Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine

Investigational New Drugs

Volumn 28, Issue 3, 2010, Pages 299-305

  Yakisich, Juan Sebastian ^a   Vita, Marina Fernanda ^a,c   Siden, Åke ^a   Tasat, Deborah Ruth ^b   Cruz, Mabel ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cerebral cortex; Glioma; Olomoucine; Purines; RG2 model; Roscovitine; Scheduled unscheduled DNA synthesis

Indexed keywords

DNA; OLOMOUCINE; ROSCOVITINE;

AGE; ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS INHIBITION; GLIOMA; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; CEREBRAL CORTEX; DNA; DNA DAMAGE; DNA REPAIR; DRUG SCREENING ASSAYS, ANTITUMOR; GLIOMA; HUMANS; KINETIN; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEIN KINASE INHIBITORS; PURINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77952241679     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9254-4     Document Type: Article

References (46)

1. L Meijer A Borgne O Mulner JPJ Chong JJ Blow N Inagaki M Inagaki J-G Delcros J-P Moulinoux 1997 Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5 Eur J Biochem 243 527 536 10.1111/j.1432-1033.1997.t01-2-00527.x 10.1111/j.1432-1033.1997.t01-2-00527.x 1:CAS:528:DyaK2sXhtVWiu7g%3D 9030781
2. J Vesely L Havlicek M Strnad JJ Blow A Donella-Deana L Pinna DS Letham J Kato L Detivaud S Leclerc L Meijer 1994 Inhibition of cyclin-dependent kinases by purine analogues Eur J Biochem 224 771 786 10.1111/j.1432-1033.1994.00771.x 10.1111/j.1432-1033.1994.00771.x 1:CAS:528:DyaK2cXmvFGktL0%3D 7925396
3. JS Yakisich Å Sidén V Idoyaga Vargas P Eneroth M Cruz 1998 Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine Biochem Biophys Res Commun 243 674 677 10.1006/bbrc.1998.8157 10.1006/bbrc.1998.8157 1:CAS:528:DyaK1cXhsFCgsbk%3D 9500988 (Pubitemid 28414137)
4. JS Yakisich J Boethius I Ohlsson Lindblom L Wallstedt V Idoyaga Vargas Å Sidén M Cruz 1999 Inhibition of DNA synthesis in human gliomas by roscovitine Neuroreport 10 2563 2567 10.1097/00001756-199908200-00023 10.1097/00001756-199908200-00023 1:CAS:528:DyaK1MXlvF2isro%3D 10574370
5. M Savio M Cerri O Cazzalini P Perucca LA Stivala P Pichierri A Franchitto L Meijer E Prosperi 2006 Replication-dependent DNA damage response triggered by roscovitine induces an uncoupling of DNA replication proteins Cell Cycle 5 2153 2159 1:CAS:528:DC%2BD28XhtlGqsr3M 16969115
6. M Ljungman MT Paulsen 2001 The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382 Mol Pharmacol 60 785 789 1:STN:280: DC%2BD3MrhsVymug%3D%3D 11562441
7. DE MacCallum J Melville S Frame K Watt S Anderson A Gianella-Borradori DP Lane SR Green 2005 Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1 Cancer Res 65 5399 5407 10.1158/0008-5472.CAN-05-0233 10.1158/0008-5472.CAN-05-0233 1:CAS:528: DC%2BD2MXltFels7w%3D 15958589 (Pubitemid 40827353)
8. S Bach M Knockaert J Reinhardt O Lozach S Schmitt B Baratte M Koken SP Coburn L Tang T Jiang 2005 Roscovitine targets, protein kinases and pyridoxal kinase J Biol Chem 280 31208 31219 10.1074/jbc.M500806200 10.1074/jbc.M500806200 1:CAS:528:DC%2BD2MXpsVCmurY%3D 15975926 (Pubitemid 41291858)
