메뉴 건너뛰기




Volumn 8, Issue 11, 2009, Pages 1794-1802

The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD

Author keywords

Alloreactive T cells; Cdk inhibitors; Cell cycle; GvHD; NF B; TNF

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ROSCOVITINE; TUMOR NECROSIS FACTOR ALPHA;

EID: 66749113138     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.11.8738     Document Type: Article
Times cited : (24)

References (37)
  • 1
    • 34247598749 scopus 로고    scopus 로고
    • Balancing autoaggressive and protective T cell responses
    • DOI 10.1016/j.jaut.2007.02.002, PII S0896841107000133, Plenary Papers on Cutting Edge Autoimmunity
    • Abbas AK, Lohr J, Knoechel B. Balancing autoaggressive and protective T cell responses. J Autoimmun 2007; 28:59-61. (Pubitemid 46670685)
    • (2007) Journal of Autoimmunity , vol.28 , Issue.2-3 , pp. 59-61
    • Abbas, A.K.1    Lohr, J.2    Knoechel, B.3
  • 2
    • 0037902480 scopus 로고    scopus 로고
    • T cell anergy and costimulation
    • DOI 10.1034/j.1600-065X.2003.00009.x
    • Appleman LJ, Boussiotis VA. T cell anergy and costimulation. Immunol Rev 2003; 192:161-180 (Pubitemid 36613331)
    • (2003) Immunological Reviews , vol.192 , pp. 161-180
    • Appleman, L.J.1    Boussiotis, V.A.2
  • 3
    • 34247849183 scopus 로고    scopus 로고
    • Effector and memory CTL differentiation
    • Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu Rev Immunol 2007; 25:171-192
    • (2007) Annu Rev Immunol , vol.25 , pp. 171-192
    • Williams, M.A.1    Bevan, M.J.2
  • 4
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • DOI 10.1101/gad.1256504
    • Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004; 18:2699-2711 (Pubitemid 39507762)
    • (2004) Genes and Development , vol.18 , Issue.22 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 5
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • DOI 10.1038/nature02650
    • Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004; 430:226-231 (Pubitemid 38902433)
    • (2004) Nature , vol.430 , Issue.6996 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 6
    • 33750123428 scopus 로고    scopus 로고
    • Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance
    • Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance. Nat Immunol 2006; 7:1157-1165
    • (2006) Nat Immunol , vol.7 , pp. 1157-1165
    • Li, L.1    Iwamoto, Y.2    Berezovskaya, A.3    Boussiotis, V.A.4
  • 7
    • 30344461633 scopus 로고    scopus 로고
    • Pathophysiology of graft-versus-host disease
    • DOI 10.1053/j.seminhematol.2005.09.001, PII S0037196305001666, Graft-Versus-Host Disease
    • Ferrara JL, Reddy P. Pathophysiology of graft-versus-host disease. Semin Hematol 2006; 43:3-10. (Pubitemid 43063330)
    • (2006) Seminars in Hematology , vol.43 , Issue.1 , pp. 3-10
    • Ferrara, J.L.M.1    Reddy, P.2
  • 9
    • 33845909549 scopus 로고    scopus 로고
    • Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
    • DOI 10.1038/nature05348, PII NATURE05348
    • Bukanov NO, Smith LA, Klinger KW, Ledbetter SR, Ibraghimov-Beskrovnaya O. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. Nature 2006; 444:949-952 (Pubitemid 46025010)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 949-952
    • Bukanov, N.O.1    Smith, L.A.2    Klinger, K.W.3    Ledbetter, S.R.4    Ibraghimov- Beskrovnaya, O.5
  • 10
    • 35748957484 scopus 로고    scopus 로고
    • P21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: Roscovitine augments p21 levels
    • DOI 10.1186/1471-2369-8-12
    • Park JY, Schutzer WE, Lindsley JN, Bagby SP, Oyama TT, Anderson S, et al. p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. BMC Nephrol 2007; 8:12. (Pubitemid 350043324)
