-
1
-
-
34247598749
-
Balancing autoaggressive and protective T cell responses
-
DOI 10.1016/j.jaut.2007.02.002, PII S0896841107000133, Plenary Papers on Cutting Edge Autoimmunity
-
Abbas AK, Lohr J, Knoechel B. Balancing autoaggressive and protective T cell responses. J Autoimmun 2007; 28:59-61. (Pubitemid 46670685)
-
(2007)
Journal of Autoimmunity
, vol.28
, Issue.2-3
, pp. 59-61
-
-
Abbas, A.K.1
Lohr, J.2
Knoechel, B.3
-
2
-
-
0037902480
-
T cell anergy and costimulation
-
DOI 10.1034/j.1600-065X.2003.00009.x
-
Appleman LJ, Boussiotis VA. T cell anergy and costimulation. Immunol Rev 2003; 192:161-180 (Pubitemid 36613331)
-
(2003)
Immunological Reviews
, vol.192
, pp. 161-180
-
-
Appleman, L.J.1
Boussiotis, V.A.2
-
3
-
-
34247849183
-
Effector and memory CTL differentiation
-
Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu Rev Immunol 2007; 25:171-192
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 171-192
-
-
Williams, M.A.1
Bevan, M.J.2
-
4
-
-
8644219655
-
Living with or without cyclins and cyclin-dependent kinases
-
DOI 10.1101/gad.1256504
-
Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004; 18:2699-2711 (Pubitemid 39507762)
-
(2004)
Genes and Development
, vol.18
, Issue.22
, pp. 2699-2711
-
-
Sherr, C.J.1
Roberts, J.M.2
-
5
-
-
3142546336
-
Cyclin-dependent kinases regulate the antiproliferative function of Smads
-
DOI 10.1038/nature02650
-
Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004; 430:226-231 (Pubitemid 38902433)
-
(2004)
Nature
, vol.430
, Issue.6996
, pp. 226-231
-
-
Matsuura, I.1
Denissova, N.G.2
Wang, G.3
He, D.4
Long, J.5
Liu, F.6
-
7
-
-
30344461633
-
Pathophysiology of graft-versus-host disease
-
DOI 10.1053/j.seminhematol.2005.09.001, PII S0037196305001666, Graft-Versus-Host Disease
-
Ferrara JL, Reddy P. Pathophysiology of graft-versus-host disease. Semin Hematol 2006; 43:3-10. (Pubitemid 43063330)
-
(2006)
Seminars in Hematology
, vol.43
, Issue.1
, pp. 3-10
-
-
Ferrara, J.L.M.1
Reddy, P.2
-
8
-
-
0031037714
-
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
-
Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 1997; 243:527-536 (Pubitemid 27060443)
-
(1997)
European Journal of Biochemistry
, vol.243
, Issue.1-2
, pp. 527-536
-
-
Meijer, L.1
Borgne, A.2
Mulner, O.3
Chong, J.P.J.4
Blow, J.J.5
Inagaki, N.6
Inagaki, M.7
Delcros, J.-G.8
Moulinoux, J.-P.9
-
9
-
-
33845909549
-
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
-
DOI 10.1038/nature05348, PII NATURE05348
-
Bukanov NO, Smith LA, Klinger KW, Ledbetter SR, Ibraghimov-Beskrovnaya O. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. Nature 2006; 444:949-952 (Pubitemid 46025010)
-
(2006)
Nature
, vol.444
, Issue.7121
, pp. 949-952
-
-
Bukanov, N.O.1
Smith, L.A.2
Klinger, K.W.3
Ledbetter, S.R.4
Ibraghimov- Beskrovnaya, O.5
-
10
-
-
35748957484
-
P21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: Roscovitine augments p21 levels
-
DOI 10.1186/1471-2369-8-12
-
Park JY, Schutzer WE, Lindsley JN, Bagby SP, Oyama TT, Anderson S, et al. p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. BMC Nephrol 2007; 8:12. (Pubitemid 350043324)
-
(2007)
BMC Nephrology
, vol.8
, pp. 12
-
-
Park, J.-Y.1
Schutzer, W.E.2
Lindsley, J.N.3
Bagby, S.P.4
Oyama, T.T.5
Anderson, S.6
Weiss, R.H.7
-
11
-
-
34248592212
-
Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus
-
DOI 10.1002/art.22593
-
Zoja C, Casiraghi F, Conti S, Corna D, Rottoli D, Cavinato RA, et al. Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus. Arthritis Rheum 2007; 56:1629-1637 (Pubitemid 46764092)
-
(2007)
Arthritis and Rheumatism
