Hormonal regulation of microsomal flavin-containing monooxygenase activity by sex steroids and growth hormone in co-cultured adult male rat hepatocytes

Biochemical Pharmacology

Volumn 56, Issue 8, 1998, Pages 1047-1051

  Coecke, Sandra ^a   Debast, Gilda ^a   Phillips, Ian R ^b   Vercruysse, Antoine ^b   Shephard, Elizabeth A ^c   Rogiers, Vera ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

17 estradiol; 5 dihydrotestosterone; Flavin containing monooxygenase; Human growth hormone; Rat hepatocytes; Testosterone

Indexed keywords

ANDROSTANOLONE; COLLAGENASE; ESTRADIOL; HUMAN GROWTH HORMONE; SEX HORMONE; TESTOSTERONE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; DRUG EFFECT; ENZYME ACTIVITY; HORMONAL REGULATION; HORMONE METABOLISM; LIVER CELL; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; COCULTURE TECHNIQUES; DIHYDROTESTOSTERONE; EPITHELIAL CELLS; ESTRADIOL; GONADAL STEROID HORMONES; HUMAN GROWTH HORMONE; LIVER; MALE; MICROSOMES, LIVER; OXYGENASES; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL MATURATION; STEROIDS; TESTOSTERONE;

EID: 0032531667     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00104-X     Document Type: Article

References (26)

1. Cashman J.R., Olsen L.D., Lambert C.E., Presas M.J. Enantioselective S-oxygenation of para-methoxyphenyl-1,3-dithiolane by various tissue preparations: Effect of estradiol. Mol Pharmacol. 37:1990;319-327.
2. Das M.L., Ziegler D.M. Rat liver oxidative N-dealkylase and N-oxidase activities as a function of animal age. Arch Biochem Biophys. 140:1970;300-306.
3. Uehleke H., Reiner O., Hellmer K.H. Perinatal development of tertiary amine N-oxidation and NADP cytochrome reduction in rat liver microsomes. Mech Ageing Dev. 25:1971;1-22.
4. 4-steroid 5α-reductase, flavin-containing monooxygenase and sex-specific cytochromes P-450. J Biol Chem. 261:1986;10728-10735.
5. Bonate P.L. Gender-related differences in xenobiotic metabolism. J Clin Pharmacol. 31:1991;684-690.
6. Skett P. Hormonal regulation and sex differences of xenobiotic metabolism. Bridges J.W., Chasseaud L.F. Progress in Drug Metabolism. 1987;85-140 Taylor & Francis Ltd, London.
7. Lemoine A., Williams D.E., Cresteil T., Leroux J.P. Hormonal regulation of microsomal flavin-containing monooxygenase: Tissue-dependent expression and substrate specificity. Mol Pharmacol. 40:1991;211-217.
8. Lee M.Y., Clark J.E., Williams D.E. Induction of flavin-containing monooxygenase in rabbit lung and kidney by sex steroids and glucocorticoids. Arch Biochem Biophys. 302:1993;332-336.
9. Vind C., Dich J., Grunnet N. Regulation by growth hormone and glucocorticoid of testosterone metabolism in long-term cultures of hepatocytes from male and female rats. Biochem Pharmacol. 44:1992;1523-1528.
10. Gebhardt R., Fitzke H., Fausel M., Eisenmann-Tappe I., Mecke D. Influence of hormones and drugs on glutathione-S-transferase levels in primary culture of adult rat hepatocytes. Cell Biol Toxicol. 6:1990;365-378.
11. Rogiers V., Vandenberghe Y., Callaerts A., Sonck W., Vercruysse A. Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes. Toxicol in Vitro. 4:1990;439-442.
12. Kocarek T.A., Schuetz E.G., Guzelian P.S. Expression of multiple forms of cytochrome P-450 mRNAs in primary cultures of rat hepatocytes maintained on Matrigel. Mol Pharmacol. 43:1993;328-334.
13. Kocarek T.A., Schuetz E.G., Guzelian P.S. Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes. Mol Pharmacol. 38:1990;440-444.
14. Maier P. Development of in vitro toxicity tests with cultures of freshly isolated rat hepatocytes. Experientia. 44:1988;807-817.
15. Guillouzo A. Hepatotoxicity. Frazier J.M. In Vitro Toxicity Testing: Applications to Safety Evaluation. 1992;45-83 Marcel Dekker Inc, New York.
16. Coecke S., Segaert A., Vercruysse A., Rogiers V. Expression of flavin-containing monooxygenase in conventional and co-cultures of adult rat hepatocytes under various culture conditions. Toxicol in Vitro. 7:1993;487-491.
17. Eisenfeld A.J., Aten R. Estrogen receptors and androgen receptors in the mammalian liver. J Steroid Biochem. 27:1987;1109-1118.
18. Rogiers V, Paeme G, Vercruysse A, and Bouwens L, Procycline metabolism in isolated rat liver cells. In: Topics in Aging Research in Europe: Pharmacological, Morphological and Physiological Aspects of Liver Ageing (Ed. van Bezooijen CFA), Vol. 1, pp. 155-163. Eurage, Rijswijk, 1984.
19. Morel-Chany E., Guillouzo C., Trincal G. Spontaneous neoplastic transformation in vitro of epithelial cell strains of rat liver: Cytology, growth and enzymatic activities. Eur J Cancer. 14:1978;1341-1352.
20. Hales B., Neims A. Induction of rat hepatic glutathione S-transferase B by phenobarbital and 3-methylcholanthrene. Biochem Pharmacol. 26:1977;555-556.
21. Coecke S., Mertens K., Segaert A., Callaerts A., Vercruysse A., Rogiers V. Spectrophotometric measurement of flavin-containing monooxygenase activity in freshly isolated rat hepatocytes and their cultures. Anal Biochem. 205:1992;285-288.
22. Bradford M.M. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle protein dye binding. Anal Biochem. 72:1976;248-254.
23. + Advanced Statistics (Ed. Norusis MJ), pp. B152-B181. SPSS Inc, Chicago, B152-B181, 1984.
24. Rogiers V., Vandenberghe Y., Callaerts A., Verleye G., Cornet M., Mertens K., Sonck W., Vercruysse A. Phase I and Phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes. Biochem Pharmacol. 40:1990;1701-1706.
25. Plapinger L., McEwen B.S.S. Gonadal steroid-brain interactions in sexual differentiation. Huchinson J.B. Biologic Determinants of Sexual Behaviour. 1978;153-218 Plenum Publishing Corp, New York.
26. Gustafsson J.-A., Mode A., Norstedt G., Skett P. Sex steroid induced changes in hepatic enzymes. Annu Rev Physiol. 45:1983;51-60.