Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A

Neurological Sciences

Volumn 35, Issue 9, 2014, Pages 1365-1371

  Yang, Lei ^a   Gu, Xiaoping ^b   Zhang, Wei ^b   Zhang, Juan ^b   Ma, Zhengliang ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Analgesic; Cdk5; Neuropathic pain; NR2A

Indexed keywords

CYCLIN DEPENDENT KINASE 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; ROSCOVITINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE;

ADULT; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; LATENT PERIOD; MALE; MECHANICAL STIMULATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; RAT; RAT MODEL; RECEPTOR DOWN REGULATION; SPINAL GANGLION; WITHDRAWAL REFLEX; ADVERSE EFFECTS; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DOWN REGULATION; DRUG EFFECTS; GENETICS; METABOLISM; NEURALGIA; PAIN MEASUREMENT; PATHOLOGY; REACTION TIME; SPRAGUE DAWLEY RAT; STIMULATION; SUBARACHNOID SPACE; TIME;

ANALYSIS OF VARIANCE; ANIMALS; CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GANGLIA, SPINAL; MALE; NEURALGIA; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; PROTEIN KINASE INHIBITORS; PURINES; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; SUBARACHNOID SPACE; TIME FACTORS;

EID: 84908356223     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-014-1713-9     Document Type: Article

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