, vol.56
, Issue.5
, pp. 1629-1637
-
-
Zoja, C.1
Casiraghi, F.2
Conti, S.3
Corna, D.4
Rottoli, D.5
Cavinato, R.A.6
Remuzzi, G.7
Benigni, A.8
-
12
-
-
48649107571
-
Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat
-
Pezzotta A, Mister M, Monteferrante G, Cassis L, Azzollini N, Aiello S, et al. Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat. Transplantation 2008; 85:1476-1482
-
(2008)
Transplantation
, vol.85
, pp. 1476-1482
-
-
Pezzotta, A.1
Mister, M.2
Monteferrante, G.3
Cassis, L.4
Azzollini, N.5
Aiello, S.6
-
13
-
-
0033561434
-
Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation
-
Tsukada N, Kobata T, Aizawa Y, Yagita H, Okumura K. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood 1999; 93:2738-2747 (Pubitemid 29181207)
-
(1999)
Blood
, vol.93
, Issue.8
, pp. 2738-2747
-
-
Tsukada, N.1
Kobata, T.2
Aizawa, Y.3
Yagita, H.4
Okumura, K.5
-
15
-
-
11144316653
-
Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells
-
DOI 10.1038/sj.leu.2403295
-
Hahntow IN, Schneller F, Oelsner M, Weick K, Ringshausen I, Fend F, et al. Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells. Leukemia 2004; 18:747-755 (Pubitemid 38500193)
-
(2004)
Leukemia
, vol.18
, Issue.4
, pp. 747-755
-
-
Hahntow, I.N.1
Schneller, F.2
Oelsner, M.3
Weick, K.4
Ringshausen, I.5
Fend, F.6
Peschel, C.7
Decker, T.8
-
16
-
-
20444477948
-
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1
-
DOI 10.1158/0008-5472.CAN-05-0233
-
MacCallum DE, Melville J, Frame S, Watt K, Anderson S, Gianella-Borradori A, et al. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and downregulation of Mcl-1. Cancer Res 2005; 65:5399-5407 (Pubitemid 40827353)
-
(2005)
Cancer Research
, vol.65
, Issue.12
, pp. 5399-5407
-
-
MacCallum, D.E.1
Melville, J.2
Frame, S.3
Watt, K.4
Anderson, S.5
Gianella-Borradori, A.6
Lane, D.P.7
Green, S.R.8
-
17
-
-
23044439051
-
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
-
DOI 10.1182/blood-2005-01-0320
-
Raje N, Kumar S, Hideshima T, Roccaro A, Ishitsuka K, Yasui H, et al. Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via downregulation of Mcl-1 in multiple myeloma. Blood 2005; 106:1042-1047 (Pubitemid 41076452)
-
(2005)
Blood
, vol.106
, Issue.3
, pp. 1042-1047
-
-
Raje, N.1
Kumar, S.2
Hideshima, T.3
Roccaro, A.4
Ishitsuka, K.5
Yasui, H.6
Shiraishi, N.7
Chauhan, D.8
Munshi, N.C.9
Green, S.R.10
Anderson, K.C.11
-
18
-
-
25444502962
-
In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas
-
Lacrima K, Valentini A, Lambertini C, Taborelli M, Rinaldi A, Zucca E, et al. In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas. Ann Oncol 2005; 16:1169-1176
-
(2005)
Ann Oncol
, vol.16
, pp. 1169-1176
-
-
Lacrima, K.1
Valentini, A.2
Lambertini, C.3
Taborelli, M.4
Rinaldi, A.5
Zucca, E.6
-
19
-
-
34247217211
-
Cyclin-dependent kinase inhibitor seliciclib shows in viotro activity in diffuse large B-cell lymphomas
-
DOI 10.1080/10428190601026562, PII 769604922
-
Lacrima K, Rinaldi A, Vignati S, Martin V, Tibiletti MG, Gaidano G, et al. Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas. Leuk Lymphoma 2007; 48:158-167 (Pubitemid 46978635)
-
(2007)
Leukemia and Lymphoma
, vol.48
, Issue.1
, pp. 158-167
-
-
Lacrima, K.1
Rinaldi, A.2
Vignati, S.3
Martin, V.4
Tibiletti, M.G.5
Gaidano, G.6
Catapano, C.7
Bertoni, F.8
-
20
-
-
21144435503
-
A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by downregulation of genes involved in transcription regulation and survival
-
