-
3
-
-
33644797510
-
Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2
-
Cicenas J, Urban P, Vuaroqueaux V, et al. Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. Breast Cancer Res 2005;7:R394-401.
-
(2005)
Breast Cancer Res
, vol.7
, pp. R394-401
-
-
Cicenas, J.1
Urban, P.2
Vuaroqueaux, V.3
-
4
-
-
44149115749
-
The potential role of Akt phosphorylation in human cancers
-
Cicenas J. The potential role of Akt phosphorylation in human cancers. Int J Biol Markers 2008;23:1-9.
-
(2008)
Int J Biol Markers
, vol.23
, pp. 1-9
-
-
Cicenas, J.1
-
5
-
-
34447266678
-
The potential role of EGFR/ErbB2 heterodimer in breast cancer
-
Cicenas J. The potential role of EGFR/ErbB2 heterodimer in breast cancer. Expert opinion Ther Patents 2007;17:607-16.
-
(2007)
Expert opinion Ther Patents
, vol.17
, pp. 607-616
-
-
Cicenas, J.1
-
6
-
-
0842305848
-
Phosphorylation, but not overexpression, of epidermal growth factor receptor is associated with poor prognosis of non-small cell lung cancer patients
-
Kanematsu T, Yano S, Uehara H, et al. Phosphorylation, but not overexpression, of epidermal growth factor receptor is associated with poor prognosis of non-small cell lung cancer patients. Oncol Res 2003;13:289-98.
-
(2003)
Oncol Res
, vol.13
, pp. 289-298
-
-
Kanematsu, T.1
Yano, S.2
Uehara, H.3
-
7
-
-
33644750227
-
Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients
-
Cicenas J, Urban P, Küng W, et al. Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients. Eur J Cancer 2006;42:636-45.
-
(2006)
Eur J Cancer
, vol.42
, pp. 636-645
-
-
Cicenas, J.1
Urban, P.2
Küng, W.3
-
8
-
-
0035253499
-
Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay
-
Eppenberger-Castori S, KuengW, Benz C, et al. Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay. J Clin Oncol 2001;19:645-56.
-
(2001)
J Clin Oncol
, vol.19
, pp. 645-656
-
-
Eppenberger-Castori, S.1
Kueng, W.2
Benz, C.3
-
9
-
-
14544277088
-
Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients
-
DiGiovanna MP, Stern DF, Edgerton SM, et al. Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients. J Clin Oncol 2005;23:1152-60.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1152-1160
-
-
DiGiovanna, M.P.1
Stern, D.F.2
Edgerton, S.M.3
-
10
-
-
79952122324
-
Increased level of phosphorylated ShcA measured by chemiluminescence-linked immunoassay is a predictor of good prognosis in primary breast cancer expressing low levels of estrogen receptor
-
Cicenas J, Küng W, Eppenberger U, et al. Increased level of phosphorylated ShcA measured by chemiluminescence-linked immunoassay is a predictor of good prognosis in primary breast cancer expressing low levels of estrogen receptor. Cancers 2010;2:153-64.
-
(2010)
Cancers
, vol.2
, pp. 153-164
-
-
Cicenas, J.1
Küng, W.2
Eppenberger, U.3
-
11
-
-
34247524653
-
Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome
-
Derenzini M, Montanaro L, Vici M, et al. Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome. Histol Histopathol 2007;22:505-13.
-
(2007)
Histol Histopathol
, vol.22
, pp. 505-513
-
-
Derenzini, M.1
Montanaro, L.2
Vici, M.3
-
13
-
-
17044391003
-
Inhibition of the cell cycle with chemical inhibitors: a targeted approach
-
Welburn JP, Endicott JA. Inhibition of the cell cycle with chemical inhibitors: a targeted approach. Semin Cell Dev Biol 2005;16:369-81.
-
(2005)
Semin Cell Dev Biol
, vol.16
, pp. 369-381
-
-
Welburn, J.P.1
Endicott, J.A.2
-
14
-
-
80054752304
-
The CDK inhibitors in cancer research and therapy
-
Cicenas J, Valius M. The CDK inhibitors in cancer research and therapy. J Cancer Res Clin Oncol 2011;137:1409-18.
