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Volumn 44, Issue 11, 2016, Pages 1839-1850

Trimethylamine and trimethylamine N-oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CARNITINE; CHOLINE; FLAVIN CONTAINING MONOOXYGENASE 3; THIONEINE; TRIMETHYLAMINE OXIDE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING); METHYLAMINE; OXYGENASE; TRIMETHYLAMINE; TRIMETHYLOXAMINE;

EID: 85015364857     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.116.070615     Document Type: Short Survey
Times cited : (276)

References (182)
  • 3
    • 0026530453 scopus 로고
    • The exogenous origin of trimethylamine in the mouse
    • Al-Waiz M, Mikov M, Mitchell SC, and Smith RL (1992) The exogenous origin of trimethylamine in the mouse. Metabolism 41:135-136.
    • (1992) Metabolism , vol.41 , pp. 135-136
    • Al-Waiz, M.1    Mikov, M.2    Mitchell, S.C.3    Smith, R.L.4
  • 4
    • 0023160321 scopus 로고
    • The metabolism of 14C-labelled trimethylamine and its N-oxide in man
    • Al-Waiz M, Mitchell SC, Idle JR, and Smith RL (1987a) The metabolism of 14C-labelled trimethylamine and its N-oxide in man. Xenobiotica 17:551-558.
    • (1987) Xenobiotica , vol.17 , pp. 551-558
    • Al-Waiz, M.1    Mitchell, S.C.2    Idle, J.R.3    Smith, R.L.4
  • 5
    • 0023124202 scopus 로고
    • The relative importance of N-oxidation and N-demethylation in the metabolism of trimethylamine in man
    • Al-Waiz M, Mitchell SC, Idle JR, and Smith RL (1987b) The relative importance of N-oxidation and N-demethylation in the metabolism of trimethylamine in man. Toxicology 43:117-121.
    • (1987) Toxicology , vol.43 , pp. 117-121
    • Al-Waiz, M.1    Mitchell, S.C.2    Idle, J.R.3    Smith, R.L.4
  • 7
    • 0024028868 scopus 로고
    • Molecular cloning, physical mapping and expression of the bet genes governing the osmoregulatory choline-glycine betaine pathway of Escherichia coli
    • Andresen PA, Kaasen I, Styrvold OB, Boulnois G, and Strøm AR (1988) Molecular cloning, physical mapping and expression of the bet genes governing the osmoregulatory choline-glycine betaine pathway of Escherichia coli. J Gen Microbiol 134:1737-1746.
    • (1988) J Gen Microbiol , vol.134 , pp. 1737-1746
    • Andresen, P.A.1    Kaasen, I.2    Styrvold, O.B.3    Boulnois, G.4    Strøm, A.R.5
  • 9
    • 70350554457 scopus 로고    scopus 로고
    • Exploring microbial diversity using 16S rRNA high-throughput methods
    • Armougom F and Raoult D (2009) Exploring microbial diversity using 16S rRNA high-throughput methods. J Comput Sci Syst Biol 2:74-92.
    • (2009) J Comput Sci Syst Biol , vol.2 , pp. 74-92
    • Armougom, F.1    Raoult, D.2
  • 11
    • 0029133243 scopus 로고
    • Dysfunctional N-oxidation of trimethylamine and the influence of testosterone treatment in man
    • Ayesh R, Mitchell SC, and Smith RL (1995) Dysfunctional N-oxidation of trimethylamine and the influence of testosterone treatment in man. Pharmacogenetics 5:244-246.
    • (1995) Pharmacogenetics , vol.5 , pp. 244-246
    • Ayesh, R.1    Mitchell, S.C.2    Smith, R.L.3
  • 12
    • 0027272625 scopus 로고
    • The fish odour syndrome: Biochemical, familial, and clinical aspects
    • Ayesh R, Mitchell SC, Zhang A, and Smith RL (1993) The fish odour syndrome: biochemical, familial, and clinical aspects. BMJ 307:655-657.
    • (1993) BMJ , vol.307 , pp. 655-657
    • Ayesh, R.1    Mitchell, S.C.2    Zhang, A.3    Smith, R.L.4
  • 13
    • 33646205972 scopus 로고    scopus 로고
    • Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis
    • Bain MA, Faull R, Fornasini G, Milne RW, and Evans AM (2006) Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis. Nephrol Dial Transplant 21:1300-1304.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 1300-1304
    • Bain, M.A.1    Faull, R.2    Fornasini, G.3    Milne, R.W.4    Evans, A.M.5
  • 14
    • 0005644035 scopus 로고
    • Choline fermentation by Desulfovibrio desulfuricans
    • Baker FD, Papiska HR, and Campbell LL (1962) Choline fermentation by Desulfovibrio desulfuricans. J Bacteriol 84:973-978.
    • (1962) J Bacteriol , vol.84 , pp. 973-978
    • Baker, F.D.1    Papiska, H.R.2    Campbell, L.L.3
  • 15
    • 0021778428 scopus 로고
    • Bacterial reduction of trimethylamine oxide
    • Barrett EL and Kwan HS (1985) Bacterial reduction of trimethylamine oxide. Annu Rev Microbiol 39:131-149.
    • (1985) Annu Rev Microbiol , vol.39 , pp. 131-149
    • Barrett, E.L.1    Kwan, H.S.2
  • 16
    • 0042464247 scopus 로고
    • Studies of Fish Spoilage: II. The origin of trimethylamine produced during the spoilage of cod muscle press juice
    • Beatty SA (1938) Studies of Fish Spoilage: II. The origin of trimethylamine produced during the spoilage of cod muscle press juice. J Fish Res Bd Can 4a:63-68.
    • (1938) J Fish Res Bd Can , vol.4 A , pp. 63-68
    • Beatty, S.A.1
  • 18
    • 0016187603 scopus 로고
    • Microbial oxidation of amines. Partial purification of a trimethylamine mono-oxygenase from Pseudomonas aminovorans and its role in growth on trimethylamine
    • Boulton CA, Crabbe MJ, and Large PJ (1974) Microbial oxidation of amines. Partial purification of a trimethylamine mono-oxygenase from Pseudomonas aminovorans and its role in growth on trimethylamine. Biochem J 140:253-263.
    • (1974) Biochem J , vol.140 , pp. 253-263
    • Boulton, C.A.1    Crabbe, M.J.2    Large, P.J.3
  • 20
    • 0013832936 scopus 로고
    • The clostridial fermentations of choline and ethanolamine. 1. Preparation and properties of cell-free extracts
    • Bradbeer C (1965) The clostridial fermentations of choline and ethanolamine. 1. Preparation and properties of cell-free extracts. J Biol Chem 240:4669-4674.
    • (1965) J Biol Chem , vol.240 , pp. 4669-4674
    • Bradbeer, C.1
  • 21
    • 0022478561 scopus 로고
    • Trimethylamine: The substance mainly responsible for the fishy odor often associated with bacterial vaginosis
    • Brand JM and Galask RP (1986) Trimethylamine: the substance mainly responsible for the fishy odor often associated with bacterial vaginosis. Obstet Gynecol 68:682-685.
    • (1986) Obstet Gynecol , vol.68 , pp. 682-685
    • Brand, J.M.1    Galask, R.P.2
  • 22
    • 85052274144 scopus 로고    scopus 로고
    • Archaebiotics: Proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease
    • Brugère J-F, Borrel G, Gaci N, Tottey W, O'Toole PW, and Malpuech-Brugère C (2014) Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease. Gut Microbes 5:5-10.
    • (2014) Gut Microbes , vol.5 , pp. 5-10
    • Brugère, J.-F.1    Borrel, G.2    Gaci, N.3    Tottey, W.4    O'Toole, P.W.5    Malpuech-Brugère, C.6
  • 23
    • 78651058918 scopus 로고
    • The action of members of the genus Achromobacter on trimethylamine oxide and related compounds
    • Campbell LL, Jr and Williams OB (1951) The action of members of the genus Achromobacter on trimethylamine oxide and related compounds. J Bacteriol 62:249-251.