Alvi AJ, Austen B, Weston VJ, Fegan C, MacCallum D, Gianella-Borradori A, et al. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by downregulation of genes involved in transcription regulation and survival. Blood 2005; 105:4484-4491
-
(2005)
Blood
, vol.105
, pp. 4484-4491
-
-
Alvi, A.J.1
Austen, B.2
Weston, V.J.3
Fegan, C.4
MacCallum, D.5
Gianella-Borradori, A.6
-
21
-
-
0034973788
-
Activation of p53 by roscovitine-mediated suppression of MDM2 expression
-
DOI 10.1038/sj.onc.1204412
-
Lu W, Chen L, Peng Y, Chen J. Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 2001; 20:3206-3216 (Pubitemid 32553673)
-
(2001)
Oncogene
, vol.20
, Issue.25
, pp. 3206-3216
-
-
Lu, W.1
Chen, L.2
Peng, Y.3
Chen, J.4
-
22
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9:47-59.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
23
-
-
38149082690
-
R-Roscovitine simultaneously targets both the p53 and NFkappaB pathways and causes potentiation of apoptosis: Implications in cancer therapy
-
Dey A, Wong ET, Cheok CF, Tergaonkar V, Lane DP. R-Roscovitine simultaneously targets both the p53 and NFkappaB pathways and causes potentiation of apoptosis: implications in cancer therapy. Cell Death Differ 2008; 15:263-273
-
(2008)
Cell Death Differ
, vol.15
, pp. 263-273
-
-
Dey, A.1
Wong, E.T.2
Cheok, C.F.3
Tergaonkar, V.4
Lane, D.P.5
-
24
-
-
0031155266
-
TNF receptor p55 controls early acute graft-versus-host disease1
-
Speiser DE, Bachmann MF, Frick TW, McKall-Faienza K, Griffiths E, Pfeffer K, et al. TNF receptor p55 controls early acute graft-versus-host disease. J Immunol 1997; 158:5185-5190 (Pubitemid 127681221)
-
(1997)
Journal of Immunology
, vol.158
, Issue.11
, pp. 5185-5190
-
-
Speiser, D.E.1
Bachmann, M.F.2
Frick, T.W.3
McKall-Faienza, K.4
Griffiths, E.5
Pfeffer, K.6
Mak, T.W.7
Ohashi, P.S.8
-
25
-
-
0034721091
-
Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation
-
Cooke KR, Hill GR, Gerbitz A, Kobzik L, Martin TR, Crawford JM, et al. Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation 2000; 70:272-279 (Pubitemid 30602742)
-
(2000)
Transplantation
, vol.70
, Issue.2
, pp. 272-279
-
-
Cooke, K.R.1
Hill, G.R.2
Gerbitz, A.3
Kobzik, L.4
Martin, T.R.5
Crawford, J.M.6
Brewer, J.P.7
Ferrara, J.L.M.8
-
26
-
-
0037443425
-
Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation
-
DOI 10.1182/blood-2002-07-2109
-
Schmaltz C, Alpdogan O, Muriglan SJ, Kappel BJ, Rotolo JA, Ricchetti ET, et al. Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation. Blood 2003; 101:2440-2445 (Pubitemid 36302094)
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2440-2445
-
-
Schmaltz, C.1
Alpdogan, O.2
Muriglan, S.J.3
Kappel, B.J.4
Rotolo, J.A.5
Ricchetti, E.T.6
Greenberg, A.S.7
Willis, L.M.8
Murphy, G.F.9
Crawford, J.M.10
Van Den Brink, M.R.M.11
-
27
-
-
51649121552
-
Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival
-
Choi SW, Kitko CL, Braun T, Paczesny S, Yanik G, Mineishi S, et al. Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival. Blood 2008; 112:1539-1542
-
(2008)
Blood
, vol.112
, pp. 1539-1542
-
-
Choi, S.W.1
Kitko, C.L.2
Braun, T.3
Paczesny, S.4
Yanik, G.5
Mineishi, S.6
-
28
-
-
0033596121
-
Activators and target genes of Rel/NFkappaB transcription factors
-
Pahl HL. Activators and target genes of Rel/NFkappaB transcription factors. Oncogene 1999; 18:6853-6866
-
(1999)
Oncogene
, vol.18
, pp. 6853-6866
-
-
Pahl, H.L.1
-
29
-
-
0032039076
-
Phosphorylation of NF-kappaB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
-
Zhong H, Voll RE, Ghosh S. Phosphorylation of NFkappaB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1998; 1:661-671 (Pubitemid 128379244)
-
(1998)
Molecular Cell
, vol.1
