TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 13437-13449

  Gong, Ping ^a,b   Angelini, Daniel J ^a,b   Yang, Shiqi ^a,b   Xia, Guanjun ^a   Cross, Alan S ^a   Mann, Dean ^b   Bannerman, Douglas D ^c   Vogel, Stefanie N ^b   Goldblum, Simeon E ^a,b  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIOLOGY; BIOLOGICAL ORGANS; CHEMICAL ACTIVATION; CHEMICAL REACTIONS; COMPUTER MONITORS; ENDOTHELIAL CELLS; NUCLEIC ACIDS; POLYSACCHARIDES; PROTEINS; RNA; SELF ASSEMBLY;

BACTERIAL INFECTIONS; BROAD SPECTRUMS; CADHERIN; CATENIN; HUMAN LUNGS; INTRACELLULAR COMPARTMENTS; KINASE ACTIVATIONS; LIPOPOLYSACCHARIDE; MICROVASCULAR ENDOTHELIAL CELLS; MICROVASCULAR ENDOTHELIUM; PARACELLULAR PERMEABILITIES; PROTEIN LEVELS; PROTEIN TYROSINE PHOSPHORYLATIONS; SELECTIVE INHIBITORS; SMALL INTERFERING RNAS; SRC FAMILIES; TYROSINE KINASES; TYROSINE PHOSPHORYLATIONS; VASCULAR ENDOTHELIUM;

PHOSPHORYLATION;

BACTERIUM LIPOPOLYSACCHARIDE; BOVINE SERUM ALBUMIN; CARBON 14; COMPLEMENTARY DNA; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GELDANAMYCIN; HERBIMYCIN A; MESSENGER RNA; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; TYROSINE; LIPOPOLYSACCHARIDE; PHOSPHOTYROSINE; TLR4 PROTEIN, HUMAN;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE EXPRESSION; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; LUNG BLOOD VESSEL; MICROVASCULATURE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SIGNAL TRANSDUCTION; VASCULAR DISEASE; VASCULAR LEAK SYNDROME; ANIMAL; CATTLE; CELL CULTURE; CELL JUNCTION; DRUG EFFECT; ENZYME SPECIFICITY; GENETICS; LUNG; METABOLISM; MICROCIRCULATION; VASCULARIZATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

ADHERENS JUNCTIONS; ANIMALS; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; LIPOPOLYSACCHARIDES; LUNG; MICROCIRCULATION; PHOSPHOTYROSINE; RNA, SMALL INTERFERING; SERUM ALBUMIN, BOVINE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTOR 4;

EID: 45149123112     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707986200     Document Type: Article

References (91)