    • (1951) J Bacteriol , vol.62 , pp. 249-251
    • Campbell, L.L.1    Williams, O.B.2
  • 25
    • 58149202381 scopus 로고    scopus 로고
    • Role of flavin-containing monooxygenase in drug development
    • Cashman JR (2008) Role of flavin-containing monooxygenase in drug development. Expert Opin Drug Metab Toxicol 4:1507-1521.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 1507-1521
    • Cashman, J.R.1
  • 26
    • 0028954243 scopus 로고
    • Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans
    • Cashman JR, Park SB, Berkman CE, and Cashman LE (1995) Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. Chem Biol Interact 96:33-46.
    • (1995) Chem Biol Interact , vol.96 , pp. 33-46
    • Cashman, J.R.1    Park, S.B.2    Berkman, C.E.3    Cashman, L.E.4
  • 30
    • 0025284239 scopus 로고
    • Formation of trimethylamine from dietary choline by Streptococcus sanguis I, which colonizes the mouth
    • Chao CK and Zeisel SH (1990) Formation of trimethylamine from dietary choline by Streptococcus sanguis I, which colonizes the mouth. J Nutr Biochem 1:89-97.
    • (1990) J Nutr Biochem , vol.1 , pp. 89-97
    • Chao, C.K.1    Zeisel, S.H.2
  • 31
    • 84858153376 scopus 로고    scopus 로고
    • Ergothioneine; antioxidant potential, physiological function and role in disease
    • Cheah IK and Halliwell B (2012) Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim Biophys Acta 1822:784-793.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 784-793
    • Cheah, I.K.1    Halliwell, B.2
  • 33
    • 0032531667 scopus 로고    scopus 로고
    • Hormonal regulation of microsomal flavin-containing monooxygenase activity by sex steroids and growth hormone in co-cultured adult male rat hepatocytes
    • Coecke S, Debast G, Phillips IR, Vercruysse A, Shephard EAE, and Rogiers V (1998) Hormonal regulation of microsomal flavin-containing monooxygenase activity by sex steroids and growth hormone in co-cultured adult male rat hepatocytes. Biochem Pharmacol 56:1047-1051.
    • (1998) Biochem Pharmacol , vol.56 , pp. 1047-1051
    • Coecke, S.1    Debast, G.2    Phillips, I.R.3    Vercruysse, A.4    Shephard, E.A.E.5    Rogiers, V.6
  • 34
    • 0015839229 scopus 로고
    • Trimethylamine metabolism in obligate and facultative methylotrophs
    • Colby J and Zatman LJ (1973) Trimethylamine metabolism in obligate and facultative methylotrophs. Biochem J 132:101-112.
    • (1973) Biochem J , vol.132 , pp. 101-112
    • Colby, J.1    Zatman, L.J.2
  • 35
    • 0019825016 scopus 로고
    • Trimethylamine N-oxide (TMAO) reductase activity in chlorate-resistant or respiration-deficient mutants of Escherichia coli
    • Cox JC and Knight R (1981) Trimethylamine N-oxide (TMAO) reductase activity in chlorate-resistant or respiration-deficient mutants of Escherichia coli. FEMS Microbiol Lett 12:249-252.
    • (1981) FEMS Microbiol Lett , vol.12 , pp. 249-252
    • Cox, J.C.1    Knight, R.2
  • 36
    • 0019143113 scopus 로고
    • Redox mechanisms in "oxidant-dependent" hexose fermentation by Rhodopseudomonas capsulata
    • Cox JC, Madigan MT, Favinger JL, and Gest H (1980) Redox mechanisms in "oxidant-dependent" hexose fermentation by Rhodopseudomonas capsulata. Arch Biochem Biophys 204:10-17.
    • (1980) Arch Biochem Biophys , vol.204 , pp. 10-17
    • Cox, J.C.1    Madigan, M.T.2    Favinger, J.L.3    Gest, H.4
  • 37
    • 84871837954 scopus 로고    scopus 로고
    • Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
    • Craciun S and Balskus EP (2012) Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proc Natl Acad Sci USA 109:21307-21312.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 21307-21312
    • Craciun, S.1    Balskus, E.P.2
  • 39
    • 0002701598 scopus 로고
    • Reduction of trimethylamine oxide to trimethylamine by Mobiluncus strains isolated from patients with bacterial vaginosis
    • Cruden DL and Galask RP (1988) Reduction of trimethylamine oxide to trimethylamine by Mobiluncus strains isolated from patients with bacterial vaginosis. Microb Ecol Health Dis 1:95-100.
    • (1988) Microb Ecol Health Dis , vol.1 , pp. 95-100
    • Cruden, D.L.1    Galask, R.P.2
  • 40
    • 0029150646 scopus 로고
    • Qualitative and quantitative characterization of spoilage bacteria from packed fish
    • Dalgaard P (1995) Qualitative and quantitative characterization of spoilage bacteria from packed fish. Int J Food Microbiol 26:319-333.
    • (1995) Int J Food Microbiol , vol.26 , pp. 319-333
    • Dalgaard, P.1
  • 41
    • 84937074210 scopus 로고    scopus 로고
    • Adaptation of anaerobic cultures of Escherichia coli K-12 in response to environmental trimethylamine-N-oxide
    • Denby KJ, Rolfe MD, Crick E, Sanguinetti G, Poole RK, and Green J (2015) Adaptation of anaerobic cultures of Escherichia coli K-12 in response to environmental trimethylamine-N-oxide. Environ Microbiol 17:2477-2491.
    • (2015) Environ Microbiol , vol.17 , pp. 2477-2491
    • Denby, K.J.1    Rolfe, M.D.2    Crick, E.3    Sanguinetti, G.4    Poole, R.K.5    Green, J.6
  • 42
    • 0028458115 scopus 로고
    • L-carnitine via enzyme-catalyzed oxidative kinetic resolution
    • Ditullio D, Anderson D, Chen CS, and Sih CJ (1994) L-carnitine via enzyme-catalyzed oxidative kinetic resolution. Bioorg Med Chem 2:415-420.
    • (1994) Bioorg Med Chem , vol.2 , pp. 415-420
    • Ditullio, D.1    Anderson, D.2    Chen, C.S.3    Sih, C.J.4
  • 44
    • 0030063145 scopus 로고    scopus 로고
    • Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04
    • Dolphin CT, Cullingford TE, Shephard EA, Smith RL, and Phillips IR (1996) Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04. Eur J Biochem 235:683-689.
    • (1996) Eur J Biochem , vol.235 , pp. 683-689
    • Dolphin, C.T.1    Cullingford, T.E.2    Shephard, E.A.3    Smith, R.L.4    Phillips, I.R.5
  • 45
    • 0030667523 scopus 로고    scopus 로고
    • Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome
    • Dolphin CT, Janmohamed A, Smith RL, Shephard EA, and Phillips IR (1997) Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nat Genet 17:491-494.
    • (1997) Nat Genet , vol.17 , pp. 491-494
    • Dolphin, C.T.1    Janmohamed, A.2    Smith, R.L.3    Shephard, E.A.4    Phillips, I.R.5
  • 46
    • 0034523352 scopus 로고    scopus 로고
    • Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome
    • Dolphin CT, Janmohamed A, Smith RL, Shephard EA, and Phillips IR (2000) Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome. Pharmacogenetics 10:799-807.
    • (2000) Pharmacogenetics , vol.10 , pp. 799-807
    • Dolphin, C.T.1    Janmohamed, A.2    Smith, R.L.3    Shephard, E.A.4    Phillips, I.R.5
  • 47
    • 0020322585 scopus 로고
    • A conductance method for the assay and study of bacterial trimethylamine oxide reduction
    • Easter MC, Gibson DM, and Ward FB (1982) A conductance method for the assay and study of bacterial trimethylamine oxide reduction. J Appl Bacteriol 52:357-365.
