. J Ethnopharmacol 2014; 157: 222-7.
    • (2014) J Ethnopharmacol , vol.157 , pp. 222-227
    • Arham, S.1    Muhammad, S.2    Paul, M.3    Glenda, C.G.4
  • 172
    • 69549135413 scopus 로고    scopus 로고
    • Lupeol, A novel anti-inflammatory and anti-cancer dietary triterpene
    • Mohammad S. Lupeol, A novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett 2009; 285: 109-15.
    • (2009) Cancer Lett , vol.285 , pp. 109-115
    • Mohammad, S.1
  • 173
    • 84856922191 scopus 로고    scopus 로고
    • Anti-snake venom activities of extracts and fractions from callus cultures of Sapindus saponaria
    • DaSilva ML, Marcussi S, Fernandes RS, et al. Anti-snake venom activities of extracts and fractions from callus cultures of Sapindus saponaria. Pharm Biol 2012; 50: 366-75.
    • (2012) Pharm Biol , vol.50 , pp. 366-375
    • Dasilva, M.L.1    Marcussi, S.2    Fernandes, R.S.3
  • 174
    • 77954146578 scopus 로고    scopus 로고
    • Chemopre-ventive potential of β -Sitosterol in experimental colon cancer model – an in vitro and in vivo study
    • Albert AB, Savarimuthu I, Gabriel MP, Khalid SAN. Chemopre-ventive potential of β -Sitosterol in experimental colon cancer model – an in vitro and in vivo study. BMC Complement Altern Med 2010; 10: 24.
    • (2010) BMC Complement Altern Med , vol.10 , pp. 24
    • Albert, A.B.1    Savarimuthu, I.2    Gabriel, M.P.3    Khalid, S.A.N.4
  • 175
    • 84861334341 scopus 로고    scopus 로고
    • Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn. Aerial parts against Ehrlich Ascites Carcinoma in mice
    • Tirtha G, Tapan KM, Jagadish S. Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn. aerial parts against Ehrlich Ascites Carcinoma in mice. Orient Pharm Exp Med 2011; 11: 41-9.
    • (2011) Orient Pharm Exp Med , vol.11 , pp. 41-49
    • Tirtha, G.1    Tapan, K.M.2    Jagadish, S.3
  • 176
    • 35549005010 scopus 로고    scopus 로고
    • Ergosterol peroxides as phospholipase A2 inhibitors from the fungus Lactarius hatsudake
    • Jin MG, Min W, La PL, et al. Ergosterol peroxides as phospholipase A2 inhibitors from the fungus Lactarius hatsudake. Phy-tomedicine 2007; 14: 821-4.
    • (2007) Phy-Tomedicine , vol.14 , pp. 821-824
    • Jin, M.G.1    Min, W.2    La, P.L.3
  • 177
    • 23844481153 scopus 로고    scopus 로고
    • Ergosterol peroxide from flowers of erigeron annuus L. As an anti-atherosclerosis agent
    • Kim DH, Sung JJ, Sik C, et al. Ergosterol peroxide from flowers of erigeron annuus L. as an anti-atherosclerosis agent. Arch Pharm Res 2005; 28: 541-5.
    • (2005) Arch Pharm Res , vol.28 , Issue.5 , pp. 541
    • Kim, D.H.1    Sung, J.J.2    Sik, C.3
  • 178
    • 33846512747 scopus 로고    scopus 로고
    • Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells
    • Kobori, M.; Yoshida, M.; Ohnishi-Kameyama, M.; Shinmoto, H. Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells. Br J Pharmacol 2007; 150: 209-19.
    • (2007) Br J Pharmacol , vol.150 , pp. 209-219
    • Kobori, M.1    Yoshida, M.2    Ohnishi-Kameyama, M.3    Shinmoto, H.4
  • 179
    • 84928485206 scopus 로고    scopus 로고
    • Effect of diterpenes isolated of the marine Alga Canistrocarpus cervicornis against some toxic effects of the venom of the Bothrops jararaca snake
    • Thaisa FSD, Magui AV, Diana NC, Eládio FS, Valéria LT, André LF. Effect of diterpenes isolated of the marine Alga Canistrocarpus cervicornis against some toxic effects of the venom of the Bothrops jararaca snake. Molecules 2015; 20: 3515-26.
    • (2015) Molecules , vol.20 , pp. 3515-3526
    • Thaisa, F.S.D.1    Magui, A.V.2    Diana, N.C.3    Eládio, F.S.4    Valéria, L.T.5    André, L.F.6
  • 180
    • 79958807631 scopus 로고    scopus 로고
    • Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom
    • Domingos, TFS, Vallim MA, Carvalho C, et al. Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom. Rev Bras Farmacogn 2011; 21: 234-8.
