Effect of phospholipase A2 silencing on acute experimental pancreatitis

European Review for Medical and Pharmacological Sciences

Volumn 17, Issue 24, 2013, Pages 3279-3284

  Zhang, K J ^a   Zhang, D L ^a   Jiao, X L ^a   Dong, C ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Gene therapeuty; Pancreatitis; Phospholipase A2; siRNA

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LYSOPHOSPHATIDYLCHOLINE; MESSENGER RNA; PHOSPHOLIPASE A2; SMALL INTERFERING RNA; TAUROCHOLIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXPERIMENTAL PANCREATITIS; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NONHUMAN; PANCREAS DUCT; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ACUTE DISEASE; ANIMALS; CELL LINE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC THERAPY; GROUP II PHOSPHOLIPASES A2; INFLAMMATION MEDIATORS; PANCREAS; PANCREATITIS; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, MESSENGER; TAUROCHOLIC ACID; TIME FACTORS; TRANSFECTION;

EID: 84891751589     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. BEGER HG, RAU B, ISENMANN R. Prevention of severe change in acute pancreatitis: prediction and prevention. J Hepatobiliary Pancreat Surg 2001; 8: 140-147.
2. BEGER HG, ISENMANN R . Surgical management of necrotizing pancreatitis. Surg Clin North Am 2009; 79: 783-790.
3. ISENMANN R, RAU B, BEGER HG. Early severe acute pancreatitis: characteristics of a new subgroup. Pancreas 2001; 22: 274-278.
4. TSIOTOS GG, LUQUE-DE LEON E, SOREIDE JA, BANNON MP, ZIETLOW SP, BAERGA-VARELA Y, SARR M. Management of necrotizing pancreatitis by repeated operative necrosectomy using a zipper technique. Am J Surg 1998; 175: 91-98.
5. STEINBERG W, TENNER S. Acute pancreatitis. N Engl J Med 1994; 330: 1198-1210.
6. AUFENANGER J, BERTSCH T. Catalytic phospholipase A2 assays. In: Uhl W, Nevalainen TJ, Büchler MW, eds. Phospholipase A2-Basic and clinical aspects in inflammatory diseases. Progress in surgery. Basel, Karger, 1997; pp. 43-49.
7. GRÖNROOS JM, NEVALAINEN TJ. Increased concentrations of synovial-type phospholipase A2 in serum and pulmonary and renal complications in acute pancreatitis. Digestion 2002; 52: 232-236.
8. MAYER J, RAU B, GREWE M, SCHOENBERG MH, NEVALAINEN TJ, BEGER HG. Secretory phospholipase A2 in patients with infected pancreatic necroses in acute pancreatitis. Pancreas 2008; 17: 272-277.
9. HIETARANTA A, KEMPPAINEN E, PUOLAKKAINEN P, SAINIO V, HAAPIAINEN R, PEURAVUORI H, KIVILAAKSO E, NEVALAINEN T. Extracellular phospholipases A2 in relation to systemic inflammatory response syndrome (SIRS) and systemic complications in severe acute pancreatitis. Pancreas 1999; 18: 385-391.
10. TOMITA Y, KUWABARA K, FURUE S, TANAKA K, YAMADA K, UENO M, ONO T, MARUYAMA T, AJIKI T, ONOYAMA H, YAMAMOTO M, HORI Y. Effect of a selective inhibitor of secretory phospholipase A2, S-5920/LY315920Na, on experimental acute pancreatitis in rats. J Pharmacol Sci 2004; 96: 144-154.
11. BRADLEY SP, RASTELLINI C, DA COSTA MA, KOWALIK TF, BLOOMENTHAL AB, BROWN M, CICALESE L, BASADONNA GP, UKNIS ME. Gene silencing in the endocrine pancreas mediated by short-interfering RNA. Pancreas 2005; 31: 373-379.