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 1409-1418
-
-
Cicenas, J.1
Valius, M.2
-
15
-
-
84919780318
-
Highlights of the Latest Advances in Research on CDK Inhibitors
-
Cicenas J, Kalyan K, Sorokinas A, et al. Highlights of the Latest Advances in Research on CDK Inhibitors. Cancers 2014;6:2224-42.
-
(2014)
Cancers
, vol.6
, pp. 2224-2242
-
-
Cicenas, J.1
Kalyan, K.2
Sorokinas, A.3
-
16
-
-
84887622751
-
Targeting cyclin-dependent kinases in anti-neoplastic therapy
-
Bruyère C, Meijer L. Targeting cyclin-dependent kinases in anti-neoplastic therapy. Curr Opin Cell Biol 2013;25:772-9.
-
(2013)
Curr Opin Cell Biol
, vol.25
, pp. 772-779
-
-
Bruyère, C.1
Meijer, L.2
-
17
-
-
67650073265
-
Cell cycle kinases as therapeutic targets for cancer
-
Lapenna S, Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov 2009;8:547-66.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 547-566
-
-
Lapenna, S.1
Giordano, A.2
-
18
-
-
84903843882
-
Molecular pathways: CDK4 inhibitors for cancer therapy
-
Dickson MA. Molecular pathways: CDK4 inhibitors for cancer therapy. Clin Cancer Res 2014;20:3379-83.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 3379-3383
-
-
Dickson, M.A.1
-
19
-
-
0031028163
-
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine
-
Azevedo WF, Leclerc S, Meijer L, et al. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem 1997;243:518-26.
-
(1997)
Eur J Biochem
, vol.243
, pp. 518-526
-
-
Azevedo, W.F.1
Leclerc, S.2
Meijer, L.3
-
20
-
-
0031037714
-
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
-
Meijer L, Borgne A, Mulner O, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 1997;243:527-36.
-
(1997)
Eur J Biochem
, vol.243
, pp. 527-536
-
-
Meijer, L.1
Borgne, A.2
Mulner, O.3
-
21
-
-
0036310685
-
Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins
-
Schang LM, Bantly A, Knockaert M, et al. Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. J Virol 2002:76:7874-82.
-
(2002)
J Virol
, vol.76
, pp. 7874-7882
-
-
Schang, L.M.1
Bantly, A.2
Knockaert, M.3
-
22
-
-
0037392942
-
The specificities of protein kinase inhibitors: an update
-
Bain J, McLauchlan H, Elliott M, at al. The specificities of protein kinase inhibitors: an update. Biochem J 2003;371:199-204.
-
(2003)
Biochem J
, vol.371
, pp. 199-204
-
-
Bain, J.1
McLauchlan, H.2
Elliott, M.3
-
23
-
-
24744437350
-
Roscovitine targets: protein kinases and pyridoxal kinase
-
Bach S, Knockaert M, Lozach O, et al. Roscovitine targets: protein kinases and pyridoxal kinase. J Biol Chem 2005;280:31208-19.
-
(2005)
J Biol Chem
, vol.280
, pp. 31208-31219
-
-
Bach, S.1
Knockaert, M.2
Lozach, O.3
-
24
-
-
13444253813
-
Mechanism of CDK5/p25 binding by CDK inhibitors
-
Mapelli M, Massimiliano L, Crovace C, et al. Mechanism of CDK5/p25 binding by CDK inhibitors. J Med Chem 2005;48:671-9.
-
(2005)
J Med Chem
, vol.48
, pp. 671-679
-
-
Mapelli, M.1
Massimiliano, L.2
Crovace, C.3
-
25
-
-
24744461692
-
Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives
-
Tang L, Li MH, Cao P, et al. Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem 2005;280:31220-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 31220-31229
-
-
Tang, L.1
Li, M.H.2
Cao, P.3
-
26
-
-
27644591251
-
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202
-
Raynaud FI, Whittaker SR, Fischer PM, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res 2005;11:4875-87.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4875-4887
-
-
Raynaud, F.I.1
Whittaker, S.R.2
Fischer, P.M.3
-
27
-
-
1642494839
-
The cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway
-
Whittaker SR, Walton MI, Garrett MD, et al. The cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Res 2004;64:262-72.