    • (1982) J Appl Bacteriol , vol.52 , pp. 357-365
    • Easter, M.C.1    Gibson, D.M.2    Ward, F.B.3
  • 48
    • 0021049657 scopus 로고
    • The induction and location of trimethylamine-N-oxide reductase in Alteromonas sp. NCMB 400
    • Easter MC, Gibson DM, and Ward FB (1983) The induction and location of trimethylamine-N-oxide reductase in Alteromonas sp. NCMB 400. Microbiology 129:3689-3696.
    • (1983) Microbiology , vol.129 , pp. 3689-3696
    • Easter, M.C.1    Gibson, D.M.2    Ward, F.B.3
  • 49
    • 36949074171 scopus 로고
    • Bacterial degradation of choline
    • Eddy BP (1953) Bacterial degradation of choline. Nature 171:573-574.
    • (1953) Nature , vol.171 , pp. 573-574
    • Eddy, B.P.1
  • 50
    • 34548016273 scopus 로고    scopus 로고
    • Dietary sources and antioxidant effects of ergothioneine
    • Ey J, Schömig E, and Taubert D (2007) Dietary sources and antioxidant effects of ergothioneine. J Agric Food Chem 55:6466-6474.
    • (2007) J Agric Food Chem , vol.55 , pp. 6466-6474
    • Ey, J.1    Schömig, E.2    Taubert, D.3
  • 51
    • 0029310470 scopus 로고
    • Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice
    • Falls JG, Blake BL, Cao Y, Levi PE, and Hodgson E (1995) Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. J Biochem Toxicol 10:171-177.
    • (1995) J Biochem Toxicol , vol.10 , pp. 171-177
    • Falls, J.G.1    Blake, B.L.2    Cao, Y.3    Levi, P.E.4    Hodgson, E.5
  • 52
    • 0023884959 scopus 로고
    • Role of carnitine in human nutrition
    • Feller AG and Rudman D (1988) Role of carnitine in human nutrition. J Nutr 118:541-547.
    • (1988) J Nutr , vol.118 , pp. 541-547
    • Feller, A.G.1    Rudman, D.2
  • 53
    • 0020680189 scopus 로고
    • Methanogenesis from choline by a coculture of Desulfovibrio sp. and Methanosarcina barkeri
    • Fiebig K and Gottschalk G (1983) Methanogenesis from choline by a coculture of Desulfovibrio sp. and Methanosarcina barkeri. Appl Environ Microbiol 45:161-168.
    • (1983) Appl Environ Microbiol , vol.45 , pp. 161-168
    • Fiebig, K.1    Gottschalk, G.2
  • 56
    • 84921636319 scopus 로고    scopus 로고
    • Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
    • Gao X, Liu X, Xu J, Xue C, Xue Y, and Wang Y (2014) Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng 118:476-481.
    • (2014) J Biosci Bioeng , vol.118 , pp. 476-481
    • Gao, X.1    Liu, X.2    Xu, J.3    Xue, C.4    Xue, Y.5    Wang, Y.6
  • 58
    • 0026391093 scopus 로고
    • The FAD-containing monooxygenase-catalyzed N-oxidation and demethylation of trimethylamine in rat liver microsomes
    • Gut I and Conney AH (1991) The FAD-containing monooxygenase-catalyzed N-oxidation and demethylation of trimethylamine in rat liver microsomes. Drug Metabol Drug Interact 9:201-208.
    • (1991) Drug Metabol Drug Interact , vol.9 , pp. 201-208
    • Gut, I.1    Conney, A.H.2
  • 59
    • 0027169242 scopus 로고
    • Trimethylamine N-oxygenation and N-demethylation in rat liver microsomes
    • Gut I and Conney AH (1993) Trimethylamine N-oxygenation and N-demethylation in rat liver microsomes. Biochem Pharmacol 46:239-244.
    • (1993) Biochem Pharmacol , vol.46 , pp. 239-244
    • Gut, I.1    Conney, A.H.2
  • 60
    • 84892921460 scopus 로고    scopus 로고
    • Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics
    • Hao X, Liu X, Wang W, Ren H, Xie J, Shen P, Lin D, and Chen N (2013) Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics. PLoS One 8:e78531.
    • (2013) PLoS One , vol.8
    • Hao, X.1    Liu, X.2    Wang, W.3    Ren, H.4    Xie, J.5    Shen, P.6    Lin, D.7    Chen, N.8
  • 61
    • 0001247440 scopus 로고
    • Anaerobic degradation of choline. I. Fermentation of choline by an anaerobic, cytochrome-producing bacterium, Vibrio cholinicus n. sp.
    • Hayward HR and Stadtman TC (1959) Anaerobic degradation of choline. I. Fermentation of choline by an anaerobic, cytochrome-producing bacterium, Vibrio cholinicus n. sp. J Bacteriol 78:557-561.
    • (1959) J Bacteriol , vol.78 , pp. 557-561
    • Hayward, H.R.1    Stadtman, T.C.2
  • 62
    • 0000824613 scopus 로고
    • Anaerobic degradation of choline. II. Preparation and properties of cell-free extracts of Vibrio cholinicus
    • Hayward HR and Stadtman TC (1960) Anaerobic degradation of choline. II. Preparation and properties of cell-free extracts of Vibrio cholinicus. J Biol Chem 235:538-543.
    • (1960) J Biol Chem , vol.235 , pp. 538-543
    • Hayward, H.R.1    Stadtman, T.C.2
  • 63
    • 0024588511 scopus 로고
    • Betaine fermentation and oxidation by marine desulfuromonas strains
    • Heijthuijsen JH and Hansen TA (1989) Betaine fermentation and oxidation by marine desulfuromonas strains. Appl Environ Microbiol 55:965-969.
    • (1989) Appl Environ Microbiol , vol.55 , pp. 965-969
    • Heijthuijsen, J.H.1    Hansen, T.A.2
  • 65
    • 1342309263 scopus 로고    scopus 로고
    • Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: Identification of novel gene and pseudogene clusters
    • Hernandez D, Janmohamed A, Chandan P, Phillips IR, and Shephard EA (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. Pharmacogenetics 14:117-130.
    • (2004) Pharmacogenetics , vol.14 , pp. 117-130
    • Hernandez, D.1    Janmohamed, A.2    Chandan, P.3    Phillips, I.R.4    Shephard, E.A.5
  • 67
    • 0018092725 scopus 로고
    • Relations between dietary choline or lecithin intake, serum choline levels, and various metabolic indices
    • Hirsch MJ, Growdon JH, and Wurtman RJ (1978) Relations between dietary choline or lecithin intake, serum choline levels, and various metabolic indices. Metabolism 27:953-960.
    • (1978) Metabolism , vol.27 , pp. 953-960
    • Hirsch, M.J.1    Growdon, J.H.2    Wurtman, R.J.3
  • 69
    • 0024369217 scopus 로고
    • Reductive cleavage of sarcosine and betaine by Eubacterium acidaminophilum via enzyme systems different from glycine reductase
    • Hormann K and Andreesen JR (1989) Reductive cleavage of sarcosine and betaine by Eubacterium acidaminophilum via enzyme systems different from glycine reductase. Arch Microbiol 153:50-59.
    • (1989) Arch Microbiol , vol.153 , pp. 50-59
    • Hormann, K.1    Andreesen, J.R.2
  • 72
    • 0018154875 scopus 로고
    • Reduction of trimethylamine N-oxide by Escherichia coli as anaerobic respiration
    • Ishimoto M and Shimokawa O (1978) Reduction of trimethylamine N-oxide by Escherichia coli as anaerobic respiration. Z Allg Mikrobiol 18:173-181.
    • (1978) Z Allg Mikrobiol , vol.18 , pp. 173-181
    • Ishimoto, M.1    Shimokawa, O.2
  • 73
    • 0035885281 scopus 로고    scopus 로고
    • Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450
    • Janmohamed A, Dolphin CT, Phillips IR, and Shephard EA (2001) Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. Biochem Pharmacol 62:777-786.
