Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4383-4405

  Kirincich, Steven J ^a   Xiang, Jason ^a   Green, Neal ^a   Tam, Steve ^a   Yang, Hui Y ^a   Shim, Jaechul ^a   Shen, Marina W H ^a   Clark, James D ^a   McKew, John C ^a  

^a PFIZER INC   (United States)

Author keywords

Arachidonic acid; Inflammation; Inhibitor; Phospholipase

Indexed keywords

4 [[4 [3 (DIPHENYLMETHYL) 7 (METHYLSULFONYL) 2,4 DIOXO 3,4 DIHYDROQUINAZOLIN 1(2H) YL]BUT 2 EN 1 YL]OXY]BENZOIC ACID; ARACHIDONIC ACID; BENZHYDRYL DERIVATIVE; CYTOSOLIC PHOSPHOLIPASE A2; CYTOSOLIC PHOSPHOLIPASE A2ALPHA; LEUKOTRIENE B4; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN F2 ALPHA; QUINAZOLINE DERIVATIVE; TERT BUTYL 4 [[4 [3 (DIPHENYLMETHYL) 2,4 DIOXO 7 (1H 1,2,4 TRIAZOL 1 YL) 3,4 DIHYDROQUINAZOLIN 1(2H) YL]BUT 2 EN 1 YL]OXY]BENZOATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; LIPOPHILICITY; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; RAT; SOLUBILITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARACHIDONIC ACID; BENZHYDRYL COMPOUNDS; BLOOD; CELL LINE; GROUP IV PHOSPHOLIPASES A2; HUMANS; QUINAZOLINONES; RATS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66449120349     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.027     Document Type: Article

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