9. L Tang MH Li P Cao F Wang WR Chang S Bach J Reinhardt Y Ferandin H Galons Y Wan 2005 Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives J Biol Chem 280 31220 31229 10.1074/jbc.M500805200 10.1074/jbc.M500805200 1:CAS:528:DC%2BD2MXpsVCmurc%3D 15985434 (Pubitemid 41291859)
10. H Iseki TC Ko XY Xue A Seapan MR Hellmich CM Townsend Jr 1997 Cyclin-dependent kinase inhibitiors blok proliferation of human gastric cancer cells Surgery 122 187 195 10.1016/S0039-6060(97)90008-8 10.1016/S0039-6060(97) 90008-8 1:STN:280:DyaK2svjsVagtA%3D%3D 9288122 (Pubitemid 27383055)
11. SJ McCLue D Blake T Clarke A Cowan L Cummings PM Fischer M MacKenzie J Melville K Stewart S Wang 2002 In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine) Int J Cancer 102 462 468 10.1002/ijc.10738 (Pubitemid 35315999)
12. JW Pippin O Qu L Meijer SJ Shankland 1997 Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with roscovitine, a novel cyclin-dependent kinase antagonist J Clin Invest 100 2512 2520 10.1172/JCI119793 10.1172/JCI119793 1:CAS:528:DyaK2sXnsVymtLY%3D 9366565
13. L Meijer 1996 Chemical inhibitors of cyclin-dependent kinases Trends Cell Biol 6 393 397 10.1016/0962-8924(96)10034-9 10.1016/0962-8924(96)10034-9 1:CAS:528:DyaK28XmsFWgtbk%3D 15157522 (Pubitemid 26315904)
14. PM Fischer A Gianella-Borradori 2005 Recent progress in the discovery and development of cyclin-dependent kinase inhibitors Expert Opin Investig Drugs 14 457 477 10.1517/13543784.14.4.457 10.1517/13543784.14.4.457 1:CAS:528:DC%2BD2MXksl2ju7Y%3D 15882121 (Pubitemid 40711855)
15. ME Noble JA Endicott LN Johnson 2004 Protein kinase inhibitors: insights into drug design from structure Science 303 1800 1805 10.1126/science.1095920 10.1126/science.1095920 1:CAS:528:DC%2BD2cXitFehurc%3D 15031492 (Pubitemid 38374863)
16. JF Costello C Plass W Arap VM Chapman WA Held MS Berger HJ Su Huang WK Cavenee 1997 Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA Cancer Res 57 1250 1254 1:STN:280:DyaK2s3jvVKqtQ%3D%3D 9102208
17. PB Dirks SL Hubbard M Murakami JT Rutka 1997 Cyclin and cyclin-dependent kinase expression in human astrocytoma cell lines J Neuropathol Exp Neurol 56 291 300 10.1097/00005072-199703000-00008 10.1097/00005072-199703000-00008 1:CAS:528:DyaK2sXislGjuro%3D 9056543
18. T Moulton G Samara WY Chung L Yuan R Desai M Sisti J Bruce B Tycko 1995 MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme Am J Pathol 146 613 619 1:STN:280:DyaK2M7ptlyiug%3D%3D 7887443
19. JJ Olson D Barnett J Yang R Assietti G Cotsonis CD James 1998 Gene amplification as a prognostic factor in primary brain tumors Clin Cancer Res 4 215 222 1:STN:280:DyaK1c7nslKiug%3D%3D 9516974
20. Y Ono T Tamiya T Ichikawa K Kunishio K Matsumoto T Furuta T Ohmoto K Ueki DN Louis 1996 Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices J Neuropathol Exp Neurol 55 1026 1031 10.1097/00005072-199655100-00002 1:STN:280:DyaK2s%2FhtV2ltA%3D%3D 8857999
21. B Rollbrocker A Waha DN Louis OD Wiestler A von Deimling 1996 Amplification of the cyclin-dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme Acta Neuropathol 92 70 74 10.1007/s004010050491 10.1007/s004010050491 1:CAS:528:DyaK28XkslSlurc%3D 8811128 (Pubitemid 26192085)