    • (2001) Biochem Pharmacol , vol.62 , pp. 777-786
    • Janmohamed, A.1    Dolphin, C.T.2    Phillips, I.R.3    Shephard, E.A.4
  • 74
    • 2942596156 scopus 로고    scopus 로고
    • Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos)
    • Janmohamed A, Hernandez D, Phillips IR, and Shephard EA (2004) Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos). Biochem Pharmacol 68:73-83.
    • (2004) Biochem Pharmacol , vol.68 , pp. 73-83
    • Janmohamed, A.1    Hernandez, D.2    Phillips, I.R.3    Shephard, E.A.4
  • 75
    • 84940707248 scopus 로고    scopus 로고
    • Structure and fubction of CutC choline lyase from human microbiota bacterium Klebsiella pneumonia
    • Kalnins G, Kuka J, Grinberga S, Makrecka-Kuka M, Liepinsh E, Dambrova M, and Tars K (2015) Structure and fubction of CutC choline lyase from human microbiota bacterium Klebsiella pneumonia. J Biol Chem 290:21732-21740.
    • (2015) J Biol Chem , vol.290 , pp. 21732-21740
    • Kalnins, G.1    Kuka, J.2    Grinberga, S.3    Makrecka-Kuka, M.4    Liepinsh, E.5    Dambrova, M.6    Tars, K.7
  • 76
    • 72949126311 scopus 로고
    • Degradation of ergothioneine by cell-free extracts of Alcaligenes faecalis
    • Kelly B and Appleman MD (1961) Degradation of ergothioneine by cell-free extracts of Alcaligenes faecalis. J Bacteriol 81:715-720.
    • (1961) J Bacteriol , vol.81 , pp. 715-720
    • Kelly, B.1    Appleman, M.D.2
  • 77
    • 0031042750 scopus 로고    scopus 로고
    • Bacterial carnitine metabolism
    • Kleber H-P (1997) Bacterial carnitine metabolism. FEMS Microbiol Lett 147:1-9.
    • (1997) FEMS Microbiol Lett , vol.147 , pp. 1-9
    • Kleber, H.-P.1
  • 78
    • 0017576238 scopus 로고
    • Utilization of trimethylammonium-compounds by Acinetobacter calcoaceticus
    • author's transl
    • Kleber H-P, Seim H, Aurich H, and Strack E (1977) [Utilization of trimethylammonium-compounds by Acinetobacter calcoaceticus (author's transl)]. Arch Microbiol 112:201-206.
    • (1977) Arch Microbiol , vol.112 , pp. 201-206
    • Kleber, H.-P.1    Seim, H.2    Aurich, H.3    Strack, E.4
  • 79
    • 0017936519 scopus 로고
    • Interrelationships between carnitine metabolism and fatty acid assimilation in Pseudomonas putida
    • author's transl
    • Kleber H-P, Seim H, Aurich H, and Strack E (1978) [Interrelationships between carnitine metabolism and fatty acid assimilation in Pseudomonas putida (author's transl)]. Arch Microbiol 116:213-220.
    • (1978) Arch Microbiol , vol.116 , pp. 213-220
    • Kleber, H.-P.1    Seim, H.2    Aurich, H.3    Strack, E.4
  • 82
    • 23044469807 scopus 로고    scopus 로고
    • Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants
    • Koukouritaki SB, Poch MT, Cabacungan ET, McCarver DG, and Hines RN (2005) Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. Mol Pharmacol 68:383-392.
    • (2005) Mol Pharmacol , vol.68 , pp. 383-392
    • Koukouritaki, S.B.1    Poch, M.T.2    Cabacungan, E.T.3    McCarver, D.G.4    Hines, R.N.5
  • 83
    • 0036157094 scopus 로고    scopus 로고
    • Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression
    • Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, and Hines RN (2002) Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. Pediatr Res 51:236-243.
    • (2002) Pediatr Res , vol.51 , pp. 236-243
    • Koukouritaki, S.B.1    Simpson, P.2    Yeung, C.K.3    Rettie, A.E.4    Hines, R.N.5
  • 84
    • 19444375492 scopus 로고    scopus 로고
    • Mammalian flavin-containing monooxygenases: Structure/function, genetic polymorphisms and role in drug metabolism
    • Krueger SK and Williams DE (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther 106:357-387.
    • (2005) Pharmacol Ther , vol.106 , pp. 357-387
    • Krueger, S.K.1    Williams, D.E.2
  • 86
    • 0021042850 scopus 로고
    • Purification and properties of trimethylamine oxide reductase from Salmonella typhimurium
    • Kwan HS and Barrett EL (1983) Purification and properties of trimethylamine oxide reductase from Salmonella typhimurium. J Bacteriol 155:1455-1458.
    • (1983) J Bacteriol , vol.155 , pp. 1455-1458
    • Kwan, H.S.1    Barrett, E.L.2
  • 87
    • 0032531915 scopus 로고    scopus 로고
    • Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: Selective catalysis by FMO3
    • Lang DH, Yeung CK, Peter RM, Ibarra C, Gasser R, Itagaki K, Philpot RM, and Rettie AE (1998) Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3. Biochem Pharmacol 56:1005-1012.
    • (1998) Biochem Pharmacol , vol.56 , pp. 1005-1012
    • Lang, D.H.1    Yeung, C.K.2    Peter, R.M.3    Ibarra, C.4    Gasser, R.5    Itagaki, K.6    Philpot, R.M.7    Rettie, A.E.8
  • 88
    • 0015365159 scopus 로고
    • The reduced nicotinamide-adenine dinucleotide phosphate- and oxygen-dependent N-oxygenation of trimethylamine by Pseudomonas aminovorans
    • Large PJ, Boulton CA, and Crabbe MJ (1972) The reduced nicotinamide-adenine dinucleotide phosphate- and oxygen-dependent N-oxygenation of trimethylamine by Pseudomonas aminovorans. Biochem J 128:137P-138P.
    • (1972) Biochem J , vol.128 , pp. 137P-138P
    • Large, P.J.1    Boulton, C.A.2    Crabbe, M.J.3
  • 89
    • 0037974644 scopus 로고    scopus 로고
    • Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: Comparative genetic and functional studies
    • Lattard V, Zhang J, Tran Q, Furnes B, Schlenk D, and Cashman JR (2003) Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studies. Drug Metab Dispos 31:854-860.
    • (2003) Drug Metab Dispos , vol.31 , pp. 854-860
    • Lattard, V.1    Zhang, J.2    Tran, Q.3    Furnes, B.4    Schlenk, D.5    Cashman, J.R.6
  • 90
    • 0017596525 scopus 로고
    • A numerical taxonomic study of some Pseudomonas-like marine bacteria
    • Lee JV, Gibson DM, and Shewan JM (1977) A numerical taxonomic study of some Pseudomonas-like marine bacteria. J Gen Microbiol 98:439-451.
    • (1977) J Gen Microbiol , vol.98 , pp. 439-451
    • Lee, J.V.1    Gibson, D.M.2    Shewan, J.M.3
  • 91
    • 0013614867 scopus 로고
    • Bacteriology of spoilage of fish muscle. 3. Characterization of spoilers
    • Lerke P, Adams R, and Farber L (1965) Bacteriology of spoilage of fish muscle. 3. Characterization of spoilers. Appl Microbiol 13:625-630.
    • (1965) Appl Microbiol , vol.13 , pp. 625-630
    • Lerke, P.1    Adams, R.2    Farber, L.3
  • 92
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, and Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444:1022-1023.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 93
    • 0024468111 scopus 로고
    • Potentiation of ferrous sulphate and ascorbate on the microbial transformation of endogenous trimethylamine N-oxide to trimethylamine and dimethylamine in squid extracts
    • Lin JK and Hurng DC (1989) Potentiation of ferrous sulphate and ascorbate on the microbial transformation of endogenous trimethylamine N-oxide to trimethylamine and dimethylamine in squid extracts. Food Chem Toxicol 27:613-618.
