Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA

Pharmacology Biochemistry and Behavior

Volumn 102, Issue 1, 2012, Pages 139-145

  Zhang, Rui ^a   Liu, Yue ^a   Zhang, Juan ^a   Zheng, Yaguo ^a   Gu, Xiaoping ^a   Ma, Zhengliang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Cancer pain; Cdk5; mRNA; NR2B; Roscovitine

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; ROSCOVITINE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; BONE CANCER; CANCER PAIN; DRUG STRUCTURE; FEMUR; HYPERALGESIA; MALE; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD;

ANIMALS; ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; INJECTIONS, SPINAL; MALE; MICE; MICE, INBRED C3H; PAIN; PROTEIN SUBUNITS; PURINES; RANDOM ALLOCATION; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 84860171584     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.03.025     Document Type: Article

References (28)

1. S. Boyce, A. Wyatt, J.K. Webb, R. O'Donnell, G. Mason, and M. Rigby Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn Neuropharmacology 38 1999 611 623 (Pubitemid 29150316)
2. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J Neurosci Methods 53 1994 55 63 (Pubitemid 24238751)
3. R. Dhavan, and L.H. Tsai A decade of CDK5 Nat Rev Mol Cell Biol 2 2001 749 759 (Pubitemid 33679837)
4. X. Gu, J. Zhang, Z. Ma, J. Wang, X. Zhou, and Y. Jin The role of N-methyl-d-aspartate receptor subunit NR2B in spinal cord in cancer pain Eur J Pain 14 2009 496 502
5. K. Hargreaves, R. Dubner, F. Brown, C. Flores, and J. Joris A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia Pain 32 1988 77 88
6. J.L. Hylden, and G.L. Wilcox Intrathecal morphine in mice: a new technique Eur J Pharmacol 67 1980 313 316 (Pubitemid 10007057)
7. T. Klein, W. Magerl, A. Hanschmann, M. Althaus, and R.D. Treede Antihyperalgesic and analgesic properties of the N-methyl-d-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia Eur J Pain 12 2008 17 29 (Pubitemid 350046361)
8. B.S. Li, M.K. Sun, L. Zhang, S. Takahashi, W. Ma, and L. Vinade Regulation of NMDA receptors by cyclin-dependent kinase-5 PNAS 98 2001 12742 12747 (Pubitemid 33020016)
9. J.M. Loftis, and A. Janowsky The N-methyl-d-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications Pharmacol Ther 97 2003 55 85 (Pubitemid 35477804)
10. A.B. Malmberg, H. Gilbert, R.T. McCabe, and A.I. Basbaum Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T Pain 101 2003 109 116 (Pubitemid 36044658)
11. C.A. McClung, and E.J. Nestler Regulation of gene expression and cocaine reward by CREB and ΔFosB Nat Neurosci 6 2003 1208 1215 (Pubitemid 37346042)
12. H. Mori, and M. Mishina Structure and function of the NMDA receptor channel Neuropharmacology 34 1995 1219 1237
13. E.J. Nestler, M.B. Kelz, and J. Chen DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity Brain Res 835 1999 10 17 (Pubitemid 29336545)
14. T.K. Pareek, and A.B. Kulkarni Cdk5: a new player in pain signal Cell Cycle 6 2006 585 588
15. C.G. Parsons NMDA receptors as targets for drug action in neuropathic pain Eur J Pharmacol 429 2001 71 78 (Pubitemid 33043983)
16. W.L. Peng, G.J. Wu, W.Z. Sun, J.C. Chen, and A.T. Huang Multidisciplinary management of cancer pain: a longitudinal retrospective study on a cohort of end-stage cancer patients J Pain Symptom Manage 32 2006 444 452 (Pubitemid 44755110)
17. H.Y. Peng, G.D. Chen, K.C. Tung, Y.W. Chien, C.Y. Lai, and M.C. Hsieh Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats Am J Pharm Educ 297 2009 416 426
18. X.X. Qu, J. Cai, M.J. Li, Y.N. Chi, F.F. Liao, and F.Y. Liu Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain Exp Neurol 215 2009 298 307
19. M.J. Schwei, P. Honore, S.D. Rogers, J.L. Salak-Johnson, M.P. Finke, and M.L. Ramnaraine Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain J Neurosci 19 1999 10886 10897 (Pubitemid 30235733)
20. M.A. Sevcik, J.R. Ghilardi, C.M. Peters, T.H. Lindsay, K.G. Halvorson, and B.M. Jonas Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization Pain 115 2005 128 141
21. A. Strube, E. Stepina, D. Mumberg, A. Scholz, P. Hauff, and S.M. Kakonen Characterization of a new renal cell carcinoma bone metastasis mouse model Clin Exp Metastasis 27 2010 319 330
22. P.H. Tan, L.C. Yang, H.C. Shih, K.C. Lan, and J.T. Cheng Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat Gene Ther 12 2005 59 66
23. T. Tanaka, Veeranna, T. Ohshima, P. Rajan, N.D. Amin, and A. Cho Neuronal cyclin-dependent kinase 5 activity is critical for survival J Neurosci 21 2001 550 558 (Pubitemid 32107444)
24. C. Ultenius, B. Linderoth, B.A. Meyerson, and J. Wallin Spinal NMDA receptor phosphorylation correlates with the presence of neuropathic signs following peripheral nerve injury in the rat Neurosci Lett 399 2006 85 90
25. P.W. Wacnik, L.J. Eikmeier, T.R. Ruggles, M.L. Ramnaraine, B.K. Walcheck, and A.J. Beitz Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain J Neurosci 21 2001 9355 9366 (Pubitemid 33096879)
26. C.H. Wang, W.Y. Chou, and K.S. Hung Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats Acta Pharmacol Sin 26 2005 46 50
27. C.J. Woolf, and M.W. Salter Neuronal plasticity: increasing the gain in pain Science 288 2000 1765 1768 (Pubitemid 30399008)
28. W. Zhang, C.X. Shi, X.P. Gu, Z.L. Ma, and W. Zhu Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats Anesth Analg 108 2009 1015 1020