-
(2004)
Cancer Res
, vol.64
, pp. 262-272
-
-
Whittaker, S.R.1
Walton, M.I.2
Garrett, M.D.3
-
28
-
-
38149082690
-
R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy
-
Dey A, Wong ET, Cheok CF, et al. R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy. Cell Death Differ 2008;15:263-73.
-
(2008)
Cell Death Differ
, vol.15
, pp. 263-273
-
-
Dey, A.1
Wong, E.T.2
Cheok, C.F.3
-
29
-
-
66749165938
-
Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine
-
Paprskárová M, Krystof V, Jorda R, et al. Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine. J Cell Biochem 2009;107:428-37.
-
(2009)
J Cell Biochem
, vol.107
, pp. 428-437
-
-
Paprskárová, M.1
Krystof, V.2
Jorda, R.3
-
30
-
-
79951807772
-
Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-a in human ER-positive breast cancer cells
-
Wesierska-Gadek J, Gritsch D, Zulehner N, et al. Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-a in human ER-positive breast cancer cells. J Cell Biochem 2011;112:761-72.
-
(2011)
J Cell Biochem
, vol.112
, pp. 761-772
-
-
Wesierska-Gadek, J.1
Gritsch, D.2
Zulehner, N.3
-
31
-
-
0347626096
-
Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2
-
Mohapatra S, Chu B, Wei S, et al. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res 2003;63:8523-30.
-
(2003)
Cancer Res
, vol.63
, pp. 8523-8530
-
-
Mohapatra, S.1
Chu, B.2
Wei, S.3
-
32
-
-
0037058678
-
In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
-
McClue SJ, Blake D, Clarke R, et al. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). Int J Cancer 2002;102:463-8.
-
(2002)
Int J Cancer
, vol.102
, pp. 463-468
-
-
McClue, S.J.1
Blake, D.2
Clarke, R.3
-
33
-
-
84916608571
-
Roscovitine-treated HeLa cells finalize autophagy later than apoptosis by downregulating Bcl-2
-
Coker-Gurkan A, Arisan ED, Obakan P, et al. Roscovitine-treated HeLa cells finalize autophagy later than apoptosis by downregulating Bcl-2. Mol Med Rep 2015;11:1968-74.
-
(2015)
Mol Med Rep
, vol.11
, pp. 1968-1974
-
-
Coker-Gurkan, A.1
Arisan, E.D.2
Obakan, P.3
-
34
-
-
77951050556
-
The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis
-
Leitch AE, Riley NA, Sheldrake TA, et al. The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis. Eur J Immunol 2010;40:1127-38.
-
(2010)
Eur J Immunol
, vol.40
, pp. 1127-1138
-
-
Leitch, A.E.1
Riley, N.A.2
Sheldrake, T.A.3
-
35
-
-
0842329845
-
Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
-
Kim EH, Kim SU, Shin DY, et al. Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP. Oncogene 2004;23:446-56.
-
(2004)
Oncogene
, vol.23
, pp. 446-456
-
-
Kim, E.H.1
Kim, S.U.2
Shin, D.Y.3
-
36
-
-
57149083267
-
Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells
-
Wesierska-Gadek J, Wandl S, Kramer MP, et al. Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells. J Cell Biochem 2008;105:1161-71.
-
(2008)
J Cell Biochem
, vol.105
, pp. 1161-1171
-
-
Wesierska-Gadek, J.1
Wandl, S.2
Kramer, M.P.3
-
37
-
-
14044257773
-
Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells
-
Wesierska-Gadek J, Gueorguieva M, Horky M. Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. Mol Cancer Ther 2005;4:113-24.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 113-124
-
-
Wesierska-Gadek, J.1
Gueorguieva, M.2
Horky, M.3
-
38
-
-
0036653127
-
Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells
-
Mihara M, Shintani S, Kiyota A, et al. Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells. Int J Oncol 2002;21:95-101.