    • (1989) Food Chem Toxicol , vol.27 , pp. 613-618
    • Lin, J.K.1    Hurng, D.C.2
  • 96
    • 0019168341 scopus 로고
    • Physiology of dark fermentative growth of Rhodopseudomonas capsulata
    • Madigan MT, Cox JC, and Gest H (1980) Physiology of dark fermentative growth of Rhodopseudomonas capsulata. J Bacteriol 142:908-915.
    • (1980) J Bacteriol , vol.142 , pp. 908-915
    • Madigan, M.T.1    Cox, J.C.2    Gest, H.3
  • 97
    • 84928820610 scopus 로고    scopus 로고
    • Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria
    • Martínez-del Campo A, Bodea S, Hamer HA, Marks JA, Haiser HJ, Turnbaugh PJ, and Balskus EP (2015) Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria. MBio 6:e00042-15.
    • (2015) MBio , vol.6 , pp. e00042-e00115
    • Martínez-Del Campo, A.1    Bodea, S.2    Hamer, H.A.3    Marks, J.A.4    Haiser, H.J.5    Turnbaugh, P.J.6    Balskus, E.P.7
  • 98
    • 9244265499 scopus 로고    scopus 로고
    • Benzydamine metabolism in vivo is impaired in patients with deficiency of flavin-containing monooxygenase 3
    • Mayatepek E, Flock B, and Zschocke J (2004) Benzydamine metabolism in vivo is impaired in patients with deficiency of flavin-containing monooxygenase 3. Pharmacogenetics 14:775-777.
    • (2004) Pharmacogenetics , vol.14 , pp. 775-777
    • Mayatepek, E.1    Flock, B.2    Zschocke, J.3
  • 99
    • 84936152910 scopus 로고    scopus 로고
    • Carnitine in bacterial physiology and metabolism
    • Meadows JA and Wargo MJ (2015) Carnitine in bacterial physiology and metabolism. Microbiology 161:1161-1174.
    • (2015) Microbiology , vol.161 , pp. 1161-1174
    • Meadows, J.A.1    Wargo, M.J.2
  • 100
    • 0019274501 scopus 로고
    • Effect of dissolved oxygen tension on the metabolism of methylated amines in Hyphomicrobium X in the absence and presence of nitrate: Evidence for "aerobic" denitrification
    • Meiberg JBM, Bruinenberg PM, and Harder W (1980) Effect of dissolved oxygen tension on the metabolism of methylated amines in Hyphomicrobium X in the absence and presence of nitrate: Evidence for "aerobic" denitrification. Microbiol 120:453-463.
    • (1980) Microbiol , vol.120 , pp. 453-463
    • Meiberg, J.B.M.1    Bruinenberg, P.M.2    Harder, W.3
  • 104
    • 33749006371 scopus 로고    scopus 로고
    • Trimethylaminuria (fish-odour syndrome) and oral malodour
    • Mitchell SC (2005) Trimethylaminuria (fish-odour syndrome) and oral malodour. Oral Dis 11 (Suppl 1):10-13.
    • (2005) Oral Dis , vol.11 , pp. 10-13
    • Mitchell, S.C.1
  • 105
    • 0035061010 scopus 로고    scopus 로고
    • Trimethylaminuria: The fish malodor syndrome
    • Mitchell SC and Smith RL (2001) Trimethylaminuria: the fish malodor syndrome. Drug Metab Dispos 29:517-521.
    • (2001) Drug Metab Dispos , vol.29 , pp. 517-521
    • Mitchell, S.C.1    Smith, R.L.2
  • 106
    • 77950821312 scopus 로고    scopus 로고
    • A physiological role for flavin-containing monooxygenase (FMO3) in humans?
    • Mitchell SC and Smith RL (2010) A physiological role for flavin-containing monooxygenase (FMO3) in humans? Xenobiotica 40:301-305.
    • (2010) Xenobiotica , vol.40 , pp. 301-305
    • Mitchell, S.C.1    Smith, R.L.2
  • 107
    • 84964820615 scopus 로고    scopus 로고
    • Trimethylamine-the extracorporeal envoy
    • Mitchell SC and Smith RL (2016) Trimethylamine-the extracorporeal envoy. Chem Senses 41:275-279.
    • (2016) Chem Senses , vol.41 , pp. 275-279
    • Mitchell, S.C.1    Smith, R.L.2
  • 108
    • 0036591308 scopus 로고    scopus 로고
    • Chemical and biological liberation of trimethylamine from foods
    • Mitchell SC, Zhang AQ, and Smith RL (2002) Chemical and biological liberation of trimethylamine from foods. J Food Compos Anal 15:277-282.
    • (2002) J Food Compos Anal , vol.15 , pp. 277-282
    • Mitchell, S.C.1    Zhang, A.Q.2    Smith, R.L.3
  • 109
    • 0020449893 scopus 로고
    • Assimilation of γ-butyrobetaine, and D-and L-carnitine by resting cell suspensions of Acinetobacter calcoaceticus and Pseudomonas putida
    • Miura-Fraboni J, Kleber H-P, and Englard S (1982) Assimilation of γ-butyrobetaine, and D-and L-carnitine by resting cell suspensions of Acinetobacter calcoaceticus and Pseudomonas putida. Arch Microbiol 133:217-221.
    • (1982) Arch Microbiol , vol.133 , pp. 217-221
    • Miura-Fraboni, J.1    Kleber, H.-P.2    Englard, S.3
  • 110
    • 0032933366 scopus 로고    scopus 로고
    • Haloanaerobacter salinarius sp. nov., a novel halophilic fermentative bacterium that reduces glycine-betaine to trimethylamine with hydrogen or serine as electron donors; emendation of the genus Haloanaerobacter
    • Mouné S, Manac'h N, Hirschler A, Caumette P, Willison JC, and Matheron R (1999) Haloanaerobacter salinarius sp. nov., a novel halophilic fermentative bacterium that reduces glycine-betaine to trimethylamine with hydrogen or serine as electron donors; emendation of the genus Haloanaerobacter. Int J Syst Bacteriol 49:103-112.
    • (1999) Int J Syst Bacteriol , vol.49 , pp. 103-112
    • Mouné, S.1    Manac'H, N.2    Hirschler, A.3    Caumette, P.4    Willison, J.C.5    Matheron, R.6
  • 111
    • 0022529568 scopus 로고
    • Degradation of various amine compounds by mesophilic clostridia
    • Möller B, Hippe H, and Gottschalk G (1986) Degradation of various amine compounds by mesophilic clostridia. Arch Microbiol 145:85-90.
    • (1986) Arch Microbiol , vol.145 , pp. 85-90
    • Möller, B.1    Hippe, H.2    Gottschalk, G.3
  • 112
    • 84878688082 scopus 로고    scopus 로고
    • Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine
    • Muramatsu H, Matsuo H, Okada N, Ueda M, Yamamoto H, Kato S, and Nagata S (2013) Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine. Appl Microbiol Biotechnol 97:5389-5400.
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 5389-5400
    • Muramatsu, H.1    Matsuo, H.2    Okada, N.3    Ueda, M.4    Yamamoto, H.5    Kato, S.6    Nagata, S.7
  • 113
    • 0033820669 scopus 로고    scopus 로고
    • The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: Comparison with cisapride and mosapride citrate
    • Mushiroda T, Douya R, Takahara E, and Nagata O (2000) The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug Metab Dispos 28:1231-1237.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1231-1237
    • Mushiroda, T.1    Douya, R.2    Takahara, E.3    Nagata, O.4
  • 114
    • 0014973421 scopus 로고
    • The metabolism of trimethylamine N-oxide by Bacillus PM6
    • Myers PA and Zatman LJ (1971) The metabolism of trimethylamine N-oxide by Bacillus PM6. Biochem J 121:10P.
