Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-d-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord

Brain Research Bulletin

Volumn 106, Issue , 2014, Pages 9-16

  Liu, Xiaojie ^a   Liu, Yue ^a   Zhang, Juan ^a   Zhang, Wei ^a   Sun, Yu E ^a   Gu, Xiaoping ^a   Ma, Zhengliang ^a  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

Author keywords

Cyclin dependent kinase 5; Metabotropic glutamate receptor 5; N methyl d aspartate receptor; Opioid induced hyperalgesia; Remifentanil

Indexed keywords

CYCLIN DEPENDENT KINASE 5; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN P25; PROTEIN P35; REMIFENTANIL; ROSCOVITINE; CDK5 PROTEIN, RAT; NARCOTIC ANALGESIC AGENT; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE;

ADULT; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; HYPERALGESIA; MALE; NONHUMAN; POSTOPERATIVE HYPERALGESIA; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; MOTOR ACTIVITY; PAIN THRESHOLD; PAIN, POSTOPERATIVE; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; TOXICITY;

ANALGESICS, OPIOID; ANIMALS; CYCLIN-DEPENDENT KINASE 5; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MOTOR ACTIVITY; PAIN THRESHOLD; PAIN, POSTOPERATIVE; PHOSPHORYLATION; PIPERIDINES; PROTEIN KINASE INHIBITORS; PURINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 84901005097     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2014.04.008     Document Type: Article

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