    • (2007) BMC Nephrology , vol.8 , pp. 12
    • Park, J.-Y.1    Schutzer, W.E.2    Lindsley, J.N.3    Bagby, S.P.4    Oyama, T.T.5    Anderson, S.6    Weiss, R.H.7
  • 12
    • 48649107571 scopus 로고    scopus 로고
    • Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat
    • Pezzotta A, Mister M, Monteferrante G, Cassis L, Azzollini N, Aiello S, et al. Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat. Transplantation 2008; 85:1476-1482
    • (2008) Transplantation , vol.85 , pp. 1476-1482
    • Pezzotta, A.1    Mister, M.2    Monteferrante, G.3    Cassis, L.4    Azzollini, N.5    Aiello, S.6
  • 13
    • 0033561434 scopus 로고    scopus 로고
    • Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation
    • Tsukada N, Kobata T, Aizawa Y, Yagita H, Okumura K. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood 1999; 93:2738-2747 (Pubitemid 29181207)
    • (1999) Blood , vol.93 , Issue.8 , pp. 2738-2747
    • Tsukada, N.1    Kobata, T.2    Aizawa, Y.3    Yagita, H.4    Okumura, K.5
  • 15
    • 11144316653 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells
    • DOI 10.1038/sj.leu.2403295
    • Hahntow IN, Schneller F, Oelsner M, Weick K, Ringshausen I, Fend F, et al. Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells. Leukemia 2004; 18:747-755 (Pubitemid 38500193)
    • (2004) Leukemia , vol.18 , Issue.4 , pp. 747-755
    • Hahntow, I.N.1    Schneller, F.2    Oelsner, M.3    Weick, K.4    Ringshausen, I.5    Fend, F.6    Peschel, C.7    Decker, T.8
  • 16
    • 20444477948 scopus 로고    scopus 로고
    • Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1
    • DOI 10.1158/0008-5472.CAN-05-0233
    • MacCallum DE, Melville J, Frame S, Watt K, Anderson S, Gianella-Borradori A, et al. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and downregulation of Mcl-1. Cancer Res 2005; 65:5399-5407 (Pubitemid 40827353)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5399-5407
    • MacCallum, D.E.1    Melville, J.2    Frame, S.3    Watt, K.4    Anderson, S.5    Gianella-Borradori, A.6    Lane, D.P.7    Green, S.R.8
  • 17
    • 23044439051 scopus 로고    scopus 로고
    • Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
    • DOI 10.1182/blood-2005-01-0320
    • Raje N, Kumar S, Hideshima T, Roccaro A, Ishitsuka K, Yasui H, et al. Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via downregulation of Mcl-1 in multiple myeloma. Blood 2005; 106:1042-1047 (Pubitemid 41076452)
    • (2005) Blood , vol.106 , Issue.3 , pp. 1042-1047
    • Raje, N.1    Kumar, S.2    Hideshima, T.3    Roccaro, A.4    Ishitsuka, K.5    Yasui, H.6    Shiraishi, N.7    Chauhan, D.8    Munshi, N.C.9    Green, S.R.10    Anderson, K.C.11
  • 18
    • 25444502962 scopus 로고    scopus 로고
    • In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas
    • Lacrima K, Valentini A, Lambertini C, Taborelli M, Rinaldi A, Zucca E, et al. In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas. Ann Oncol 2005; 16:1169-1176
    • (2005) Ann Oncol , vol.16 , pp. 1169-1176
    • Lacrima, K.1    Valentini, A.2    Lambertini, C.3    Taborelli, M.4    Rinaldi, A.5    Zucca, E.6
  • 20
    • 21144435503 scopus 로고    scopus 로고
    • A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by downregulation of genes involved in transcription regulation and survival
    • Alvi AJ, Austen B, Weston VJ, Fegan C, MacCallum D, Gianella-Borradori A, et al. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by downregulation of genes involved in transcription regulation and survival. Blood 2005; 105:4484-4491
    • (2005) Blood , vol.105 , pp. 4484-4491
    • Alvi, A.J.1    Austen, B.2    Weston, V.J.3    Fegan, C.4    MacCallum, D.5    Gianella-Borradori, A.6
  • 21
    • 0034973788 scopus 로고    scopus 로고