    • (1971) Biochem J , vol.121 , pp. 10P
    • Myers, P.A.1    Zatman, L.J.2
  • 115
    • 0020698168 scopus 로고
    • Betaine: New oxidant in the Stickland reaction and methanogenesis from betaine and l-alanine by a Clostridium sporogenes-Methanosarcina barkeri coculture
    • Naumann E, Hippe H, and Gottschalk G (1983) Betaine: New oxidant in the Stickland reaction and methanogenesis from betaine and l-alanine by a Clostridium sporogenes-Methanosarcina barkeri coculture. Appl Environ Microbiol 45:474-483.
    • (1983) Appl Environ Microbiol , vol.45 , pp. 474-483
    • Naumann, E.1    Hippe, H.2    Gottschalk, G.3
  • 118
    • 49449109115 scopus 로고    scopus 로고
    • Diversity of human vaginal bacterial communities and associations with clinically defined bacterial vaginosis
    • Oakley BB, Fiedler TL, Marrazzo JM, and Fredricks DN (2008) Diversity of human vaginal bacterial communities and associations with clinically defined bacterial vaginosis. Appl Environ Microbiol 74:4898-4909.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 4898-4909
    • Oakley, B.B.1    Fiedler, T.L.2    Marrazzo, J.M.3    Fredricks, D.N.4
  • 119
    • 84884175034 scopus 로고    scopus 로고
    • The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway
    • Obeid R (2013) The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients 5:3481-3495.
    • (2013) Nutrients , vol.5 , pp. 3481-3495
    • Obeid, R.1
  • 120
    • 84959885103 scopus 로고    scopus 로고
    • Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism
    • Obeid R, Awwad HM, Rabagny Y, Graeber S, Herrmann W, and Geisel J (2016) Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism. Am J Clin Nutr 103:703-711.
    • (2016) Am J Clin Nutr , vol.103 , pp. 703-711
    • Obeid, R.1    Awwad, H.M.2    Rabagny, Y.3    Graeber, S.4    Herrmann, W.5    Geisel, J.6
  • 121
  • 122
    • 24944435434 scopus 로고    scopus 로고
    • Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin
    • Parte P and Kupfer D (2005) Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. Drug Metab Dispos 33:1446-1452.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1446-1452
    • Parte, P.1    Kupfer, D.2
  • 125
    • 37249028167 scopus 로고    scopus 로고
    • The flavin-containing monooxygenases (FMOs): Genetic variation and its consequences for the metabolism of therapeutic drugs
    • Phillips IR, Francois AA, and Shephard EA (2007) The flavin-containing monooxygenases (FMOs): genetic variation and its consequences for the metabolism of therapeutic drugs. Curr Pharmacogenomics 5:292-313.
    • (2007) Curr Pharmacogenomics , vol.5 , pp. 292-313
    • Phillips, I.R.1    Francois, A.A.2    Shephard, E.A.3
  • 126
    • 44549087470 scopus 로고    scopus 로고
    • Flavin-containing monooxygenases: Mutations, disease and drug response
    • Phillips IR and Shephard EA (2008) Flavin-containing monooxygenases: mutations, disease and drug response. Trends Pharmacol Sci 29:294-301.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 294-301
    • Phillips, I.R.1    Shephard, E.A.2
  • 127
    • 0025765643 scopus 로고
    • Metabolic fate of dietary carnitine in human adults: Identification and quantification of urinary and fecal metabolites
    • Rebouche CJ and Chenard CA (1991) Metabolic fate of dietary carnitine in human adults: identification and quantification of urinary and fecal metabolites. J Nutr 121:539-546.
    • (1991) J Nutr , vol.121 , pp. 539-546
    • Rebouche, C.J.1    Chenard, C.A.2
  • 128
    • 0031816464 scopus 로고    scopus 로고
    • Carnitine metabolism and its regulation in microorganisms and mammals
    • Rebouche CJ and Seim H (1998) Carnitine metabolism and its regulation in microorganisms and mammals. Annu Rev Nutr 18:39-61.
    • (1998) Annu Rev Nutr , vol.18 , pp. 39-61
    • Rebouche, C.J.1    Seim, H.2
  • 129
    • 0021141418 scopus 로고
    • Amino acid and lactate catabolism in trimethylamine oxide respiration of Alteromonas putrefaciens NCMB 1735
    • Ringø E, Stenberg E, and Strøm AR (1984) Amino acid and lactate catabolism in trimethylamine oxide respiration of Alteromonas putrefaciens NCMB 1735. Appl Environ Microbiol 47:1084-1089.
    • (1984) Appl Environ Microbiol , vol.47 , pp. 1084-1089
    • Ringø, E.1    Stenberg, E.2    Strøm, A.R.3
  • 130
    • 76949128011 scopus 로고
    • A mechanism of halophilism in Micrococcus halodenitrificans
    • Robinson J, Gibbons NE, and Thatcher FS (1952) A mechanism of halophilism in Micrococcus halodenitrificans. J Bacteriol 64:69-77.
    • (1952) J Bacteriol , vol.64 , pp. 69-77
    • Robinson, J.1    Gibbons, N.E.2    Thatcher, F.S.3
  • 131
    • 84930004775 scopus 로고    scopus 로고
    • Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide
    • Romano KA, Vivas EI, Amador-Noguez D, and Rey FE (2015) Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio 6:e02481.
    • (2015) MBio , vol.6 , pp. e02481
    • Romano, K.A.1    Vivas, E.I.2    Amador-Noguez, D.3    Rey, F.E.4
  • 132
    • 84859101744 scopus 로고    scopus 로고
    • Halitology (breath odour: Aetiopathogenesis and management)
    • Scully C and Greenman J (2012) Halitology (breath odour: aetiopathogenesis and management). Oral Dis 18:333-345.
    • (2012) Oral Dis , vol.18 , pp. 333-345
    • Scully, C.1    Greenman, J.2
  • 133
    • 77952368044 scopus 로고    scopus 로고
    • In vitro reconstitution of Mycobacterial ergothioneine biosynthesis
    • Seebeck FP (2010) In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. J Am Chem Soc 132:6632-6633.
    • (2010) J Am Chem Soc , vol.132 , pp. 6632-6633
    • Seebeck, F.P.1
  • 134
    • 0020080137 scopus 로고
    • Formation of γ-butyrobetaine and trimethylamine from quaternary ammonium compounds structure-related to L-carnitine and choline by Proteus vulgaris
    • Seim H, Löster H, Claus R, Kleber H-P, and Strack E (1982a) Formation of γ-butyrobetaine and trimethylamine from quaternary ammonium compounds structure-related to L-carnitine and choline by Proteus vulgaris. FEMS Microbiol Lett 13:201-205.
    • (1982) FEMS Microbiol Lett , vol.13 , pp. 201-205
    • Seim, H.1    Löster, H.2    Claus, R.3    Kleber, H.-P.4    Strack, E.5
  • 135
    • 0020434812 scopus 로고
    • Splitting of the C-N bond in carnitine by an enzyme (trimethylamine forming) from membranes of Acinetobacter calcoaceticus
    • Seim H, Löster H, Claus R, Kleber H-P, and Strack E (1982b) Splitting of the C-N bond in carnitine by an enzyme (trimethylamine forming) from membranes of Acinetobacter calcoaceticus. FEMS Microbiol Lett 15:165-167.
    • (1982) FEMS Microbiol Lett , vol.15 , pp. 165-167
    • Seim, H.1    Löster, H.2    Claus, R.3    Kleber, H.-P.4    Strack, E.5
  • 136
    • 0022154525 scopus 로고
    • Catabolic pathways for high-dosed L(-)- or D(+)-carnitine in germ-free rats?
    • Seim H, Schulze J, and Strack E (1985) Catabolic pathways for high-dosed L(-)- or D(+)-carnitine in germ-free rats? Biol Chem Hoppe Seyler 366:1017-1021.