22. KS Srivenugopal F Ali-Osman 1996 Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells Oncogene 12 2029 2034 1:CAS:528:DyaK28XivF2ktLc%3D 8649864
23. B Westermark M Nister 1995 Molecular genetics of human glioma Curr Opin Oncol 7 220 225 10.1097/00001622-199505000-00005 10.1097/00001622-199505000- 00005 1:CAS:528:DyaK2sXkt1amt70%3D 7654823
24. G Bernert M Nemethova M Herrera-Marschitz N Cairns G Lubec 1996 Decreased cyclin dependent kinase in brain of patients with Down syndrome Neurosci Lett 216 68 70 10.1016/0304-3940(96)12988-8 10.1016/0304-3940(96)12988-8 1:CAS:528:DyaK28Xmt1ais78%3D 8892394
25. B Lubec E Dell'Anna S Fang-Kircher M Marx M Herrera-Marschitz G Lubec 1997 Decrease of brain protein kinase C, protein kinase A, and cyclin-dependent kinase correlating with pH precedes neuronal death in neonatal asphyxia J Investig Med 45 284 294 1:STN:280:DyaK2szptlGjug%3D%3D 9250002 (Pubitemid 127454841)
26. A McShea PL Harris KR Webster AF Wahl MA Smith 1997 Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease Am J Pathol 150 1933 1939 1:STN:280:DyaK2szhvFCrtg%3D%3D 9176387
27. JJ Pei H Braak CX Gong I Grundke-Iqbal K Iqbal B Winblad RF Cowburn 2002 Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration Acta Neuropathol 104 369 376 1:CAS:528:DC%2BD38XmsFGrtro%3D 12200623
28. JJ Pei I Grundke-Iqbal K Iqbal N Bogdanovic B Winblad RF Cowburn 1998 Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration Brain Res 797 267 277 10.1016/S0006-8993(98)00296-0 10.1016/S0006-8993(98)00296-0 1:CAS:528: DyaK1cXjvFOjsb4%3D 9666145 (Pubitemid 28332739)
29. M van Lookeren Campagne R Gill 1998 Cell cycle-related gene expression in the adult rat brain: selective induction of cyclin G1 and p21WAF1/CIP1 in neurons following focal cerebral ischemia Neuroscience 84 1097 1112 10.1016/S0306-4522(97)00580-0 10.1016/S0306-4522(97)00580-0 9578398 (Pubitemid 28157026)
30. I Vincent G Jicha M Rosado DW Dickson 1997 Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain J Neurosci 17 3588 3598 1:CAS:528:DyaK2sXjt1WktL8%3D 9133382
31. J Altman GD Das 1966 Autoradiographic and histopathological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions J Comp Neurol 126 337 390 10.1002/cne.901260302 10.1002/cne.901260302 1:STN:280:DyaF287ktF2ktA%3D%3D 5937257
32. ZP Chen A McQuillan G Mohr LC Panasci 1998 Excision repair cross-complementing rodent repair deficiency gene 2 expression and chloroethylnitrosourea resistance in human cell lines Neurosurgery 42 1112 1119 10.1097/00006123-199805000-00094 10.1097/00006123-199805000-00094 1:STN:280:DyaK1c3ksl2ksw%3D%3D 9588557 (Pubitemid 28196524)
33. M Vita M Abdel-Rehim S Olofsson Z Hassan L Meurling A Sidén M Sidén T Pettersson M Hassan 2005 Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat Eur J Pharm Sci 25 91 103 10.1016/j.ejps.2005.02.001 10.1016/j.ejps.2005.02.001 1:CAS:528: DC%2BD2MXjs1Kmsro%3D 15854805 (Pubitemid 40602199)
34. EH Kim SU Kim DY Shin KS Choi 2004 Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP Oncogene 23 446 456 10.1038/sj.onc.1207025 10.1038/sj.onc.1207025 1:CAS:528: DC%2BD2cXjtFKhsQ%3D%3D 14724573 (Pubitemid 38174999)