    • (2011) Rev Bras Farmacogn , vol.21 , pp. 234-238
    • Domingos, T.F.S.1    Vallim, M.A.2    Carvalho, C.3
  • 181
    • 33646513029 scopus 로고    scopus 로고
    • Daboia russellii and Naja kaouthia venom neutralization by lupeol acetate isolated from the root extract of Indian sarsaparilla Hemidesmus indicus R.Br
    • Chatterjee, I, Chakravarty AK, Gomes A. Daboia russellii and Naja kaouthia venom neutralization by lupeol acetate isolated from the root extract of Indian sarsaparilla Hemidesmus indicus R.Br. J Ethnopharmacol 2006; 106: 38-43.
    • (2006) J Ethnopharmacol , vol.106 , pp. 38-43
    • Chatterjee, I.1    Chakravarty, A.K.2    Gomes, A.3
  • 182
    • 85015662301 scopus 로고    scopus 로고
    • Isolation of phospholipase A2 inhibitor from Cryptolepis oblongifolia (Meins) Schltr
    • Saifullahi U, Ahmed A, Hajara I, Balarabe AS, October N. Isolation of phospholipase A2 inhibitor from Cryptolepis oblongifolia (Meins) Schltr. J Nat Sci Res 2014; 4: 63-7.
    • (2014) J Nat Sci Res , vol.4 , pp. 63-67
    • Saifullahi, U.1    Ahmed, A.2    Hajara, I.3    Balarabe, A.S.4    October, N.5
  • 183
    • 0022508741 scopus 로고
    • 1-Stearyl, 2-stearoylaminodeoxy phosphatidylcholine, a potent reversible inhibitor of phospholipase A2
    • Davidson FF, Hajdu J, Dennis EA. 1-Stearyl, 2-stearoylaminodeoxy phosphatidylcholine, a potent reversible inhibitor of phospholipase A2. Biochem. Biophys. Research Commu 1986; 137: 587-92.
    • (1986) Biochem. Biophys. Research Commu , vol.137 , pp. 587-592
    • Davidson, F.F.1    Hajdu, J.2    Dennis, E.A.3
  • 184
    • 0022545857 scopus 로고
    • Fluoro ketone phospholipid analogs: New inhibitors of phospholipase A2
    • Gelb MH. Fluoro ketone phospholipid analogs: new inhibitors of phospholipase A2. J Am Chem Soc 1986; 108: 3146-7.
    • (1986) J am Chem Soc , vol.108 , pp. 3146-3147
    • Gelb, M.H.1
  • 185
    • 45749122698 scopus 로고    scopus 로고
    • Inhibition of Ca2+-independent phospholipase A2 decreases prostate cancer cell growth by p53-dependent and independent mechanisms
    • Sun B, Zhang X, Talathi S, Cummings BS. Inhibition of Ca2+-independent phospholipase A2 decreases prostate cancer cell growth by p53-dependent and independent mechanisms. J Pharmacol Exp Ther 2008; 326: 59-68.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 59-68
    • Sun, B.1    Zhang, X.2    Talathi, S.3    Cummings, B.S.4
  • 186
    • 80052464802 scopus 로고    scopus 로고
    • 2 with paclitaxel is highly effective in blocking ovarian cancer development
    • 2 with paclitaxel is highly effective in blocking ovarian cancer development. Am J Pathol 2011; 179: 452-61.
    • (2011) Am J Pathol , vol.179 , pp. 452-461
    • Hui, L.1    Zhenwen, Z.2    Caryl, A.3
  • 187
    • 0028172301 scopus 로고
    • Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity
    • Tramposch, KM, Chilton FH, Stanely PL, et al. Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity. J Pharm Exp Ther 1994: 271: 852-9.
    • (1994) J Pharm Exp Ther , vol.271 , pp. 852-859
    • Tramposch, K.M.1    Chilton, F.H.2    Stanely, P.L.3
  • 188
    • 0028853452 scopus 로고
    • Mechanism of inhibition of human nonpancreatic secreted phospholipase A2 by the anti-inflammatory agent BMS-181162
    • Burke JR, Gregor KR, Tramposch KM. Mechanism of inhibition of human nonpancreatic secreted phospholipase A2 by the anti-inflammatory agent BMS-181162. J Biol Chem 1995; 270: 274-80.
