Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α

Journal of Medicinal Chemistry

Volumn 50, Issue 6, 2007, Pages 1380-1400

  Lee, Katherine L ^a   Foley, Megan A ^a   Chen, Lihren ^a   Behnke, Mark L ^a   Lovering, Frank E ^a   Kirincich, Steven J ^a   Wang, Weiheng ^a   Shim, Jaechul ^b   Tam, Steve ^a   Shen, Marina W H ^a   Khor, SooPeang ^c   Xu, Xin ^c   Goodwin, Debra G ^a   Ramarao, Manjunath K ^a   Nickerson Nutter, Cheryl ^a   Donahue, Frances ^d   Ku, M Sherry ^d   Clark, James D ^a   McKew, John C ^a  

^a PFIZER INC   (United States)

^b Chemical Sciences   (United States)

^c Drug Safety and Metabolism   (United States)

^d Chemical and Pharmaceutical Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; ECOPLADIB; INDOLE DERIVATIVE; NAPROXEN; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE A2ALPHA; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BOLUS INJECTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG INDICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MICELLE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PAIN; PAW EDEMA; RAT; RHEUMATOID ARTHRITIS; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOIC ACIDS; CARRAGEENAN; CYTOSOL; EDEMA; HUMANS; INDOLES; MALE; PHOSPHOLIPASES A; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33947732957     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061131z     Document Type: Article

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