1. Martin, G. S., Mannino, D. M., Eaton, S., and Moss, M. (2003) N. Engl. J. Med. 348, 1546-1554
2. Bone, R. C. (1993) Clin. Microbiol. Rev. 6, 57-68
3. Ulevitch, R. J., Cochrane, C. G., Henson, P. M., Morrison, D. C., and Doe, W. F. (1975) J. Exp. Med. 142, 1570-1590
4. Brigham, K. L., and Meyrick, B. (1986) Am. Rev. Respir. Dis. 133, 913-927
5. Brandtzaeg, P., Kierulf, P., Gaustad, P., Skulberg, A., Bruun, J. N., Halvorsen, S., and Sorensen, E. (1989) J. Infect. Dis. 159, 195-204
6. Bannerman, D. D., Fitzpatrick, M. J., Anderson, D. Y., Bhattacharjee, A. K., Novitsky, T. J., Hasday, J. D., Cross, A. S., and Goldblum, S. E. (1998) Infect. Immun. 66, 1400-1407
7. Cross, A. (1996) Shock 6, Suppl. 1, 71-74
8. Dauphinee, S. M., and Karsan, A. (2006) Lab. Invest. 86, 9-22
9. Volk, T., and Kox, W. J. (2000) Inflamm. Res. 49, 185-198
10. Angelini, D. J., Hyun, S. W., Grigoryev, D. N., Garg, P., Gong, P., Singh, I. S., Passaniti, A., Hasday, J. D., and Goldblum, S. E. (2006) Am. J. Physiol. 291, L1232-L1245
11. Bannerman, D. D., and Goldblum, S. E. (1997) Am. J. Physiol. 273, L217-L226
12. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B. (1998) Science 282, 2085-2088
13. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., and Akira, S. (1999) J. Immunol. 162, 3749-3752
14. Andreakos, E., Sacre, S. M., Smith, C., Lundberg, A., Kiriakidis, S., Stonehouse, T., Monaco, C., Feldmann, M., and Foxwell, B. M. (2004) Blood 103, 2229-2237
15. Dunzendorfer, S., Lee, H. K., Soldau, K., and Tobias, P. S. (2004) FASEB J. 18, 1117-1119
16. Zhang, F. X., Kirschning, C. J., Mancinelli, R., Xu, X. P., Jin, Y., Faure, E., Mantovani, A., Rothe, M., Muzio, M., and Arditi, M. (1999) J. Biol. Chem. 274, 7611-7614
17. Faure, E., Equils, O., Sieling, P. A., Thomas, L., Zhang, F. X., Kirschning, C. J., Polentarutti, N., Muzio, M., and Arditi, M. (2000) J. Biol. Chem. 275, 11058-11063
18. Spitzer, J. H., Visintin, A., Mazzoni, A., Kennedy, M. N., and Segal, D. M. (2002) Eur. J. Immunol. 32, 1182-1187
19. Dunzendorfer, S., Lee, H. K., Soldau, K., and Tobias, P. S. (2004) J. Immunol. 173, 1166-1170
20. Guillot, L., Medjane, S., Le-Barillec, K., Balloy, V., Danel, C., Chignard, M., and Si-Tahar, M. (2004) J. Biol. Chem. 279, 2712-2718
21. Hornef, M. W., Frisan, T., Vandewalle, A., Normark, S., and Richter-Dahlfors, A. (2002) J. Exp. Med. 195, 559-570
22. Frey, E. A., Miller, D. S., Jahr, T. G., Sundan, A., Bazil, V., Espevik, T., Finlay, B. B., and Wright, S. D. (1992) J. Exp. Med. 176, 1665-1671
23. Beekhuizen, H., Blokland, I., Corsel-van Tilburg, A. J., Koning, F., and van Furth, R. (1991) J. Immunol. 147, 3761-3767
24. Jersmann, H. P., Hii, C. S., Hodge, G. L., and Ferrante, A. (2001) Infect. Immun. 69, 479-485
25. von Asmuth, E. J., Dentener, M. A., Bazil, V., Bouma, M. G., Leeuwenberg, J. F., and Buurman, W. A. (1993) Immunology 80, 78-83
26. Goldblum, S. E., Ding, X., Brann, T. W., and Campbell-Washington, J. (1993) J. Cell. Physiol. 157, 13-23
27. Horwood, N. J., Mahon, T., McDaid, J. P., Campbell, J., Mano, H., Brennan, F. M., Webster, D., and Foxwell, B. M. (2003) J. Exp. Med. 197, 1603-1611
28. Jefferies, C. A., Doyle, S., Brunner, C., Dunne, A., Brint, E., Wietek, C., Walch, E., Wirth, T., and O'Neill, L. A. (2003) J. Biol. Chem. 278, 26258-26264
29. Napolitani, G., Bortoletto, N., Racioppi, L., Lanzavecchia, A., and D'Oro, U. (2003) Eur. J. Immunol. 33, 2832-2841
30. Henricson, B. E., Carboni, J. M., Burkhardt, A. L., and Vogel, S. N. (1995) Mol Med 1, 428-435