, Issue.5
, pp. 661-671
-
-
Zhong, H.1
Voll, R.E.2
Ghosh, S.3
-
30
-
-
0025100777
-
Graft-versus-leukemia reactions after bone marrow transplantation
-
Horowitz MM, Gale RP, Sondel PM, Goldman JM, Kersey J, Kolb HJ, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75:555-562 (Pubitemid 20069191)
-
(1990)
Blood
, vol.75
, Issue.3
, pp. 555-562
-
-
Horowitz, M.M.1
Gale, R.P.2
Sondel, P.M.3
Goldman, J.M.4
Kersey, J.5
Kolb, H.-J.6
Rimm, A.A.7
Ringden, O.8
Rozman, C.9
Speck, B.10
Truitt, R.L.11
Zwaan, F.E.12
Bortin, M.M.13
-
31
-
-
33748462267
-
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
-
DOI 10.1038/nm1468, PII NM1468
-
Rossi AG, Sawatzky DA, Walker A, Ward C, Sheldrake TA, Riley NA, et al. Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med 2006; 12:1056-1064 (Pubitemid 44353387)
-
(2006)
Nature Medicine
, vol.12
, Issue.9
, pp. 1056-1064
-
-
Rossi, A.G.1
Sawatzky, D.A.2
Walker, A.3
Ward, C.4
Sheldrake, T.A.5
Riley, N.A.6
Caldicott, A.7
Martinez-Losa, M.8
Walker, T.R.9
Duffin, R.10
Gray, M.11
Crescenzi, E.12
Martin, M.C.13
Brady, H.J.14
Savill, J.S.15
Dransfield, I.16
Haslett, C.17
-
32
-
-
39049183044
-
Regulation and function of IKK and IKK-related kinases
-
Hacker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE 2006; 2006:13.
-
(2006)
Sci STKE
, vol.2006
, pp. 13
-
-
Hacker, H.1
Karin, M.2
-
33
-
-
30444458109
-
NF-kappaB as a target for the prevention of graft-versus-host disease: Comparative efficacy of bortezomib and PS-1145
-
DOI 10.1182/blood-2005-05-1820
-
Vodanovic-Jankovic S, Hari P, Jacobs P, Komorowski R, Drobyski WR. NFkappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood 2006; 107:827-834 (Pubitemid 43076412)
-
(2006)
Blood
, vol.107
, Issue.2
, pp. 827-834
-
-
Vodanovic-Jankovic, S.1
Hari, P.2
Jacobs, P.3
Komorowski, R.4
Drobyski, W.R.5
-
34
-
-
34447517654
-
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2
-
DOI 10.1128/MCB.00029-07
-
Berthet C, Rodriguez-Galan MC, Hodge DL, Gooya J, Pascal V, Young HA, et al. Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2. Mol Cell Biol 2007; 27:5079-5089 (Pubitemid 47068283)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.14
, pp. 5079-5089
-
-
Berthet, C.1
Rodriguez-Galan, M.C.2
Hodge, D.L.3
Gooya, J.4
Pascal, V.5
Young, H.A.6
Keller, J.7
Bosselut, R.8
Kaldis, P.9
-
35
-
-
34548574658
-
Effect of the Cdk-inhibitor roscovitine on mouse hematopoietic progenitors in vivo and in vitro
-
DOI 10.1007/s00280-007-0431-x
-
Song H, Vita M, Sallam H, Tehranchi R, Nilsson C, Siden A, et al. Effect of the Cdk-inhibitor roscovitine on mouse hematopoietic progenitors in vivo and in vitro. Cancer Chemother Pharmacol 2007; 60:841-849 (Pubitemid 47389390)
-
(2007)
Cancer Chemotherapy and Pharmacology
, vol.60
, Issue.6
, pp. 841-849
-
-
Song, H.1
Vita, M.2
Sallam, H.3
Tehranchi, R.4
Nilsson, C.5
Siden, A.6
Hassan, Z.7
-
36
-
-
50949094104
-
Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain
-
Sallam H, Jimenez P, Song H, Vita M, Cedazo-Minguez A, Hassan M. Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain. Pharmacol Res 2008; 58:32-37
-
(2008)
Pharmacol Res
, vol.58
, pp. 32-37
-
-
Sallam, H.1
Jimenez, P.2
Song, H.3
Vita, M.4
Cedazo-Minguez, A.5
Hassan, M.6
-
37
-
-
33846674886
-
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
-
DOI 10.1158/0008-5472.CAN-06-3964
-
Chen S, Dai Y, Harada H, Dent P, Grant S. Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 2007; 67:782-791 (Pubitemid 46192219)
-
(2007)
Cancer Research
, vol.67
, Issue.2
, pp. 782-791
-
-
Chen, S.1
Dai, Y.2
Harada, H.3
Dent, P.4
Grant, S.5
|