35. C Schmitz B Axmacher U Zunker H Korr 1999 Age-related changes of DNA repair and mitocondrial DNA synthesis in the mouse brain Acta Neuropathol 97 71 81 10.1007/s004010050957 10.1007/s004010050957 1:CAS:528:DyaK1cXns1Wntb4%3D 9930897 (Pubitemid 29132648)
36. S Sawada S Asakura H Daimon C Furihata 1995 Comparison of autoraadiography, liquid scintillation counting and immunoenzymatic satining of 5-bromo-2′deoxyuridine for measurement of unscheduled DNA synthesis and replicative DNA synthesis in rat liver Mutat Res 344 109 116 10.1016/0165-1218(95)00039-9 10.1016/0165-1218(95)00039-9 1:CAS:528: DyaK2MXpsV2rs7s%3D 7491128
37. C Heyting L van't Veer 1981 Repair of ethylnitrosourea-induced DNA damage in the newborn rat. II. Localization of unscheduled DNA synthesis in the developing rat brain Carcinogenesis 2 1171 1180 10.1093/carcin/2.11.1173 10.1093/carcin/2.11.1173
38. RB Painter JE Cleaver 1969 Repair replication, unscheduled DNA synthesis, and the repair of mammalian DNA Radiat Res 37 451 466 10.2307/3572686 10.2307/3572686 1:CAS:528:DyaF1MXnsVehsQ%3D%3D 5775536
39. CE Agrelo BJ Severn 1981 A simplified method for measuring scheduled and unscheduled DNA synthesis in human fibroblasts Toxicology 21 151 158 10.1016/0300-483X(81)90125-6 10.1016/0300-483X(81)90125-6 1:CAS:528: DyaL3MXls1eiurY%3D 7281203 (Pubitemid 11047130)
40. JS Yakisich Å Sidén V Idoyaga Vargas P Eneroth M Cruz 1998 Fast and sensitive method for simultaneous measurement of cell proliferation rate and drug sensitivity in rat cerebral cortex Exp Neurol 151 194 202 10.1006/exnr.1998.6814 10.1006/exnr.1998.6814 1:CAS:528:DyaK1cXkt1Kju7s%3D 9628754 (Pubitemid 28285899)
41. JS Yakisich Å Sidén V Idoyaga Vargas P Eneroth M Cruz 1999 Early effects of protein kinase modulator on DNA synthesis in rat cerebral cortex Exp Neurol 159 164 176 10.1006/exnr.1999.7121 10.1006/exnr.1999.7121 1:CAS:528:DyaK1MXlvVWqsr8%3D 10486185 (Pubitemid 29444913)
42. LU Wahlberg PM Almqvist MJ Glantz J Boethius 1996 Polymeric controlled-release amsacrine chemotherapy in an experimental glioma model Acta Neurochir (Wien) 138 1323 1329 10.1007/BF01411063 10.1007/BF01411063 1:STN:280:DyaK2s7jsFWqug%3D%3D discussion 1329-1330
43. MM Vilenchik TM Tretjak 1977 Evidence for unscheduled DNA synthesis in rat brain J Neurochem 29 1159 1161 10.1111/j.1471-4159.1977.tb06526.x 10.1111/j.1471-4159.1977.tb06526.x 1:CAS:528:DyaE1cXhtFygsLk%3D 599347
44. C Perrone-Capano G D'Onofrio A Giuditta 1982 DNA turnover in rat cerebral cortex J Neurochem 38 52 56 10.1111/j.1471-4159.1982.tb10852.x 10.1111/j.1471-4159.1982.tb10852.x 1:CAS:528:DyaL38Xks12qtrg%3D 7108534
45. H Sallam P Jimenez H Song M Vita A Cedazo-Minguez M Hassan 2008 Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain Pharmacol Res 58 32 37 10.1016/j.phrs.2008.05.010 10.1016/j.phrs.2008.05.010 1:CAS:528:DC%2BD1cXhtVygtLbI 18588979
46. C Benson J White J De Bono A O'Donnell F Raynaud C Cruickshank H McGrath M Walton P Workman S Kaye 2007 A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days Br J Cancer 96 29 37 10.1038/sj.bjc.6603509 10.1038/sj.bjc.6603509 1:CAS:528:DC%2BD2sXis1Khug%3D%3D 17179992 (Pubitemid 46094635)