31. Hazeki, K., Masuda, N., Funami, K., Sukenobu, N., Matsumoto, M., Akira, S., Takeda, K., Seya, T., and Hazeki, O. (2003) Eur. J. Immunol. 33, 740-747
32. Hamajima, Y., Fujieda, S., Sunaga, H., Yamada, T., Moribe, K., Watanabe, N., and Murakami, S. (2007) Auris Nasus Larynx 34, 49-56
33. Zhou, Y. Q., Chen, Y. Q., Fisher, J. H., and Wang, M. H. (2002) J. Biol. Chem. 277, 38104-38110
34. Lidington, D., Tyml, K., and Ouellette, Y. (2002) J. Cell Physiol. 193, 373-379
35. Shen, Y., Sultana, C., Arditi, M., Kim, K. S., and Kalra, V. K. (1998) Am. J. Physiol. 275, E479-E486
36. Andriopoulou, P., Navarro, P., Zanetti, A., Lampugnani, M. G., and Dejana, E. (1999) Arterioscler. Thromb. Vasc. Biol. 19, 2286-2297
37. Goldblum, S. E., Young, B. A., Wang, P., and Murphy-Ullrich, J. E. (1999) Mol. Biol. Cell 10, 1537-1551
38. Young, B. A., Wang, P., and Goldblum, S. E. (1998) Biochem. Biophys. Res. Commun. 251, 320-327
39. Esser, S., Lampugnani, M. G., Corada, M., Dejana, E., and Risau, W. (1998) J. Cell Sci. 111, 1853-1865
40. Dejana, E., Corada, M., and Lampugnani, M. G. (1995) FASEB J. 9, 910-918
41. Lampugnani, M. G., and Dejana, E. (1997) Curr. Opin. Cell Biol. 9, 674-682
42. McIntire, F. C., Sievert, H. W., Barlow, G. H., Finley, R. A., and Lee, A. Y. (1967) Biochemistry 6, 2363-2372
43. Sui, X. F., Kiser, T. D., Hyun, S. W., Angelini, D. J., Del Vecchio, R. L., Young, B. A., Hasday, J. D., Romer, L. H., Passaniti, A., Tonks, N. K., and Goldblum, S. E. (2005) Am. J. Pathol. 166, 1247-1258
44. Bannerman, D. D., and Goldblum, S. E. (1999) Lab. Invest. 79, 1181-1199
45. Dobrovolskaia, M. A., Medvedev, A. E., Thomas, K. E., Cuesta, N., Toshchakov, V., Ren, T., Cody, M. J., Michalek, S. M., Rice, N. R., and Vogel, S. N. (2003) J. Immunol. 170, 508-519
46. Martin, G. S. (2001) Nat. Rev. Mol. Cell Biol. 2, 467-475
47. Boggon, T. J., and Eck, M. J. (2004) Oncogene 23, 7918-7927
48. Bull, H. A., Brickell, P. M., and Dowd, P. M. (1994) FEBS Lett. 351, 41-44
49. Achen, M. G., Clauss, M., Schnurch, H., and Risau, W. (1995) Differentiation 59, 15-24
50. Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., and Connelly, P. A. (1996) J. Biol. Chem. 271, 695-701
51. Blake, R. A., Broome, M. A., Liu, X., Wu, J., Gishizky, M., Sun, L., and Courtneidge, S. A. (2000) Mol. Cell Biol. 20, 9018-9027
52. Scheifele, D. W., Olsen, E. M., and Pendray, M. R. (1985) Am. J. Clin. Pathol. 83, 227-229
53. Stief, T. W., Ijagha, O., Weiste, B., Herzum, I., Renz, H., and Max, M. (2007) Blood Coagul. Fibrinolysis 18, 179-186
54. Feingold, K. R., Funk, J. L., Moser, A. H., Shigenaga, J. K., Rapp, J. H., and Grunfeld, C. (1995) Infect. Immun. 63, 2041-2046
55. Gegner, J. A., Ulevitch, R. J., and Tobias, P. S. (1995) J. Biol. Chem. 270, 5320-5325
56. Prins, J. M., van Agtmael, M. A., Kuijper, E. J., van Deventer, S. J., and Speelman, P. (1995) J. Infect. Dis. 172, 886-891
57. Dofferhoff, A. S., Nijland, J. H., de Vries-Hospers, H. G., Mulder, P. O., Weits, J., and Bom, V. J. (1991) Scand. J. Infect. Dis. 23, 745-754
58. Paludan, S. R. (2000) J. Leukocyte Biol. 67, 18-25
59. Chaouat, G. (1994) Cell Immunol. 157, 328-340
60. Geller, D. A., Nussler, A. K., Di Silvio, M., Lowenstein, C. J., Shapiro, R. A., Wang, S. C., Simmons, R. L., and Billiar, T. R. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 522-526
61. Wu, N. Z., and Baldwin, A. L. (1992) Am. J. Physiol. 262, H1238-H1247