    • (1985) Biol Chem Hoppe Seyler , vol.366 , pp. 1017-1021
    • Seim, H.1    Schulze, J.2    Strack, E.3
  • 137
    • 0036066808 scopus 로고    scopus 로고
    • Growth of Campylobacter jejuni supported by respiration of fumarate, nitrate, nitrite, trimethylamine-N-oxide, or dimethyl sulfoxide requires oxygen
    • Sellars MJ, Hall SJ, and Kelly DJ (2002) Growth of Campylobacter jejuni supported by respiration of fumarate, nitrate, nitrite, trimethylamine-N-oxide, or dimethyl sulfoxide requires oxygen. J Bacteriol 184:4187-4196.
    • (2002) J Bacteriol , vol.184 , pp. 4187-4196
    • Sellars, M.J.1    Hall, S.J.2    Kelly, D.J.3
  • 139
    • 0014266391 scopus 로고
    • Psychrophilic spoilage bacteria of fish
    • Shaw BG and Shewan JM (1968) Psychrophilic spoilage bacteria of fish. J Appl Bacteriol 31: 89-96.
    • (1968) J Appl Bacteriol , vol.31 , pp. 89-96
    • Shaw, B.G.1    Shewan, J.M.2
  • 140
    • 84939269158 scopus 로고    scopus 로고
    • Clinical utility gene card for: Trimethylaminuria - Update 2014
    • Shephard EA, Treacy EP, and Phillips IR (2015) Clinical utility gene card for: Trimethylaminuria - update 2014. Eur J Hum Genet DOI: 10.1038/ejhg.2014.226.
    • (2015) Eur J Hum Genet
    • Shephard, E.A.1    Treacy, E.P.2    Phillips, I.R.3
  • 141
  • 142
    • 84899067156 scopus 로고    scopus 로고
    • Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population
    • Shimizu M, Allerston CK, Shephard EA, Yamazaki H, and Phillips IR (2014) Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population. Br J Clin Pharmacol 77:839-851.
    • (2014) Br J Clin Pharmacol , vol.77 , pp. 839-851
    • Shimizu, M.1    Allerston, C.K.2    Shephard, E.A.3    Yamazaki, H.4    Phillips, I.R.5
  • 144
    • 84888134623 scopus 로고    scopus 로고
    • Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients
    • Söderberg MM, Haslemo T, Molden E, and Dahl M-L (2013) Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients. Pharmacogenomics J 13:544-550.
    • (2013) Pharmacogenomics J , vol.13 , pp. 544-550
    • Söderberg, M.M.1    Haslemo, T.2    Molden, E.3    Dahl, M.-L.4
  • 145
    • 0020077680 scopus 로고
    • Trimethylamine oxide respiration in Proteus sp. strain NTHC153: Electron transfer-dependent phosphorylation and L-serine transport
    • Stenberg E, Styrvold OB, and Strøm AR (1982) Trimethylamine oxide respiration in Proteus sp. strain NTHC153: electron transfer-dependent phosphorylation and L-serine transport. J Bacteriol 149:22-28.
    • (1982) J Bacteriol , vol.149 , pp. 22-28
    • Stenberg, E.1    Styrvold, O.B.2    Strøm, A.R.3
  • 146
    • 0018772359 scopus 로고
    • Trimethylamine oxide: A terminal electron acceptor in anaerobic respiration of bacteria
    • Strøm AR, Olafsen JA, and Larsen H (1979) Trimethylamine oxide: a terminal electron acceptor in anaerobic respiration of bacteria. J Gen Microbiol 112:315-320.
    • (1979) J Gen Microbiol , vol.112 , pp. 315-320
    • Strøm, A.R.1    Olafsen, J.A.2    Larsen, H.3
  • 147
    • 0019840536 scopus 로고
    • Proton translocation coupled to trimethylamine N-oxide reduction in anaerobically grown Escherichia coli
    • Takagi M, Tsuchiya T, and Ishimoto M (1981) Proton translocation coupled to trimethylamine N-oxide reduction in anaerobically grown Escherichia coli. J Bacteriol 148:762-768.
    • (1981) J Bacteriol , vol.148 , pp. 762-768
    • Takagi, M.1    Tsuchiya, T.2    Ishimoto, M.3
  • 148
    • 84880208801 scopus 로고    scopus 로고
    • Fish intake and risks of total and cause-specific mortality in 2 population-based cohort studies of 134,296 men and women
    • Takata Y, Zhang X, Li H, Gao Y-T, Yang G, Gao J, Cai H, Xiang Y-B, Zheng W, and Shu X-O (2013) Fish intake and risks of total and cause-specific mortality in 2 population-based cohort studies of 134,296 men and women. Am J Epidemiol 178:46-57.
    • (2013) Am J Epidemiol , vol.178 , pp. 46-57
    • Takata, Y.1    Zhang, X.2    Li, H.3    Gao, Y.-T.4    Yang, G.5    Gao, J.6    Cai, H.7    Xiang, Y.-B.8    Zheng, W.9    Shu, X.-O.10
  • 149
    • 84925862053 scopus 로고    scopus 로고
    • Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease
    • Tang WHW, Wang Z, Kennedy DJ, Wu Y, Buffa JA, Agatisa-Boyle B, Li XS, Levison BS, and Hazen SL (2015) Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res 116:448-455.
    • (2015) Circ Res , vol.116 , pp. 448-455
    • Tang, W.H.W.1    Wang, Z.2    Kennedy, D.J.3    Wu, Y.4    Buffa, J.A.5    Agatisa-Boyle, B.6    Li, X.S.7    Levison, B.S.8    Hazen, S.L.9
  • 153
    • 84942364182 scopus 로고    scopus 로고
    • TMAO: A small molecule of great expectations
    • Ufnal M, Zadlo A, and Ostaszewski R (2015) TMAO: A small molecule of great expectations. Nutrition 31:1317-1323.
    • (2015) Nutrition , vol.31 , pp. 1317-1323
    • Ufnal, M.1    Zadlo, A.2    Ostaszewski, R.3
  • 154
    • 0013852731 scopus 로고
    • Intracellular localization and properties of trimethylamine-N-oxide reductase in Vibrio parahaemolyticus
    • Unemoto T, Hayashi M, Miyaki K, and Hayashi M (1965) Intracellular localization and properties of trimethylamine-N-oxide reductase in Vibrio parahaemolyticus. Biochim Biophys Acta 110:319-328.
    • (1965) Biochim Biophys Acta , vol.110 , pp. 319-328
    • Unemoto, T.1    Hayashi, M.2    Miyaki, K.3    Hayashi, M.4
  • 155
    • 0014028717 scopus 로고
    • Formation of trimethylamine from DL-carnitine by Serratia marcescens
    • Unemoto T, Hayashi M, Miyaki K, and Hayashi M (1966) Formation of trimethylamine from DL-carnitine by Serratia marcescens. Biochim Biophys Acta 121:220-222.
    • (1966) Biochim Biophys Acta , vol.121 , pp. 220-222
    • Unemoto, T.1    Hayashi, M.2    Miyaki, K.3    Hayashi, M.4
  • 156
    • 84956700594 scopus 로고    scopus 로고
    • Trimethylaminuria and dimethylglycine dehydrogenase deficiency
    • (Saudubray J-M, van den Berghe G, and Walker JH, eds) Springer, Berlin, Germany
    • Walker V and Wevers RA (2012) Trimethylaminuria and dimethylglycine dehydrogenase deficiency, in Inborn Metabolic Diseases (Saudubray J-M, van den Berghe G, and Walker JH, eds) pp 431-435, Springer, Berlin, Germany.
    • (2012) Inborn Metabolic Diseases , pp. 431-435
    • Walker, V.1    Wevers, R.A.2
  • 161
    • 80054996041 scopus 로고    scopus 로고
    • Individuals reporting idiopathic malodor production: Demographics and incidence of trimethylaminuria
    • Wise PM, Eades J, Tjoa S, Fennessey PV, and Preti G (2011) Individuals reporting idiopathic malodor production: demographics and incidence of trimethylaminuria. Am J Med 124:1058-1063.