12. UHL W, SCHRAG HJ, SCHMITTER N, AUFENANGER J, NEVALAINEN TJ, BÜCHLER MW. Experimental study of a novel phospholipase A2 inhibitor in acute pancreatitis. Br J Surg 2008; 85: 618-623.
13. BRADLEY EL III. A clinically based classification system of acute pancreatitis. Arch Surg 1993; 128: 586-590.
14. CHIARI H. Über die Selbstverdauung des menschlichen Pankreas. Z Heilk 1896; 17: 69-96.
15. ADLER G, KERN HF, SCHEELE GA. Experimental models and concepts of acute pancreatitis. In: Go VLW, Brooks FP, DiMagno EP, Gardner JD, Lebenthal E, Scheele GA, eds. The Exocrine Pancreas. Biology, pathophysiology, and diseases. New York: Raven Press, 2006; pp. 407-421.
16. KUDO I, MURAKAMI M, HARA S, INOUE K. Mammalian nonpancreatic phospholipase A. Biochim Biophys Acta 2003; 117: 217-231.
17. VADAS P, HAY JB. Involvement of circulating phospholipase A2 in the pathogenesis of the hemodynamic changes in endotoxin shock. Can J Physiol Pharmacol 1983; 61: 561-566.
18. BAUR M, SCHMID O, LANDAUER B. Role of phospholipase A in multiorgan failure with special reference to ARDS and acute renal failure (ARF). Klin Wochenschr 1989; 67: 196-202.
19. UHL W, BÜCHLER M, NEVALAINEN TJ, DELLER A, BEGER HG. Serum phospholipase A2 in patients with multiple injuries. J Trauma 2000; 30: 1285-1290.
20. BÜCHLER M, DELLER A, MALFERTHEINER P, KLEINE HO, UHL W. Serum phospholipase A2 in intensive care patients with peritonitis, multiple injury, and necrotizing pancreatitis. Klin Wochenschr 1989; 67: 217-221.
21. UHL W, BEGER HG, HOFFMAN G, HANISCH E, SCHILD A, WAYDHAS CH. A multicenter study of phospholipase A2 in patients in intensive care units. J Am Coll Surg 2007; 180: 323-331.
22. BÜCHLER M, MALFERTHEINER P, SCḦADLICH H, NEVALAINEN TJ, FRIESS H, BEGER HG. Role of phospholipase A2 in human acute pancreatitis. Gastroenterology 1989; 97: 1521-1526.
23. BIRD NC, GOODMAN AJ, JOHNSON AG . Phospholipase A2 activity in acute pancreatitis: an early guide to severity. Br J Surg 1989; 76: 731-732.
24. KORTESUO PT, NEVALAINEN TJ, BÜCHLER M, UHL W. Characterization of two phospholipases A2 in serum of patients with sepsis and acute pancreatitis. Eur J Clin Chem Clin Biochem 1992; 30: 263-269.
25. UHL W, SCHRAG HJ, SCHMITTER N, NEVALAINEN TJ, AUFENANGER J, WHEATLEY AM, BÜCHLER MW: Pathophysiological role of secretory type I and II phospholipase A2 in acute pancreatitis: an experimental study in rats.Gut 2007; 40: 386-392.
26. NEVALAINEN TJ, GRÖNROOS JM, KORTESUO PT. Pancreatic and synovial type phospholipase A2 in serum samples from patients with severe acute pancreatitis. Gut 1993; 34: 1133-1136.
27. YOSHIKAWA T, NARUSE S, KITAGAWA M, ISHIGURO H, NAKAE Y, ONO T, HAYAKAWA T. Effect of a new inhibitor of type II phospholipase A2 on experimental acute pancreatitis in rats. Pancreas 1999; 19: 193-198.
28. MASAMUNE A, SAKAI Y, YOSHIDA M, SATOH A, SATOH K, SHIMOSEGAWA T. Lysophosphatidylcholine activates transcription factor NF-kappaB and AP-1 in AR42J cells. Dig Dis Sci 2001; 46: 1871-1881.