62. Coughlin, S. R. (2000) Nature 407, 258-264
63. Adamson, R. H., Zeng, M., Adamson, G. N., Lenz, J. F., and Curry, F. E. (2003) Am. J. Physiol. 285, H406-H417
64. Puhlmann, M., Weinreich, D. M., Farma, J. M., Carroll, N. M., Turner, E. M., and Alexander, H. R., Jr. (2005) J. Transl. Med. 3, 37
65. Andonegui, G., Bonder, C. S., Green, F., Mullaly, S. C., Zbytnuik, L., Raharjo, E., and Kubes, P. (2003) J. Clin. Invest. 111, 1011-1020
66. Medvedev, A. E., Piao, W., Shoenfelt, J., Rhee, S. H., Chen, H., Basu, S., Wahl, L. M., Fenton, M. J., and Vogel, S. N. (2007) J. Biol. Chem. 282, 16042-16053
67. Johnsen, I. B., Nguyen, T. T., Ringdal, M., Tryggestad, A. M., Bakke, O., Lien, E., Espevik, T., and Anthonsen, M. W. (2006) EMBO J. 25, 3335-3346
68. Wang, K. Z., Wara-Aswapati, N., Boch, J. A., Yoshida, Y., Hu, C. D., Galson, D. L., and Auron, P. E. (2006) J. Cell Sci. 119, 1579-1591
69. Funakoshi-Tago, M., Tago, K., Sonoda, Y., Tominaga, S., and Kasahara, T. (2003) Eur. J. Biochem. 270, 1257-1268
70. Mukundan, L., Milhorn, D. M., Matta, B., and Suttles, J. (2004) Cell. Signal. 16, 375-384
71. Shao, M. X., Ueki, I. F., and Nadel, J. A. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11618-11623
72. Kang, J. L., Lee, H. W., Lee, H. S., Pack, I. S., Chong, Y., Castranova, V., and Koh, Y. (2001) Am. J. Respir. Crit. Care Med. 164, 2206-2212
73. Ruetten, H., and Thiemermann, C. (1997) Br. J. Pharmacol. 122, 59-70
74. Schmitz, G., and Orso, E. (2002) Curr. Opin. Lipidol. 13, 513-521
75. Kang, J. L., Lee, H. W., Kim, H. J., Lee, H. S., Castranova, V., Lim, C. M., and Koh, Y. (2005) J. Toxicol. Environ. Health A 68, 1643-1662
76. Kox, M., Wijetunge, S., Pickkers, P., and Hughes, A. D. (2007) Vascul. Pharmacol. 46, 195-200
77. Paul, R., Zhang, Z. G., Eliceiri, B. P., Jiang, Q., Boccia, A. D., Zhang, R. L., Chopp, M., and Cheresh, D. A. (2001) Nat. Med. 7, 222-227
78. Castano, J., Solanas, G., Casagolda, D., Raurell, I., Villagrasa, P., Bustelo, X. R., Garcia de Herreros, A., and Dunach, M. (2007) Mol. Cell. Biol. 27, 1745-1757
79. Severgnini, M., Takahashi, S., Tu, P., Perides, G., Homer, R. J., Jhung, J. W., Bhavsar, D., Cochran, B. H., and Simon, A. R. (2005) Am. J. Respir. Crit. Care Med. 171, 858-867
80. Eliceiri, B. P., Paul, R., Schwartzberg, P. L., Hood, J. D., Leng, J., and Cheresh, D. A. (1999) Mol. Cell 4, 915-924
81. Piedra, J., Miravet, S., Castano, J., Palmer, H. G., Heisterkamp, N., Garcia de Herreros, A., and Dunach, M. (2003) Mol. Cell Biol. 23, 2287-2297
82. Loo, L. W., Kanemitsu, M. Y., and Lau, A. F. (1999) Mol. Carcinog. 25, 187-195
83. Kanemitsu, M. Y., Loo, L. W., Simon, S., Lau, A. F., and Eckhart, W. (1997) J. Biol. Chem. 272, 22824-22831
84. Lu, T. T., Barreuther, M., Davis, S., and Madri, J. A. (1997) J. Biol. Chem. 272, 14442-14446
85. Wallez, Y., Cand, F., Cruzalegui, F., Wernstedt, C., Souchelnytskyi, S., Vilgrain, I., and Huber, P. (2007) Oncogene 26, 1067-1077
86. Lilien, J., Balsamo, J., Arregui, C., and Xu, G. (2002) Dev. Dyn. 224, 18-29
87. Reynolds, A. B., Daniel, J., McCrea, P. D., Wheelock, M. J., Wu, J., and Zhang, Z. (1994) Mol. Cell Biol. 14, 8333-8342
88. Alema, S., and Salvatore, A. M. (2007) Biochim. Biophys. Acta. 1773, 47-58
89. Anastasiadis, P. Z., and Reynolds, A. B. (2000) J. Cell Sci. 113, 1319-1334
90. Lampugnani, M. G., Corada, M., Andriopoulou, P., Esser, S., Risau, W., and Dejana, E. (1997) J. Cell Sci. 110, 2065-2077
91. Lowell, C. A., and Soriano, P. (1996) Genes Dev. 10, 1845-1857