    • (2011) Am J Med , vol.124 , pp. 1058-1063
    • Wise, P.M.1    Eades, J.2    Tjoa, S.3    Fennessey, P.V.4    Preti, G.5
  • 162
    • 73649165875 scopus 로고
    • Ergothionase from Escherichia coli
    • Wolff JB (1962) Ergothionase from Escherichia coli. J Biol Chem 237:874-881.
    • (1962) J Biol Chem , vol.237 , pp. 874-881
    • Wolff, J.B.1
  • 163
    • 0036876295 scopus 로고    scopus 로고
    • Trimethylamine content in vaginal secretion and its relation to bacterial vaginosis
    • Wolrath H, Borén H, Hallén A, and Forsum U (2002) Trimethylamine content in vaginal secretion and its relation to bacterial vaginosis. APMIS 110:819-824.
    • (2002) APMIS , vol.110 , pp. 819-824
    • Wolrath, H.1    Borén, H.2    Hallén, A.3    Forsum, U.4
  • 164
    • 85015357123 scopus 로고
    • A primary division of the genus Shigella based on the trimethylamine test
    • Wood AJ, Baird EA, and Keeping FE (1943) A primary division of the genus Shigella based on the trimethylamine test. J Bacteriol 46:106-107.
    • (1943) J Bacteriol , vol.46 , pp. 106-107
    • Wood, A.J.1    Baird, E.A.2    Keeping, F.E.3
  • 165
    • 84931232146 scopus 로고
    • The formation of trimethylamine from choline as a characteristic of Shigella alkalescens
    • Wood AJ and Keeping FE (1944) The formation of trimethylamine from choline as a characteristic of Shigella alkalescens. J Bacteriol 47:309-310.
    • (1944) J Bacteriol , vol.47 , pp. 309-310
    • Wood, A.J.1    Keeping, F.E.2
  • 166
    • 79958233687 scopus 로고    scopus 로고
    • Methylotrophic bacteria in trimethylaminuria and bacterial vaginosis
    • (Timmis KN, McGenity TJ, van der Meer JR, and de Lorenzo V, eds) Springer, Berlin, Germany
    • Wood AP, Warren FJ, and Kelly DP (2010) Methylotrophic bacteria in trimethylaminuria and bacterial vaginosis, in Handbook of Hydrocarbon and Lipid Microbiology (Timmis KN, McGenity TJ, van der Meer JR, and de Lorenzo V, eds) pp 3227-3240, Springer, Berlin, Germany.
    • (2010) Handbook of Hydrocarbon and Lipid Microbiology , pp. 3227-3240
    • Wood, A.P.1    Warren, F.J.2    Kelly, D.P.3
  • 167
    • 84969261931 scopus 로고    scopus 로고
    • A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat
    • Xu R, Wang Q, and Li L (2015) A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat. BMC Genomics 16 (Suppl 7):S4.
    • (2015) BMC Genomics , vol.16 , pp. S4
    • Xu, R.1    Wang, Q.2    Li, L.3
  • 168
    • 84877609807 scopus 로고    scopus 로고
    • Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities
    • Yamazaki H and Shimizu M (2013) Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities. Biochem Pharmacol 85:1588-1593.
    • (2013) Biochem Pharmacol , vol.85 , pp. 1588-1593
    • Yamazaki, H.1    Shimizu, M.2
  • 169
    • 70449187131 scopus 로고
    • Degradation of ergothioneine by Alcaligenes faecalis
    • Yanasugondha D and Appleman MD (1957) Degradation of ergothioneine by Alcaligenes faecalis. J Bacteriol 74:381-385.
    • (1957) J Bacteriol , vol.74 , pp. 381-385
    • Yanasugondha, D.1    Appleman, M.D.2
  • 170
    • 84908439879 scopus 로고    scopus 로고
    • Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy
    • Yang Y, Liu Y, Zheng L, Wu T, Li J, Zhang Q, Li X, Yuan F, Wang L, and Guo J (2014) Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. Mol Biosyst 10:3170-3178.
    • (2014) Mol Biosyst , vol.10 , pp. 3170-3178
    • Yang, Y.1    Liu, Y.2    Zheng, L.3    Wu, T.4    Li, J.5    Zhang, Q.6    Li, X.7    Yuan, F.8    Wang, L.9    Guo, J.10
  • 172
    • 0025151131 scopus 로고
    • Choline deficiency
    • Zeisel SH (1990) Choline deficiency. J Nutr Biochem 1:332-349.
    • (1990) J Nutr Biochem , vol.1 , pp. 332-349
    • Zeisel, S.H.1
  • 173
    • 0024335291 scopus 로고
    • Conversion of dietary choline to trimethylamine and dimethylamine in rats: Dose-response relationship
    • Zeisel SH, daCosta KA, Youssef M, and Hensey S (1989) Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship. J Nutr 119:800-804.
    • (1989) J Nutr , vol.119 , pp. 800-804
    • Zeisel, S.H.1    DaCosta, K.A.2    Youssef, M.3    Hensey, S.4
  • 174
    • 0038333251 scopus 로고    scopus 로고
    • Concentrations of choline-containing compounds and betaine in common foods
    • Zeisel SH, Mar M-H, Howe JC, and Holden JM (2003) Concentrations of choline-containing compounds and betaine in common foods. JNutr133:1302-1307.
    • (2003) JNutr , vol.133 , pp. 1302-1307
    • Zeisel, S.H.1    Mar, M.-H.2    Howe, J.C.3    Holden, J.M.4
  • 175
    • 0020623387 scopus 로고
    • Formation of methylamines from ingested choline and lecithin
    • Zeisel SH, Wishnok JS, and Blusztajn JK (1983) Formation of methylamines from ingested choline and lecithin. J Pharmacol Exp Ther 225:320-324.
    • (1983) J Pharmacol Exp Ther , vol.225 , pp. 320-324
    • Zeisel, S.H.1    Wishnok, J.S.2    Blusztajn, J.K.3
  • 177
    • 0033029263 scopus 로고    scopus 로고
    • Dietary precursors of trimethylamine in man: A pilot study
    • Zhang AQ, Mitchell SC, and Smith RL (1999) Dietary precursors of trimethylamine in man: a pilot study. Food Chem Toxicol 37:515-520.
    • (1999) Food Chem Toxicol , vol.37 , pp. 515-520
    • Zhang, A.Q.1    Mitchell, S.C.2    Smith, R.L.3
  • 180
    • 0023783557 scopus 로고
    • Eubacterium acidaminophilum sp. nov., a versatile amino acid-degrading anaerobe producing or utilizing H2 or formate
    • Zindel U, Freudenberg W, Rieth M, Andreesen JR, Schnell J, and Widdel F (1988) Eubacterium acidaminophilum sp. nov., a versatile amino acid-degrading anaerobe producing or utilizing H2 or formate. Arch Microbiol 150:254-266.
    • (1988) Arch Microbiol , vol.150 , pp. 254-266
    • Zindel, U.1    Freudenberg, W.2    Rieth, M.3    Andreesen, J.R.4    Schnell, J.5    Widdel, F.6
  • 181
    • 54349126970 scopus 로고    scopus 로고
    • High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota
    • Zoetendal EG, Rajilic-Stojanovic M, and de Vos WM (2008) High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut 57:1605-1615.
    • (2008) Gut , vol.57 , pp. 1605-1615
    • Zoetendal, E.G.1    Rajilic-Stojanovic, M.2    De Vos, W.M.3
  • 182
    • 0034129542 scopus 로고    scopus 로고
    • Biochemical and molecular studies in mild flavin monooxygenase 3 deficiency
    • Zschocke J and Mayatepek E (2000) Biochemical and molecular studies in mild flavin monooxygenase 3 deficiency. J Inherit Metab Dis 23:378-382.
    • (2000) J Inherit Metab Dis , vol.23 , pp. 378-382
    • Zschocke, J.1    Mayatepek, E.2


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