-
(2002)
Int J Oncol
, vol.21
, pp. 95-101
-
-
Mihara, M.1
Shintani, S.2
Kiyota, A.3
-
39
-
-
80051539377
-
Transcriptional modulation of apoptosis regulators by roscovitine and related compounds
-
Garrofé-Ochoa X, Cosialls AM, Ribas J, et al. Transcriptional modulation of apoptosis regulators by roscovitine and related compounds. Apoptosis 2011;16:660-70.
-
(2011)
Apoptosis
, vol.16
, pp. 660-670
-
-
Garrofé-Ochoa, X.1
Cosialls, A.M.2
Ribas, J.3
-
40
-
-
54249104991
-
Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model
-
Lambert LA, Qiao N, Hunt KK, et al. Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res 2008;68:7966-74.
-
(2008)
Cancer Res
, vol.68
, pp. 7966-7974
-
-
Lambert, L.A.1
Qiao, N.2
Hunt, K.K.3
-
41
-
-
58149237962
-
Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells
-
Abaza MS, Bahman AM, Al-Attiyah RJ. Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells. World J Gastroenterol 2008;14:5162-75.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 5162-5175
-
-
Abaza, M.S.1
Bahman, A.M.2
Al-Attiyah, R.J.3
-
42
-
-
36348933980
-
Roscovitine in B-chronic lymphocytic leukemia cells: high apoptosis-inducing efficacy and synergism with alemtuzumab independent of the patients' pretreatment status
-
Weingrill E, Wölfler A, Strunk D, et al. Roscovitine in B-chronic lymphocytic leukemia cells: high apoptosis-inducing efficacy and synergism with alemtuzumab independent of the patients' pretreatment status Haematologica 2007;92:1286-8.
-
(2007)
Haematologica
, vol.92
, pp. 1286-1288
-
-
Weingrill, E.1
Wölfler, A.2
Strunk, D.3
-
43
-
-
33847679550
-
Seliciclib (CYC202; r-roscovitine) in combination with cytotoxic agents in human uterine sarcoma cell lines
-
Coley HM, Shotton CF, Thomas H. Seliciclib (CYC202; r-roscovitine) in combination with cytotoxic agents in human uterine sarcoma cell lines. Anticancer Res 2007;27:273-8.
-
(2007)
Anticancer Res
, vol.27
, pp. 273-278
-
-
Coley, H.M.1
Shotton, C.F.2
Thomas, H.3
-
44
-
-
48249141097
-
Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents
-
Fleming IN, Hogben M, Frame S, et al. Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents. Clin Cancer Res 2008;14:4326-35.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4326-4335
-
-
Fleming, I.N.1
Hogben, M.2
Frame, S.3
-
45
-
-
34247102225
-
The effects of the CDK inhibitor seliciclib alone or in combination with cisplatin in human uterine sarcoma cell lines
-
Coley HM, Shotton CF, Kokkinos MI, et al. The effects of the CDK inhibitor seliciclib alone or in combination with cisplatin in human uterine sarcoma cell lines. Gynecol Oncol 2007;105:462-9.
-
(2007)
Gynecol Oncol
, vol.105
, pp. 462-469
-
-
Coley, H.M.1
Shotton, C.F.2
Kokkinos, M.I.3
-
46
-
-
0038519961
-
Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo
-
Maggiorella L, Deutsch E, Frascogna V, et al. Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo. Cancer Res 2003;63:2513-7.
-
(2003)
Cancer Res
, vol.63
, pp. 2513-2517
-
-
Maggiorella, L.1
Deutsch, E.2
Frascogna, V.3
-
47
-
-
1642373327
-
Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line
-
Abal M, Bras-Goncalves R, Judde JG, et al. Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line. Oncogene 2004;23:1737-44.
-
(2004)
Oncogene
, vol.23
, pp. 1737-1744
-
-
Abal, M.1
Bras-Goncalves, R.2
Judde, J.G.3
-
48
-
-
13444268947
-
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response
-
Maude SL, Enders GH. Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. Cancer Res 2005;65:780-6.
