The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 Å resolution provides an insight into the catalytic mechanism

Biochemistry

Volumn 41, Issue 52, 2002, Pages 15468-15476

  Edwards, Suzanne H ^a   Thompson, Darren ^a   Baker, Sharon F ^a   Wood, Stephen P ^a   Wilton, David C ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL ACTIVITIES;

CATALYSIS; CONTAMINATION; CRYSTALLIZATION; ENZYMES; HYDROGEN BONDS; INTERFACES (MATERIALS); PHOSPHOLIPIDS;

CRYSTAL STRUCTURE;

ACUTE PHASE PROTEIN; CALCIUM ION; GLUTAMINE; HISTIDINE; PHOSPHOLIPASE A2;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; HYDROGEN BOND; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; SIGNAL TRANSDUCTION;

ANIONS; ASPARAGINE; BINDING SITES; CATALYSIS; CATIONS, DIVALENT; CELL MEMBRANE; COBALT; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; GLUTAMINE; HISTIDINE; HUMANS; HYDROLYSIS; MICROCOCCUS LUTEUS; MUTAGENESIS, SITE-DIRECTED; NICKEL; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPASES A; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

APOIDEA; BOVINAE;

EID: 0037207142     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020485z     Document Type: Article

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