N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 22, 2000, Pages 2557-2561

  Boyd, Helen F ^a   Fell, Stephen C M ^a   Flynn, Sean T ^a   Hickey, Deirdre M B ^a   Ife, Robert J ^a   Leach, Colin A ^a   Macphee, Colin H ^a   Milliner, Kevin J ^a   Moores, Kitty E ^a   Pinto, Ivan L ^a   Porter, Rod A ^a   Rawlings, D Anthony ^a   Smith, Stephen A ^a   Stansfield, Ian G ^a   Tew, David G ^a   Theobald, Colin J ^a   Whittaker, Caroline M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PYRIMIDINONE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0034694360     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00510-2     Document Type: Article

References (11)