-
(2005)
Cancer Res
, vol.65
, pp. 780-786
-
-
Maude, S.L.1
Enders, G.H.2
-
49
-
-
79251510568
-
Tamoxifen enhances the anti-proliferative effect of roscovitine, a selective cyclin-dependent kinase inhibitor, on human ER-positive human breast cancer cells
-
Gritsch D, Maurer M, Zulehner N, et al. Tamoxifen enhances the anti-proliferative effect of roscovitine, a selective cyclin-dependent kinase inhibitor, on human ER-positive human breast cancer cells. J Exp Ther Oncol 2011;9:37-45.
-
(2011)
J Exp Ther Oncol
, vol.9
, pp. 37-45
-
-
Gritsch, D.1
Maurer, M.2
Zulehner, N.3
-
50
-
-
27644591251
-
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202
-
Raynaud FI, Whittaker SR, Fischer PM, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res 2005;11:4875-87.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4875-4887
-
-
Raynaud, F.I.1
Whittaker, S.R.2
Fischer, P.M.3
-
51
-
-
27144512221
-
Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo
-
Tirado OM, Mateo-Lozano S, Notario V. Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo. Cancer Res 2005;65:9320-7.
-
(2005)
Cancer Res
, vol.65
, pp. 9320-9327
-
-
Tirado, O.M.1
Mateo-Lozano, S.2
Notario, V.3
-
52
-
-
33646239607
-
Discovery and evaluation of dual CDK1 and CDK2 inhibitors
-
Payton M, Chung G, Yakowec P, et al. Discovery and evaluation of dual CDK1 and CDK2 inhibitors. Cancer Res 2006;66:4299-308.
-
(2006)
Cancer Res
, vol.66
, pp. 4299-4308
-
-
Payton, M.1
Chung, G.2
Yakowec, P.3
-
53
-
-
33845317656
-
Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor
-
Iurisci I, Filipski E, Reinhardt J, et al. Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor. Cancer Res 2006;66:10720-8.
-
(2006)
Cancer Res
, vol.66
, pp. 10720-10728
-
-
Iurisci, I.1
Filipski, E.2
Reinhardt, J.3
-
54
-
-
58249091745
-
Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model
-
Appleyard MV, O'Neill MA, Murray KE, et al. Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model. Int J Cancer 2009;124:465-72.
-
(2009)
Int J Cancer
, vol.124
, pp. 465-472
-
-
Appleyard, M.V.1
O'Neill, M.A.2
Murray, K.E.3
-
55
-
-
84872030780
-
Roscovitine sensitizes leukemia and lymphoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
-
Molinsky J, Klanova M, Koc M, et al. Roscovitine sensitizes leukemia and lymphoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Leuk Lymphoma 2013;54:372-80.
-
(2013)
Leuk Lymphoma
, vol.54
, pp. 372-380
-
-
Molinsky, J.1
Klanova, M.2
Koc, M.3
-
56
-
-
80053209796
-
Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells
-
Nair BC, Vallabhaneni S, Tekmal RR, et al. Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. Breast Cancer Res 2011;13:R80.
-
(2011)
Breast Cancer Res
, vol.13
-
-
Nair, B.C.1
Vallabhaneni, S.2
Tekmal, R.R.3
-
57
-
-
77952241679
-
Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine
-
Yakisich JS, Vita MF, Siden A, et al. Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine. Invest New Drugs 2010;28:299-305.
-
(2010)
Invest New Drugs
, vol.28
, pp. 299-305
-
-
Yakisich, J.S.1
Vita, M.F.2
Siden, A.3
-
58
-
-
78649634707
-
Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies
-
Le Tourneau C, Faivre S, Laurence V, et al. Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies. Eur J Cancer 2010;46:3243-50.
-
(2010)
Eur J Cancer
, vol.46
, pp. 3243-3250
-
-
Le Tourneau, C.1
Faivre, S.2
Laurence, V.3
-
59
-
-
33846254185
-
A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days
-
Benson C, White J, De Bono J, et al. A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br J Cancer 2007;96:29-37.