    • (1995) J Biol Chem , vol.270 , pp. 274-280
    • Burke, J.R.1    Gregor, K.R.2    Tramposch, K.M.3
  • 189
    • 27944472180 scopus 로고    scopus 로고
    • Inhibitors of secretory phospholipase A2 group IIA
    • Reid RC. Inhibitors of secretory phospholipase A2 group IIA. Curr Med Chem 2005; 12: 3011-26.
    • (2005) Curr Med Chem , vol.12 , pp. 3011-3026
    • Reid, R.C.1
  • 190
    • 85015634098 scopus 로고    scopus 로고
    • Chengzhi Z. Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2. U.S. Patent 20,110,306,552
    • Tadimeti R, Chengzhi Z. Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2. U.S. Patent 20,110,306,552, December 15, 2011.
    • (2011) December , pp. 15
    • Tadimeti, R.1
  • 191
    • 85015651199 scopus 로고    scopus 로고
    • Chengzhi Z. Quinolone inhibitors of lipoprotein-associated phospholipase A2. U.S. Patent 20,110,136,861
    • Tadimeti R, Chengzhi Z. Quinolone inhibitors of lipoprotein-associated phospholipase A2. U.S. Patent 20,110,136,861, June 9, 2011.
    • (2011) June , pp. 9
    • Tadimeti, R.1
  • 192
    • 84907487577 scopus 로고    scopus 로고
    • Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo
    • Kokotos G, Feuerherm AJ, Barbayianni E, et al. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem 2014; 57: 7523-35.
    • (2014) J Med Chem , vol.57 , pp. 7523-7535
    • Kokotos, G.1    Feuerherm, A.J.2    Barbayianni, E.3
  • 193
    • 0029075934 scopus 로고
    • SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock
    • Marshall LA, Hall RH, Winkler JD, et al. SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock. J Pharmacol Exp Ther 1995; 274: 1254-62.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1254-1262
    • Marshall, L.A.1    Hall, R.H.2    Winkler, J.D.3
  • 194
    • 34247560277 scopus 로고    scopus 로고
    • Synthesis and evaluation of tricyclic dipyrido diazepinone derivatives as inhibitors of secretory phospholipase A2 with anti-inflammatory activity
    • Thimmegowda NR, Dharmappa, KK, Ananda KCS, et al. Synthesis and evaluation of tricyclic dipyrido diazepinone derivatives as inhibitors of secretory phospholipase A2 with anti-inflammatory activity. Curr Top Med Chem 2007; 7: 811-20.
    • (2007) Curr Top Med Chem , vol.7 , pp. 811-820
    • Thimmegowda, N.R.1    Dharmappa, K.K.2    Ananda, K.C.S.3
  • 195
    • 0028997717 scopus 로고
    • Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2
    • Schevitz RW, Bach NJ, Carlson DG, et al. Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat Struct Biol 1995; 2: 458-65.
    • (1995) Nat Struct Biol , vol.2 , pp. 458-465
    • Schevitz, R.W.1    Bach, N.J.2    Carlson, D.G.3
  • 196
    • 0037352612 scopus 로고    scopus 로고
    • Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure
    • Abraham E, Naum C, Bandi V, et al. Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure. Crit Care Med 2003; 31: 718-28.
    • (2003) Crit Care Med , vol.31 , pp. 718-728
    • Abraham, E.1    Naum, C.2    Bandi, V.3
  • 197
    • 15044357202 scopus 로고    scopus 로고
    • A randomized, dou-ble-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis
    • Bradley JD, Dmitrienko AA, Kivitz AJ et al. A randomized, dou-ble-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis. J Rheumatol 2005; 32: 417-23.
    • (2005) J Rheumatol , vol.32 , pp. 417-423
    • Bradley, J.D.1    Dmitrienko, A.A.2    Kivitz, A.J.3
  • 198
    • 85015619790 scopus 로고    scopus 로고
    • http://clinicaltrials.gov, Identifier: NCT00743925
  • 199
    • 84891142213 scopus 로고    scopus 로고
    • Varespladib and cardiovascular events in patients with an acute coronary syndrome: The VISTA-16 randomized clinical trial
    • Nicholls SJ, Kastelein JP, Schwartz GG, et al. Varespladib and cardiovascular events in patients with an acute coronary syndrome: The VISTA-16 randomized clinical trial. JAMA 2014; 311: 252-262.
    • (2014) JAMA , vol.311 , pp. 252-262
    • Nicholls, S.J.1    Kastelein, J.P.2    Schwartz, G.G.3
  • 200
    • 33947732957 scopus 로고    scopus 로고
    • Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha
    • Lee KL, Foley, MA, Chen, L, et al. Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem 2007; 50: 1380-400.