    • Activation of p53 by roscovitine-mediated suppression of MDM2 expression
    • DOI 10.1038/sj.onc.1204412
    • Lu W, Chen L, Peng Y, Chen J. Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 2001; 20:3206-3216 (Pubitemid 32553673)
    • (2001) Oncogene , vol.20 , Issue.25 , pp. 3206-3216
    • Lu, W.1    Chen, L.2    Peng, Y.3    Chen, J.4
  • 22
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9:47-59.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 23
    • 38149082690 scopus 로고    scopus 로고
    • R-Roscovitine simultaneously targets both the p53 and NFkappaB pathways and causes potentiation of apoptosis: Implications in cancer therapy
    • Dey A, Wong ET, Cheok CF, Tergaonkar V, Lane DP. R-Roscovitine simultaneously targets both the p53 and NFkappaB pathways and causes potentiation of apoptosis: implications in cancer therapy. Cell Death Differ 2008; 15:263-273
    • (2008) Cell Death Differ , vol.15 , pp. 263-273
    • Dey, A.1    Wong, E.T.2    Cheok, C.F.3    Tergaonkar, V.4    Lane, D.P.5
  • 27
    • 51649121552 scopus 로고    scopus 로고
    • Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival
    • Choi SW, Kitko CL, Braun T, Paczesny S, Yanik G, Mineishi S, et al. Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival. Blood 2008; 112:1539-1542
    • (2008) Blood , vol.112 , pp. 1539-1542
    • Choi, S.W.1    Kitko, C.L.2    Braun, T.3    Paczesny, S.4    Yanik, G.5    Mineishi, S.6
  • 28
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NFkappaB transcription factors
    • Pahl HL. Activators and target genes of Rel/NFkappaB transcription factors. Oncogene 1999; 18:6853-6866
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 29
    • 0032039076 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappaB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
    • Zhong H, Voll RE, Ghosh S. Phosphorylation of NFkappaB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1998; 1:661-671 (Pubitemid 128379244)
    • (1998) Molecular Cell , vol.1 , Issue.5 , pp. 661-671
    • Zhong, H.1    Voll, R.E.2    Ghosh, S.3
  • 32
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hacker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE 2006; 2006:13.
    • (2006) Sci STKE , vol.2006 , pp. 13
    • Hacker, H.1    Karin, M.2
  • 33
    • 30444458109 scopus 로고    scopus 로고
    • NF-kappaB as a target for the prevention of graft-versus-host disease: Comparative efficacy of bortezomib and PS-1145
    • DOI 10.1182/blood-2005-05-1820
    • Vodanovic-Jankovic S, Hari P, Jacobs P, Komorowski R, Drobyski WR. NFkappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood 2006; 107:827-834 (Pubitemid 43076412)
    • (2006) Blood , vol.107 , Issue.2 , pp. 827-834
    • Vodanovic-Jankovic, S.1    Hari, P.2    Jacobs, P.3    Komorowski, R.4    Drobyski, W.R.5
  • 36
    • 50949094104 scopus 로고    scopus 로고
    • Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain
    • Sallam H, Jimenez P, Song H, Vita M, Cedazo-Minguez A, Hassan M. Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain. Pharmacol Res 2008; 58:32-37
    • (2008) Pharmacol Res , vol.58 , pp. 32-37
    • Sallam, H.1    Jimenez, P.2    Song, H.3    Vita, M.4    Cedazo-Minguez, A.5    Hassan, M.6
  • 37
    • 33846674886 scopus 로고    scopus 로고
    • Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
    • DOI 10.1158/0008-5472.CAN-06-3964
    • Chen S, Dai Y, Harada H, Dent P, Grant S. Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 2007; 67:782-791 (Pubitemid 46192219)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 782-791
    • Chen, S.1    Dai, Y.2    Harada, H.3    Dent, P.4    Grant, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.