-
(2007)
Br J Cancer
, vol.96
, pp. 29-37
-
-
Benson, C.1
White, J.2
De Bono, J.3
-
60
-
-
19044371037
-
Recent progress in the discovery and development of cyclin-dependent kinase inhibitors
-
Fischer PM, Gianella-Borradori A. Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert Opin Investig Drugs 2005;14:457-77.
-
(2005)
Expert Opin Investig Drugs
, vol.14
, pp. 457-477
-
-
Fischer, P.M.1
Gianella-Borradori, A.2
-
61
-
-
84873259705
-
Effects of roscovitine, a cell cyclin [correction of cycling]-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage
-
Kasai H, Imamura T, Tsuruma K, et al. Effects of roscovitine, a cell cyclin [correction of cycling]-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage. Neurosci Lett 2013;535:95-9.
-
(2013)
Neurosci Lett
, vol.535
, pp. 95-99
-
-
Kasai, H.1
Imamura, T.2
Tsuruma, K.3
-
62
-
-
0030781307
-
Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist
-
Pippin JW, Qu Q, Meijer L, et al. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. J Clin Invest 1997;100:2512-20.
-
(1997)
J Clin Invest
, vol.100
, pp. 2512-2520
-
-
Pippin, J.W.1
Qu, Q.2
Meijer, L.3
-
63
-
-
13544252453
-
Mycophenolate mofetil and roscovitine decrease cyclin expression and increase p27(kip1) expression in anti Thy1 mesangial proliferative nephritis
-
Chiara M, Menegatti E, Di Simone D, et al. Mycophenolate mofetil and roscovitine decrease cyclin expression and increase p27(kip1) expression in anti Thy1 mesangial proliferative nephritis. Clin Exp Immunol 2005;139:225-35.
-
(2005)
Clin Exp Immunol
, vol.139
, pp. 225-235
-
-
Chiara, M.1
Menegatti, E.2
Di Simone, D.3
-
64
-
-
66749113138
-
The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD
-
Li L, Wang H, Kim Js, et al. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle 2009;8:1794-802.
-
(2009)
Cell Cycle
, vol.8
, pp. 1794-1802
-
-
Li, L.1
Wang, H.2
Kim, J.S.3
-
66
-
-
16244415855
-
R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury
-
Milovanceva-Popovska M, Kunter U, Ostendorf T, et al. R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury. Kidney Int 2005;67:1362-70.
-
(2005)
Kidney Int
, vol.67
, pp. 1362-1370
-
-
Milovanceva-Popovska, M.1
Kunter, U.2
Ostendorf, T.3
-
67
-
-
84866764681
-
R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae
-
Hoogendijk AJ, Roelofs JJ, Duitman J, et al. R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae. Mol Med 2012;18:1086-95.
-
(2012)
Mol Med
, vol.18
, pp. 1086-1095
-
-
Hoogendijk, A.J.1
Roelofs, J.J.2
Duitman, J.3
-
68
-
-
0036755765
-
Protective effect of roscovitine on renal ischemia-reperfusion injury
-
Aydemir A, Abbasoglu O, Topaloglu S, et al. Protective effect of roscovitine on renal ischemia-reperfusion injury. Transplant Proc 2002;34:2027-8.
-
(2002)
Transplant Proc
, vol.34
, pp. 2027-2028
-
-
Aydemir, A.1
Abbasoglu, O.2
Topaloglu, S.3
-
69
-
-
85015463574
-
-
http://meetinglibrary.asco.org/content/33727-65
-
-
-
-
70
-
-
79953666757
-
Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine
-
Patrick C, Crews L, Desplats P, et al. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. Am J Pathol 2011;178:1646-61.
-
(2011)
Am J Pathol
, vol.178
, pp. 1646-1661
-
-
Patrick, C.1
Crews, L.2
Desplats, P.3
-
72
-
-
84860171584
-
Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA
-
Zhang R, Liu Y, Zhang J, et al. Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA. Pharmacol Biochem Behav 2012;102:139-45.
-
(2012)
Pharmacol Biochem Behav
, vol.102
, pp. 139-145
-
-
Zhang, R.1
Liu, Y.2
Zhang, J.3
-
73
-
-
84908356223
-
Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A
-
Yang L, Gu X, Zhang W, et al. Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A. Neurol Sci 2014;35:1365-71.
