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Volumn 41, Issue 36, 2002, Pages 10914-10919
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Structural basis of phospholipase A2 inhibition for the synthesis of prostaglandins by the plant alkaloid aristolochic acid from a 1.7 Å crystal structure
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Author keywords
[No Author keywords available]
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Indexed keywords
BINDING SITES;
DIMERS;
ENZYMES;
HYDROGEN BONDS;
HYDROPHOBICITY;
ORGANIC ACIDS;
PLANTS (BOTANY);
CRYSTAL STRUCTURE;
ALKALOID;
ARACHIDONIC ACID;
ARISTOLOCHIC ACID;
ASPARTIC ACID;
CALCIUM;
DIMER;
HISTAMINE;
HYDROGEN;
PHOSPHOLIPASE A2;
PROSTAGLANDIN;
ARTICLE;
BINDING AFFINITY;
BINDING SITE;
CALCIUM BINDING;
CARBOXY TERMINAL SEQUENCE;
COMPLEX FORMATION;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
CRYSTALLOGRAPHY;
DIMERIZATION;
ENZYME BINDING;
ENZYME INHIBITION;
ENZYME STRUCTURE;
HYDROGEN BOND;
HYDROPHOBICITY;
NONHUMAN;
PLANT;
PRIORITY JOURNAL;
PROSTAGLANDIN SYNTHESIS;
PROTEIN CONFORMATION;
PROTEIN INTERACTION;
SNAKE;
SYNTHESIS;
ANIMALS;
ARISTOLOCHIA;
ARISTOLOCHIC ACIDS;
BINDING, COMPETITIVE;
CRYSTALLIZATION;
CRYSTALLOGRAPHY, X-RAY;
ENZYME INHIBITORS;
MODELS, MOLECULAR;
PHENANTHRENES;
PHOSPHOLIPASES A;
PROSTAGLANDINS;
PROTEIN CONFORMATION;
RUSSELL'S VIPER;
STRUCTURE-ACTIVITY RELATIONSHIP;
VIPER VENOMS;
SERPENTES;
VIPERA;
VIPERA RUSSELLI;
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EID: 0036714237
PISSN: 00062960
EISSN: None
Source Type: Journal
DOI: 10.1021/bi0258593 Document Type: Article |
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Times cited : (76)
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References (26)
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