The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

European Journal of Immunology

Volumn 40, Issue 4, 2010, Pages 1127-1138

  Leitch, Andrew E ^a   Riley, Nicola A ^a   Sheldrake, Tara A ^a   Festa, Michela ^a   Fox, Sarah ^a   Duffin, Rodger ^a   Haslett, Christopher ^a   Rossi, Adriano G ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Apoptosis; Cyclin dependent kinase inhibition; Inflammation; Neutrophil

Indexed keywords

BIM PROTEIN; CD11B ANTIGEN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; L SELECTIN; LIPOCORTIN 5; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN MCL 1; ROSCOVITINE; SUPEROXIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CELL ISOLATION; CELL LABELING; CELL SHAPE; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; LEUKOCYTE AGGREGATION; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ADULT; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASES; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; NEUTROPHILS; NF-KAPPA B; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PURINES; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951050556     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939664     Document Type: Article

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