-
(2014)
Neurol Sci
, vol.35
, pp. 1365-1371
-
-
Yang, L.1
Gu, X.2
Zhang, W.3
-
74
-
-
84901005097
-
Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-D-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord
-
Liu X, Liu Y, Zhang J, et al. Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-D-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord. Brain Res Bull 2014;106:9-16.
-
(2014)
Brain Res Bull
, vol.106
, pp. 9-16
-
-
Liu, X.1
Liu, Y.2
Zhang, J.3
-
75
-
-
33845909549
-
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitorroscovitine
-
Bukanov NO, Smith LA, Klinger KW, et al. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitorroscovitine. Nature 2006;444:949-52.
-
(2006)
Nature
, vol.444
, pp. 949-952
-
-
Bukanov, N.O.1
Smith, L.A.2
Klinger, K.W.3
-
76
-
-
84869398488
-
CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD
-
Bukanov NO, Moreno SE, Natoli TA, et al. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle 2012;11:4040-6.
-
(2012)
Cell Cycle
, vol.11
, pp. 4040-4046
-
-
Bukanov, N.O.1
Moreno, S.E.2
Natoli, T.A.3
-
77
-
-
84873729483
-
Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins
-
Zencak D, Schouwey K, Chen D, et al. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A 2013;110:E593-601.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E593-601
-
-
Zencak, D.1
Schouwey, K.2
Chen, D.3
-
78
-
-
84870925614
-
Prevention of radiation-induced salivary gland dysfunction utilizing a CDK inhibitor in a mouse model
-
Martin KL, Hill GA, Klein RR, et al. Prevention of radiation-induced salivary gland dysfunction utilizing a CDK inhibitor in a mouse model. PLoS One 2012;7:e51363.
-
(2012)
PLoS One
, vol.7
-
-
Martin, K.L.1
Hill, G.A.2
Klein, R.R.3
-
79
-
-
34248592212
-
Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus
-
Zoja C, Casiraghi F, Conti S, et al. Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus. Arthritis Rheum 2007;56:1629-37.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 1629-1637
-
-
Zoja, C.1
Casiraghi, F.2
Conti, S.3
-
80
-
-
84859701022
-
CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury
-
Kabadi SV, Stoica BA, Hanscom M, et al. CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury. Neurotherapeutics 2012;9:405-21.
-
(2012)
Neurotherapeutics
, vol.9
, pp. 405-421
-
-
Kabadi, S.V.1
Stoica, B.A.2
Hanscom, M.3
-
81
-
-
51849106058
-
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1
-
Oumata N, Bettayeb K, Ferandin Y, at al. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J Med Chem 2008;51:5229-42.
-
(2008)
J Med Chem
, vol.51
, pp. 5229-5242
-
-
Oumata, N.1
Bettayeb, K.2
Ferandin, Y.3
-
82
-
-
54049089030
-
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine
-
Bettayeb K, Sallam H, Ferandin Y, et al. N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine. Mol Cancer Ther 2008;7:2713-24.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2713-2724
-
-
Bettayeb, K.1
Sallam, H.2
Ferandin, Y.3
-
83
-
-
74549214867
-
A novel roscovitine derivative potently induces G1-phase arrest in platelet-derived growth factor-BB-activated vascular smooth muscle cells
-
Sroka IM, Heiss EH, Havlicek L, et al. A novel roscovitine derivative potently induces G1-phase arrest in platelet-derived growth factor-BB-activated vascular smooth muscle cells. Mol Pharmacol 2010;77:255-61.
-
(2010)
Mol Pharmacol
, vol.77
, pp. 255-261
-
-
Sroka, I.M.1
Heiss, E.H.2
Havlicek, L.3
-
84
-
-
84907432562
-
Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents
-
Houzé S, Hoang NT, Lozach O, et al. Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents. Molecules 2014;19:15237-57.
-
(2014)
Molecules
, vol.19
, pp. 15237-15257
-
-
Houzé, S.1
Hoang, N.T.2
Lozach, O.3
|