    • (2007) J Med Chem , vol.50 , pp. 1380-1400
    • Lee, K.L.1    Foley, M.A.2    Chen, L.3
  • 201
    • 45749141743 scopus 로고    scopus 로고
    • Indole cytosolic phospholipase A2 alpha inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl] amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib
    • McKew JC, Lee KL, Shen MW, et al. Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl] amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib. J Med Chem 2008; 51: 3388-413.
    • (2008) J Med Chem , vol.51 , pp. 3388-3413
    • McKew, J.C.1    Lee, K.L.2    Shen, M.W.3
  • 203
    • 84880499932 scopus 로고    scopus 로고
    • Cytosolic phospholipasea2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models
    • Thotala D, Craft JM, Ferraro DJ, et al. Cytosolic phospholipasea2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models. PLoS One 2013; 8: e69688.
    • (2013) Plos One , vol.8
    • Thotala, D.1    Craft, J.M.2    Ferraro, D.J.3
  • 204
    • 66449120349 scopus 로고    scopus 로고
    • Benzhydrylquinazolinedi-ones: Novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties
    • Kirincich SJ, Xiang J, Green N, et al. Benzhydrylquinazolinedi-ones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties. Bioorg Med Chem 2009; 17: 4383-405.
    • (2009) Bioorg Med Chem , vol.17 , pp. 4383-4405
    • Kirincich, S.J.1    Xiang, J.2    Green, N.3
  • 205
    • 84921457246 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors
    • Tomoo T, Nakatsuka T, Katayama T, et al. Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors. J Med Chem 2014; 57: 7244-62.
    • (2014) J Med Chem , vol.57 , pp. 7244-7262
    • Tomoo, T.1    Nakatsuka, T.2    Katayama, T.3
  • 206
    • 0034694360 scopus 로고    scopus 로고
    • N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
    • Boyd HF, Fell SC, Flynn ST, et al. N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett 2000; 10: 2557-61.
    • (2000) Bioorg Med Chem Lett , vol.10 , pp. 2557-2561
    • Boyd, H.F.1    Fell, S.C.2    Flynn, S.T.3
  • 207
    • 0037463766 scopus 로고    scopus 로고
    • The identification of clinical candidate SB-480848: A potent inhibitor of lipoprotein-associated phospholipase A2
    • Blackie JA, Bloomer JC, Brown MJ, et al. The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett 2003; 13: 1067-70.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1067-1070
    • Blackie, J.A.1    Bloomer, J.C.2    Brown, M.J.3
  • 208
    • 75849124774 scopus 로고    scopus 로고
    • Clinical trials. A Phase 2 Clinical Study to Investigate Effects of Darapladib in Subjects With Diabetic Macular Edema. Available from: http://ClinicalTrials.gov Identifier:NCT01506895
    • Clinical trials
  • 210
    • 84907007906 scopus 로고    scopus 로고
    • Effect of darapladib on major coronary events after an acute coronary syndrome The SOLID-TIMI 52 randomized clinical trial
    • O’Donoghue ML. Effect of darapladib on major coronary events after an acute coronary syndrome The SOLID-TIMI 52 randomized clinical trial. JAMA 2014; 312: 1006-15.
    • (2014) JAMA , vol.312 , pp. 1006-1015
    • O’Donoghue, M.L.1
  • 212
    • 84873723337 scopus 로고    scopus 로고
    • 2 inhibitors and the unexpected discovery of highly potent quaternary ammonium salts
    • 2 inhibitors and the unexpected discovery of highly potent quaternary ammonium salts. Bioorg Med Chem Lett 2013; 23: 1187-92.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 1187-1192
    • Kai, W.1    Wenwei, X.2    Yang, L.3
  • 214
    • 84929297951 scopus 로고    scopus 로고
    • Synthesis, molecular modeling, and biological evaluation of novel 1, 3-Diphenyl-2-propen-1-one based pyrazolines as anti-inflammatory agents
    • Syed NAB, Xin Z, Ibrahim J, Hai-Liang Z, Muhammad WA, Vijay HM. Synthesis, molecular modeling, and biological evaluation of novel 1, 3-Diphenyl-2-propen-1-one based pyrazolines as anti-inflammatory agents. Chem Biol Drug Des 2015; 85(6): 729-42.
