Phosphorylation, but not Overexpression, of Epidermal Growth Factor Receptor is Associated with Poor Prognosis of Non-Small Cell Lung Cancer Patients

Oncology Research

Volumn 13, Issue 5, 2002, Pages 289-298

  Kanematsu, Takanori ^a   Yano, Seiji ^a   Uehara, Hisanori ^a   Bando, Yoshimi ^a   Sone, Saburo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Epidermal growth factor receptor (EGFR); HER2; Immunohistochemistry; Multivariate analysis; Non small cell lung cancer; Phosphorylated EGFR

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN TYROSINE KINASE;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; CONFIDENCE INTERVAL; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; PROPORTIONAL HAZARDS MODEL; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; CONFIDENCE INTERVALS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHOSPHORYLATION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SURVIVAL RATE; TUMOR CELLS, CULTURED;

EID: 0842305848     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504003108748348     Document Type: Article

References (27)

1. Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell 103:211-225; 2000.
2. Raben, D.; Helfrich, B. A.; Chan, D.; Johnson, G.; Bunn, P. A., Jr. ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer. Semin. Oncol. 29(Suppl. 4):37-46; 2002.
3. Cohen, S. The epidermal growth factor (EGF). Cancer 51: 1787-1791; 1983.
4. Derynck, R. Transforming growth factor-α. Cell 54:593-595; 1988.
5. Fontanini, G.; Vignati, S.; Bigini, D.; Mussi, A.; Lucchi, H.; Angeletti, C. A.; Pingitore, R.; Pepe, S.; Basolo, F.; Bevilacqua, G. Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in squamous subtype. Eur. J. Cancer 31:178-183; 1995.
6. Gorgoulis, V.; Aninos, D.; Mikou, P.; Kanavaros, P.; Karameris, A.; Joardanoglou, J.; Rasidakis, A.; Veslemes, M.; Ozanne, B.; Spandidos, D. A. Expression of EGF, TGF-α and EGFR in squamous cell lung carcinoma. Anticancer Res. 12:1183-1187; 1992.
7. Veale, D.; Ashcroft, T.; Marsh, C.; Gibson, G. J.; Harris, A. L. Epidermal growth factor receptors in non-small cell lung cancer. Br. J. Cancer 55:513-516; 1987.
8. Tateishi, M.; Ishida, T.; Mitsudomi, T.; Kaneko, S.; Sugimachi, K. Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung. Cancer Res. 50:7077-7080, 1990.
9. Lai, W. W.; Chen, F. F.; Wu, M. H.; Chow, N. H.; Su, W. C.; Ma, M. C.; Su, P. F.; Chen, H.; Lin, M. Y.; Tseng, Y. L. Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer. Ann. Thorac. Surg. 72:1868-1876; 2001.
10. Dazzi, H.; Hasleton, P. S.; Thatcher, N.; Barnes, D. M.; Wilkes, S.; Swindell, R.; Lawson R. A. M. Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumor size, node status and survival. Br. J. Cancer 59:746-749; 1989.
11. Rusch, V.; Baselga, J.; Cordon-Cardo, C.; Orazem, J.; Zaman, M.; Hoda, S.; McIntosh, J.; Kurie, J.; Dmitrovsky, E. Differetial expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res. 53:2379-2385; 1993.
12. Rusch, V.; Klimstra, D.; Venkatraman, E.; Pisters, P. W. T.; Langenfeld, J.; Dmitrovsky, E. Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor a is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin. Cancer Res. 3:515-522; 1997.
13. Fontanini, G.; De Laurentiis, M.; Vignati, S.; Chine, S.; Lucchi, M.; Silvestri, V.; Mussi, A.; De Placido, S.; Tortora, G.; Bianco, A. R.; Gullick, W.; Angeletti, C. A.; Bevilacqua, G.; Ciardiello, F. Evaluation of epidermal growth factor-related growth factors and receptors and neoangiogenesis in completely resected stage I-IIIA non-small cell lung cancer: Amphiregulin and microvessel count are independent prognostic indicators of survival. Clin. Cancer Res. 4:241-249; 1998.
14. Nicholson, R. I.; Gee, J. M. W.; Harper, M. E. EGFR and cancer prognosis. Eur. J. Cancer 37:S9-S15; 2001.
15. Coussens, L.; Yang-Feng, T. L.; Liao, Y. C.; Chen, E.; Gray, A.; McGrath, J.; Seeburg, P. H.; Liebermann, T. A.; Schlessinger, J.; Francke, U.; et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with Neu oncogene. Science 230:1132-1139; 1985.
16. Prigent, S. A.; Lemoine, N. R. The type I (EGFR-related) family of growth factor receptors and their ligands. Prog. Growth Factor Res. 4:1-24; 1992.
17. Goldman, R.; Ben Levy, R.; Peles, E.; Yarden, Y. Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: A mechanism for receptor transregulation. Biochemistry 29:11024-11028; 1990.
18. Wada, T.; Qian, X. L.; Greene, M. I. Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function. Cell 61:1339-1347; 1990.
19. Hirsch, F. R.; Varella-Garcia, M.; Franklin, W. A.; Veve, R.; Chen, L.; Helfrich, B.; Zeng, C.; Baron, A.; Bunn, P. A., Jr. Evaluation of HER2/neu gene amplification and protein expression in non-small cell lung carcinomas. Br. J. Cancer 86:1449-1456; 2002.
20. Mendoza, N.; Phillips, G. L.; Silva, J.; Schwall, R.; Wickramasinghe, D. Inhibition of ligand-mediated HER2 activation in androgen-independent prostate cancer. Cancer Res. 62:5485-5488; 2002.
21. Biscardi, J. S.; Maa, M. C.; Tice, D. A.; Cox, M. E.; Leu, T. H.; Parsons, S. J. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J. Biol. Chem. 274:8335-8343; 1999.
22. Lenferink, A. E.; Pinkas-Kramarski, R.; van de Poll, M. L.; van Vugt, M. J.; Klapper, L. N.; Tzahar, E.; Waterman, H.; Sela, M.; van Zoelen, E. J.; Yarden, Y. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17:3385-3397; 1998.
23. Karunagaran, D.; Tzahar, E.; Beerli, R. R.; Chen, X.; Graus-Porta, D.; Ratzkin, B. J.; Seger, R.; Hynes, N. E.; Yarden, Y. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer. EMBO J. 15:254-264; 1996.
24. Pinkas-Kramarski, R.; Soussan, L.; Waterman, H.; Levkowitz, G.; Alroy, I.; Klapper, L.; Lavi, S.; Seger, R.; Ratzkin, B. J.; Sela, M.; Yarden, Y. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 15: 2452-2467; 1996.
25. Harris, A. L.; Nicholson, S.; Sainsbury, J. R.; Farndon, J.; Wright, C. Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu. J. Steroid Biochem. 34:123-131; 1989.
26. Moasser, M. M.; Basso, A.; Averbuch, S. D.; Rosen, N. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 61:7184-7188; 2001.
27. Fukuoka, M.; Yano, S.; Giaccone, G.; et al. Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small-cell lung cancer (IDEAL 1). Proc. Am. Soc. Clin. Oncol. 21:298a; 2002.