    • (2015) Chem Biol Drug Des , vol.85 , Issue.6 , pp. 729-742
    • Syed, N.A.B.1    Xin, Z.2    Ibrahim, J.3    Hai-Liang, Z.4    Muhammad, W.A.5    Vijay, H.M.6
  • 216
    • 0007298594 scopus 로고
    • The action of cobra poison on the blood: A contribution to the study of passive immunity
    • Stephens JWW, John LWS, Myers W. The action of cobra poison on the blood: A contribution to the study of passive immunity. J Pathol Bacteriol 1898; 5 (3): 279-301
    • (1898) J Pathol Bacteriol , vol.5 , Issue.3 , pp. 279-301
    • Stephens, J.W.W.1    John, L.W.S.2    Myers, W.3
  • 217
    • 84873551946 scopus 로고    scopus 로고
    • 2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells
    • 2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells. Toxins 2013; 5(2): 203-23.
    • (2013) Toxins , vol.5 , Issue.2 , pp. 203-223
    • Mari, S.1    Heiki, V.2    Imbi, K.3
  • 218
    • 49449090767 scopus 로고    scopus 로고
    • Biochemistry and physiology of mammalian secreted phospholipases A2
    • Lambeau G, Gelb MH. Biochemistry and physiology of mammalian secreted phospholipases A2. Annu Rev Biochem 2008; 77: 495-520.
    • (2008) Annu Rev Biochem , vol.77 , pp. 495-520
    • Lambeau, G.1    Gelb, M.H.2
  • 219
    • 0034050455 scopus 로고    scopus 로고
    • Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    • Suzuki N, Ishizaki J, Yokota Y, et al. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. J Biol Chem 2000; 275: 5785-93.
    • (2000) J Biol Chem , vol.275 , pp. 5785-5793
    • Suzuki, N.1    Ishizaki, J.2    Yokota, Y.3
  • 220
    • 84878235675 scopus 로고    scopus 로고
    • PLA2G3 promotes mast cell maturation and function
    • Starkl P, Marichal T, Galli, SJ. PLA2G3 promotes mast cell maturation and function. Nat Immunol 2013; 14: 527-9.
    • (2013) Nat Immunol , vol.14 , pp. 527-529
    • Starkl, P.1    Marichal, T.2    Galli, S.J.3
  • 222
    • 0038532314 scopus 로고    scopus 로고
    • Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (Groups III and XII)
    • Murakami M, Masuda S, Shimbara S, et al. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII). J Biol Chem 2003; 278: 10657-67.
    • (2003) J Biol Chem , vol.278 , pp. 10657-10667
    • Murakami, M.1    Masuda, S.2    Shimbara, S.3
  • 223
    • 79251523149 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A₂ GXIIB
    • Guan M, Qu L, Tan W, Chen L, Wong, CW. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A₂ GXIIB. Hepatology 2011; 53: 458-66.
    • (2011) Hepatology , vol.53 , pp. 458-466
    • Guan, M.1    Qu, L.2    Tan, W.3    Chen, L.4    Wong, C.W.5
  • 224
    • 34249745247 scopus 로고    scopus 로고
    • Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts
    • Ghosh M, Loper R, Ghomashchi F, et al. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. J Biol Chem 2007; 282: 11676-86.
    • (2007) J Biol Chem , vol.282 , pp. 11676-11686
    • Ghosh, M.1    Loper, R.2    Ghomashchi, F.3
  • 226
    • 0034616106 scopus 로고    scopus 로고
    • The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A2
    • Mancuso DJ, Jenkins CM, Gross RW. The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A2. J Biol Chem 2000; 275: 9937-45.
    • (2000) J Biol Chem , vol.275 , pp. 9937-9945
    • Mancuso, D.J.1    Jenkins, C.M.2    Gross, R.W.3
  • 227
    • 53549093853 scopus 로고    scopus 로고
    • Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
    • Wilensky L, Shi Y, Mohler IER, et al. Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med 2008; 14: 1059-66.
    • (2008) Nat Med , vol.14 , pp. 1059-1066
    • Wilensky, L.1    Shi, Y.2    Mohler, I.E.R.3
  • 228
    • 59649089306 scopus 로고    scopus 로고
    • AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency
    • Jaworski K, Ahmadian M, Duncan RE, et al. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med 2009; 15: 159-68.
    • (2009) Nat Med , vol.15 , pp. 159-168
    • Jaworski, K.1    Ahmadian, M.2    Duncan, R.E.3
  • 229
    • 36248959287 scopus 로고    scopus 로고
    • Toll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signaling
    • Lee JG, Lee SH, Park DW, et al. Toll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signaling. Cell Signal 2008; 20(1): 105-11.
    • (2008) Cell Signal , vol.20 , Issue.1 , pp. 105-111
    • Lee, J.G.1    Lee, S.H.2    Park, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.